Medicine and Health Sciences Commons^™

Pandemic Simulator (Issue 3, 3 May 2020), Nazar Zaki, Tetiana Habuza, Stefanache Cornel

Covid19 Newsletters

No abstract provided.

2020-05-02/03 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Melissa Cossé, Samantha Paltrow-Krulwich, Stephen Esguerra, Hannah Dowdy-Sue, Ariel Hurwitz, Alexandra Yingling, Clinton Onyango, Tudor I. Oprea, Gregory Mertz, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

More NM cases. Free Shiprock testing. Prison release demands. 8 state parks reopen. Higher US deaths. NY PPE case dismissed. Orthopedic Tx down. European deaths down. UK mortality factors. People leaving large cities. Ending lockdown strategies. Public mask impact. Taiwan tracing. Homeless shelter prevalence. Homeless shelter outbreak. 50-state R0. COVID-19 decades later. US county tracking site. Hospital management model. COVID-19 behavioral transformation. Practice guidelines for: cardiology, IBD surgery, and rheumatic physical inactivity. Roche antibody test approved. Abbott antibody test EU-certified. Home anosmia assessment. CVD and ACE/ARBs. Tocilizumab early evidence. Tocilizumab systematic review. WHO vaccines trial. HCQ slower viral …

Oral Care And Ventilator Associated Pneumonia Prevention, Rachel Baber

MSN Capstone Projects

With rising healthcare costs and increasing demands placed on healthcare workers, it is no wonder that decreasing hospital length of stay for patients is high priority for hospitals today. Hospital acquired infections are one of the culprits keeping so many patients hospitalized. Specifically, in intensive care units (ICU) and intermediate care (IMC) units that care for mechanically ventilated patients, ventilator associated pneumonia secondary to intubation is a complication and cost that is being sought to be avoided. Hospitals have been pro-active to prevent ventilator associated pneumonia from occurring by placing oral care bundles or protocols in place to care for …

Health Care Access For Children In Latinx Immigrant Families In The Greater Philadelphia Area, Sophia King

Politics Honors Papers

This work examines the gap that exists in access to health care in the Greater Philadelphia Region for children of Latinx immigrant families in comparison to other children in the nation. It provides a critical analysis of the gap in access to coverage, noting that this exists despite wide support for a human right to health. This study draws on existing scholarly research as well as interviews with staff at two health clinics and one community outreach center that are located in Greater Philadelphia. It demonstrates that Latinx immigrant families are less likely to have health insurance and get primary …

Apc-Β-Catenin-Tcf Signaling Silences The Intestinal Guanylin-Gucy2c Tumor Suppressor Axis., Erik S Blomain, Jeffrey A Rappaport, Amanda M Pattison, Babar Bashir, Ellen Caparosa, Jonathan Stem, Adam E Snook, Scott A Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the crypt-surface axis opposing tumorigenesis. Here, we reveal that expression of the guanylin hormone, but not the GUCY2C receptor, is lost at the earliest stages of transformation in APC-dependent tumors in humans and mice. Hormone loss, which silences GUCY2C signaling, reflects transcriptional repression mediated by mutant APC-β-catenin-TCF programs in the nucleus. These studies support a pathophysiological model of intestinal tumorigenesis in which mutant APC-β-catenin-TCF transcriptional regulation …

Replacing A Single Tooth: Single Implant Vs. Three Unit Bridge, Ibeth Erazo, Aneeza Hussain

Publications and Research

There are more than two options for restoring a single tooth but our research includes a three-unit bridge and a single-tooth implant as the main options. In this paper, we discuss the advantages and disadvantages of these methods and the factors that must be considered when choosing between them for the replacement of a single tooth. Although in some cases a three-unit bridge is the most appropriate choice, implants have the advantage of allowing preservation of the integrity of sound teeth adjacent to the edentulous area. Many factors must be considered when choosing between a three-unit bridge and an implant …

2020-05-02_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

2020-05-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Report: The Beat Stops Here: A Nurse-Driven Protocol To Manage Telemetry Orders, Holly Dripps, Kirk Hummer

Doctor of Nursing Practice Scholarly Projects

At a large midwestem healthcare organization, cardiac telemetry monitoring orders are not aligned with clinical guidelines developed by the American Heart Association (AHA). A nurse-driven protocol, based on AHA guidelines, to manage cardiac telemetry orders may reduce telemetry usage. Donabedian' s quality improvement framework of strnch1re-process-outcomes was utilized as the theoretical framework for this project, with the purpose to reduce telemetry days within 30 days on a selected acute care unit utilizing AHA guidelines. Project objectives included developing an assessment tool based on AHA guidelines, educating pe1iinent stakeholders on the nurse assessment tool, and implementation of the tool on the …

2020-05-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-02_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

Poster: The Beat Stops Here: A Nurse-Driven Protocol To Manage Telemetry Orders, Holly Dripps, Kirk Hummer

Doctor of Nursing Practice Scholarly Projects

At a large midwestem healthcare organization, cardiac telemetry monitoring orders are not aligned with clinical guidelines developed by the American Heart Association (AHA). A nurse-driven protocol, based on AHA guidelines, to manage cardiac telemetry orders may reduce telemetry usage. Donabedian' s quality improvement framework of strnch1re-process-outcomes was utilized as the theorical framework for this project, with the purpose to reduce telemetry days within 30 days on a selected acute care unit utilizing AHA guidelines. Project objectives included developing an assessment tool based on AHA guidelines, educating pe1iinent stakeholders on the nurse assessment tool, and implementation of the tool on the …

Report: Creating And Piloting A Survey To Determine Readiness In Rural Populations In Ohio, Annie Bowen, Kay Ball

Doctor of Nursing Practice Scholarly Projects

In 2015, the Affordable Care Act and Medicaid expansion allowed over 700,000 Ohioans to gain access to healthcare insurance, but having health insurance did not improve access to healthcare providers. In rural populations in Ohio, there are several counties in which less than five healthcare providers are available for the entire county with little or no specialists available for patients. People in rural areas of Ohio may have significant travel time and distance to see a provider which decreases preventative health visits. Telehealth is the next big wave of technology and advancement for healthcare, but most rural populations in Ohio …

Poster: Creating And Piloting A Survey To Determine Readiness In Rural Populations In Ohio, Annie Bowen, Kay Ball

Doctor of Nursing Practice Scholarly Projects

In 2015, the Affordable Care Act and Medicaid expansion allowed over 700,000 Ohioans to gain access to healthcare insurance, but having health insurance did not improve access to healthcare providers. In rural populations in Ohio, there are several counties in which less than five healthcare providers are available for the entire county with little or no specialists available for patients. People in rural areas of Ohio may have significant travel time and distance to see a provider which decreases preventative health visits. Telehealth is the next big wave of technology and advancement for healthcare, but most rural populations in Ohio …

Poster: Impact Of Educational Modules On Knowledge Among Neuroscience Nurses Working In The Epilepsy Monitoring Unit (Emu), Shivani Bhatnagar, Joy Shoemaker

Doctor of Nursing Practice Scholarly Projects

Background: Little data exists about nursing care and knowledge on an epilepsy monitoring unit (EMU). This study evaluated the impact of an educational series (three modules) on nursing knowledge and confidence in providing care, using a pre-test/post-test design. Objectives: There were three objectives for this study. The first objective was to improve nursing knowledge and competence in educating patients and families. The second, to increase nursing confidence in providing care and decision-making for the specialized patient population on the EMU. The third, to evaluate the effectiveness of educational modules. Subjects: Thirty-eight nurses working in the neuroscience unit participated in the …

Prevalence Of Hypertension And Its Risk Factors Among Cotton Textile Workers In Low- And Middle-Income Countries: A Protocol For A Systematic Review, Naureen Akber Ali, Anam Shahil Feroz

School of Nursing & Midwifery

Background: Cotton workers are exposed to various hazards in the textile industry that might result in different ailments including hypertension (HTN). However, few attempts have been made to systematically review the prevalence of hypertension and its risk factor among cotton textile workers in low-and middle-income countries (LMICs). The objective of this study will be to evaluate the prevalence of hypertension and its risk factors among adult cotton textile workers in low- and middle-income countries.
Methods: We designed and registered a study protocol for a systematic review of descriptive epidemiology data. We will include observational studies (e.g., cross-sectional, cohort, surveys) on …

Application Of Condition‐Based Maintenance In Health Care: A Concept Analysis, Lindsey J. Ryan Phd, Rn, Acns‐Bc, Ne‐Bc

School of Nursing and Health Science: Student Scholarship

Chronic illness burdens individuals, organizations and society, costing the US $3.5 trillion annually. Transposed from the engineering industry, condition‐based maintenance is a novel concept that holds great promise for alleviating this burden by enhancing current health care delivery methods. Aims of this concept analysis include, (a) develop an operational definition for the term condition‐based maintenance and (b) discuss the applicability and effectiveness of condition‐based maintenance as applied to health care. A search of engineering and health care literature was completed. The search term “condition‐based maintenance” was entered into the PubMed, Wiley Interscience Journals, CINAHL, Journals@Ovid, ProQuest Nursing & Allied Health …

Autonomy And The Patient’S Perspective On Physician-Assisted Suicide, Anna Dykhuis

Nursing Masters Papers

Introduction: Physician-assisted suicide (PAS) is an end of life (EOL) option that involves a patient ingesting a lethal medication that has been prescribed by a physician after a complex vetting process. In certain countries and states within the United States (US) where PAS is legal, patients avoid EOL suffering and may have more control over the dying process.

Scholarly Inquiry Question: Do patients who seek end-of-life care by means of PAS have a greater sense of control of their dying process versus those patients who do not or are not allowed to participate in PAS?

Supporting Evidence: Physical and …

Otosclerosis: Experience With Stapes Surgery, Muhammad Shaheryar Ahmed Rajput, Asif Ali Arain, Arsalan A. Rajput, Mohammad Adeel, Anwar Suhail, Mohammad Sohail Awan

Section of Ophthalmology

Introduction: Otosclerosis is a disorder in which the footplate of the stapes is replaced by an abnormal bone, thereby affecting sound transmission to the inner ear at the level of the oval window. The solution to this condition is to reestablish this mechanism back to normal via the ossicular chain to the inner ear. The aim of stapes surgery is to improve the hearing level to thresholds appropriate enough to obviate the need for hearing aid. The hearing improvement achieved after surgery often lasts for many years. The purpose of the current study was to review our experience and find …

Phenylpyrazalopyrimidines As Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, And Molecular Simulations, Bhupender S. Chhikara, Sajda Ashraf, Saghar Mozaffari, Nicole St. Jeans, Dindyal Mandal, Rakesh Kumar Tiwari, Zaheer Ul-Haq, Keykavous Parang

Pharmacy Faculty Articles and Research

N1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a chalcone reaction with differently substituted aromatic aldehydes. The Src kinase enzyme assay revealed modest inhibitory activity (half maximal inhibitory concentration, IC₅₀ = 21.7–192.1 µM) by a number of PhPP derivatives. Antiproliferative activity of the compounds was evaluated on human leukemia (CCRF-CEM), human ovarian adenocarcinoma (SK-OV-3), breast carcinoma (MDA-MB-231), and colon adenocarcinoma (HT-29) cells in vitro. 4-Chlorophenyl carbo-enyl substituted 3-phenylpyrazolopyrimidine (10) inhibited the cell proliferation of HT-29 and SK-OV-3 by 90% …

2020-05-02_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

Report:Impact Of Educational Modules On Knowledge Among Neuroscience Nurses Working In The Epilepsy Monitoring Unit (Emu), Shivani Bhatnagar, Joy Shoemaker

Doctor of Nursing Practice Scholarly Projects

Background: Little data exists about nursing care and knowledge on an epilepsy monitoring unit (EMU). This study evaluated the impact of an educational series (three modules) on nursing knowledge and confidence in providing care, using a pre-test/post-test design. Objectives: There were three objectives for this study. The first objective was to improve nursing knowledge and competence in educating patients and families. The second, to increase nursing confidence in providing care and decision-making for the specialized patient population on the EMU. The third, to evaluate the effectiveness of educational modules. Subjects: Thirty-eight nurses working in the neuroscience unit participated in the …

Dnp Final Report: Building A Comprehensive Guideline To Improve The Treatment Of Infants With Neonatal Abstinence Syndrome: An Evidence-Based Innovation Project, Cyndi B. Kelley

DNP Final Reports

Background: The incidence of Neonatal Abstinence Syndrome (NAS) has increased nationally; however, only 55% of NICUs indicated having a written NAS treatment plan as recommended by the American Association of Pediatrics. Current practice included symptom management via morphine only; however, non-pharmacological interventions were not routinely delivered.

Purpose: The purpose of this project was to standardize and improve the care provided to patients with NAS.

Methods: A systematic search was conducted using keywords and subject headings from the PICOT question. Retrieved synthesized evidence suggested that adding breastfeeding and rooming-in as first-line treatment options reduced the length of hospital stay and medication …

Dnp Final Report: Diabetic Foot Care In Hispanic Females With Type Ii Diabetes: An Evidence-Based Quality Improvement Initiative, Barbara Chapman

DNP Final Reports

Diabetes affects 30.5 million people in the United States at an annual cost of approximately 245 billion dollars. 176 billion dollars are spent on debilitating often life threatening complications affecting the heart, kidney, eye, and nervous system. Over 69 billion dollars are spent on reduced workforce productivity. Approximately 9.9% of the United States population has diabetes, the diabetic population in Texas is 11.4% and in Collin County population is 10.2%. Hispanic populations are at a higher risk of developing diabetes at approximately 12.2% nationally.

Peripheral neuropathy commonly occurs in the lower extremities of diabetic patients increasing risks of foot complications …

A Positive Framed Message To Improve Cpap Compliance For Patients With Osa, Frances Clark

Evidence-Based Practice Project Reports

Obstructive sleep apnea (OSA) affects 24% of the US population (DiNapoli, 2014). Untreated OSA causes many diseases, affects one’s quality of life, and increases mortality (Pengo et al., 2018). Continuous positive airway pressure (CPAP) is the lifelong treatment for OSA; yet 30%-80% of OSA patients are CPAP noncompliant within one year. The purpose of this EBP project was to determine if implementing a positive frame message intervention would improve CPAP compliance for newly diagnosed OSA patients. Based on the evidence, implementation of behavioral interventions, such as a positive framed message, was effective in improving CPAP compliance (Pengo et al., 2018). …

The Role Of Allergy Testing In Eczematic Patients: A Benchmark Study, Ashley E. Cox

MSN Capstone Projects

Eczema or atopic dermatitis (AD) is the first visible sign that indicates a much bigger and more complex problem within the body. The first presentation of symptoms is typically in individuals less than six months of age. Concerned parents bring their child to the pediatrician where a course of topical corticosteroids is prescribed, according to current AD treatment guidelines (Weston, & Howe, 2019). Long term use of corticosteroids has proven to be detrimental to the patient’s health, especially pediatric patients, in many ways such as gynecomastia, hypertrichosis, staphylococcal infections, skin atrophy, and worsening of skin diseases, just to name a …

Effectiveness Of Ultraviolet-C Light And A High-Level Disinfection Cabinet For Decontamination Of N95 Respirators, Curtis J. Donskey

Faculty Scholarship

Background: Shortages of personal protective equipment (PPE) including N95 respirators are an urgent concern in the setting of the global COVID-19 pandemic. Decontamination of PPE could be useful to maintain adequate supplies, but there is uncertainty regarding the efficacy of decontamination technologies. Methods: A modification of the American Society for Testing and Materials standard quantitative carrier disk test method (ASTM E-2197-11) was used to examine the effectiveness of 3 methods, including ultraviolet-C (UV-C) light, a high-level disinfection cabinet that generates aerosolized peracetic acid and hydrogen peroxide, and dry heat at 70°C for 30 minutes. We assessed the decontamination of 3 …

Head And Neck Survivorship Care In The Times Of The Sars-Cov-2 Pandemic, Victoria Huang

Faculty Scholarship

With the arrival of the coronavirus disease (SARS-CoV-2) in the United States, care practice paradigms have drastically changed. Data from China suggest that the new virus poses additional risks as case fatality of patients with cancer was higher at 5.6% compared to 2.3% of the general population. There are three proposed major strategies to address care for patients with cancer in this SARS-CoV-2 pandemic with postponing treatment for those with stable cancer, increasing personal protection provisions for patients with cancer, and increasing monitoring if a patient becomes infected with SARS-CoV-2. In this present commentary, we discuss the unique mental health …

How Big Data And Artificial Intelligence Can Help Better Manage The Covid-19 Pandemic, Giovanni Damiani

Faculty Scholarship

SARS-CoV2 is a novel coronavirus, responsible for the COVID-19 pandemic declared by the World Health Organization. Thanks to the latest advancements in the field of molecular and computational techniques and information and communication technologies (ICTs), artificial intelligence (AI) and Big Data can help in handling the huge, unprecedented amount of data derived from public health surveillance, real-time epidemic outbreaks monitoring, trend now-casting/forecasting, regular situation briefing and updating from governmental institutions and organisms, and health facility utilization information. The present review is aimed at overviewing the potential applications of AI and Big Data in the global effort to manage the pandemic. …

Parsmurf, A High-Performance Computing Tool For The Genome-Wide Detection Of Pathogenic Variants., Alessandro Petrini, Marco Mesiti, Max Schubach, Marco Frasca, Daniel Danis, Matteo Re, Giuliano Grossi, Luca Cappelletti, Tiziana Castrignanò, Peter N Robinson, Giorgio Valentini

Faculty Research 2020

BACKGROUND: Several prediction problems in computational biology and genomic medicine are characterized by both big data as well as a high imbalance between examples to be learned, whereby positive examples can represent a tiny minority with respect to negative examples. For instance, deleterious or pathogenic variants are overwhelmed by the sea of neutral variants in the non-coding regions of the genome: thus, the prediction of deleterious variants is a challenging, highly imbalanced classification problem, and classical prediction tools fail to detect the rare pathogenic examples among the huge amount of neutral variants or undergo severe restrictions in managing big genomic …