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Full-Text Articles in Pharmaceutics and Drug Design
Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols, Robert M. Bennett
Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols, Robert M. Bennett
MUSC Theses and Dissertations
Current transdermal drug delivery systems are limited to delivery, via passive diffusion, of a few substances exhibiting natural skin penetrability. These substances are low molecular weight, highly potent agents possessing a certain degree of hydrophilicity as well as lipophilicity. These limitations are dictated by the outermost layer of the skin, the stratum corneum, which acts as a barrier. The stratum corneum consists mostly of the protein keratin. The barrier strength of keratin is attributed to its extensive disulfide bond cross-linking. In order to expand the spectrum of transdermal drug candidates this keratin barrier must be overcome. Low molecular weight primary …
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
MUSC Theses and Dissertations
The purpose of this research was to evaluate the effect of the poorly soluble diluents; calcium sulfate dihydrate, dibasic calcium phosphate dihydrate, and tribasic calcium phosphate on medicament release from solid dosage forms. Initial findings led to an investigation of the use of these diluents as matrix forming agents in the formulation of sustained release solid dosage farms. An existing single station tablet press was instrumented with a transducer strain gauge apparatus to monitor compression force applied during tablet manufacture. An automated dissolution system was used to determine medicament release from the dosage forms under investigation. These three diluents when …