Medical Specialties Commons^™

Cortisol In The Ovine Fetus : Its Regulation And Role In Parturition, Ede Marie Apostolakis

Loma Linda University Electronic Theses, Dissertations & Projects

In fetal sheep, circulating cortisol increase during late gestation to abruptly rise 72 hours preceding birth. Although the surge in cortisol is thought to initiate the endocrine cascade which triggers parturition, it is not known what drives the prepartum rise in fetal cortisol. The first study tested the hypothesis that basal cortisol secretion is regulated by adrenocorticotropin (ACTH) which in turn, is controlled by arginine vasopressin (AVP). The fetus challenged with AVP increased plasma ACTH and cortisol concentrations. Pretreatment with an AVP V₁ receptor antagonist blocked AVP-induced plasma ACTH cortisol but failed to alter basal ACTH or cortisol. To …

Shared Responsibility For Medication Use : An Experiment, Marjorie Tessner

Loma Linda University Electronic Theses, Dissertations & Projects

Medication adherence is an important part of effective therapy for gastrointestinal disease. Theory has suggested that the more involved the individual is in their care the more adherent they will be to their medication regime. However, such management is often complicated by patient psychological factors, health beliefs, self-efficacy, and lack of knowledge about medication.

In this experimental study of the impact of shared responsibility for medication use: an experiment, 60 patients from four ethnic groups were randomly assigned to three groups of 20 each: 1) routine discharge medication group, 2) formal education group, and 3) self medication and shared responsibility …

Soft Tissue Changes Of The Upper Lip Following Isolated Le Fort I Osteotomies, Kendall E. James

Loma Linda University Electronic Theses, Dissertations & Projects

Pre-operative (T-1) and post-operative (T-3) radiographs were obtained and traced for fifty-one non-growing patients who had undergone isolated Le Fort I osteotomies. These tracings were then digitized with the results arranged in a data file and subjected to statistical analysis. The purpose of this study was to establish ratios for certain hard to soft tissue movements that could be used to aid the clinician in post-surgical soft tissue profile prediction. The results showed that even though a large sample was used, individual patient variability remained high particularly in the horizontal directions. Most ratios found in this study were consistent with …

Condylar Angulations As Related To Submental-Vertex Radiographs, Jady L. Chiakowsky

Loma Linda University Electronic Theses, Dissertations & Projects

Pretreatment submental-vertex radiographs were obtained for 637 adolescent patients (307 males, 330 females) who had presented themselves for orthodontic treatment. The purpose of this study was to: (1) determine the relationship between condylar angulations and depth of cut with the variables: age, sex, and race, and (2) establish normative values for the categories studied. The results indicated that no significant differences existed between the condylar angulations for the variables measured. However, significant differences did exist between the depth of cut for the variables measured and there was significant interaction between age and race with respect to the depth of cut. …

The Effect Of Electrical Stimulation Of The Dorsal Raphe Nucleus On Local Cerebral Glucose Metabolism And Epileptogenesis In The Rat, Clifford C. Douglas

Loma Linda University Electronic Theses, Dissertations & Projects

Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the 2-deoxy-d-glucose (2-DG) method, and second by the effect of dorsal raphé electrical stimulation on kindled seizure in the rat. In the 2-DG study, differences in local rates of cerebral glucose metabolism were quantified. The pattern of 2-DG uptake differed significantly from controls (animals with electrodes placed and not receiving an electrical stimulus) and subjects stimulated in the pontine oral reticular …

Neutron Fluence And Dose From A Varian Clinic 1800 Accelerator, Richard A. Jackson

Theses and Dissertations

The goals of this study were (1) to verify calibration factors determined by previous experiment for relating counts from activated gold foils to neutron fluences, and (2) to use the method to determine neutron fluences under various operating conditions of the Varian Clinac 1800 (18-MeV) electron accelerator at the WPAFB Medical Center. For comparison similar measurements were made of the CGM Saturne 1 at Kettering Memorial Hospital, Dayton, Ohio. Cadmium-difference pairs in a standard graphite pile were employed to verify the counting efficiency of the Geiger-Mueller beta counting system used to count the foil activity. They were also used to …

Alternative Splicing Of Human Prostaglandin G/H Synthase Mrna And Evidence Of Differential Regulation Of The Resulting Transcripts By Transforming Growth Factor Beta 1, Interleukin 1 Beta, And Tumor Necrosis Factor Alpha., Arturo Diaz, Anthony M. Reginato, Sergio A. Jimenez

Department of Medicine Faculty Papers

Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of this clone showed that (a) it contained the entire translated region of PGG/HS and (b) it displayed an in-frame splicing of the last 111 base pairs encoded by exon 9, which resulted in the elimination of the N-glycosylation site at residue 409. Polymerase chain reaction amplification with specific oligonucleotides of reverse-transcribed mRNA from diverse human tissues and cultured cells yielded …

University Of New England Board Of Trustees: Reynolds To Kirmes 1992-5-19, Thomas H. Reynolds

William Kirmes, D.O. Collection

A letter from University of New England President, Thomas H. Reynolds to Dr. Kirmes discussing possible ways in which a donation of $5000 could be used.

Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim

Section of Gastroenterology

Prompt treatment with empirical antibiotics in neutropenic febrile patients reduces morbidity and mortality. Most patients have been treated with parenteral combination antibiotics, but newer antibiotics with broad-spectrum bactericidal activity have made monotherapy feasible. Ofloxacin, a broad-spectrum fluoroquinolone, has the additional advantage that bactericidal concentrations can be achieved with oral administration. We have compared ofloxacin as an oral single agent with standard parenteral combination antibiotics for the management of neutropenic febrile patients in a prospective, randomised trial. Patients with severe neutropenia (absolute neutrophil count less than or equal to 0.5 x 10(9)/l), fever above 38 degrees C, and ability to take …

The Ratio Of Heinz Body Formation In Different Hemoglobin Zurich Subjects, Yenya Hu

Masters Theses & Specialist Projects

Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.

Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes …

Cytolytic T Lymphocytes Specific For Tumors And Infected Cells From Mice With A Retrovirus-Induced Immunodeficiency Syndrome., Jennifer G. Erbe, Kathy A. Green, Karen M. Crassi, Herbert C. Morse, W R. Green

Dartmouth Scholarship

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.

Uhs-Communicator, Spring 1992: Alumni Involvement In Strategic Planning, University Of Health Sciences College Of Osteopathic Medicine, Uhs-Com Alumni Association

Communicator (1991-2012)

Contents: Strategic Planning -- Campus Renovations -- Clock Tower to Return to UHS-Campus -- Appointment of New Dean, Anthony J. Silvagni, D.O. -- Foundation Looks to Fund Learning Resource Center in Renovation Project -- Torchbearers' Society -- Student Development Council -- John Peterangelo, D.O., Realizes Long-Time Dream -- Inauguration of President Perrin -- DOings -- Corner of the World -- Alumni Association President's Message.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1992), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1992 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Osteopathic Medical Center Forges Ahead: President’s Perspective
• Major Hospital Upgrades and New Research Program
• Philanthropy Comes in Many Forms
• Doctors Marrying Doctors
• They Remember When: PCOM's More Mature Grads Return for Founders Day
• PCOM Alumnus Heals the Faithful and Famous
• On Campus
• Just Published
• Class Acts
• In Memoriam
• Coming Events

The Effects Of Orthopaedic Surgery And Dorsal Rhizotomy On Selected Gait Characteristics Of Cerebral Palsy Children, Danielle M. Lanoue

Rehabilitation Sciences Theses & Dissertations

Surgical management of cerebral palsy children typically involves multiple orthopaedic surgeries in order to achieve and maintain the maximum functional level of ambulation. Orthopaedic intervention to address lower extremity spasticity often includes: muscle lengthenings, muscle releases and tendon transfers. The most recent advance in management of lower extremity spasticity has been through a neurosurgical approach; selective dorsal rhizotomy. The long term effects of dorsal rhizotomy are still being investigated. Through the use of instrumented gait analysis, the specific objective results of both of these types of surgeries can be investigated. The purpose of this retrospective study was to examine the …

Ms211: Letter To Dr Louis Sullivan, Armin Weinberg

Works on Radiation Effects: 1990-2020

This was a note sent to the Secretary of Health and Human Services seeing if he would like to offer a point of contact to our efforts noting that Dr Claude Lenfant (then NIH's Director of the National Heart Lung and Blood Institute) who had agreed to assist. See more at Armin Weinberg, PhD Papers and its finding aid.

Aids And The Homeless Of Boston, James J. O'Connell, Joan Lebow

New England Journal of Public Policy

Homeless persons with AIDS and HIV infection face significant health hazards during the daily struggle for survival on the streets and in the crowded shelters of our cities. This article offers a historical perspective on the evolution of the AIDS epidemic within the homeless population of Boston and examines the demographics, risk behaviors, and survival statistics of that epidemic. The Boston Health Care for the Homeless Program is presented as a model of service delivery that offers quality health care to homeless persons with AIDS while addressing the special needs of those bound by the immediacy of the next meal …

Ms211: Agenda For Penchas Visit March 1992, Armin Weinberg

Works on Radiation Effects: 1990-2020

This is the agenda for the March visit with Dr. Penchas who was the Director General of Hadassah from Israel. Includes schedule for Radio KTRH and various TMC and Hadassah and THMRF meetings. See more at Armin Weinberg, PhD Papers and its finding aid.

Ms211: Texas Hadassah Medical Research Foundation (Thmrf) Board Announcing Foundation's Goals, Armin Weinberg

Works on Radiation Effects: 1990-2020

This looks like draft Press Release piece of the announced the affiliation with The Methodist Hospital Health Care Network. Talks about initial plans to organize a conference, list of additional member of the effort, including a Tx Congressman Martin Frost as honorary member, and a report from an Israeli scientist from Hadassah Zeev Weshler on the issue facing them with immigrants to Israel from the contaminated areas. See more at Armin Weinberg, PhD Papers and its finding aid.

University Of New England Board Of Trustees: Kirmes To Parfitt 1992-3-19, William Kirmes D.O.

William Kirmes, D.O. Collection

A letter from Dr. Kirmes to Dee Parfitt, relating the projects he has been working on, the growth of her husbands former practice, and opportunities to donate to the University of New England College of Medicine.

Health Care Linkage Project: Improving Access To Care, Martha G. Ferguson, Lon Berkeley, Louis Fourcher, Belinda Guyton, Linda Ross Reiner

Henry Ford Hospital Medical Journal

The primary objective of the Health Care Linkage Project, funded by a grant from the Chicago Community Trust, is to develop, implement, and evaluate a primary health care linkage network within the city of Chicago that creates formalized linkages between community health centers, the Chicago Department of Health clinics, and hospitals. Six linkage networks are currently operational, with an additional two sites phased in during 1991. The success of the pilot project has been demonstrated by hundreds of patients receiving primary care and ancillary services on a more timely basis, by greater coordination between the public and private sector, by …

Urban Health Care: An Integral Part Of The United States Health Care System, Sander M. Levin

Henry Ford Hospital Medical Journal

No abstract provided.

Mount Sinai: A Special Hospital For A Special Community, Benn Greenspan

Henry Ford Hospital Medical Journal

No abstract provided.

Management Of Impotence After Treatment Of Carcinoma Of The Prostate, Dinesh J. Telang, Riad N. Farah

Henry Ford Hospital Medical Journal

Impotence commonly occurs as a result of treatment of carcinoma of the prostate. We review the etiology, evaluation, and treatment options available for these patients as well as our experience with fifty prostate cancer patients who underwent placement of penile prostheses. Several excellent alternatives are available for patients with impotence resulting from treatment of carcinoma of the prostate.

Urban Health Care: Solutions For The 1990s, David R. Nerenz, David W. Benfer

Henry Ford Hospital Medical Journal

No abstract provided.

Urban Health Solutions In The 1990s: No Time For False Promises, Seth Foldy

Henry Ford Hospital Medical Journal

No abstract provided.

Urban Health And The Social Contract: Poverty, Race, And Death, H. Jack Geiger

Henry Ford Hospital Medical Journal

No abstract provided.

Community Health Centers: A Resource For Service And Training, Joan Hedgecock, Maria Castro, William B. Cruikshank

Henry Ford Hospital Medical Journal

The American Medical Student Association (AMSA) Foundation is assisting the U.S. Public Health Service in increasing the number of primary care physicians trained and committed to practice in medically underserved areas. In collaboration with the American Academy of Family Physicians, the Ambulatory Pediatrics Association, and the Society of General Internal Medicine, AMSA conducted an assessment of federally-funded residency programs to identify and describe their affiliations with federally-funded community and migrant health centers (CIMHCs). Of the 260 programs assessed and the 147 responses, 125 offer community-based training. Of these, 73 offer training in primary care centers and 39 offer training in …

Health Care Consortia: A Mechanism For Increasing Access For The Medically Indigent, Patricia A. Caplan, Bonnie Lefkowitz, Lynn Spector

Henry Ford Hospital Medical Journal

In response to poor coordination among health and social service providers, health care consortia have emerged in many areas of the United States. Consortia link multiple providers in a common structure to create comprehensive systems of care. They can he formally structured or informal combinations of providers that engage in coordination hut otherwise do not comprise an independent organization. The functions most common among all types of consortia are shared services and service coordination; however, a number of consortia also operate outreach/education programs. Consortia represent an innovative response to the need both for vertical integration—case management of all levels of …

An Update On The Role Of Ploidy In Prostate Carcinoma, Jill M. Peters-Gee

Henry Ford Hospital Medical Journal

One of the characteristic features of prostate carcinoma is its marked variation in biologic behavior. DNA quantitation has been studied in prostate carcinoma using a variety of techniques. Evaluation of tumor ploidy suggests that this may be the best predictor of the biologic behavior of prostate cancer in individual patients. This comprehensive review addresses the current studies, stage by stage, to clarify the clinical significance of these findings.

Primary Papillary Serous Carcinoma Of The Peritoneum: A Case Of Complete Remission Of Bulky Peritoneal Disease After Chemotherapy, Walid A. Saleh, Cosmas J. M. Van De Ven, Wooshin Kim

Henry Ford Hospital Medical Journal

Peritoneal papillary serous carcinoma is a rare tumor that involves the surface of the pelvic and/or abdominal peritoneum. Long-term survival among patients with this tumor has been rare. Most patients with this cancer have been treated with debulking surgery and postoperative chemotherapy. A case of incompletely resected peritoneal papillary serous carcinoma with a complete response to cisplatin-based chemotherapy is reported. Subsequent laparotomy revealed no residual tumor. This case suggests that primary chemotherapy may be successful in treating unresectable primary papillary serous tumors of the peritoneum.