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Articles 1 - 30 of 71
Full-Text Articles in Nervous System Diseases
‘Concussion’: Advocating For The Truth About Brain Diseases, Kenneth P. Serbin
‘Concussion’: Advocating For The Truth About Brain Diseases, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Twas The Morning After Christmas – And Huntington's Disease Hit Us Like A Ton Of Bricks, Kenneth P. Serbin
‘Twas The Morning After Christmas – And Huntington's Disease Hit Us Like A Ton Of Bricks, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang
The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang
Theses & Dissertations
There are nearly 26 million people with diabetes mellitus (DM) in the US, and half of chronic DMs develop somatosensory deficits due to diabetic polyneuropathy or diabetic peripheral neuropathy (DPN). The absence or impaired somatosensory feedback (e.g. touch sensation or joint proprioception) resulted from the damage of large nerve fiber, and motor deficits such as attenuated muscle strength and abnormal plantar pressure of lower extremity have been identified in DPN, and these sensorimotor impairments lead to an increased number of falls. To reduce the risk of falling, a well-coordinated and adapted limb movement driven by the feedforward (anticipatory) and feedback …
How To Make Law Enforcement A Friend – Not A Foe – Of People With Huntington's Disease (And Other Disabilities), Kenneth P. Serbin
How To Make Law Enforcement A Friend – Not A Foe – Of People With Huntington's Disease (And Other Disabilities), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Levels Of Glycosaminoglycans In The Cerebrospinal Fluid Of Healthy Young Adults, Surrogate-Normal Children, And Hunter Syndrome Patients With And Without Cognitive Impairment., Christian J Hendriksz, Joseph Muenzer, Adeline Vanderver, Jonathan M Davis, Barbara K Burton, Nancy J Mendelsohn, Nan Wang, Luying Pan, Arian Pano, Ann J Barbier
Levels Of Glycosaminoglycans In The Cerebrospinal Fluid Of Healthy Young Adults, Surrogate-Normal Children, And Hunter Syndrome Patients With And Without Cognitive Impairment., Christian J Hendriksz, Joseph Muenzer, Adeline Vanderver, Jonathan M Davis, Barbara K Burton, Nancy J Mendelsohn, Nan Wang, Luying Pan, Arian Pano, Ann J Barbier
Neurology Faculty Publications
In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.
With More Huntington’S Disease Clinical Trials, Volunteers Need Help With Comparison Shopping, Kenneth P. Serbin
With More Huntington’S Disease Clinical Trials, Volunteers Need Help With Comparison Shopping, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Might I Finally Take Part In A Huntington’S Disease Clinical Trials? An Update On The Latest Research, Kenneth P. Serbin
Might I Finally Take Part In A Huntington’S Disease Clinical Trials? An Update On The Latest Research, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Physiology And Psychology Of Exercise And Parkinson's Disease, Jess Gibson
The Physiology And Psychology Of Exercise And Parkinson's Disease, Jess Gibson
Senior Honors Theses
Parkinson’s disease is one of the most common degenerative neurological disorders and is currently lacking a cure. While physicians have long debated over the best treatment for Parkinson’s symptoms, treatments such as oral medication and deep brain stimulation have not yet shown to be a permanent solution to the disease. Recently, exercise has emerged as a contender in the fight against Parkinson’s and physicians and physiotherapists have been investigating the benefits of prescribing exercise programs to patients in an effort to slow progression of Parkinson’s symptoms. The following presents an analysis of the effects of exercise on Parkinson’s symptoms and …
Local And Distributed Pib Accumulation Associated With Development Of Preclinical Alzheimer's Disease, Matthew R. Brier, John E. Mccarthy, Tammie L.S. Benzinger, Ari Stern, Yi Su, Karl A. Friedrichsen, John C. Morris, Beau M. Ances, Andrei G. Vlassenko
Local And Distributed Pib Accumulation Associated With Development Of Preclinical Alzheimer's Disease, Matthew R. Brier, John E. Mccarthy, Tammie L.S. Benzinger, Ari Stern, Yi Su, Karl A. Friedrichsen, John C. Morris, Beau M. Ances, Andrei G. Vlassenko
Mathematics Faculty Research
Amyloid-beta plaques are a hallmark of Alzheimer's disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years follow-up, 16 participants with a previously normal PiB scan had conversion to PiB scans consistent with preclinical AD. We investigated the multivariate …
Cross-Sectional Survey Of Relevant Literatures As To The Current Proposed Disease Mechanisms And Treatments Of Amyotrophic Lateral Sclerosis (Als), Zachary Sanford
Cross-Sectional Survey Of Relevant Literatures As To The Current Proposed Disease Mechanisms And Treatments Of Amyotrophic Lateral Sclerosis (Als), Zachary Sanford
Marshall Journal of Medicine
Amyotrophic Lateral Sclerosis (ALS), more commonly referred to as Lou Gehrig’s disease, is a progressively degenerative neuromuscular disorder affecting both the upper and lower motor neurons and preferentially affecting males in their forties to seventies. Although the pathology of ALS has been clearly elucidated elsewhere, the precise mechanisms by which the disease progresses and the means by which it is acquired are still poorly understood areas of medicine. Current genomic and proteomic studies in human and animal models have yielded exciting and promising new findings that may help elucidate this pathology. It is the purpose of this review article to …
Huntington’S Disease Patients Get First Dosing In Historic Isis Pharmaceuticals' Gene-Silencing Drug Trial, Kenneth P. Serbin
Huntington’S Disease Patients Get First Dosing In Historic Isis Pharmaceuticals' Gene-Silencing Drug Trial, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
At-Risk Angels Pitcher Joe Smith At Huntington’S Fundraiser: 'I'D Give Every Dime I Have For A Cure', Kenneth P. Serbin
At-Risk Angels Pitcher Joe Smith At Huntington’S Fundraiser: 'I'D Give Every Dime I Have For A Cure', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
At Key Fda Meeting, Huntington's Disease Community Insists On Faster Search For Treatments, Kenneth P. Serbin
At Key Fda Meeting, Huntington's Disease Community Insists On Faster Search For Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Initial Validation Of A Novel Method Of Presurgical Language Localization Through Functional Connectivity (Fcmri), Stephanie M. Noble, Dustin Scheinost, Susan Y. Bookheimer, Patricia Walshaw, R Todd Constable, Christopher F. Benjamin
Initial Validation Of A Novel Method Of Presurgical Language Localization Through Functional Connectivity (Fcmri), Stephanie M. Noble, Dustin Scheinost, Susan Y. Bookheimer, Patricia Walshaw, R Todd Constable, Christopher F. Benjamin
Yale Day of Data
OBJECTIVE: Neurosurgery is potentially curative in chronic epilepsy but can only be offered to patients if the surgical risk to language is known. Clinical functional magnetic resonance imaging (fMRI) is an ideal, noninvasive method for localizing language cortex yet remains to be validated for this purpose. We have recently presented a novel method for localizing language cortex. Here we present a preliminary evaluation of this method’s validity. We hypothesized language regions identified using this novel method would demonstrate stronger functional connectivity than randomly generated set of proximal networks. METHOD: fMRI data were collected from sixteen temporal lobe patients …
As He Lay Dying: Fda And Huntington’S Disease Families Meet To Ponder Potential Treatments, Kenneth P. Serbin
As He Lay Dying: Fda And Huntington’S Disease Families Meet To Ponder Potential Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
New Film Unmasks The Raw Reality Of Huntington’S Disease, Kenneth P. Serbin
New Film Unmasks The Raw Reality Of Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Reinforcing The Global Fight Against Huntington’S Disease: A Visit To Brazil And A Reminder Of Our Common Struggles, Kenneth P. Serbin
Reinforcing The Global Fight Against Huntington’S Disease: A Visit To Brazil And A Reminder Of Our Common Struggles, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Isis Pharmaceuticals Launches Historic Clinical Trial To Silence Huntington's Disease Gene, Kenneth P. Serbin
Isis Pharmaceuticals Launches Historic Clinical Trial To Silence Huntington's Disease Gene, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Multiple Sclerosis And The Implications Of Anesthesia, Timothy B. Maiden
Multiple Sclerosis And The Implications Of Anesthesia, Timothy B. Maiden
Nursing Student Class Projects (Formerly MSN)
Multiple Sclerosis (MS) is an autoimmune process characterized by inflammation and demyelination of axons in the brain and spinal cord (Schneider, 2005). According to Maclean (2010), MS is one of the most common debilitating neurological disorders in young adults. My intent of this research project is to explain the pathophysiological process and become familiar with the implications of anesthesia related to MS. This research will enable me to prepare a safe, individualized anesthetic plan, taking all essential precautions when caring for a patient with multiple sclerosis.
Juvenile Myoclonic Epilepsy, April Britton
Juvenile Myoclonic Epilepsy, April Britton
Nursing Student Class Projects (Formerly MSN)
Juvenile myoclonic epilepsy (JME) is one of the most common epilepsies of childhood (Korff, Nordli, & Eichler, 2014). JME typically occurs in otherwise healthy teenagers, and is characterized by one or more of the following seizure types: myoclonic jerks, generalized tonic clonic seizures, and absence seizures (Korff, Nordli, & Eichler, 2014). JME is thought to have genetically mediated factors (Park, Shahid, & Jammoul, 2015). JME is considered to be gender equal (Korff, Nordli, & Eichler, 2014). Most JME patients are diagnosed between 12 and 18 years of age (Korff, Nordli, & Eichler, 2014). Triggers linked to onset of seizure activity …
Cervical Spinal Cord Injury, Melissa Schimmel
Cervical Spinal Cord Injury, Melissa Schimmel
Nursing Student Class Projects (Formerly MSN)
A spinal cord injury (SCI) can occur at any level of the spinal cord. A SCI involves an interruption between the brain and the body due to an injury or damage to the spinal cord (Sheppard Center, 2011, p1.). The location and extent of the injury is important because it will determine the severity and extent of dysfunction. The higher the injury is to the spinal cord, the more severe the loss of motor function (Sheppard Center, 2011, p.4). The spinal cord injuries are classified by based on the extent of injury, motor and sensory losses. The injury is considered …
Unraveling The Mysteries Of The Mitochondria In Huntington's Disease – And Getting Fast, Clear, And Useful Results From Research Studies, Kenneth P. Serbin
Unraveling The Mysteries Of The Mitochondria In Huntington's Disease – And Getting Fast, Clear, And Useful Results From Research Studies, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Connectivity Measures Are Robust Biomarkers Of Cortical Function And Plasticity After Stroke, Jennifer Wu, Erin Burke Quinlan, Lucy Dodakian, Alison Mckenzie, Nikhita Kathuria, Robert J. Zhou, Renee Augsburger, Jill See, Vu H. Lee, Ramesh Srinivasan, Steven C. Cramer
Connectivity Measures Are Robust Biomarkers Of Cortical Function And Plasticity After Stroke, Jennifer Wu, Erin Burke Quinlan, Lucy Dodakian, Alison Mckenzie, Nikhita Kathuria, Robert J. Zhou, Renee Augsburger, Jill See, Vu H. Lee, Ramesh Srinivasan, Steven C. Cramer
Physical Therapy Faculty Articles and Research
Valid biomarkers of motor system function after stroke could improve clinical decision-making. Electroencephalography-based measures are safe, inexpensive, and accessible in complex medical settings and so are attractive candidates. This study examined specific electroencephalography cortical connectivity measures as biomarkers by assessing their relationship with motor deficits across 28 days of intensive therapy. Resting-state connectivity measures were acquired four times using dense array (256 leads) electroencephalography in 12 hemiparetic patients (7.3 ± 4.0 months post-stroke, age 26–75 years, six male/six female) across 28 days of intensive therapy targeting arm motor deficits. Structural magnetic resonance imaging measured corticospinal tract injury and infarct volume. …
Overcoming The Fear Of The Lion: A Courageous Film About Genetic Testing And Huntington's Disease, Kenneth P. Serbin
Overcoming The Fear Of The Lion: A Courageous Film About Genetic Testing And Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann
Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann
The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University
Amyotrophic lateral sclerosis is a degenerative neurological disease that damages nerve cells in the brain, in particular the neurons that are involved in voluntary muscle movements. Internationally the disorder is also known as Charcot’s disease and motor neuron disease. In the United States, amyotrophic lateral sclerosis is often referred to as Lou Gehrig’s disease, motor neuron disease, and more colloquially ALS. Amyotrophic Lateral Sclerosis is the most prominent of the five motor neuron diseases, distinguishing itself from the others through degeneration of both upper motor neurons (UMN) and lower motor neurons (LMN) respectively. The “Father of neurology” Jean-Marie Charcot founded …
Novel Advances In Alzheimer's Disease, Jacob P. Naumann
Novel Advances In Alzheimer's Disease, Jacob P. Naumann
The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University
Alzheimer’s disease, the most common form of dementia in adults, is a progressive degenerative neurological disease that affects memory, cognition, and behavior. Dr. Alois Alzheimer discovered and diagnosed the irreversible disease in 1906 after documenting the famous case of Auguste Deter.1 Since the discovery of the disease, numerous advances have made it possible to not only better understand the causal factors, but also to improve the medical diagnosis and preventative measures that healthcare providers can implement. For the first time since 1984, the National Institute on Aging (NIAA) and the Alzheimer’s Association (AA) proposed and published new diagnostic guideline …
The Search For Huntington's Disease Treatments Is Indeed 'Rocket Science' – And We Can All Help Build The Rocket, Kenneth P. Serbin
The Search For Huntington's Disease Treatments Is Indeed 'Rocket Science' – And We Can All Help Build The Rocket, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Deciphering Signals From Huntington’S Disease Brains In The Search For Treatments, Kenneth P. Serbin
Deciphering Signals From Huntington’S Disease Brains In The Search For Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Age-Dependent Breakdown Of The Blood Brain Barrier And Associated Changes In S100b Ko Mice, Eric V. Brown
Age-Dependent Breakdown Of The Blood Brain Barrier And Associated Changes In S100b Ko Mice, Eric V. Brown
Graduate School of Biomedical Sciences Theses and Dissertations
Autoantibodies play an important role in many autoimmune diseases. Recent research has shown that breakdown of the blood brain barrier (BBB) occurs concomitant to generation of brain reactive autoantibodies in many neurodegenerative diseases, which serve as biomarkers and drivers of pathology. SI00B, a calcium binding protein found most highly expressed in astrocytes which ensheathe the BBB, has many functions in neural development and signaling. Currently literature indicates that S100B KO mice develop normally, with no phenotypic abnormalities. Here, it is demonstrated that S100B KO mice seem to develop a chronic BBB breakdown similar to that seen in human neurodegenerative diseases. …
Alzheimer's Disease: From Clinical Tragedy To Reason For Hope, Kenneth Adams
Alzheimer's Disease: From Clinical Tragedy To Reason For Hope, Kenneth Adams
Bridgewater Review
No abstract provided.