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Articles 1 - 10 of 10
Full-Text Articles in Nervous System Diseases
Disease, Denial, And Support: The Many Kinds Of Family, Kenneth P. Serbin
Disease, Denial, And Support: The Many Kinds Of Family, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Roots Of Our Stigma, Kenneth P. Serbin
The Roots Of Our Stigma, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Distinct Functions Of Autoreactive Memory And Effector Cd4+ T Cells In Experimental Autoimmune Encephalomyelitis, Wassim Elyaman, Pia Kivisäkk, Jay Reddy, Tanuja Chitnis, Khadir Raddassi, Jaime Imitola, Elizabeth Bradshaw, Vijay K. Kuchroo, Hideo Yagita, Mohamed H. Sayegh, Samia J. Khoury
Distinct Functions Of Autoreactive Memory And Effector Cd4+ T Cells In Experimental Autoimmune Encephalomyelitis, Wassim Elyaman, Pia Kivisäkk, Jay Reddy, Tanuja Chitnis, Khadir Raddassi, Jaime Imitola, Elizabeth Bradshaw, Vijay K. Kuchroo, Hideo Yagita, Mohamed H. Sayegh, Samia J. Khoury
Jay Reddy Publications
The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental autoimmune encephalomyelitis (EAE). We found that memory CD4+ T cells up-regulated the activation marker CD44 as well as CXCR3 and ICOS, proliferated more and produced more interferon-γ and less interleukin-17 compared to effector T cells. Moreover, adoptive transfer of memory T cells into T cell receptor (TCR)αβ-/- recipients induced more severe disease than did effector CD4+ T cells with marked central nervous system inflammation and …
A Non-Randomized Study Of Safety And Efficacy Of Heparin For Dvt Prophylaxis In Intracerebral Haemorrhage, Mohammad Wasay, Saqibuddin Khan, Khawaja S. Zaki, Bhojo A. Khealani, Ayeesha Kamal, Iqbal Azam, Ismail A. Khatri
A Non-Randomized Study Of Safety And Efficacy Of Heparin For Dvt Prophylaxis In Intracerebral Haemorrhage, Mohammad Wasay, Saqibuddin Khan, Khawaja S. Zaki, Bhojo A. Khealani, Ayeesha Kamal, Iqbal Azam, Ismail A. Khatri
Department of Medicine
Objective: To evaluate the safety and efficacy of subcutaneous heparin for deep venous thrombosis (DVT) prophylaxis in patients with intracerebral haemorrhage (ICH) during acute phase in comparison to elastic stockings.
Methods: The diagnosis of ICH was based on imaging (CT or MRI) and DVT was based on Doppler ultrasound.
Results: A total of 458 patients were identified over a period of 5 years (1997-2001). Median age was 59 years (range:12-99 years). Two hundred (44%) patients received heparin (heparin group) in addition to elastic stockings and 258 (56%) patients were only given elastic stockings (stockings group). These two groups were not …
Huntington's Disease, Destroyer Of Families, Kenneth P. Serbin
Huntington's Disease, Destroyer Of Families, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Building A ‘Laser-Guided Missile’ To Attack Huntington's Disease, Kenneth P. Serbin
Building A ‘Laser-Guided Missile’ To Attack Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Observing The Cure In Progress, Kenneth P. Serbin
Observing The Cure In Progress, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Time For Optimism: A Cure For Huntington's Could Be Near, Kenneth P. Serbin
Time For Optimism: A Cure For Huntington's Could Be Near, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Keeping Calm In The Face Of Huntington's, Kenneth P. Serbin
Keeping Calm In The Face Of Huntington's, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Novel And Generalizable Organotypic Slice Platform To Evaluate Stem Cell Potential For Targeting Pediatric Brain Tumors., Shengwen Calvin Li, William Gunter Loudon
A Novel And Generalizable Organotypic Slice Platform To Evaluate Stem Cell Potential For Targeting Pediatric Brain Tumors., Shengwen Calvin Li, William Gunter Loudon
Department of Cancer Biology Faculty Papers
Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed. One emerging strategy is to use the tumor tracking capacity inherent in many stem cell populations to deliver therapeutic agents to the brain cancer cells. Current limitations of the stem cell therapy strategy include that stem cells are treated as a single entity and lack of uniform technology is adopted for selection of clinically relevant sub-populations of stem cells. Specifically, therapeutic success relies on the selection of a clinically competent …