Medicine and Health Sciences Commons^™

Selective Targeting Of Cyp3a5 Through Chemical And Genetic Approaches, William C. Wright

Theses and Dissertations (ETD)

Cytochrome P450 enzymes function to catalyze a wide range of reactions important for various biological processes. In humans, the CYP3A subfamily is particularly critical for drug response. Within this family are CYP3A4 and CYP3A5, which collectively metabolize greater than half of all currently prescribed drugs. These promiscuous enzymes can bind a broad and structurally diverse array of compounds, in turn leading to an increased risk of their modulation via small molecules. In the case of CYP3A5, which is over-expressed in some cancers, this leads to chemoresistance. Such aberrant expression and corresponding drug resistance merit a need to selectively target CYP3A5. …

Understanding Human Astrovirus From Pathogenesis To Treatment, Virginia Hargest

Theses and Dissertations (ETD)

While human astroviruses (HAstV) were discovered nearly 45 years ago, these small positive-sense RNA viruses remain critically understudied. These studies provide fundamental new research on astrovirus pathogenesis and disruption of the gut epithelium by induction of epithelial-mesenchymal transition (EMT) following astrovirus infection. Here we characterize HAstV-induced EMT as an upregulation of SNAI1 and VIM with a down regulation of CDH1 and OCLN, loss of cell-cell junctions most notably at 18 hours post-infection (hpi), and loss of cellular polarity by 24 hpi. While active transforming growth factor- (TGF-) increases during HAstV infection, inhibition of TGF- signaling does not hinder EMT induction. …

Complementary And Alternative Medicine Use Among Latino College Students, Andrea Pineda

Electronic Theses, Projects, and Dissertations

Objective: The objective of this study is to understand the need of CAM methods among college students.

Methods: The method used for this study was a secondary analysis of an anonymous cross-sectional survey. Students were asked different questions about their CAM uses and the reason behind them.

Results: 96.9%of students stated that they have use a form of CAM before. This shows how prevalent CAM is among college students. 47.5% of students rated their health average to below poor. It indicated how important it is to understand college students’ health and help them feel above average.

Conclusion: CAM uses are …

Scope Of Attention Variation As A Function Of Anxiety And Depression, Kathleen Anne O'Donnell

Electronic Theses, Projects, and Dissertations

As a social species, correct emotional perception is so vital, that the human brain has evolved a mechanism to control attentional choices by exerting a narrowed field of perception during danger, called the scope of attention (SoA). The SoA determines what information will be focused on or ignored by blocking the perception of non-relevant items and increasing selective focus on danger; even if danger is merely a sad-face. The emotional items blocked from perception cannot be remembered because they were never perceived. But, attention-control to emotional stimuli also varies with mood, as seen in mood-disorders. A mood-disorder’s effect upon the …

Design Thinking Intervention In Healthcare, Mohammed Ali Alshehri

Dissertations and Theses Collection (Open Access)

The healthcare industry is currently experiencing numerous challenges. Lack of skilled and innovative practitioners in healthcare organizations disrupts operational functions, administration, and service delivery. Dentistry is full of complex problems. There is currently a significant gap between the desired solutions dental providers offer to solve these problems and the actual outcomes. So, dental providers must rethink their approach to solving healthcare problems. One of the desirable approaches is design thinking.

Application of design thinking in business and healthcare has demonstrated improved results. In this research, the objective was to investigate the application of design thinking in dentistry and its effects …

Children’S Mercy Covid-19 Venous Thromboembolism (Vte) Prophylactic Guidelines, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Initial Acute Otitis Media Antibiotic Treatment, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Cystic Fibrosis-Related Diabetes: The Unmet Need, Leonardo Pozo, Fatimah Bello, Yamely Mendez, Salim Surani

School of Medicine Publications

Cystic fibrosis (CF) is a common autosomal recessive disease. Life expectancy of patients with CF continues to improve mainly driven by the evolving therapies for CF-related organ dysfunction. The prevalence of CF-related diabetes (CFRD) increases exponentially as patients’ age. Clinical care guidelines for CFRD from 2010, recommend insulin as the mainstay of treatment. Many patients with CFRD may not require exogenous insulin due to the heterogeneity of this clinical entity. Maintenance of euglycemia by enhancing endogenous insulin production, secretion and degradation with novel pharmacological therapies like glucagonlike peptide-1 agonist is an option that remains to be fully explored. As such, …

Differential Relationships Between Waist Circumference And Cardiorespiratory Fitness Among People With And Without Type 2 Diabetes, Andrew Ortaglia, Samantha M. Mcdonald, Christina Supino, Michael D. Wirth, Xuem Sui, Matteo Bottai

Faculty Publications

Adults with type 2 diabetes mellitus tend to exhibit an increased level of central adiposity, augmenting their risk of further non-communicable diseases (NCDs). Importantly, consistent evidence demonstrates a significant, negative association between cardiorespiratory fitness (CRF) and waist circumference (WC). However, no previous studies have investigated differences in these CRF-related reductions in WC between adults with and without diabetes.

This study used data from the Aerobic Center for Longitudinal Studies, conducted between 1970 and 2006 among predominately Non-Hispanic White, middle-to-upper class adults in Texas. Quantile regression models were used to estimate CRF-related differences in WC between persons with and without diabetes. …

N Y State Dent J June-July 2020

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Covid-19 And Latinos In Massachusetts, Lorna Rivera, Phillip Granberry, Lorena Estrada-Martínez, Miren Uriarte, Eduardo Siqueira, Ana Rosa Linde-Arias, Gonzalo Bacigalupe

Gastón Institute Publications

This report focuses on the Latino population of Massachusetts and uses 2014–2018 American Community Survey (ACS) demographic data to explore both Latinos’ vulnerability to COVID-19 infection and the key predictive factors. We explore what is known about the social determinants of health previously identified as critical to understanding the spread and differential infection rates of COVID-19 across populations—for example, opportunities for infection due to employment and housing conditions—and how these apply to the Latino population in Massachusetts. We also briefly explore those factors that lead to COVID-19 severe illness and possibly death from the disease, including the age of the …

An Analysis Of A Herd-Based Lactation Curve Reveals The Seasonal Effect From Dairy Cows Fed Under High Ambient Temperatures, Sumpun Thammacharoen, Somchai Chanpongsang, Narongsak Chaiyabutr, Supattra Teedee, Attapol Pornprapai, Aemwika Insam-Ang, Channarong Srisa-Ard, Niran Channacoop

The Thai Journal of Veterinary Medicine

The presentinvestigation was carried out to demonstratethe effect of high ambient temperature (HTa) on lactation performance with herd-based measurement. One large dairy farm in Thailandwith more than 300crossbred Holstein cows milking each monthwas selected. The meteorological data was recorded once a week during the period of observation. Milking cows (n=90) were observed for a 10-month lactation curve based on their calving seasons: Summer, rainy and winter. The lactation curve was fitted by nonlinear regression using the reduced lactation persistency model.The climatic conditions revealed a high degree of temperature and humidity index (THI). The average THI throughout the year was 84.8 …

Pharmacokinetics Of Enrofloxacin In Meat Pigeons After A Single Intramuscular And Oral Administration, Xun Wang, Fei Shi, Yuhong Gou, Qiong Jiang, Jie Gong, Huaqiao Tang, Gang Ye, Chen Fang, Yinlun Li, Ling Zhao

The Thai Journal of Veterinary Medicine

The pharmacokinetic properties of enrofloxacin were investigated after a single intra-muscular (i.m.) and oral administration of 10 mg/kg b.w. to 12 healthy adult pigeons. Twelve pigeons were randomly divided to two groups. Blood samples were collected at different time points following drug administration. Plasma enrofloxacin concentrations were determined by reverse-phase high-performanceliquidchromatography. Pharmacokinetic analysis was conducted using non-compartmental methods via the ncappc package in R. The mean concentration area under curve (AUClast) for enrofloxacin was determined to be 21.75±5.67 μg·h/mL for i.m., administration and 17.30±4.94μg·h/mL for oral administration. The elimination half-life (T1/2λz) was 9.51±5.72 and 6.87±1.81 h for the i.m., and …

Trends In Hospitalisation For Human Immunodeficiency Virus In A Tertiary Hospital In Dar Es Salaam, Tanzania: A Case Study, Grace Shayo, Tumaini Nagu, Lilian Msele, Patricia Munseri, Columba Mbekenga, Stephen Kibusi, Kisali Pallangyo, Ferdinand Mugusia

School of Nursing & Midwifery, East Africa

Background: Reports on a systematic evaluation of the impact of antiretroviral therapy(ART) on patients’ hospitalisation in Sub Saharan Africa (SSA) and Tanzania, in particular, are scarce. We aimed at documenting the trends of hospital admissions at Muhimbili National Hospital (MNH) following scale-up of free access to ART in Tanzania.

Methods: Records for all admissions at MNH from June 2005 to June 2015 were reviewed. We extracted data from the Hospital Information Management System as well as from patients’ charts. Data extracted included diagnosis at discharge, the reason for admission and thereafter assessed admission trends over the decade. We summarised …

A Systematic Review Of Epidemiological Patterns And Proposed Interventions To Address Pediatric Burns In Nigeria, Srikanta Banerjee, Constance Shumba

School of Nursing & Midwifery, East Africa

Background: Unintentional injuries from burns comprise a significant proportion of public health morbidity in Nigeria. In order to understand the type and impact of burns on youth in Low-and-Middle-Income countries, the epidemiology of burns must be adequately assessed.

Methods: This review describes the epidemiological patterns of burn occurrences in the pediatric populations and pro- poses interventions using the Haddon Matrix to address injuries in specific populations in Nigeria. A literature search was conducted using the Proquest, CINAHL, and PubMed databases at the Johns Hopkins University library (January 1, 1990 to August 14, 2018), on burns or thermal injury …

The Development Of The Compulsive Sexual Behavior Disorder Scale (Csbd-19): An Icd-11 Based Screening Measure Across Three Languages, Beáta Bőthe, Marc N. Potenza, Mark D. Griffiths, Shane W. Kraus, Verena Klein, Johannes Fuss, Zsolt Demetrovics

Psychology Faculty Research

Background Compulsive Sexual Behavior Disorder (CSBD) is included in the eleventh edition of The International Classification of Diseases (ICD-11) as an impulse-control disorder. AimsThe aim of the present work was to develop a scale (Compulsive Sexual Behavior Disorder Scale–CSBD-19) that can reliably and validly assess CSBD based on ICD-11 diagnostic guidelines. Method Four independent samples of 9,325 individuals completed self-reported measures from three countries (the United States, Hungary, and Germany). The psychometric properties of the CSBD-19 were examined in terms of factor structure, reliability, measurement invariance, and theoretically relevant correlates. A potential threshold was determined to identify individuals with an …

Validation Of A Brief Pornography Screen Across Multiple Samples, Shane W. Kraus, Mateusz Gola, Joshua B. Grubbs, Ewelina Kowalewska, Rani A. Hoff, Michał Lew-Starowicz, Steve Martino, Steven D. Shirk, Marc N. Potenza

Psychology Faculty Research

Background and Aims To address current gaps around screening for problematic pornography use (PPU), we initially developed and tested a six-item Brief Pornography Screen (BPS) that asked about PPU in the past six months. Methods and Participants We recruited five independent samples from the U.S. and Poland to evaluate the psychometric properties of the BPS. In Study 1, we evaluated the factor structure, reliability, and elements of validity using a sample of 224 U.S. veterans. One item from the BPS was dropped in Study 1 due to low item endorsement. In Studies 2 and 3, we further investigated the five-item …

Status Of Women In Nevada: Health Snapshot (Part 1), Ana Rosas, Aika Dietz, Caryll Batt Dziedziak, Jean Munson

Research Briefs

A breakthrough for women's health and racial health inequity is the passing of Public Health Service Act section 492B and National Institute of Health (NIH) Revitalization Act of 1993 (P.L. 103-43) and the implementation by NIH to support full or partially funded clinical research by establishing guidelines to include sex and race of the participant in these studies.

Biography Of Leann L Birch, Phd, 25 June 1946 – 26 May 2019, Stephani Anzman-Frasca, Kirsten K. Davison, Jennifer O. Fisher, Lori A. Francis, Susan L. Johnson, Justin A. Lavner, Ian M. Paul, Alison K. Ventura, Jennifer S. Savage

Kinesiology and Public Health

On 26 May, 2019, the nutrition community lost a visionary ambassador, trusted advisor, and cherished mentor. Leann Birch was a pioneer in bringing a developmental psychology perspective to the study of children's nutrition as a means to respond to real-world questions raised by parents. Leann Elsie Traub was born in Owosso, Michigan 25 June, 1946. She grew up primarily in Southern California and received a bachelor's degree in psychology from California State University, Long Beach, in 1971. She completed her graduate studies at the University of Michigan where she received a master's degree in 1973 and a doctorate in 1975, …

Functional Heterogeneity And Metabolic Adaptation Of Fibroblasts In Cancer, Lisa Becker

Dissertations and Theses (Open Access)

The tumor microenvironment is comprised of a multitude of cell types producing a milieu of cytokines, growth factors an extracellular matrix. Together, this intricate network of cells plays highly critical roles in determining a tumor’s potential to progress and metastasize. As the predominant cell types in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are a key component in the regulation of tumor development and progression, but their exact functions in tumorigenesis remain poorly understood. This is partly due to the considerable heterogeneity amongst these cells, which confounds the characterization of their roles within the tumor microenvironment. Nevertheless, recent studies have provided …

La Determinación Social De La Enfermedad Renal Crónica De Causas No Tradicionales (Ercnt) En Guatemala / The Social Determination Of Chronic Kidney Disease Of Non-Traditional Causes (Ckdnt) In Guatemala, Alejandro Cerón

Anthropology: Faculty Scholarship

La Enfermedad Renal Crónica de Causas no Tradicionales (ERCnT) ha aumentado en los últimos 20 años, convirtiéndose en un problema de salud pública importante que se observa principalmente en países de Centroamérica y Asia, afectando especialmente a trabajadores agrícolas jóvenes. La presencia de factores de riesgo relacionados con toxinas, medio ambiente y condiciones laborales sugiere una causa multifactorial, la cual puede que involucre la exposición a agroquímicos, contaminantes ambientales, y episodios repetidos de deshidratación. La comprensión de las condiciones sociales que unen estos factores en grupos específicos de población es fundamental para el desarrollo de programas de salud pública tendientes …

Intergrowth-21st Project International Inter-Nda Standards For Child Development At 2 Years Of Age: An International Prospective Population-Based Study, Michelle Fernandes, José Villar, Alan Stein, Eleonora Staines Urias, Cutberto Garza, Cesar G. Victora, Fernando C. Barros, Enrico Bertino, Maria Carvalho, Amina Abubakar, Roseline Ochieng

Obstetrics and Gynaecology, East Africa

Objectives To describe the construction of the international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting the cognitive, language, motor and behaviour outcomes in optimally healthy and nourished children in the INTERGROWTH-21st Project.

Design Population-based cohort study, the INTERGROWTH-21st Project.

Setting Brazil, India, Italy, Kenya and the UK.

Participants 1181 children prospectively recruited from early fetal life according to the prescriptive WHO approach, and confirmed to be at low risk of adverse perinatal and postnatal outcomes.

Primary measures Scaled INTER-NDA domain scores for cognition, language, fine and gross motor skills and behaviour; vision outcomes measured …

Ca2+ Dependency Of Limb Muscle Fiber Contractile Mechanics In Young And Older Adults, Laura E. Teigen, Christopher W. Sundberg, Lauren J. Kelly, Sandra K. Hunter, Robert H. Fitts

Exercise Science Faculty Research and Publications

Age-induced declines in skeletal muscle contractile function have been attributed to multiple cellular factors, including lower peak force (P_o), decreased Ca²⁺ sensitivity, and reduced shortening velocity (V_o). However, changes in these cellular properties with aging remain unresolved, especially in older women, and the effect of submaximal Ca²⁺ on contractile function is unknown. Thus, we compared contractile properties of muscle fibers from 19 young (24 ± 3 yr; 8 women) and 21 older adults (77 ± 7 yr; 7 women) under maximal and submaximal Ca²⁺ and assessed the abundance of three proteins thought to …

The Effects Of A Baseball Season On Various Body Composition Measurements And Assessment Of Dietary Intake In Ncaa Di Baseball Players, Jordan Marthens

Master's Theses

Despite the known importance of body composition in relation to performance and health of athletes, this study appears to be the first, or one of very few, to evaluate body composition measures from the beginning to end of season for NCAA DI collegiate baseball players and assess their dietary intake. Baseball players from the 2015-2019 seasons were included in the study (n=78; age=19.8±1.28). DXA scans performed at the start and end of season were analyzed and 3-day food records analyzed via ESHA software were utilized to assess dietary intake. Groups were stratified to examine differences in players’ positions (Pitchers vs. …

Access To Eye Care Before And After Vision Loss: A Qualitative Study Investigating Eye Care Among Persons Who Have Become Blind, Tosha Zaback, Stephanie Lam, Joan Randall, Teresa Field, Mitchell V. Brinks

The Qualitative Report

Navigating access to eye care requires that patients recognize the need for screening and care, employ limited financial and social resources, manage complex health insurance policies, and access specialty clinical care. We investigated the experience of patients through the progression of vision loss to blindness, utilizing qualitative methods. We conducted structured telephone interviews with 28 persons with blindness throughout Oregon. Utilizing closed and open-ended questions, we explored patient experience on the events preceding avoidable blindness. Coding for emergent themes was conducted independently by two researchers using a constant comparative method. Participants described important barriers to accessing eye care: at the …

Mental Health Challenges Among Ethnic Minorities College Students, Fiorella G. Valles, Ruben Gonzalez

Electronic Theses, Projects, and Dissertations

This research study explored the challenges of mental health-seeking services of college students of color in the San Bernardino area. College students of different ethnicities have unique needs and challenges that contrast with the general student population. Previous research stated that students of color deal with a greater number of unmet mental health needs and indicates a connection between mental health and attaining a college degree (Arria et al., 2013). To increase the utilization of mental health amongst students of color, this study aimed to identify the influencing factors that prevented students from help-seeking. The research design of this research …

Suicidal Ideation Among United States Veterans: A Systematic Review, Champagne D. Moore

Electronic Theses, Projects, and Dissertations

Objective: The goal of this study was to conduct a systematic review of suicidal ideation and associated factors among US veterans.

Methods: PRISMA guidelines for identifying and collecting published peer-reviewed articles were employed. Article characteristics were assessed, and trends were analyzed.

Results: Study results show that US veterans have higher rates of suicide as compared to non-US veterans. Among US veterans, the most common means of suicide was firearms, especially among males. Factors such as gun legislation was related to suicide rate among the population.

Conclusion: Veteran suicide prevention must be a public health priority. Prevention measures should further address …

A Case Study Of Factors That Influence The Implementation Of Full Spectrum Contraceptive Care In A University Student Health Center, Cecile Dahlquist

Electronic Theses, Projects, and Dissertations

Large, prospective cohort studies such as The Contraceptive Choice Project have been conducted regarding safety, efficacy, satisfaction, and usage of Long-Acting Reversible Contraception (LARC) such as the Contraceptive Implant (Nexplanon) and Intrauterine Contraception (Winner, Peipert, Zhao, Buckel, Madden, Allsworth & Secura (2012). Despite these findings, access and financial barriers remain for many women, and less than 7 percent of women utilize the most effective methods of contraception in the United States (Winner et al., 2012). Barriers to effective LARC methods exist at a higher rate with our young, poor, and non-white marginalized populations (Finer & Zolna, 2016).

Unplanned pregnancies have …

The California Healthy Youth Act: A Policy Analysis On California's Comprehensive Sex Education Mandate, Rae Chelle D. Gabriel

Electronic Theses, Projects, and Dissertations

Background: The California Healthy Youth Act is the policy that mandates California public schools to implement comprehensive sex education in middle and high school. Since its enactment in 2016, sexually transmitted infections have reached its highest rates with young people accounting for half of all new cases. Likewise, teen dating violence and sexual violence (including sex trafficking) continue to burden adolescents, especially among minorities. Policy enhancements are recommended to bridge the gaps in implementation to ensure compliance and sustainability of the policy.

Methods: A policy analysis was conducted using Bardach’s 8-fold path and a SWOT analysis. Data was gathered through …

What Are The Relationships Between Adverse Childhood Experiences And Age Of Initiaton Of Substance Use?, Alisha Dozier

Electronic Theses, Projects, and Dissertations

ABSTRACT

Child abuse and substance abuse are significant health problems in the United States and they negatively impact the physical, emotional, and biological health of millions of individuals. It is estimated that one in four children experience child abuse, which is a risk factor for the development of substance abuse problems later in life (U.S. Department of Health and Human Services [HHS], 2018). Rates of substance abuse are increasing nationally, making the relationship between child abuse and the development of substance abuse problems important to study.

This research project analyzes the relationship between adverse childhood experiences and subsequent age of …