Medicine and Health Sciences Commons^™

Music As A Scaffold For Listening To Speech: Better Neural Phase-Locking To Song Than Speech, Christina M. Vanden Bosch Der Nederlanden, Marc F. Joanisse, Jessica A. Grahn

Brain and Mind Institute Researchers' Publications

© 2020 The Authors Neural activity synchronizes with the rhythmic input of many environmental signals, but the capacity of neural activity to entrain to the slow rhythms of speech is particularly important for successful communication. Compared to speech, song has greater rhythmic regularity, a more stable fundamental frequency, discrete pitch movements, and a metrical structure, this may provide a temporal framework that helps listeners neurally track information better than the rhythmically irregular rhythms of speech. The current study used EEG to examine whether entrainment to the syllable rate of linguistic utterances, as indexed by cerebro-acoustic phase coherence, was greater when …

The "Inferior Temporal Numeral Area" Distinguishes Numerals From Other Character Categories During Passive Viewing: A Representational Similarity Analysis, Darren J. Yeo, Courtney Pollack, Rebecca Merkley, Daniel Ansari, Gavin R. Price

Brain and Mind Institute Researchers' Publications

A region in the posterior inferior temporal gyrus (pITG) is thought to be specialized for processing Arabic numerals, but fMRI studies that compared passive viewing of numerals to other character types (e.g., letters and novel characters) have not found evidence of numeral preference in the pITG. However, recent studies showed that the engagement of the pITG is modulated by attention and task contexts, suggesting that passive viewing paradigms may be ill-suited for examining numeral specialization in the pITG. It is possible, however, that even if the strengths of responses to different category types are similar, the distributed response patterns (i.e., …

Expanding The Search For Genetic Biomarkers Of Parkinson's Disease Into The Living Brain, Simon M. Benoit, Hu Xu, Susanne Schmid, Roumiana Alexandrova, Gaganjot Kaur, Bhooma Thiruvahindrapuram, Sergio L. Pereira, Mandar Jog, Matthew O. Hebb

Brain and Mind Institute Researchers' Publications

Altered gene expression related to Parkinson's Disease (PD) has not been described in the living brain, yet this information may support novel discovery pertinent to disease pathophysiology and treatment. This study compared the transcriptome in brain biopsies obtained from living PD and Control patients. To evaluate the novelty of this data, a comprehensive literature review also compared differentially expressed gene (DEGs) identified in the current study with those reported in PD cadaveric brain and peripheral tissues. RNA was extracted from rapidly cryopreserved frontal lobe specimens collected from PD and Control patients undergoing neurosurgical procedures. RNA sequencing (RNA-Seq) was performed and …

Relationship Of Head Circumference And Age In The Prediction Of The Real-Ear-To-Coupler Difference (Recd), Kelli M. Watts, Marlene Bagatto, Sandra Clark-Lewis, Samantha Henderson, Susan Scollie, Judith Blumsack

Communication Sciences and Disorders Publications

Background Pediatric hearing instrument fitting is optimally performed with individually obtained real-ear-to-coupler difference (RECD) measurements. If these measurements cannot be obtained, predicted values based on age are used. Recent evidence obtained from children aged 3-11 years suggests that head circumference (HC) may be a viable alternative or addition to age for use in RECD prediction. Purpose The purpose of the present study was to determine if HC can be used to predict RECDs in infants, children, and adults. Research Design A correlational design was used. HC and RECD values were measured in all participants. Study Sample Participants were 278 North …

Alumni Journal - Volume 91, Number 2, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
6 | From the Dean

News
8 | School of Medicine News
10 | Alumni News
11 | AIMS Report
12 | Students

Graduation 2020
13 | Graduation Feature: A letter to the graduates, awards, photos, residency information, and more
14 | The Missing Regalia: Debra L. Stottlemyer '86 shares how alumni supported the senior class

Features
30 | Gloves: Hannah C. Lokos '20 tells a story of how she saw a glimpse of God
32 | Department Reports: Emergency Medicine and Urology: E. Lea Walters '94 and Herbert …

Combating Stress In Nursing During Covid-19 Pandemic, Amanda Illingworth Bsn, Rn, Tara Weber Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

How Can Econometrics Help Fight The Covid'19 Pandemic?, Kevin Alvarez, Vladik Kreinovich

Departmental Technical Reports (CS)

The current pandemic is difficult to model -- and thus, difficult to control. In contrast to the previous epidemics whose dynamics was smooth and well described by the existing models, the statistics of the current pandemic is highly oscillating. In this paper, we show that these oscillations can be explained if we take into account the disease's long incubation period -- as a result of which our control measures are determined by outdated data, showing number of infected people two weeks ago. To better control the pandemic, we propose to use the experience of economics, where also the effect of …

The Gut Microbiome And Xenobiotics: Identifying Knowledge Gaps, Vicki L. Sutherland, Charlene A. Mcqueen, Donna Mendrick, Donna Gulezian, Carl Cerniglia, Steven Foley, Sam Forry, Sangeeta Khare, Xue Liang, Jose E. Manautou, Donald Tweedie, Howard A. Young, Alexander V. Alekseyenko, Frank Burns, Rod Dietert, Alan Wilson, Connie Chen

United States Public Health Resources

There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, the Health and Environmental Sciences Institute (HESI) held a workshop, "The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity" (https://hesiglobal.org/event/the-gut-microbiome-workshop) to identify data gaps in determining how gut microbiome alterations may affect human health. Speakers and stakeholders from academia, government, and industry addressed multiple topics including the current science on the gut microbiome, endogenous and exogenous metabolites, biomarkers, and model systems. The workshop presentations and breakout group discussions formed the …

Multi-Omics: Differential Expression Of Ifn-Γ Results In Distinctive Mechanistic Features Linking Chronic Inflammation, Gut Dysbiosis, And Autoimmune Diseases, Heekyong R. Bae, Patrick S. C. Leung, Deborah L. Hodge, John M. Fenimore, Seon Min Jeon, Vishal Thovarai, Amiran Dzutsev, Andrew A. Welcher, Michael Boedigheimer, Michael A. Damore, Myung Sook Choi, Richard A. Fravell, Giorgio Trinchieri, M. Eric Gershwin, Howard A. Young

United States Public Health Resources

Low grade, chronic inflammation is a critical risk factor for immunologic dysfunction including autoimmune diseases. However, the multiplicity of complex mechanisms and lack of relevant murine models limit our understanding of the precise role of chronic inflammation. To address these hurdles, we took advantage of multi-omics data and a unique murine model with a low but chronic expression of IFN-γ, generated by replacement of the AU-rich element (ARE) in the 3’ UTR region of IFN-γ mRNA with random nucleotides. Herein, we demonstrate that low but differential expression of IFN-γ in mice by homozygous or heterozygous ARE replacement triggers distinctive gut …

Severe Weather In Nebraska: Impacts On Nonmetropolitan Nebraskans. 2020 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl Burkhart-Kriesel, Bradley Lubben, L. J. Mcelravy, Timothy Meyer, Steve Schulz, Jason L. Weigle

Rural Futures Institute: Publications

In March 2019, a bomb cyclone produced a historic blizzard as well as flooding that impacted many counties in Nebraska. Given that, did rural Nebraskans experience extreme weather events or natural disasters in 2019? To what extent were they harmed by these weather events? What personal impacts did they experience? How concerned are they about weather events? This paper provides a detailed analysis of these questions. This report details 1,979 responses to the 2020 Nebraska Rural Poll, the 25th annual effort to understand rural Nebraskans’ perceptions. Respondents were asked a series of questions about weather events. Comparisons are made among …

Switching Warfarin To Direct Oral Anticoagulants In Atrial Fibrillation: Insights From The Ncdr Pinnacle Registry, Christopher T. Sciria, Thomas M. Maddox, Lucas Marzec, Benjamin Rodwin, Salim S. Virani, Amarnath Annapureddy, James V. Freeman, Ali O'Hare, Yuyin Liu

Office of the Provost

Background: Previous studies examining the use of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) have largely focused on patients newly initiating therapy. Little is known about the prevalence/patterns of switching to DOACs among AF patients initially treated with warfarin.
Hypothesis: To examine patterns of anticoagulation among patients chronically managed with warfarin upon the availability of DOACs and identify patient/practice-level factors associated with switching from chronic warfarin therapy to a DOAC.
Methods: Prospective cohort study of AF patients in the NCDR PINNACLE registry prescribed warfarin between May 1, 2008 and May 1, 2015. Patients were followed at least 1 year …

Defining A Research Agenda For Layperson Prehospital Hemorrhage Control: A Consensus Statement, Eric Goralnic, Chibuike Ezeib, Muhammad Ali Chaudhary, Justin Mccarty, Juan P. Herrera-Escobar, Tomas Andriotti, Elzerie De Jager, Daniel Ospina-Delgado, Craig Goolsby, Adil H. Haider

Section of General Surgery

Importance: Trauma is the leading cause of death for US individuals younger than 45 years, and uncontrolled hemorrhage is a major cause of trauma mortality. The US military's medical advancements in the field of prehospital hemorrhage control have reduced battlefield mortality by 44%. However, despite support from many national health care organizations, no integrated approach to research has been made regarding implementation, epidemiology, education, and logistics of prehospital hemorrhage control by layperson immediate responders in the civilian sector.
Objective: To create a national research agenda to help guide future work for prehospital hemorrhage control by laypersons.
Evidence review: The 2-day, …

Thinking Outside The Box In Liver Tox, Kimberly Brizell, Geoffrey L. Goldsberry

West Florida Division GME Research Day 2020

DILI is the most common cause of acute liver failure in the United States. However, it is important to consider that the agent at play may not be common to the United States. We aim to highlight the importance of using a "global mindset" when treating international and frequent traveling patients, but also demonstrate the severe hepatotoxic risks associated with Nimesulide.

A Novel Indication For Oocyte Cryopreservation Prior To Autologous Hematopoietic Cell Transplantation For Refractory Multiple Sclerosis, Neal R. Trulock, Luke Ying, Edward Zbella, Mark Sanchez

West Florida Division GME Research Day 2020

Multiple sclerosis (MS) is an immune mediated inflammatory diseases of the central nervous system characterized by focal ovoid like lesions of demyelination seen on MRI(1,2). The etiology of MS is unknown, however inflammation followed by CNS demyelination and axonal degeneration are known to be part of the pathologic processes that lead to the disease (1). The mean age of onset of MS is 28-31 years old and tends to affect women more often then men with a ratio of 2.3:1 (3,4) . Other risk factors associated with MS include vitamin D deficiency, smoking, and certain viruses (5). The pattern of …

Sepsis Screening Education, Brittany R. Horn

Doctor of Nursing Practice Scholarly Project

Sepsis is a significant burden to the healthcare field with 1.7 million Americans annually diagnosed with this condition. Earlier diagnosis and treatment are the most effective ways of reducing morbidity and mortality related to sepsis. The current sepsis screening tool in place at Stormont-Vail Hospital, in Topeka, Kansas, is the systemic inflammatory response (SIRS) criteria; however, this screening tool has proven to be less effective than other screening tools available. The screening tools proven more effective than the SIRS criteria, are the quick sequential organ failure assessment (qSOFA) and the sequential organ failure assessment (SOFA). For this project, nursing staff …

H2s Donor Gyy4137 Ameliorates Paclitaxel-Induced Neuropathic Pain In Mice, Bedoor Qabazard, Willias Masocha, Maitham Khajah, Philip Adebayo

Faculty of Health Sciences, East Africa

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect that largely affects the patient’s quality of life and may limit the use of the drug as a chemotherapeutic agent for treating metastatic breast cancer and other solid tumors. Recently, a putative role for the gaseous mediator hydrogen sulfide (H2S) in nociception modulation has been suggested. The aim of the present study was to investigate the potential efficacy of the slow release H2S donor GYY4137 to alleviate and prevent PINP. Female BALB/c mice that were intraperitoneally (i.p.) injected with paclitaxel (2 mg/kg) for 5 consecutive days developed thermal hyperalgesia, cold and …

Acute Syphilitic Posterior Placoid Chorioretinopathy: A Case Report, Rehman Siddiqui, Syed Zohaib Maroof Hussain, Irfan Jeeva, Raeefuddin Ahmed

Section of Ophthalmology

A 25-year-old male presented with a complaint of acute visual loss in his right eye for two days. There was a history of visual loss in the left eye six months ago. Comprehensive eye examination showed evidence of posterior uveitis, and a placoid lesion on the right fundus. Further physical examination showed maculopapular rashes on the upper back which was highly suggestive of syphilis. Blood tests for venereal disease research laboratory (VDRL) test and fluorescent treponemal antibody absorption (FTA-ABS) test were ordered, which were both positive. Ocular syphilis should be suspected in all cases of uveitis. Early diagnosis and prompt …

Detroit Food Metrics Report 2019, Alex B. Hill

Urban Studies and Planning Faculty Research Publications

This report provides a snapshot of data and information on Detroit’s food system as well as trends over time. The report includes a broad range of programs and initiatives that local organizations, the Detroit Food Policy Council, and the City of Detroit are undertaking to address food insecurity, increase healthy food access and awareness, and support a more sustainable and just food system.

Health Service Utilization Among Migrant Mothers Of Under-Five Children In Shivamogga District Of Karnataka, Anupama D. S Ms, Baby S. Nayak Dr, Jyothi Chakrabarty Dr

Manipal Journal of Nursing and Health Sciences

Introduction: Migrant mothers residing in the slum area always underutilize the health services rendered by the government. Objective: The objective of this study was to assess the health services utilization for children among migrant mothers of under-five children. Method: A cross-sectional descriptive survey approach was used for this study. The study was conducted among 320 mothers from selected migrant areas of Shivamogga District of Karnataka. Results: Results revealed that the majority (99.1%) of the mothers had utilized hospital services for delivery. Around 82.2% of the mothers were aware of Janani Suraksha Yojana. However, 57.5% of the mothers have not received …

Black Midwifery In The United States: Past, Present, And Future, Alicia Suarez

Sociology & Anthropology Faculty publications

While sociologists have long explored health and illness, much of it has been androcentric and White-centered. Scholars began to focus more on women’s health including pregnancy and birth in the 1970s yet have historically largely ignored Black women’s birth experiences. Midwifery in the United States was once the standard practice for prenatal care and birth. However, the vast majority of births have been medicalized and now occur in hospital settings. In this review, I will highlight the role of race in the historical shifts in the provision of care to Black pregnant and birthing women, the marginalization of Black midwives …

Patterns Of Regional Cerebral Blood Flow As A Function Of Obesity In Adults., Daniel G Amen, Joseph Wu, Noble George, Andrew Newberg

Marcus Institute of Integrative Health Faculty Papers

BACKGROUND: While obesity has been shown to be a risk factor for Alzheimer's disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons.

OBJECTIVE: To identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight categories, including overweight or obese status.

METHODS: A large psychiatric cohort of 35,442 brain scans across 17,721 adults (mean age 40.8±16.2 years, range 18-94 years) were imaged with SPECT during baseline and concentration scans, the latter done after each participant completed the Connors Continuous Performance Test II. ANOVA …

Health And Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Alumna Working to Make Athletic Trainers a Standard in Campus Recreation

• Health Sciences and Kinesiology Students and Faculty Conduct Research on Peripheral Neuropathy

Atrial Fibrillation, Ayushma Neupane

Nursing Student Class Projects (Formerly MSN)

Atrial fibrillation is one of the most common cardiac arrhythmias. Patient can be either symptomatic or asymptomatic. Atrial fibrillation poses a high risk for the development of thromboembolitic stroke and heart failure along with other complications. Nursing provider must take a responsibility to educate the patient regarding the knowledge of disease and importance of adherence to medication and anticoagulants to ensure the quality of life. Understanding the pathophysiology of atrial fibrillation is essential to treat a patient and also to estimate the lifetime risk of atrial fibrillation in various subgroups with one or multiple elevated or borderline-elevated risk factors might …

Jefferson Digital Commons Quarterly Report: April-June 2020, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• New Collection: COVID-19 Papers, Posters, and Presentations
• Articles
• Collaborative Research and Evidence Among Therapists and Educators (CREATE) Day Presentations
• COVID-19 Working Papers
• Dissertations
• Doctorate of Occupational Therapy (OTD) Capstones
• Educational Materials
• From the Archives
• Grand Rounds and Lectures
• House Staff Quality Improvement and Patient Safety Posters
• JeffMD Scholarly Inquiry Abstracts
• Journals and Newsletters
• Master of Public Health Capstone Presentations
• Posters
• Spread the Science, NOT the Virus Seminar Series
• What People are Saying About the Jefferson the Digital Commons

Significance Of Micro-Rna Expression In Patients With Meningioma, Rida Mitha, Muhammad Shahzad Shamim

Section of Neurosurgery

Recent brain tumour research has shown abnormalities in gene expression as key features for almost all common brain tumours investigated. However, there is increasing evidence that epigenetic abnormalities are also crucial for tumorigenesis. Epigenetic abnormalities are heritable alterations affecting gene expression without changing the primary DNA sequence. Epigenetic abnormalities in meningiomas include abnormal microRNA expression, altered DNA methylation and histone and chromatin modifications. In this review we identify the role of altered expression of microRNA in the development and recurrence of meningioma. Based on the review of current literature, extensive knowledge of micro-RNA expression cannot only determine tumour recurrence and …

Effectiveness Of High-Fidelity Simulation In Nursing Education For End-Of-Life Care: A Quasi-Experimental Design, Salma Rattani, Zohra Kurji, Amina Aijaz Khowaja Ap, Jacqueline Maria Dias, Anila Naz Alisher

School of Nursing & Midwifery

Background: Providing end of life (EOL) care is a component of palliative care but dealing with dying patients and their family members is stressful for the healthcare providers. To prepare them for providing EOL care, the high-fidelity simulation could be used as a pedagogy in which real-life scenarios are used on the computerized manikins mimicking the real patients.
Aims: The aim of this study was to measure the effectiveness of high-fidelity simulation to teach EOL care in the palliative nursing course in the undergraduate nursing education program at the School of Nursing and Midwifery at Aga Khan University which is …

Association Of Circulatory Kisspeptin Levels And Hormonal Interplay With Male Infertility: A Cross-Sectional Study In Karachi, Pakistan, Rehana Rehman, Kaleem Ahmed, Nida Zahid, Faiza Alam, Syeda Sadia Fatima

Department of Biological & Biomedical Sciences

Objectives: To determine the impact of Kisspeptin on male reproductive axis in a selected urban population.
Methods: The cross-sectional study was conducted at the Sindh Institute of Reproductive Medicine in collaboration with Aga Khan University, Karachi, from July, 2017, to February, 2018, and comprised infertile males with abnormal sperm parameters who were placed in Group A and fertile males with normal sperm parameters placed in Group B. Serum samples were estimated for Kisspeptin, follicle stimulating hormone, luteinizing hormone, testosterone and sex hormone-binding globulin using enzyme-linked immunosorbent assay. Data was analysed using SPSS 22.
Results: Of the 313 male subjects, 178(57%) …

A Phase Ii Single-Arm Study Of Pembrolizumab With Enzalutamide In Men With Metastatic Castration-Resistant Prostate Cancer Progressing On Enzalutamide Alone., Julie N Graff, Tomasz M Beer, Joshi J Alumkal, Rachel E Slottke, William L. Redmond, George V Thomas, Reid F Thompson, Mary A Wood, Yoshinobu Koguchi, Yiyi Chen, Emile Latour, Raymond C Bergan, Charles G Drake, Amy E Moran

Articles, Abstracts, and Reports

BACKGROUND: Checkpoint inhibitors can induce profound anticancer responses, but programmed cell death protein-1 (PD-1) inhibition monotherapy has shown minimal activity in prostate cancer. A published report showed that men with prostate cancer who were resistant to the second-generation androgen receptor inhibitor enzalutamide had increased programmed death-ligand 1 (PD-L1) expression on circulating antigen-presenting cells. We hypothesized that the addition of PD-1 inhibition in these patients could induce a meaningful cancer response.

METHODS: We evaluated enzalutamide plus the PD-1 inhibitor pembrolizumab in a single-arm phase II study of 28 men with metastatic castration-resistant prostate cancer (mprogressing on enzalutamide alone. Pembrolizumab 200 mg …

Medication Use, Renin-Angiotensin System Inhibitors, And Acute Care Utilization After Hospitalization In Patients With Chronic Kidney Disease., Joshua J Neumiller, Kenn Daratha, Radica Alicic, Robert A Short, Haleigh Miller, Liza Gregg, Brian J Gates, Cynthia F Corbett, Sterling M Mcpherson, Katherine Tuttle

Articles, Abstracts, and Reports

OBJECTIVES: The aims of this secondary analysis were to: (a) characterize medication use following hospital discharge for patients with chronic kidney disease (CKD), and (b) investigate relationships of medication use with the primary composite outcome of acute care utilization 90 days after hospitalization.

METHODS: The CKD-Medication Intervention Trial (CKD-MIT) enrolled acutely ill hospitalized patients with CKD stages 3-5 not dialyzed (CKD 3-5 ND). In this post hoc analysis, data for medication use were characterized, and the relationship of medication use with the primary outcome was evaluated using Cox proportional hazards models.

RESULTS: Participants were taking a mean of 12.6 (standard …

Ct-Nib Taxonomy For Nursing Information Behavior: Ko In The Pandemic, Elizabeth Milonas, Sergey Zherebchevsky, Richard P. Smiraglia

Publications and Research

As COVID-19 emerged on the world stage a challenge arose to help inform the knowledge base in home health-care nursing. Connecting current experience with the Pajarillo theory "The Nub of Nursing Information Behavior (NIB" was a first step. To provide a taxonomy of NIB, standard domain analytical tools for ontology extraction were employed using Pajarillo's text. Analysis generated frequency distributions of terms and phrases which were then sorted and disambiguated to generate a list of phenomena. Co-word analysis generated visualizations to suggest regions that might constitute facets and sub-facets. Facet analysis yielded six major facets and 17 sub-facets. The NANDA …