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Pharmaceutics and Drug Design Commons™
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- Aqueous antioxidants (1)
- CXCL1 (1)
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- Delayed-action preparations (1)
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Articles 1 - 5 of 5
Full-Text Articles in Pharmaceutics and Drug Design
Engineering Cxcr2-Ligand-Based Fusion Proteins To Modulate Myeloid Cell Trafficking In Pancreatic Cancer, Benjamin N. Christopher
Engineering Cxcr2-Ligand-Based Fusion Proteins To Modulate Myeloid Cell Trafficking In Pancreatic Cancer, Benjamin N. Christopher
MUSC Theses and Dissertations
Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of all cancers, and limited treatment options exist. Immunotherapy is effective in some cancer types, but the immunosuppressive tumor microenvironment (TME) of PDAC is a barrier to effective immunotherapy. CXCR2+ myeloid-derived suppressor cells (MDSCs) are abundant in PDAC tumors in humans and in mouse models. MDSCs suppress effector cell function, making them attractive targets for restoring anti-tumor immunity. The studies outlined in this dissertation (1) link tumor-intrinsic oncogenic signaling to dysregulated myeloid activity in PDAC, (2) describe a rationally designed fusion protein and potent inhibitor of CXCR2+ myeloid …
Identification And Characterization Of Novel, Small Molecule Inhibitors Of Spermine Oxidase, Amelia Bryn Furbish
Identification And Characterization Of Novel, Small Molecule Inhibitors Of Spermine Oxidase, Amelia Bryn Furbish
MUSC Theses and Dissertations
The major intracellular polyamines spermine and spermidine are abundant endogenous compounds that are essential for cellular growth and development. Dysregulation of polyamine metabolism has been implicated as a key mechanism of injury across multiple forms of clinically challenging pathologies. Of the enzymes within the polyamine pathway, the catabolic enzyme spermine oxidase (SMOX) is of particular interest as it is subject to induction in response to infection, neuronal excitotoxicity, ischemia, and oxidative stress. In addition to the loss of radical scavenging capabilities associated with spermine depletion, catabolism of spermine by SMOX results in the production of toxic byproducts, including H2 …
Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols, Robert M. Bennett
Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols, Robert M. Bennett
MUSC Theses and Dissertations
Current transdermal drug delivery systems are limited to delivery, via passive diffusion, of a few substances exhibiting natural skin penetrability. These substances are low molecular weight, highly potent agents possessing a certain degree of hydrophilicity as well as lipophilicity. These limitations are dictated by the outermost layer of the skin, the stratum corneum, which acts as a barrier. The stratum corneum consists mostly of the protein keratin. The barrier strength of keratin is attributed to its extensive disulfide bond cross-linking. In order to expand the spectrum of transdermal drug candidates this keratin barrier must be overcome. Low molecular weight primary …
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
MUSC Theses and Dissertations
The purpose of this research was to evaluate the effect of the poorly soluble diluents; calcium sulfate dihydrate, dibasic calcium phosphate dihydrate, and tribasic calcium phosphate on medicament release from solid dosage forms. Initial findings led to an investigation of the use of these diluents as matrix forming agents in the formulation of sustained release solid dosage farms. An existing single station tablet press was instrumented with a transducer strain gauge apparatus to monitor compression force applied during tablet manufacture. An automated dissolution system was used to determine medicament release from the dosage forms under investigation. These three diluents when …
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
MUSC Theses and Dissertations
Oxygen sensitive drugs in aqueous solutions are very susceptible to oxidative degradation. Antioxidants are frequently used to protect these drugs from oxidation. A 2-level resolution VI factorial was used to evaluate a glucose oxidase-catalase-glucose system and compare it to commonly used aqueous antioxidants. The drug models used to test the effectiveness of the enzyme system were ascorbic acid, morphine sulfate, and isoproterenol hydrochloride. The glucose oxidase system successfully protected the isoproterenol hydrochloride and was significantly better than the other systems tested. The glucose oxidase system was just as effective as the other antioxidants in protecting morphine sulfate. None of the …