Medical Specialties Commons^™

Calcitonin Gene Peptides: The Diagnostic Value Of Measurement In Medullary Thyroid Carcinoma, Samia I. Girgis, Catherine Lynch, Carmel J. Hillyard, John C. Stevenson, Patricia A. Hill, David W. R. Macdonald, Iain Macintyre

Henry Ford Hospital Medical Journal

The calcitonin gene encodes a family of peptides, at least three of which normally circulate in man: calcitonin (CT), a calcium-lowering hormone; katacalcin (KC), a peptide of unknown function; and calcitonin gene-related peptide (CGRP), a neuropeptide and potent vasodilator. In a study of 45 patients with medullary thyroid carcinoma (MTC), plasma CGRP was elevated in approximately 50% of cases. Furthermore, CGRP levels did not correlate with CT levels. However, plasma KC was elevated in all cases, with a good correlation with CT levels, as has been noted previously. Measurement of CT or KC appears to be superior to measurement of …

Clinical Value Of Calcitonin And Carcinoembryonic Antigen Doubling Times In Medullary Thyroid Carcinoma, Charles E. Jackson, Robert A. Norum, Gary B. Talpos, Carolyn S. Feldkamp, Armen H. Tashjian Jr.

Henry Ford Hospital Medical Journal

Doubling times of basal and stimulated calcitonin (CT) levels and of random carcinoembryonic antigen (CEA) levels were compared over time in 11 patients with residual medullary thyroid carcinoma (MTC)—five with the sporadic MTC and six with the hereditary MTC. Four patients with an indolent form of the disease showed little change in CT levels over three to eight years and little change in CEA doubling times (42 to 70+ months). Seven patients showing rapid progression of disease had CT doubling times of three to 11 months and CEA doubling times of two to 12 months (however, one patient showed no …

Importance Of Ultrasound Examination For The Follow-Up Of Medullary Thyroid Carcinoma: Comparison With Other Localization Methods, Karin Frank, Friedhelm Raue, Dorothea Lorenz, Christian Herfarth, Reinhard Ziegler

Henry Ford Hospital Medical Journal

Ultrasound examinations for the follow-up of 41 patients with histologically proven medullary thyroid carcinoma (MTC) were done regularly at three- to six-month intervals. In patients with elevated serum calcitonin (CT) levels, other localization methods such as computed tomography, selective venous catheterization with measurement of CT levels, and fine-needle aspiration were performed. Thirty-four tumor recurrences in the neck were suspected by ultrasound examination in 23 patients with postoperatively elevated CT levels. The smallest occult MTC nodule had a diameter of 8 mm. One nodule was hyperechogenic with hypoechoic lesions, one was isoechoic with a halo, and all others were hypoechoic. Seventeen …

Radionuclide Imaging In Medullary Thyroid Carcinoma: Evaluation Of Two New Radiopharmaceuticals, S. E. M. Clarke, C. R. Lazarus, M. N. Maisey

Henry Ford Hospital Medical Journal

We assessed the uptake of two new radiopharmaceuticals, 131I meta-iodo-benzylguanidine (MIBG) and 99mTc(V) dimercaptosuccinic acid (DMSA), in patients with histologically proven medullary thyroid carcinoma (MTC). MIBG detected tumor in 40% of patients with known primary or recurrent tumor. 99m Tc(V) DMSA successfully demonstrated primary and recurrent tumor in 86% of patients imaged, with true negative results in 100% of patients imaged after successful surgical resection and a false-negative rate of 14%. We therefore suggest that 99m Tc(V) DMSA is the imaging agent of choice in patients with both primary and recurrent disease. 131I MIBG, with its high false-negative rate, has …

A Two-Site Immunoradiometric Assay For Serum Calcitonin Using Monoclonal Anti-Peptide Antibodies, Philippe Motte, Malika Ait-Abdellah, Pascal Vauzelle, Paule Gardet, Claude Bohuon, Dominique Bellet

Henry Ford Hospital Medical Journal

We have produced a library of monoclonal antibodies of various affinities by immunizing mice with synthetic calcitonin (CT) 1-32. These monoclonal antibodies defined two antigenic determinants on the molecule of CT. The first was located in the 11-17 region of the hormone: the second was present on the 26-32 portion of CT. The C-terminal epitope was restricted to the mature form of the hormone and immunologically silent on synthetic peptides with sequences analogous lo the biosynthetic precursors for CT. Using two high-affinity monoclonal antibodies, designated as CT07 and CT08, we developed a two-site immunoradiometric assay (m-lRMA) for serum CT. This …

In Vitro Secretion Of Peptides Of The Calcitonin Family: Calcitonin, Katacalcin, And Calcitonin Gene-Related Peptide, Friedhelm Raue, Hubert Serve, Eckard Rix, Reinhard Ziegler

Henry Ford Hospital Medical Journal

A tissue culture explant and a primary cell culture of malignant C-cells have been estabUshed to study the secretion pattern of calcitonin (CT), katacalcin (KC), and CT gene-related peptide (CGRP) in vitro under different conditions. Within the first five days of culture the spontaneous secretion of the peptides in both systems dropped to and remained at a constant level. With increasing calcium (Ca) concentration in the medium, a dose dependent release of CT, KC and, in cell culture, of CGRP was observed. BAY-K-8644. an analog of the Ca channel blocker nifedipine, enhanced the CT secretion to the same extent as …

Localization Of A Radiolabeled Monoclonal Antibody To Calcitonin In Rat Medullary Thyroid Carcinoma Allografts, Naguib A. Samaan, Kuo-Pao Yang

Henry Ford Hospital Medical Journal

A radiolabeled anticalcitonin monoclonal antibody (MoAb) was testedfor tumor-localizing capability in WAG/Rij rats allografted with cultured medullary thyroid carcinoma cells (line 44-2). 131I-labeled anticalcitonin IgG was taken up by the tumors in a time-dependent and dose-dependent manner. Tumor tissue uptake of the injected MoAb was 0.7 to 1.3%/g of tumor tissue when tested with a dose range of 40 lo 250 μg/kg of body weight. Distribution ratios of the radiolabeled MoAb were 1.2:1 for tumor-to-blood and 2-20:1 for tumor-to-organs. In rats injected with control IgG, disiribution ratios of radioactivity were 0.4:1 for tumor-to-blood, and 0.6-2:1 for tumor-to-organs. These results suggested …

Studies Of Multiple Endocrine Neoplasia Type 2a Syndrome: Linkage Analyses And Comparison Of Constitutional And Tumor Genotypes, Hideo Tateishi, Shin-Ichiro Takai, Isamu Nishisho, Tetsuro Miki, Kazuyoshi Motomura, Makoto Okazaki, Akira Miyauchi, Tatsuro Ikeuchi, Kohtaro Yamamoto, Tatsuo Hattori, Yuichi Kumahara, Hideo Matsumoto, Tasuko Honjo, Takesada Mori

Henry Ford Hospital Medical Journal

Linkage analyses were carried out in nine Japanese kindreds with multiple endocrine neoplasia type 2A (MEN-2A) using polymorphic classical markers and DNA markers. We excluded close linkage of the MEN-2A gene (MEN2A) locus with Gm, JK, PGMl, and a DNA segment, D20S5, which is assigned to band 12 of the short arm of chromosome 20 (20p12.2). Assuming that MEN2A is recessive at the cellular level as in retinoblastoma (RB) and Wilms' tumor (WT). comparison of constitutional and tumor genotypes may be useful in the search for the MEN2A locus. When DNA samples from 12 patients with medullary thyroid carcinoma (MTC) …

Where Is The Locus For Multiple Endocrine Neoplasia Type 2a?, Nancy E. Simpson, Kenneth K. Kidd

Henry Ford Hospital Medical Journal

Attempts to map the locus of the gene (MEN2A) for the multiple endocrine neoplasia type 2A (MEN-2A) syndrome over the past II years are reviewed. Lod scores from family linkage studies of polymorphisms for 26 proteins and 64 DNA markers (restriction fragment length polymorphisms or RFLPs) were pooled from the published literature and the authors' unpublished data. The pooled data excluded 32% of the genome as possible sites for the MEN2A locus. This represents a considerable increase in the area of exclusion over that of the 6% reported at the first workshop. Linkage studies of RFLPs recognized by DNA sequences …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1987), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1987 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• George Hylander, DO
• The Classy '87s
• Hospital Ins & Outs
• On Campus
• Joann Cozza, DO
• Neurology Fellowship Abroad
• Class Acts
• In Memoriam
• Calendar

Vital Signs, Spring 1987, Boonshoft School Of Medicine

Vital Signs

A thirty six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1987), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1987 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Imperatives for Success
• Osteopathic's Surgicenter
• Tage N. Kvist, Ph.D.
• Research at OMCP
• The Changing Challenge of Student Recruitment
• On Campus
• PCOM's Rugby Triumph
• Class Acts
• In Memoriam
• Calendar

Health Care Policy Issues Related To Aids: Lessons Learned From The Henry Ford Hospital Experience, David W. Benfer

Henry Ford Hospital Medical Journal

No abstract provided.

Extensive Morphea-Form Basal Cell Carcinoma Invasion Of The Iris And The Orbital Content, David Barsky, William J. Vasileff

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Small Bowel Perforations Secondary To Cytomegalovirus In A Patient With Acquired Immunodeficiency Syndrome, Herman P. Houin, James C. Gruenberg, Evelyn J. Fisher, Eugene Mezger

Henry Ford Hospital Medical Journal

Cytomegalovirus gastroenteritis can be a life-threatening infection in patients with the acquired immunodeficiency syndrome. Although gastrointestinal ulcerations from cytomegalovirus have been widely reported, our patient is only the second case reported with actual perforations in the small bowel.

Clinical Review Of Epidemic Kaposi's Sarcoma With Focus On Treatment Modalities, Judie Goodman, Robert Chapman, Eyal Meiri

Henry Ford Hospital Medical Journal

No abstract provided.

Book Review: Osteosclerosis, Hyperostosis And Related Disorders, Malachi J. Mckenna

Henry Ford Hospital Medical Journal

No abstract provided.

T-Lymphocyte Subset Studies To Monitor Patients With Aids And Aids-Related Complex, Hajime Hayashi, Eugene Mezger, Michael J. Deegan, Evelyn J. Fisher, Norman Markowitz

Henry Ford Hospital Medical Journal

Multiple specimens from 124 patients from our clinic were evaluated for T4/T8 cell ratio over three to 28 months. Twenty-nine of 30 patients with the acquired immunodeficiency syndrome (AIDS), 58 of 71 patients with AIDS-related complex (ARC), and four of 23 patients at risk showed initial T4/T8 cell ratios of less than 0.8. which either remained unchanged or decreased. Seventeen of 23 AIDS patients and two of 20 ARC patients with a consistently low ratio (0.3 or less) died during the follow-up period. This indicated that the severity of disease could be predicted by periodical T4/T8 cell ratio studies. These …

Gastrointestinal Complications Of Aids: Radiologic Findings, Marc A. Bernstein, Jeremy J. Hollerman, Peter J. Feczko

Henry Ford Hospital Medical Journal

The acquired immunodeficiency syndrome (AIDS) is a significant health problem. Patients with this disease develop unusual infections and neoplasms, many within the gastrointestinal tract. Of the 66 AIDS patients seen over a three-year period at Henry Ford Hospital, 25 patients had AIDS-related gastrointestinal disease, with one death attributed to this cause. The radiologic findings and pathologic correlation of this experience are presented.

Mechanical Ventilation: New Modes, Old Modes, John Popovich Jr.

Henry Ford Hospital Medical Journal

No abstract provided.

The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson

Henry Ford Hospital Medical Journal

Creutzfeldt-Jakob disease, a transmissible, rapidly progressive dementia of unknown etiology, mimics Alzheimer's disease, presents in middle life, and affects many central nervous system structures. The disease progresses in three distinct stages, culminating in death. Its occurrence is sporadic and its distribution worldwide. Pathological changes are varied, but spongy degeneration of the neuropil is classic. Research on scrapie, the animal model of Creutzfeldt-Jakob disease, has demonstrated that this unconventional, slow disease is transmitted via a small (less than 50,000 mW) particle, which is composed principally of protein. How this infectious particle, variably named prion, virino, or slow virus, invokes disease or …

Renal Involvement In The Acquired Immunodeficiency Syndrome: Presentation, Clinical Course, And Therapy, Robert Provenzano, Warren Kupin, Godofredo C. Santiago

Henry Ford Hospital Medical Journal

Acute renal failure developing during the clinical course of the acquired immunodeficiency syndrome (AIDS) has been related to complications of sepsis, nephrotoxic antibiotics, and recently to the development of glomerular lesions. Of 114 AIDS patients admitted to our hospital between January 1985 and June 1986. II patients (9.6%) developed acute renal failure. None of these II patients had a history of intravenous drug abuse or hypertension. All patients were male with an average age of 35 years old, 81% were black, and all were bisexual or homosexual. Renal failure was attributed to AIDS-related focal glomerulosclerosis (five cases), prerenal azotemia (one …

A Tribute To C. Leslie Mitchell, Md, David Mitchell

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Aids Update, Evelyn J. Fisher

Henry Ford Hospital Medical Journal

No abstract provided.

Primary Neurologic Complications Of The Acquired Immunodeficiency Syndrome, Stuart N. Kieran

Henry Ford Hospital Medical Journal

No abstract provided.

Pulmonary Complications Of Aids: Henry Ford Hospital Experience Between January 1984 And July 1986, Barry Lesser, Joan Price, Phillip Bruno, Evelyn J. Fisher, John Popovich Jr., Michael S. Eichenhorn

Henry Ford Hospital Medical Journal

We have retrospectively reviewed our bronchoscopic experience in patients with suspected pulmonary complications of the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex at Henry Ford Hospital between 1984 and 1986. The charts of 52 patients, representing a total of 87 bronchoscopic examinations, were available for review. The bronchoscopic findings as well as correlative chest roentgenograms and arterial blood gases are reviewed, and implications for therapy are discussed.

The Aids Challenge: A Psychosocial Perspective, Madelyn S. Plotkin, Margaret Dietz Domanski

Henry Ford Hospital Medical Journal

No abstract provided.

Ultrasonic Evaluation In The Management Of Postpartum Infection, Chang Y. Lee, Beatrice L. Madrazo, Sheryl Parks, Michael Sandler

Henry Ford Hospital Medical Journal

To evaluate the effectiveness of ultrasound in the management of postpartum problems, ultrasonographic examination was performed on 98 patients with suspected postpartum infection. The study includes only those patients who did not respond to antibiotic treatment for at least 48 hours and those patients who were readmitted to the hospital with suspected postpartum infection. Echogenic tissue was found in the uterine cavity in 12 patients, and significant fluid collection was found in 24 patients. Gas collection appeared in the uterine cavity in five patients and around the uterine incision in four patients. Fluid collection was found around the uterine incision …