Medical Specialties Commons^™

Supervised Training Of Practical Procedures In The Internal Medicine Residency, Z Abbas, S Abid, J A. Khan, A Jabbar

Section of Gastroenterology

In order to get feedback whether the medical residents are getting adequate supervised training to perform practical procedures, a questionnaire was distributed among the residents asking their involvement in sixteen frequently performed procedures in the medical unit of the Aga Khan University Medical Centre. Though the residents were satisfied about their training in doing lumbar punctures, pleural and peritoneal aspirations, bone marrow aspiration and trephine and chest tubes placement, they showed their concern about training in putting central lines, venous cut downs, cardiac pacing and biopsies. A better schedule training programme, organized subspecialty rotation, continuous evaluation of resident's skill, credentialing …

Regulation Of Transforming Growth Factor-Beta 1 Gene Expression By Glucocorticoids In Normal Human T Lymphocytes., O. Ayanlarbatuman, A. P. Ferrero, Arturo Diaz, Sergio A. Jimenez

Department of Medicine Faculty Papers

Glucocorticoids (GC) modulate immune function in a number of ways, including suppression of T cell proliferation and other IL-2-mediated T cell functions. These inhibitory effects are similar to those induced by transforming growth factor-beta 1 (TGF-beta 1), a cytokine with potent T cell inhibiting activities. We examined the hypothesis that GC effects may be at least partially achieved through modulation of the expression of the TGF-beta 1 gene in activated T cells. Normal T cells were cultured with or without purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) in the presence or absence of the synthetic GC, dexamethasone (100-200 …

Fc Receptors For Igg (Fc Gamma Rs) On Human Monocytes And Macrophages Are Not Infectivity Receptors For Human Immunodeficiency Virus Type 1 (Hiv-1): Studies Using Bispecific Antibodies To Target Hiv-1 To Various Myeloid Cell Surface Molecules, Including The Fc Gamma R., R I. Connor, N B. Dinces, A L. Howell, J L. Romet-Lemonne, J L. Pasquali, M W. Fanger

Dartmouth Scholarship

Fc gamma Rs (Fc gamma RI, Fc gamma RII, and Fc gamma RIII) are highly expressed on human mononuclear phagocytes and function in the clearance of immune complexes and opsonized pathogens. We have examined the role of Fc gamma R in mediating antibody-dependent clearance of HIV-1 by human monocytes and monocyte-derived macrophages by using bispecific antibodies (BsAbs) to independently target the virus to Fc gamma RI, Fc gamma RII, or Fc gamma RIII. Virus production was markedly reduced in monocytes cultured with strain HIV-1IIIB opsonized with BsAbs that target the virus to either Fc gamma RI or Fc gamma RII …

Yet Another Cause Of Chronic Viral Hepatitis?, H A. Shah, S Abid, S Hamid, S W. Jafri, Z Abbas, T Qaseem, H Shaikh, A H. Khan

Section of Gastroenterology

The clinical features, course and histology of liver in 20 patients; mostly middle aged to elderly females, closely resembling chronic Non A Non B hepatitis is presented. They presented quite late in their disease and therefore, complications such as variceal bleeds, ascites and encephalopathy were frequent. Our patients were negative for hepatitis B and C virus serology. Metabolic and immune causes of chronic liver disease were also ruled out. To the best of our knowledge, this is the first study of its kind elaborating the clinical features, course and histology of liver in chronic Non B Non C hepatitis and …

Enterolithiasis Secondary To Intestinal Tuberculosis, M Y. Sheikh, I H. Rizvi, S A. Naeem, I Ahmad

Department of Radiology

No abstract provided.

Uhs-Communicator, Fall 1991: New Uhs-Com President, University Of Health Sciences College Of Osteopathic Medicine, Uhs-Com Alumni Association

Communicator (1991-2012)

Contents: New President -- Physio Computers Vault UHS Into Education Forefront -- UHS Foundation Announces $50 Million Program -- UHS Financial Statement -- 1991 Entering Class Receives Warm Welcome to UHS, Kansas City -- Alumni Homecoming 1991 -- New Recruiting Tools -- DOings -- Special Invitation: President's Inauguration.

Vital Signs, October 1991, Boonshoft School Of Medicine

Vital Signs

A nine page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Oncolog, Volume 36, Issue 04, October-December 1991, Stephen S. Kroll M.D., James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Antisense RNA technology successfully blocks K-ras-induced cancer
• Immediate breast reconstruction reduces the trauma of mastectomy
• The human face of data

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Renovations and New Construction Continue
• PCOM Fundraising Goes Back to Basics
• Curriculum Changes
• President's Perspective
• Geriatric Care to be Stressed Early, Often
• PCOM Hosts Conference in Osteopathic Hospitals and Medical Education
• Unique DO-MBA Program Teaches the Business of Medicine
• PCOM Students Go Far for Rural Clinical Experience
• Where are Our 111 Residents?
• On Campus
• A "3-D" View of the Future
• Class Acts
• In Memoriam
• Coming Events

Congenital Pyloric Atresia And Epidermolysis Bullosa, Zafar Nazir, Zeba Batool Attar, Farhat Moazam

Section of Paediatric Surgery

Congenital pyloric atresia with epidermolysis bul­losa is recognized as a rare but distinct entity which is uniformly fatal^1,2. Until 1990 only 20 cases have been reported in the English literature^3,4. We present an additional case managed at the Aga Khan University Hospital to demonstrate the difficulties encountered in the management of such infants.

Instrumentation And Control For A Microprocessor-Based Coronary Perfusion System, Daniel L. Priester

Master's Theses (1922-2009) Access restricted to Marquette Campus

No abstract provided.

Transplantation Of The Mammalian Pineal Gland: Studies Of Survival, Revascularization, Reinnervation And Recovery Of Function, Wutian Wu

Theses and Dissertations in Biomedical Sciences

The survival, revascularization, reinnervation, and recovery of function of transplanted newborn rat pineal glands were studied following grafting into four different locations in pinealectomized rats. These locations were the third cerebral ventricle, in situ (where the pineal gland is normally located), the renal capsule, and the anterior chamber of the eye.

Pinealocytes in the grafts maintained high metabolic activity as evidenced by the presence of euchromatic nuclei, prominent nucleoli, infolded nuclear envelopes, numerous mitochondria and Golgi apparati, and relatively abundant endoplasmic reticulum and ribosomes. In addition, morphological correlates of two putative secretory processes were observed in the grafts. The first …

Statistical Interpretation Of Dna Typing Data, R Chakraborty

Faculty, Staff and Student Publications

No abstract provided.

The Role Of Gaba In Reproductive Neuroendocrine Systems, Robert Carter Mcree

Theses and Dissertations in Biomedical Sciences

Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.

Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) during two hormonal states with each model. In the intact rat the proestrus and estrus states were examined, and in the ovariectomized rat in-vitro release was determined with (OVX₂) and without (OVX) estradiol treatment.

In-vivo experiments studied the effect of stimulation of GABA receptors …

Non-Q Wave Myocardial Infarction, Steven Borzak, Howard S. Rosman

Henry Ford Hospital Medical Journal

Non-Q wave myocardial infarction is a distinct and changing clinical entity characterized by lower initial mortality and a higher rate of reinfarction compared to Q wave infarction. Clinical and pathologic data suggest that the syndrome results from transient or incomplete coronary occlusion resulting in an infarct which is smaller than when Q waves are present. High-risk patients can be identified during hospitalization, allowing for aggressive therapy aimed at revascularization. Relatively few clinical trials have examined initial therapy or secondary prevention in this group of patients. These studies are reviewed and management guidelines suggested.

Intravenous Nitroglycerin For Acute Myocardial Infarction, Steven Borzak

Henry Ford Hospital Medical Journal

Intravenous nitroglycerin (IV TNG) has been increasingly used in the setting of acute myocardial infarction. The seven randomized trials comparing IV TNG with placebo, and one trial comparing IV isosorbide dinitrate with furosemide, were reviewed for evidence of beneficial clinical effects. IV TNG in low dosage is safe in the setting of acute myocardial infarction and modestly effective in relieving chest pain. Favorable hemodynamic effects are most pronounced in patients with congestive heart failure. Limited evidence suggests that IV TNG, particularly when administered early, reduces both infarct size and mortality when given prophylactically.

Psychological Factors Relevant To The Prehospital And In-Hospital Phases Of Acute Myocardial Infarction, Lori W. Kenyon, Mark W. Ketterer, Richard C. Preisman

Henry Ford Hospital Medical Journal

Recognition and treatment of psychological factors relevant to the acute prehospital and in-hospital phases of myocardial infarction (Ml) are reviewed. Various emotions and personality characteristics can be both risk factors for and consequences of acute Ml. Components of the Type A behavior pattern and levels of somatic and emotional awareness have been linked with excessive treatment-seeking delay for Ml patients. Psychiatric conditions such as panic disorder may mimic symptomatic presentation of Ml and therefore have implications for differential diagnosis in the emergency room. Additionally. anxiety, depression, and neurobehavioral disorders such as delirium are relatively common during the hospitalization period and …

Beta-Adrenergic Blocking Agents In The Treatment Of Patients After A Myocardial Infarction, Sidney Goldstein

Henry Ford Hospital Medical Journal

Beta-adrenergic blocking agents have been widely used in ischemic heart disease. They have achieved their greatest benefit in the secondary prevention of recurrent events in patients following acute myocardial infarction (Ml). This is a review of the major clinical investigations exploring the effects of beta-adrenergic blocking agents in patients following acute Ml and in a variety of patient subsets. These data indicate that the routine use of beta-adrenergic blocking agents in postinfarction patients results in a 25% to 35% decrease in mortality and has increased relative and absolute benefit in patients with ventricular ectopy and left ventricular dysfunction. The adverse …

Special Feature: Management Of Acute Myocardial Infarction: Introduction, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Prehospital Care Of Acute Myocardial Infarction: A Review, Asit R. Gokli, Jay L. Kovar, Terry Kowalenko, Richard M. Nowak

Henry Ford Hospital Medical Journal

Each year more than 1 million people in the United States suffer from acute myocardial infarction (Ml) with most of the deaths occurring within hours of symptom onset. Over the last 25 years, different prehospital systems have evolved throughout the world which allow early cardiac monitoring and treatment of acute Ml patients. Thrombolytic therapy in acute Ml has been shown to decrease mortality and preserve left ventricular function when administered early after onset of symptoms. The potential role of Emergency Medical Services or Mobile Coronary Care Units in achieving early thrombolysis is under investigation. Several studies of prehospital interventions to …

Calcium Channel Blockers In The Management Of Myocardial Infarction Patients, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Recent Concepts In Clinical Psychiatry: Drug Treatment In Schizophrenia, Shahin H. Hussain

Department of Psychiatry

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Neuroendocrine Responses To Acute Myocardial Infarction, Arlene B. Levine, T. Barry Levine

Henry Ford Hospital Medical Journal

No abstract provided.

Recovery Of Left Ventricular Function Following Acute Myocardial Infarction, Hani N. Sabbah, Paul D. Stein, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Biochemical Diagnosis Of Myocardial Infarction, Craig C. Foreback

Henry Ford Hospital Medical Journal

A rapid, sensitive, and specific marker for the diagnosis of acute myocardial infarction (MI) and the assessment of reperfusion following thrombolytic therapy has been sought by research workers for years. Creatine kinase-MB (CK-MB) is the best biochemical marker currently available to the cardiologist and the emergency room physician for the assessment of patients presenting with symptoms of acute Ml. CK-MB is best measured using immunoassay techniques at 3- to 4-hour time intervals during the first 12 hours after onset of.symptoms. Other currently available markers include lactate dehydrogenase and its isoenzymes and myoglobin. Future developments include assays for troponin, reported to …

The Role Of Echocardiography In Acute Myocardial Infarction, Mohsin Alam

Henry Ford Hospital Medical Journal

Our institutional experience with two-dimensional echocardiography and color flow Doppler tests, as welt as a review of the literature, reveals that echocardiography is useful in diagnosing myocardial infarction. Furthermore, complications of myocardial infarction such as mitral regurgitation with or without papillary muscle rupture, acquired ventricular septal defect, true and false left ventricular aneurysms, left ventricular thrombi, right ventricular infarction, and pericardial effusion in the setting of acute infarction can he detected by cardiac ultrasound. Echocardiography is also useful in assessing prognosis of postinfarction patients based on degree of left ventricular dysfunction. This test, however, is not 100% sensitive and specific …

Antiplatelet And Anticoagulant Therapy In Acute Myocardial Infarction, Syed M. Jafri

Henry Ford Hospital Medical Journal

No abstract provided.

Thrombolytic Therapy In Acute Myocardial Infarction: An Emergency Department Perspective, Bradford L. Walters

Henry Ford Hospital Medical Journal

No abstract provided.

Lidocaine Prophylaxis In Acute Myocardial Infarction, James E. Tisdale

Henry Ford Hospital Medical Journal

The prophylactic administration of lidocaine for the prevention of primary ventricular fibrillation (VF) following suspected acute myocardial infarction (Ml) is controversial. The incidence of primary VF following acute Ml ranges from 1.8% to 10.5%. "Warning arrhythmias" have not been shown to be reliable predictors of VF. In-hospital prophylactic administration of lidocaine has been shown to decrease the incidence of primary VF. whereas prehospital administration has not. However, prophylactic administration of lidocaine has not been shown to have a beneficial effect on mortality and may in fact increase mortality. The incidence of lidocaine-induced adverse effects during prophylaxis ranges from 4% to …