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Articles 3481 - 3510 of 14488

Full-Text Articles in Medical Education

Optimal Ranges Of Training Load And Recovery Status Prior To The Game To Maximize Game-Day Performance In Soccer, Cherish Keeney, Kelly B. Elliott, Jan-Joseph S. Rolloque, Ruben Moya, Kathryn E. Southall, Kealey J. Wohlgemuth, Jacob A. Mota, Yasuki Sekiguchi Feb 2024

Optimal Ranges Of Training Load And Recovery Status Prior To The Game To Maximize Game-Day Performance In Soccer, Cherish Keeney, Kelly B. Elliott, Jan-Joseph S. Rolloque, Ruben Moya, Kathryn E. Southall, Kealey J. Wohlgemuth, Jacob A. Mota, Yasuki Sekiguchi

International Journal of Exercise Science: Conference Proceedings

Identifying ideal ranges of training load (TL) and recovery status before soccer games is essential to maximize game-day performance. PURPOSE: To determine how accumulative TL and subjective fatigue affect performance during the game. METHODS: Twenty-one male semi-professional soccer players (mean ± standard deviation; age: 22 ± 2 years; mass: 77.3 ± 6.9 kg) wore a player tracking device to monitor TL during each practice and game. A 7-day accumulation of high speed running and sprinting (HSR+Sprint, ³12.30 mph), total distance (TD), low acceleration (LowACC: 0.50-1.99 m×s-2), and high acceleration (HighACC: 2.00-50.00 m×s …

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Tailored Injury Prevention In Ncaa Women’S Soccer: A 18-Year Team-Specific Epidemiological Analysis, Molly Gillikin, Rachel Lifson, Paul Mentele, Jessica Henslee, Carson Molaro, Xavier Smith, Ernest Rimer, Andreas Stamatis Feb 2024

Tailored Injury Prevention In Ncaa Women’S Soccer: A 18-Year Team-Specific Epidemiological Analysis, Molly Gillikin, Rachel Lifson, Paul Mentele, Jessica Henslee, Carson Molaro, Xavier Smith, Ernest Rimer, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Accurate understanding of injury patterns in athletes is essential for crafting effective prevention and rehabilitation strategies, enhancing player well-being and career longevity. However, relying solely on general NCAA injury surveillance data or broad epidemiological studies might not fully capture the specific injury trends in a particular NCAA team. Variations in team-specific factors could lead to deviations from these general patterns, underscoring the importance of analyzing team-specific data. This tailored approach ensures that training and rehabilitation protocols are optimally adjusted to the unique needs and injury risks of each specific team. PURPOSE: To identify common types of injuries, their frequencies, …

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The Association Between Parent's Perception And Child's Actual Motor Skills In Preschool-Age Children, Katherine L. Breault, Mitchell P. Kay, Darius L. Mobley, Emily F. Jenkins, Cianna S. Edmondson, Kacie Gray, Crystal Alvarez, Priscila Tamplain, Jerraco L. Johnson Feb 2024

The Association Between Parent's Perception And Child's Actual Motor Skills In Preschool-Age Children, Katherine L. Breault, Mitchell P. Kay, Darius L. Mobley, Emily F. Jenkins, Cianna S. Edmondson, Kacie Gray, Crystal Alvarez, Priscila Tamplain, Jerraco L. Johnson

International Journal of Exercise Science: Conference Proceedings

The preschool years is a critical time for the optimal development of children's fine and gross motor skills for future engagement in physical activity. Parents play a critical role in the development of these skills and early identification of potential developmental delays in their children. Early identification of developmental delay is essential for early intervention and rely on accurate child screenings that are often administered by parents. Few studies have compared the accuracy of parent’s perceptions across two different measurements with children's actual motor skills. PURPOSE: This study compared parents' perceptions of their child’s motor skills on two assessments with …

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Different Orders Of Combined Upper- And Lower-Body Resistance Exercise Induce Different Pulse Wave Reflection Responses Induce In Resistance-Trained Young Women, Andrea Toledo, Yu Lun Tai, Alissa Olvera, Sophia Moreno, Abigail Gomez, Melody Cantu, Ryan D. Russell Feb 2024

Different Orders Of Combined Upper- And Lower-Body Resistance Exercise Induce Different Pulse Wave Reflection Responses Induce In Resistance-Trained Young Women, Andrea Toledo, Yu Lun Tai, Alissa Olvera, Sophia Moreno, Abigail Gomez, Melody Cantu, Ryan D. Russell

International Journal of Exercise Science: Conference Proceedings

Varying the orders of UL and LU resistance exercise (RE) has been shown to induce different cardiovascular responses in active men. However, various orders of upper- and lower-body RE on pulse wave reflection in resistance-trained young women is unknown. PURPOSE: To evaluate the pulse wave reflection in resistance-trained young women based on the effects of different orders of upper- and lower-body RE. METHODS: Twelve resistance-trained young women (22±2 yrs) completed the study. Pulse wave reflection was assessed at rest, 10 (R1), and 20 (R2) minutes after either upper- and lower-body RE (UL) or lower- and upper-body RE (LU) for …

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Firefighters Versus Law Enforcement Officers: A Comparison Of Cardiovascular Disease Risk, Bethany C. Guerra, Hunter Martaindale, Steven E. Martin, Lisa C. Colvin, Drew E. Gonzalez, Matthew J. Mcallister Feb 2024

Firefighters Versus Law Enforcement Officers: A Comparison Of Cardiovascular Disease Risk, Bethany C. Guerra, Hunter Martaindale, Steven E. Martin, Lisa C. Colvin, Drew E. Gonzalez, Matthew J. Mcallister

International Journal of Exercise Science: Conference Proceedings

Firefighters (FF) and law enforcement officers (LEO) have heightened cardiovascular disease (CVD) risk due to the stressful nature of their occupations. Data suggest that 45% of on-duty FF fatalities are related to CVD, while LEO have a 1.7 times higher CVD prevalence compared to the general public. To our knowledge, studies comparing FF to LEO, in terms of CVD risk factors, have not been published. This information is necessary to better understand differences in occupational disease risk, as well as to help bridge the gap between stress and CVD markers. PURPOSE: To compare CVD risk biomarkers, fitness, and body …

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Validation Of A Non-Invasive Physiological Stress Assessment: Agreement Of Salivary And Blood Cortisol Among Firefighters, Caiti Dodge, Hunter Martaindale, Steven E. Martin, Lisa C. Colvin, Drew E. Gonzalez, Matthew J. Mcallister Feb 2024

Validation Of A Non-Invasive Physiological Stress Assessment: Agreement Of Salivary And Blood Cortisol Among Firefighters, Caiti Dodge, Hunter Martaindale, Steven E. Martin, Lisa C. Colvin, Drew E. Gonzalez, Matthew J. Mcallister

International Journal of Exercise Science: Conference Proceedings

Salivary cortisol has been used as an indicator of stress exposure among tactical personnel (i.e., firefighters). Assessing cortisol concentrations, whether via blood or saliva samples, can provide valuable insight into the physiological stress load placed upon the firefighter. Cortisol levels provide a reflection of the hypothalamic-pituitary-adrenal (HPA) axis activity. Salivary cortisol is unbound and has been suggested to provide a better reflection of HPA axis activity compared to blood cortisol, which is bound to soluble corticosteroid-binding globulin. Importantly, the use of salivary biosample collection also offers a more practical and non-invasive method to assess physiological stress biomarkers when blood sample …

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The Relationship Between Shoulder Mobility And Upper Body Muscle Mass On 2-Rm Bench Press Performance, Raquel J. Cavazos, Francesca Aquilino, Ernesto Balderrama, Chaehyun Byun, Shelby Gerner, Cheyenne Martinez, Austin Riffe, Vipa Bernhardt, Michael D. Oldham Feb 2024

The Relationship Between Shoulder Mobility And Upper Body Muscle Mass On 2-Rm Bench Press Performance, Raquel J. Cavazos, Francesca Aquilino, Ernesto Balderrama, Chaehyun Byun, Shelby Gerner, Cheyenne Martinez, Austin Riffe, Vipa Bernhardt, Michael D. Oldham

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Upper body strength is one of the most important factors in American football and thus tested frequently. However, strength may come at the cost of mobility as recent studies have reported an inverse relationship between shoulder range of motion (ROM) and strength, with an increase in strength causing a decrease in ROM (Shitara et al., 2022). PURPOSE: The purpose of this study was to determine if upper body muscle mass or shoulder mobility are associated with two-repetition max (2-RM) bench press performance in collegiate football players. METHODS: Data from 80 Division I varsity football players (20.5 ± 1.4 …

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Intermuscular Emg Coherence Between Shoulder Muscles During Fatigue In Older Adults With And Without Rotator Cuff Disease, Xinyu Li, Huiying Zhu, Lisa Griffin Feb 2024

Intermuscular Emg Coherence Between Shoulder Muscles During Fatigue In Older Adults With And Without Rotator Cuff Disease, Xinyu Li, Huiying Zhu, Lisa Griffin

International Journal of Exercise Science: Conference Proceedings

The risk of degenerative rotator cuff disease (RCD) increases with age, partly due to changes in neuromuscular control, especially during fatiguing contractions. Intermuscular electromyographic (EMG) coherence, reflecting shared neural inputs between motor neuron pools, is essential for maintaining shoulder joint stability. PURPOSE: To determine differences in EMG coherence within the rotator cuff muscles, and between the rotator cuff and deltoid muscles, during sustained isometric fatiguing contractions in older adults with and without RCD. METHODS: Thirteen older adults with RCD (68 ± 8 yrs) and 20 without RCD (69 ± 8yrs) participated. Intramuscular EMG was recorded from the supraspinatus …

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Body Fat Percentage Estimation From Smartphone Three-Dimensional Optical Imaging, Christine M. Florez, Christian Rodriguez, Madelin R. Siedler, Ethan Tinoco, Grant M. Tinsley Feb 2024

Body Fat Percentage Estimation From Smartphone Three-Dimensional Optical Imaging, Christine M. Florez, Christian Rodriguez, Madelin R. Siedler, Ethan Tinoco, Grant M. Tinsley

International Journal of Exercise Science: Conference Proceedings

Body composition is an important component of overall health. The development of digital assessment methods has led to increased interest in devices that allow users to monitor their own body composition. Smartphone applications with three-dimensional optical imaging (3DO) capabilities are a user-friendly technology capable of predicting percent body fat (BF%) from relevant body measurements. PURPOSE: To determine the validity of two BF% equations using smartphone 3DO data, as compared to a 4-compartment (4C) model criterion, and to produce a new BF% estimation equation. METHODS: At a single laboratory visit, 60 participants (28 F, 32 M; [mean ± SD] …

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Habitual Fluid Intake Does Not Affect Sleep Parameters In Young Women., Ruben E. Moya, Hui-Ying Luk, Casey Appell, Alan Ky, Kelly B. Elliott, Cherish Dunlap, Nigel Jiwan, Yasuki Sekiguchi Feb 2024

Habitual Fluid Intake Does Not Affect Sleep Parameters In Young Women., Ruben E. Moya, Hui-Ying Luk, Casey Appell, Alan Ky, Kelly B. Elliott, Cherish Dunlap, Nigel Jiwan, Yasuki Sekiguchi

International Journal of Exercise Science: Conference Proceedings

Sleep is essential for optimal physical performance, cognitive function, recovery, and overall health. Similarly, hydration status has been shown to influence physical and cognitive functions. Dehydration can lead to impaired cognition and possibly impaired sleep. However, the effect of habitual total water intake (TWI) on sleep and recovery measures have not been examined. PURPOSE: To examine the effect of TWI on sleep and recovery measures in young women. METHODS: Twenty-two young women (age: 22.8±4.6 yrs; body mass: 60.0±9.5 kg; height: 164.6±6.1 cm) collected fluid intake and food consumption information across a 5 day period, and average TWI was calculated based …

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Vitamin D3 Supplementation Alters Gut Microbiome Composition And Increases Stability In Healthy Individuals, Madhur Wyatt, Ankan Choudhury, Gabriella Von Dohlen, Jeffery L. Heileson, Jeff S. Forsse, Leigh Greathouse Feb 2024

Vitamin D3 Supplementation Alters Gut Microbiome Composition And Increases Stability In Healthy Individuals, Madhur Wyatt, Ankan Choudhury, Gabriella Von Dohlen, Jeffery L. Heileson, Jeff S. Forsse, Leigh Greathouse

International Journal of Exercise Science: Conference Proceedings

Early onset colorectal cancer incidence has increased significantly. Evidence links serum 25(OH)D levels and the gut microbiome to colon carcinogenesis, with vitamin D pivotal in modulating the immune system and intestinal epithelial function. The effect of supplemental vitamin D3 on the gut microbiome in healthy adults is unclear. PURPOSE: Investigate the effect of a 12-week oral dose of 4000 IU vitamin D3 on acute and long-term gut microbiome changes in healthy adults. METHODS: Forty-three participants, aged 18-53, were randomized based on baseline serum 25(OH)D levels into treatment (n=21) and placebo groups (n=22). Fecal samples …

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Sleep Duration Is Increased Following Muscle Damaging Exercise In Hot Environmental Conditions, Marcos Keefe, Ryan A. Dunn, Casey R. Appell, Nigel C. Jiwan, Jan-Joseph S. Rolloque, Hui-Ying Luk, Yasuki Sekiguchi Feb 2024

Sleep Duration Is Increased Following Muscle Damaging Exercise In Hot Environmental Conditions, Marcos Keefe, Ryan A. Dunn, Casey R. Appell, Nigel C. Jiwan, Jan-Joseph S. Rolloque, Hui-Ying Luk, Yasuki Sekiguchi

International Journal of Exercise Science: Conference Proceedings

Sleep and recovery measures are typically negatively affected by a muscle-damaging bout of exercise. However, it remains unknown if the additive effects of hot environmental conditions, resulting in increased core temperature and other thermoregulatory responses during the exercise bout, further progress changes in quantity and performance quality of sleep duration. PURPOSE: To investigate the effect of muscle-damaging exercise in the heat, compared to a thermoneutral condition, on sleep and recovery measures. METHODS: Ten healthy males (age: 23 ± 3yr; body mass: 78.7 ± 11.5kg; height: 176.9 ± 5cm; lactate threshold [LT]: 9.7 ± 1.0km.hr-1) performed two …

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Effect Of Bungee Unweighting On Vo2, Heart Rate, Rpe, And Body Weight While Walking, Jaelynn Barrera, Ariel Perez, John D. Smith Feb 2024

Effect Of Bungee Unweighting On Vo2, Heart Rate, Rpe, And Body Weight While Walking, Jaelynn Barrera, Ariel Perez, John D. Smith

International Journal of Exercise Science: Conference Proceedings

Unweighting systems are commonly used for rehabilitation and training purposes, and can alter energy expenditure, pain perception, and joint stress. The Lightspeed Lift is a relatively new unweighting system that uses bungees to support the user and is less expensive than more common unweighting systems. This study seeks to explore the difference in energy expenditure during walking while bearing normal body weight compared to when using the Lightspeed Lift at low, intermediate, and high unweighting. PURPOSE: To explore the effect of using a treadmill bungee support system (Lightspeed lift) on oxygen consumption (VO2), heart rate (HR), and …

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Effects Of Massage Gun Treatment On Calf Muscle Soreness, Jasmin K. Brown, John D. Smith Feb 2024

Effects Of Massage Gun Treatment On Calf Muscle Soreness, Jasmin K. Brown, John D. Smith

International Journal of Exercise Science: Conference Proceedings

Massage gun devices are relatively new and verification of their claims to reduce muscle soreness is needed. PURPOSE: The purpose of this study is to determine the effects of percussive treatment using a massage gun on calf muscle soreness. METHODS: The session included measurement of age (22.5±4.0), height (164.1±9.6), and body weight (77.7±15.9) for 37 participants, Participants performed one trial of heel raises with a 4.5 kg (males) or 2.3 kg (females) dumbbell to a 70 b/min cadence to exhaustion, followed by 1-min rest and another trial in the same way but without weight. Two types of written …

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Hemodynamic Responses To Blood Flow Restriction Exercise With Different Types Of Cuffs, Lin-Sheng Chen, Philippe Brosselin Perez Palma, Natalie Mclaurin, Daniela Charry Segura, Francisco Aguilar, Hirofumi Tanaka Feb 2024

Hemodynamic Responses To Blood Flow Restriction Exercise With Different Types Of Cuffs, Lin-Sheng Chen, Philippe Brosselin Perez Palma, Natalie Mclaurin, Daniela Charry Segura, Francisco Aguilar, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

While blood flow restriction (BFR) training has gained popularity, the original narrow elastic (NE) design featured in the Kaatsu bands has been gradually replaced by wide-rigid (WR) nylon blood pressure cuffs that are cheaper and easily available. We demonstrated that using WR cuffs resulted in marked increases in blood pressure and myocardial oxygen demand during BFR walking exercise compared with NE bands. Currently, the hemodynamic responses to BFR resistance exercise using different types of cuffs are unknown. PURPOSE: To compare blood pressure and physiological responses before and after BFR resistance exercise with WR cuffs and NE bands. METHODS: …

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Alternating Muscle Activation Patterns Across The Deltoid Muscles During Sustained Fatiguing Contractions, Ningzhen Zhao, Xin Yu, Lisa Griffin Feb 2024

Alternating Muscle Activation Patterns Across The Deltoid Muscles During Sustained Fatiguing Contractions, Ningzhen Zhao, Xin Yu, Lisa Griffin

International Journal of Exercise Science: Conference Proceedings

Alternating muscle activation (AMA) across synergists has been identified in lower-extremity muscles that may function to prolong force output during sustained contractions; however, this has not yet been identified in upper extremity muscles. AMA consists of two periods: co-activation (Co-A), in which a pair of synergists are simultaneously increasing or decreasing EMG amplitude, and trade-off (TO), in which the EMG amplitude of one muscle is increasing while the EMG amplitude of a synergist is decreasing. We hypothesized that TO duration would increase and Co-A duration would decrease during fatigue. PURPOSE: To investigate AMA patterns during sustained submaximal isometric fatiguing …

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De Novo Microdeletion Spanning Ywhae And Crk In An Individual With Intellectual Disability And Stunted Growth, Eden E. Pope, John A. Kriak, Kyle B. Bills, David W. Sant Feb 2024

De Novo Microdeletion Spanning Ywhae And Crk In An Individual With Intellectual Disability And Stunted Growth, Eden E. Pope, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

In this report, we present a case of a 20-year-old female with congenital intellectual disability, stunted growth, and hypothyroidism. Competitive genetic hybridization (CHG) revealed a loss of a portion of 17p13.3 at least 195 Kb in size, not present in either parent. This area of chromosome 17 is associated with Miller-Dieker Syndrome (MDS) and Isolated Lissencephaly Sequence (ILS), but these conditions are related predominantly to PAFAH1B1, which is not included in the patient’s deletion.

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Investigating The Interplay Between Glucose Regulation, Neural Activity, And Motivation: A Novel Approach Utilizing Vibration Stimulation, Blake D. Harris, Patrick Tanner Brain, Alessandra Maisie Rivera, Tiffany Nguyen, James Barber, Amar Paul, John Dougherty Jr., Matthew Jennings, Bridger Gunter, David W. Sant, Christina A. Small, Scott Steffenson, Kyle B. Bills Feb 2024

Investigating The Interplay Between Glucose Regulation, Neural Activity, And Motivation: A Novel Approach Utilizing Vibration Stimulation, Blake D. Harris, Patrick Tanner Brain, Alessandra Maisie Rivera, Tiffany Nguyen, James Barber, Amar Paul, John Dougherty Jr., Matthew Jennings, Bridger Gunter, David W. Sant, Christina A. Small, Scott Steffenson, Kyle B. Bills

Annual Research Symposium

This research explores the intricate relationship between glucose regulation, neural activity, and motivation in key brain regions, including the hypothalamus, basal ganglia, ventral tegmental area (VTA), and nucleus accumbens (NA). We aim to unravel the potential relationship of these factors on dopamine (DA) release and the broader implications for mental health, glucose regulation, well-being, and overall health. Our innovative approach involves using a chair that causes heterodyned whole-body vibration designed to stimulate DA release from the VTA and NA, areas associated with motivation and rewards.

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Trichomonas Vaginalis Infection In Emergency Department Patients, Owen Christian Schubert Feb 2024

Trichomonas Vaginalis Infection In Emergency Department Patients, Owen Christian Schubert

Annual Research Symposium

Trichomonas vaginalis (TV) is a common sexually transmitted infection (STI) that affects around 2.3 million women and 1.4 million men in the United States. TV infection in females can cause vaginal discharge, dysuria and abdominal pain and can be complicated by pelvic inflammatory disease, infertility, cervical neoplasia and increased transmission rates of other STIs. In males, TV can cause urethral discharge and dysuria, but is often asymptomatic and therefore not often studied. We seek to determine the rates of TV infection among male and female patients presenting to EDs for STI evaluation in the Las Vegas metropolitan area, and compare …

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Exploring The Interconnected Role Of The Oral Microbiome And Periodontal Disease In The Development And Progression Of Oral Squamous Cell Carcinoma, Malak Al-Regib, Claudia M. Tellez Freitas Feb 2024

Exploring The Interconnected Role Of The Oral Microbiome And Periodontal Disease In The Development And Progression Of Oral Squamous Cell Carcinoma, Malak Al-Regib, Claudia M. Tellez Freitas

Annual Research Symposium

This comprehensive review explores the complex linkage among the oral microbiome, periodontal disease, and the onset and progression of oral squamous cell carcinoma (OSCC).

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Establishing Optimal Tools For An Anatomy Laboratory On The Six-Point Mastery Learning Model, Alice Akunyili, Kanee Lerwill, Dietrich Lorke Feb 2024

Establishing Optimal Tools For An Anatomy Laboratory On The Six-Point Mastery Learning Model, Alice Akunyili, Kanee Lerwill, Dietrich Lorke

Annual Research Symposium

Roseman University of Health Sciences (RU) is establishing a new College of Medicine in Southern Nevada with the goal of transforming Medical Education and Healthcare delivery. To this end, facilities and resources for an integrated anatomy education need to be established, considering best practices for anatomy education. At Roseman University the six-point learning mastery model is at the center of the process of delivering the study materials. This combination of anatomy lab design and educational resources, i.e., plastinated human organs, anatomical models, simulators and virtual anatomy tools, within our block curriculum, will allow for an innovative and inclusive competency-based anatomy …

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Non-Hodgkin's Lymphoma Of The Oral Cavity - A Rare Entity, Anita J. Florence Dr, Karpagaselvi Sanjai Prof & Dr Feb 2024

Non-Hodgkin's Lymphoma Of The Oral Cavity - A Rare Entity, Anita J. Florence Dr, Karpagaselvi Sanjai Prof & Dr

Annual Research Symposium

Non-Hodgkin’s lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extra nodal sites, including the gastro-intestinal tract, Waldeyer’s ring, bone, skin and brain. Intraoral NHL is uncommon and may affect either the jaw bones or occur within the soft tissues of the oral cavity. Here we report an unusual case of non-Hodgkin’s lymphoma in a 54-year-old male patient who presented with a growth from the right lower molar extraction socket with pus discharge.

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2024 February 20 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University Feb 2024

2024 February 20 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

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Success And Challenges Of Infrazygomatic Crest Implants In Orthodontics, Gauri Gill Feb 2024

Success And Challenges Of Infrazygomatic Crest Implants In Orthodontics, Gauri Gill

Annual Research Symposium

Poster on success rates of mini implants used in the infrazygomatic region for orthodontic anchorage , as well as the factors that influence the success of the mini implant placed in IZC region.

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Dna Extraction Method Development For Ocular Tissues, Conrad K. Ashby, Michael C. Trapnell, Walker C. Kay, Jonathon C. Reynolds, Noah R. Schultz, Brandon J. Burger, Christina A. Small, John A. Kriak, Kyle B. Bills, David W. Sant Feb 2024

Dna Extraction Method Development For Ocular Tissues, Conrad K. Ashby, Michael C. Trapnell, Walker C. Kay, Jonathon C. Reynolds, Noah R. Schultz, Brandon J. Burger, Christina A. Small, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Purpose: DNA extraction kits are traditionally developed to work with liquid tissues such as blood, saliva, and swabs, but some have been proposed to work with solid tissues. Somatic variation in cancers can be important for tumor subtyping and treatment guidance, including ocular tumors. Additionally, epigenetic marks such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are tissue-specific and change in disease states, particularly evident in diabetic retinopathy and age-related macular degeneration. Commercial DNA extraction kits are available from several vendors, but the various kits have different strengths and weaknesses, and the removal of PCR inhibitors will vary with each kit. This …

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Non-Traditional Presenting Grade Ii Brain Meningioma: A Case Study, Alessandra M. Rivera, Garret Phillips, Serin Baker, Michael Trapnell, Conrad Ashby, Jacob Hill, Prina Patel, Alexander Ruiz, Elden Jenkins, Johan A. Kriak, Kyle B. Bills, Voicu S. Ciobanu, Tipsuda Bahri, David W. Sant Feb 2024

Non-Traditional Presenting Grade Ii Brain Meningioma: A Case Study, Alessandra M. Rivera, Garret Phillips, Serin Baker, Michael Trapnell, Conrad Ashby, Jacob Hill, Prina Patel, Alexander Ruiz, Elden Jenkins, Johan A. Kriak, Kyle B. Bills, Voicu S. Ciobanu, Tipsuda Bahri, David W. Sant

Annual Research Symposium

Meningioma is a relatively common form of cancer, occurring in approximately 97 out of 100,000 individuals. Although it arises from the meninges surrounding the central nervous system (CNS) rather than from neurons, it is classified with CNS tumors due to overlapping symptoms caused by compression of nerves and vessels in the head. Extracranial metastasis is rare, at less than 1%, and correlates with reduced survival rates.

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Neurocognitive Considerations And Impacts In Chronic Migraines, Kennedy Madrid, Jacob Warner, Jordyn Huecker, Cassidy Byers, Kyle Reaveley, Kailee Edwards, Luke Sanders, Christina A. Small, David W. Sant, John A. Kriak, Kyle B. Bills Feb 2024

Neurocognitive Considerations And Impacts In Chronic Migraines, Kennedy Madrid, Jacob Warner, Jordyn Huecker, Cassidy Byers, Kyle Reaveley, Kailee Edwards, Luke Sanders, Christina A. Small, David W. Sant, John A. Kriak, Kyle B. Bills

Annual Research Symposium

Migraine, characterized by moderate-to-severe headache, may arise from neurological, psychological, orthopedic, metabolic, or endocrine origins. Pain associated with migraine, while commonly cited as the primary patient concern, only represents a small portion of short- and long-term effects caused by the condition. Many presenting cases include neuromuscular dysfunction, increased neuronal firing, inflammation, and cortical spreading depression. These effects can induce multiple symptoms such as pain, aura, brain fog, confusion, hangover, multiple hypersensitivities, and decreased memory capacity. These effects and symptoms can lead to neurocognitive and neuropsychological deficiencies in many patients. This study aims to investigate the relationship between migraines and neurocognitive …

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Neuropsychological Findings In Idiopathic Adult-Onset Epilepsy Case Study: Noorda Com Student Investigation, Jacob Warner, Michael Milius, Jordyn Huecker, Tiffany Nguyen, Luke Sanders, Joseph Harbold, Kennedy Madrid, Nicholas Curtis, Chase Taylor, James Barber, Jayne Stuter, Ethan Zaugg, Aaron Andrews, John A. Kriak, David W. Sant, Kyle B. Bills Feb 2024

Neuropsychological Findings In Idiopathic Adult-Onset Epilepsy Case Study: Noorda Com Student Investigation, Jacob Warner, Michael Milius, Jordyn Huecker, Tiffany Nguyen, Luke Sanders, Joseph Harbold, Kennedy Madrid, Nicholas Curtis, Chase Taylor, James Barber, Jayne Stuter, Ethan Zaugg, Aaron Andrews, John A. Kriak, David W. Sant, Kyle B. Bills

Annual Research Symposium

We report the case of a 25-year-old male patient with idiopathic adult-onset epilepsy. The patient presented with a chief complaint of recurrent seizures and no identifiable cause. These seizures were associated with a lack of extremity control, muscle spasms, and loss of cognitive function. His condition began while living in Thailand, where he experienced multiple environmental stressors including hostile living conditions and tense situations, approximately five years before being seen in the clinic. Over the past several years, the seizures have not ceased, and the patient now notes a loss or decrease of several special senses.

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Development Of A Protocol For Obtaining Biological Samples For Genetic Testing From Remote Individuals, Noah R. Schultz, Brandon J. Burger, Jacob Warner, Alfred Amendolara, Jameson Williams, Molly Henley, Layla Risdon, Alessandra Maisie Rivera, Amanda Page, Millicent Jiang, Denisse Castaneda, Garret Phillips, John A. Kriak, Kyle B. Bills, David W. Sant Feb 2024

Development Of A Protocol For Obtaining Biological Samples For Genetic Testing From Remote Individuals, Noah R. Schultz, Brandon J. Burger, Jacob Warner, Alfred Amendolara, Jameson Williams, Molly Henley, Layla Risdon, Alessandra Maisie Rivera, Amanda Page, Millicent Jiang, Denisse Castaneda, Garret Phillips, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Pharmacogenomic sequencing allows individuals to learn more about how they will respond to certain medications but requires shipping of a biological sample. One complication of sending biological samples to remote laboratories is stability. Blood generally yields sufficient quantities of high-quality DNA but requires a clinic visit. Saliva and buccal swabs are routinely used for DNA extractions, but the DNA quality is notoriously low due to the presence of bacteria in the mouth. Additionally, elderly individuals have difficulty producing enough saliva for testing, and the tubes contain several milliliters of liquid and shipping requires special considerations. Dried blood spot cards, which …

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Dna Extraction Method Development For Solid Tissues, Ryan Powers, Noah R. Schultz, Brandon J. Burger, John Dougherty Jr., Ezenna Obilor, Alexander Ruiz, Corwin Frey, Nathaniel Hill, Lara Laughrey, Patrick Tanner Brain, Sara Mcmahon, Parker Feltner, Steven Tung, Daoud Sajady, Elden Jenkins, Julian Jarquin, Serin Baker, Aaron Andrews, John A. Kriak, Kyle B. Bills, David W. Sant Feb 2024

Dna Extraction Method Development For Solid Tissues, Ryan Powers, Noah R. Schultz, Brandon J. Burger, John Dougherty Jr., Ezenna Obilor, Alexander Ruiz, Corwin Frey, Nathaniel Hill, Lara Laughrey, Patrick Tanner Brain, Sara Mcmahon, Parker Feltner, Steven Tung, Daoud Sajady, Elden Jenkins, Julian Jarquin, Serin Baker, Aaron Andrews, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Although germline variation testing is traditionally performed using DNA obtained from blood or other liquid samples, determining somatic variation in cancer samples requires DNA extraction directly from tissues. Additionally, epigenetic markers, such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are tissue-specific and change in selected disease states. However, several substances present in tissues are known to inhibit downstream reactions, including polymerase chain reaction PCR). For this project, we are assessing the quantity and quality of DNA obtained from extractions of various vital organs using 30 different commercially available DNA extraction kits to determine optimal kits for each tissue.

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