Medical Specialties Commons^™

Mexican-Descent Latinas’ Compliance With Cervical Cancer Screening Guidelines, Evelinn A. Borrayo, Awilda Reyes

University Libraries Faculty Publications

No abstract provided.

Prostate Specific Membrane Antigen (Psma): Immunoassay Development And Characterization Of Transcriptional Regulation, Zhen Xiao

Theses and Dissertations in Biomedical Sciences

Prostate cancer (PCA) is the most common cancer and the second leading cause of death among American men. The high mortality is greatly attributed to the lack of early detection tools and effective treatment for metastasis and relapses. Biomarkers that can discriminate benign from malignant tumor and signal the development of androgen independent and metastatic tumor are needed. A biomarker designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a clinically useful immunoassay for quantitation of serum PSMA and to study the molecular mechanism underlying the upregulation of …

Medical Education Digest, Vol. 4 No. 2 (March 15, 2002), Nova Southeastern University

Medical Education Digest

No abstract provided.

Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad

Clinical & Translational Sciences

We previously cloned Siva-1 by using the cytoplasmic tail of CD27, a member of the tumor necrosis factor receptor family, as the bait in the yeast two-hybrid system. The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate splice form, Siva-2, lacks exon 2 coding sequence. Various groups have demonstrated a role for Siva-1 in several apoptotic pathways. Interestingly, the proapoptotic properties of Siva-1 are lacking in Siva-2. The fact that Siva-1 is partly localized to mitochondria despite the absence of any mitochondrial targeting signal, it harbors a 20-aa-long putative amphipathic …

Transitions Along The Continuum Of Care: Elderly And Disabled Persons In New York, Lisa Sprague, Nora Super

National Health Policy Forum

This site visit examined transitions along the continuum of care for elderly and disabled persons in New York. The state offers its residents an extensive array of services, including nursing homes, home health care, personal care, and community-based services. New York spends more than any other state on its Medicaid program, which is reflected in a comprehensive benefit package, full-cost reimbursement of hospitals, high nursing home rates, and extensive coverage of personal care services. Site visitors were briefed on the history and development of long-term care in the state as well as the various care settings available. Panels discussed transitions …

Predictors Of Mortality In Brain Abscess, H U. Qureshi, A A. Habib, A A. Siddiqui, T Mozaffar, A R. Sarwari

Section of Neurosurgery

Objective: Brain abscess carries significant morbidity and mortality. Our objective was to elucidate the clinical presentation of brain abscess and to assess predictors of mortality in these patients.
Methods: All patients with a brain abscess presenting to the Aga Khan University Hospital, a tertiary care referral center in Karachi, Pakistan, were studied retrospectively. Statistical analysis involved univariate analysis and a logistic regression model.
Results: Among the 66 patients analyzed, a distant metastatic focus of infection was the most commonly identified predisposing factor (29%). Otogenic infection was the commonest contiguous source and sinusitis was noticeably absent. Multiple abscesses were frequent (35%). …

Prevention Of Radiation-Induced Skin Reactions In Breast Cancer External Irradiation, Cathy Ammerman

Masters Theses & Specialist Projects

Radiation dermatitis is a common side effect of external beam radiation therapy. The purpose of this study was to evaluate the effectiveness of applying an aloe vera based skin gel to the target area skin in preventing the development of radiation dermatitis to postlumpectomy/ mastectomy patients receiving external beam radiation therapy in an ambulatory radiation-oncology clinic in the southeastern region of the United States. In this descriptive correlational study, a convenience sample of willing participants (n=18) was followed from initial treatment through the one-month follow-up examination to assess the intensity of their skin reaction. Five research questions were examined pertaining …

View Box Case--3 Hepatic Hemangioma, I Masroor, R Hashmi

Department of Radiology

No abstract provided.

Oncolog, Volume 47, Number 03, March 2002, Vickie J. Williams, Michael Worley, Noelle Heinze, Richard J. Babaian Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Largest-Ever Cancer Prevention Study to Examine the Effects of Selenium and Vitamin E on Prostate Cancer Occurrence
• Protocols: Prostate Cancer Clinical Trials
• House Call: Understanding Metastasis
• DiaLog: The Prostate--Specific Antigen Test: Reliability and Recommended Use, by Richard J. Babaian, MD, Professor, Department of Urology
• Trouble Spots: Early Detection Is Key to the Successful Treatment of Melanoma

Vital Signs, Spring 2002, Boonshoft School Of Medicine

Vital Signs

A twenty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes feature articles, an alumni profile, class notes, and more.

Epidermal Growth Factor Receptor (Egfr) As A Prognostic Marker: An Immunohistochemical Study On 315 Consecutive Breast Carcinoma Patients, S. A. Aziz, Shahid Pervez, N. Kayani, M. H. Rahbar, S. Khan

Department of Pathology and Laboratory Medicine

Objective: To assess the independent and interdependent prognostic value of epidermal growth factor receptor (EGFR) in carcinoma of breast in female population. The Type I family of growth factor receptors includes epidermal growth factor receptor (EGFR also known as EGFRI).

Methods: The expression of EGFR protein was analysed immunohistochemically on 315 tumour specimens of infiltrating ductal carcinoma of breast. These patients also had axillary lymph nodes sampling.

Results: Overexpression and/or amplification of EGFR was observed in 70 (22.00%) tumours. Eleven (16%) were grade I, 43 (61%) grade II and 16 (23%) grade Ill tumours. Axillary lymph node metastasis had significant …

Enhancement Of Anti-Hiv-1 Ribozyme Activities By Rev Binding And Multimerization, Yuksel Yildiz

Loma Linda University Electronic Theses, Dissertations & Projects

To effectively apply hammerhead ribozymes as therapeutic agents it is necessary to co-localize them with the desired target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on env gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the env transcript termed the Rev Binding Element (RBE). In anti-HIV gene therapy employing ribozymes to increase the co-localization of anti- HIV ribozymes with target HIV mRNAs, it has been proposed that when the native HIV- 1 RBE is appended to a ribozyme as a decoy molecule, simultaneous binding of Rev monomers to the RBE sequences in both …

Circulating Testosterone And Prostate-Specific Antigen In Nipple Aspirate Fluid And Tissue Are Associated With Breast Cancer., Edward R Sauter, David S Tichansky, Inna Chervoneva, Eleftherios P Diamandis

Department of Surgery Faculty Papers

Preliminary evidence has associated testosterone and prostate-specific antigen (PSA) with breast cancer. Our objective was to determine whether a) testosterone levels in nipple aspirate fluid (NAF), serum, or breast tissue are associated with breast cancer; b) testosterone levels in serum are associated with levels in NAF; c) PSA in NAF, serum, or breast tissue is associated with breast cancer; and d) serum PSA is associated with NAF PSA levels. We obtained 342 NAF specimens from 171 women by means of a modified breast pump. Additionally, we collected 201 blood samples from 99 women and 51 tissue samples from 41 subjects …

Reduction In The Incidence Of Type 2 Diabetes With Lifestyle Intervention Or Metformin., William C. Knowler, Elizabeth Barrett-Connor, Sarah E. Fowler, Richard F. Hamman, John M. Lachin, Elizabeth A. Walker, David M. Nathan, P. G. Watson, J. T. Mendoza, K. A. Smith, J. Caro, B. Goldstein, C. Lark, L. Menefee, L. Murphy, C. Pepe, J. M. Spandorfer

Department of Medicine Faculty Papers

BACKGROUND: Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes.

METHODS: We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load plasma glucose concentrations to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7 percent weight loss and at least …

View Box Case--2 Mid-Colic Intussusception, I Masroor, R Hashmi

Department of Radiology

No abstract provided.

Oncolog, Volume 47, Number 02, February 2002, Kerry L. Wright, Charles F. Leverbeck Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Molecular Therapies Target Bone Metastasis
• "I'm Here to Help You" Patient Advocates Serve as Liaisons Between Patients and Care Centers
• DiaLog: Patient Advocates: Solving Problems and Building Bridges, by Charles F. Leverback, MD, Associate Professor, Department of Gynecologic Oncology
• House Call: Keeping the Heart Healthy in Patients with Cancer

Cd8+-T-Cell Immunity Against Toxoplasma Gondii Can Be Induced But Not Maintained In Mice Lacking Conventional Cd4+ T Cells, Lori Casciotti, Kenneth H. Ely, Martha E. Williams, Imtiaz A. Khan

Dartmouth Scholarship

T-cell immunity is critical for survival of hosts infected with Toxoplasma gondii. Among the cells in the T-cell population, CD8⁺ T cells are considered the major effector cells against this parasite. It is believed that CD4⁺ T cells may be crucial for induction of the CD8⁺-T-cell response against T. gondii. In the present study, CD4^−/− mice were used to evaluate the role of conventional CD4⁺ T cells in the immune response against T. gondii infection. CD4^−/− mice infected with T. gondii exhibited lower gamma interferon (IFN-γ) messages in the majority of their …

Typical Symptoms Are Predictive Of Acute Coronary Syndromes In Women, Kerry A. Milner, Marjorie Funk, Amy L. Arnold, Viola Vaccarino

Nursing Faculty Publications

Background: Previous research suggests that the presentation of acute coronary syndromes (ACS) may differ in women and men. No study has prospectively evaluated the role of a comprehensive set of typical and atypical symptoms and whether different symptoms on presentation predict ACS diagnosis in women and men. Methods and Results: We directly observed 246 women and 276 men seen in the emergency department with symptoms suggestive of ACS and documented their symptoms verbatim. ACS was eventually diagnosed in 89 (36%) women and 124 (45%) men on the basis of standard electrocardiogram and cardiac enzyme criteria. Presence of typical symptoms (chest …

Prostatic Carcinoma With Emphasis On Gleason’S Grading: An Institution Based Experience., Zaid Ahmed, Suhail Muzaffar

Department of Pathology and Laboratory Medicine

Abstract

Objective:To grade prostatic carcinomas according to the Gleason’s Grading System and see whether the frequency of incidental carcinoma is significant. Method:Retrospective study of all consecutive cases of prostatic adenocarcinoma diagnosed at Aga Khan University Hospital (AKUH) between January 1st, 1996 and December 31st, 1999. Setting:The histopathology section of AKUH, Karachi. Observation:Prostatic adenocarcinomas comprised 14.2% of all prostate specimens. There were 3 types of specimens i.e. transurethral resection, suprapubic prostatectomies and core bIopsies. The mean age was 72.1 years; 68.1% patients were 65 years or older. The majority of the tumours were moderately differentiated (Gleason’s scores 5,6 or 7). Grading …

Medical Education Digest, Vol. 4 No. 1 (January 15, 2002), Nova Southeastern University

Medical Education Digest

No abstract provided.

Com Outlook Winter 2001-2002, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Using Validation As A Consultant In A Richmond, Virginia Continuing Care Retirement Community, John Colletti

Case Studies from Age in Action

Educational Objectives

1. Familiarize readers with the intricacies of setting up a behavioral program for persons diagnosed with Alzheimer's type dementia in a long term care facility.

2. Exemplify importance of interdisciplinary work.

3. Outline the future of the Validation Method in Virginia.

Older Adults, Social Techniques, And Memory, Karla K. Ziegenbalg

Case Studies from Age in Action

Educational Objectives

1. To use a social psychological perspective to examine memory abilities of older adults.

2. To understand in what ways the social environment, through direct social interaction, affects the memory performance of older adults.

3. To find out what, if any, social factors support memory performance in older adults.

Older Homeless Women: Beneath The Safety Net, Anne J. Kisor, Lynne Kendal-Wilson

Case Studies from Age in Action

Educational Objectives

1. Discuss how there is no stereotypical experience of, or explanation for, homelessness among older women.

2. Discuss why it is important to study the experiences of older homeless women.

3. Discuss policy and practice recommendations and specific ways to bridge efforts of aging and homeless service providers.

Are You At Risk For Blindness? Don't Keep Glaucoma A Family Secret! Older Age Is A Risk Factor, Mary Price

Case Studies from Age in Action

Educational Objectives

1. Raise awareness of risk factors for glaucoma.

2. Encourage health care providers to educate the patient about glaucoma risk factors.

3. Educate glaucoma patients to encourage family members to seek a glaucoma examination.

2001 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on Wilms' Tumor.

The Long-Term Clinical Prognosis In Patients With Anterior Wall And Non-Anterior Wall Acute Myocardial Infarction Referred To Primary Percutaneous Transluminal Coronary Angioplasty, Mingzhong Zhao, Dayi Hu, Tianchang Li, Sanqing Jia

Journal of the Hong Kong College of Cardiology

Objective: To investigate the long-term clinical prognosis in patients with anterior wall acute myocardial infarction (AW-AMI) and non AW-AMI (NAW-AMI) referred to primary percutaneous transluminal coronary angioplasty (P-PTCA). Methods: 287 patients with AMI who underwent P-PTCA were divided into AW-AMI group (142 cases) and NAW AMI group (145 cases) according to different sites of AMI. The baseline characteristics and coronary artery lesions of patients were analysed. The primary end points were in-hospital mortality and the major cardiovascular events (MACE) during a mean 17.3±9.8 months follow-up including the occurrences of non-fatal myocardial infarction, non-fatal congestive heart failure, revascularization of target vessels …

Appropriate Use Of Clopidogrel, Cyrus R Kumana, Bernard Man-Yung Cheung, Ij Lauder

Journal of the Hong Kong College of Cardiology

Clopidogrel (Plavix®) is an orally administered pro-drug, whose pharmacology and therapeutic role has been extensively reviewed in recent publications.1-5 In essence, it results in selective and irreversible antagonism of ADP-induced platelet aggregation. Such aggregation normally results in the surface expression of platelet glycoprotein (GP) IIb/IIIa receptors, which facilitate fibrinogen binding as well as consequential further platelet aggregation – the final common pathway of vascular occlusion. Specific cytochrome P450 enzymes are thought to generate the responsible active metabolite (believed to persist transiently). However, dosage adjustment is not recommended in hepatic impairment (unless severe) and drug-drug interactions and co-administration with meals are …

Frequency Of Use Of Complementary And Alternative Medicine In Women With Breast Cancer, Cecile A. Lengacher, Mary Bennett, Kevin E. Kip, Rosemary Keller, Melisa S. Lavance, Lynette S. Smith, Charles E. Cox

Nursing Faculty Publications

No abstract provided.

The University Of Health Sciences College Of Osteopathic Medicine, Kansas City, Missouri, University Of Health Sciences College Of Osteopathic Medicine

Historical Postcards (1908-2007)

Postcard shows photographs of four buildings on the campus of the University of Health Sciences College of Osteopathic Medicine in 2002.

Top left: Butterworth Alumni Center. Top right: Darwin J. and Suzanne Strickland Educational Pavilion. Bottom left: Leonard Smith Hall, which was originally the nurses' dormitory for Children's Mercy Hospital. Bottom right: Administration Building, originally Children's Mercy Hospital.