Nervous System Diseases Commons^™

Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney

Articles

Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is generally …

Disclosure Of At-Risk Status For Huntington's Disease: Is There A "Right Time?", Krysten Ann Shipley

Honors Program Theses

The disclosure of at-risk status for HD can be a complicated and stress inducing process. The most difficult people to disclose this information to are most often those who are also at-risk, notably the children of individuals who are themselves at-risk for developing the disease or know that they will develop the disease. How and when a child finds out that he or she is at risk for a debilitating disease can have a tremendous impact on the development of the child. The purpose of this thesis is to assess the ideal course of action in dealing with how and …

Feel The Love: A Family Faces Juvenile Huntington’S Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Smelling The Flowers At Thanksgiving, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

No Time For Fear, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Creating Hope, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

My New Profession: Hd Activist, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

An Experiment And A Death, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Unending 'Thank You', Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

In The Midst Of The Hurricane, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Imagining A World Without Huntington's, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Pondering An Exit From The Hd Closet, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Ten Years After The Test, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A New Attitude About Huntington’S Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Great Reasons To Be A Guinea Pig, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Life-Or-Death Walk Into The Future, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Time Is Ripe, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

To Flee Or To Fight, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Hd: Hurtling Towards Death, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Huntington's Warrior Lays Down His Shield, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Our Economic Comeback And The Cure Industry, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Holiday Message: Hope For The Forsaken Of Huntington's, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

In A Time Of Crisis, The Best Investment Of All, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Asian Cerebral Venous Thrombosis Registry: Study Protocolv, Mohammad Wasay, Ayeesha Kamal, Bhojo Khealani

Department of Medicine

Introduction:

Cerebral venous thrombosis (CVT) is a well known but poorly reported entity. Most of the studies and registries related to CVT are reported from European countries. No large multi-center or multi- national data base or registry has been reported from Asian countries. CVT is not uncommon in Asia especially in south Asian subcontinent including India, Pakistan and Bangladesh. One study reported from India that CVT accounted for half of all strokes in the young and 40% of strokes in women. Review of CVT cases from Asian countries is suggestive of differences in risk factors profile and outcome in these …

Fight Against Chronic Diseases (High Blood Pressure, Stroke, Diabetes And Cancer) In Pakistan; Cost-Effective Interventions, Mohammad Wasay, Abdul Jabbar

Department of Medicine

No abstract provided.

Neuropsychological Assessment Of Working Memory, Processing Speed, And Cognitive Fatigue Among Individuals With Sickle Cell Disease: A Biopsychosocial Developmental Perspective, Laura J. Tagliareni

Seton Hall University Dissertations and Theses (ETDs)

,

Disease, Denial, And Support: The Many Kinds Of Family, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Roots Of Our Stigma, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Distinct Functions Of Autoreactive Memory And Effector Cd4+ T Cells In Experimental Autoimmune Encephalomyelitis, Wassim Elyaman, Pia Kivisäkk, Jay Reddy, Tanuja Chitnis, Khadir Raddassi, Jaime Imitola, Elizabeth Bradshaw, Vijay K. Kuchroo, Hideo Yagita, Mohamed H. Sayegh, Samia J. Khoury

Jay Reddy Publications

The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental autoimmune encephalomyelitis (EAE). We found that memory CD4⁺ T cells up-regulated the activation marker CD44 as well as CXCR3 and ICOS, proliferated more and produced more interferon-γ and less interleukin-17 compared to effector T cells. Moreover, adoptive transfer of memory T cells into T cell receptor (TCR)αβ^-/- recipients induced more severe disease than did effector CD4⁺ T cells with marked central nervous system inflammation and …

A Non-Randomized Study Of Safety And Efficacy Of Heparin For Dvt Prophylaxis In Intracerebral Haemorrhage, Mohammad Wasay, Saqibuddin Khan, Khawaja S. Zaki, Bhojo A. Khealani, Ayeesha Kamal, Iqbal Azam, Ismail A. Khatri

Department of Medicine

Objective: To evaluate the safety and efficacy of subcutaneous heparin for deep venous thrombosis (DVT) prophylaxis in patients with intracerebral haemorrhage (ICH) during acute phase in comparison to elastic stockings.

Methods: The diagnosis of ICH was based on imaging (CT or MRI) and DVT was based on Doppler ultrasound.

Results: A total of 458 patients were identified over a period of 5 years (1997-2001). Median age was 59 years (range:12-99 years). Two hundred (44%) patients received heparin (heparin group) in addition to elastic stockings and 258 (56%) patients were only given elastic stockings (stockings group). These two groups were not …