Nervous System Diseases Commons^™

It’S Playoff Time – And A Reminder That Brain Health Comes First, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Creating A Christmas Memory For A Huntington’S Family, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

‘Alive And Well’ Captures Struggle Against Untreatable Brain Disorder, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Cell And Molecular Biology Of Neurodegenerative Diseases: An Overview, Heather L. Montie, Thomas M. Durcan

PCOM Scholarly Works

There is no abstract for this article.

A Huntington’S Thanksgiving Message: Gratitude For Health And The Ability To Work, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Braving Bioethical Challenges: The Importance Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

One Year Out Of The Terrible, Lonely Huntington’S Disease Closet, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan, Bushra Afroze, Mohammad Wasay

Department of Medicine

Biotinidase deficiency is an inherited disorder in which the vitamin biotin is not recycled. If untreated, affected individuals develop neurological and cutaneous symptoms. Untreated individuals with biotinidase deficiency either succumb to disease or are left with significant morbidity. We describe clinical course and follow-up of 4 children from Pakistan. All 4 presented with classical symptoms of biotinidase deficiency and responded dramatically to oral biotin within days to weeks. Biotinidase deficiency is reported in Pakistani children from different part of world, however; there is no such report from Pakistan. This highlights lack of awareness of biotinidase deficiency among physicians in Pakistan

‘Tired Of Waiting,’ Huntington’S Disease Families Engrossed In Efforts To Conduct Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The End Of Fear And Exclusion: Informing My Health Insurance Plan About The Risk Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Heading To Rio For The 2013 World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, Jutta Elisabeth Ataie

Dissertations and Theses

This study used photovoice methodology to explore how people with early-stage dementia use their perceived strength and resources to cope with the illness. Purposive sampling was used to recruit participants. Thirteen women and seven men age 57 to 90 (mean 73.4) with MMSE scores ranging from 20 to 28 (mean 25.6) participated in the project. Participants were provided with a disposable camera and invited to take photographs relevant to their well-being. The photographs provided the means for participants to take the lead in dialogue sessions about their coping response.

Grounded theory analysis revealed that initially, early-stage dementia precipitated a disruption …

Going With The Flow Of Time, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Fighting For The Option To Care For Huntington’S Disease Patients At Home, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Diabetes Mellitus And Hypercholesterolemia Are Risk Factors For Alzheimer’S Disease And Appear To Affect The Integrity Of The Blood Brain Barrier, Jacqueline Dash

Graduate School of Biomedical Sciences Theses and Dissertations

Studies have shown that the vascular risk factors common to diabetes mellitus and hypercholesterolemia are also risk factors for Alzheimer’s disease (AD). It is currently unknown how these diseases are associated with AD, but they may cause a leak in the blood brain barrier (BBB), which is one of the hallmarks of AD. In this preliminary study, over 150 pig brain slides were tested for the expression levels of tight junction proteins occludin and claudin V in the BBB microvasculature. There were three groups of pig brains used in this study namely, control pigs, pigs with diabetes mellitus and hypercholesterolemia …

A Descriptive Study To Find Possible Correlation Between Mri Findings Of Pituitary Gland And Serum Prolactin Level, Muhammad Azeemuddin, Rohana Naqi, Mohammad Wasay

Department of Medicine

Objective: To explore equation, if any, between findings of magnetic resonance imaging of pituitary gland and serum prolactin level.

Methods: The retrospective, descriptive study was conducted at the Department of Radiology, Aga Khan University Hospital, Karachi, and related to patients\' records from April 19, 2006 to April 23, 2009. Seventy patients underwent magnetic resonance imaging of brain for pituitary gland. Inclusion criteria were all patients referred with relevant clinical symptoms or deranged serum prolactin level. Patients who were claustrophobic or had a pacemaker, aneurysm clip, metallic foreign body in the orbit or with no laboratory investigation were excluded from the …

Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, Megan Welter

Masters Theses

Multiple System Atrophy (MSA) is a sporadic, neurodegenerative disease that consists of three conditions: autonomic dysfunction, Parkinsonism and cerebellar ataxia. Our lab conducted an Affymetrix global gene expression analysis using pons tissue of MSA patients to determine genes that are differentially expressed when compared to non- MSA controls. This study identified upregulated genes, including the C-X-C chemokine receptor type 4, CXCR4, to which stromal cell-derived factor-I (SDF-1) is the natural ligand. The CXCR4/SDF-1 signaling pair has been sho.wn to play multiple roles in the brain, such as inducing neuronal apoptosis and promoting leukocyte recruitment during inflammation. The MSA cerebellum presents …

Strangling Of Patient In Nursing Home A Shuddering Reminder Of Subpar Care For Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Do We Need To Shock The World To Strengthen The Huntington's Disease Cause, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Memories Of Genetic Testing: From My Mom To Angelina Jolie, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Key New Ally In The Search For Huntington’S Disease Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Feeling The Hope, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Quickening The Pace Towards A Huntington’S Disease Gene-Silencing Clinical Trials: Pharma Giant Roche, Isis Enter Partnership, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Intensive Goal-Directed Treatments In Enriched Environments Augments Patient Outcomes Post-Stroke, Blake A. Kandah, Michael A. Klonowski, Ryan M. Pelo, Nicole M. Williams, Raquel V. Santiago, Christopher K. Thompson, Kristan A. Leech, Carey L. Holleran, Abigail L. Leddy, T. George Hornby

GW Research Days 2013

Objective: Previous research indicates that patients post-stroke, average 400-800 steps within physical therapy sessions and demonstrate heart rate values of 24-35% of HR Max. This dosage and intensity is inadequate to promote neuroplastic changes and maximize recovery. The goal of this study was to quantify and examine the amount of high-intensity stepping practice that was delivered within an Acute Inpatient Rehabilitation (AIR) setting for individuals with sub-acute stroke.

Methods: 14 patients with a diagnosis of sub-acute stroke were admitted to AIR. Standardized outcomes included the 6-Minute Walk Test (6MWT), 10-Meter Walk Test (10MWT), the Berg Balance Scale (BBS) and the …

Brazil’S Big Place On The Huntington’S Disease Map, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.