Medicine and Health Sciences Commons^™

Right Hemisphere Capacities For Word-Finding: Bilateral Modulation Of Event-Related Potentials In Healthy Adults And Adults With Aphasia, Amanda C. Alton

Dissertations

Language tasks are typically lateralized to the language dominant left hemisphere in healthy right-handed adults. Additionally, lesions in left frontotemporal areas typically result in a variety of language impairments called aphasia. Interestingly, increased activation in right cerebral regions homologous to left side lesions has been observed in patients with aphasia during word-finding tasks. The neural mechanism and the impact on word-finding remain unclear. There are two competing theories concerning compensatory right hemisphere activation. One view is that the right hemisphere plays a supportive role, taking over functions of the damaged left hemisphere. The other perspective is that rightward laterality is …

Racial Microaggressions: Effects On Achieving Health Equity From The Classroom To The Wards, Yaritzy M. Astudillo, Camille A. Clare, Melissa Marseille, Pedro Laureano

NYMC Faculty Posters

No abstract provided.

Bruna Barbosa, Bruna Barbosa

Spring 2017

Meet Bruna Barbosa—one of Andrews University's most brilliant personalities! This story covers Bruna’s transition from “living for comfort” to “living for mission.” Although her journey went through a few awkward turns, she finally found her purpose on the small island of Palau, and this purpose now fuels her pursuit of a speech-pathology degree. Read how Bruna’s decision to fly halfway across the world provided the motivation she needed to find her passion, her purpose and her profession.

Read Bruna's full story in Stories of Andrews at andrews.edu/stories.

Thank you, Bruna, for sharing your story. You are part of the …

Out In The Cold: Ingredients In Over-The-Counter Cold Medicines Can Wreak Havod On A Trainer's Livelihood And An Owner's Prized Racehorse, Clara Fenger, Tanya Boulmetis, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

No abstract provided.

Glenohumeral Internal Rotation Deficit In Division Three Collegiate Football Quarterbacks, Anthony Wene

Undergraduate Honors Thesis Projects

The research looked at the internal rotation loss in collegiate football quarterbacks. A goniometer was used to measure the internal and external rotation of the shoulder for each subject. These measurements were then compared to what is considered glenohumeral internal rotation deficit, GIRD, as defined in the literature. A majority of the current literature focused on GIRD and its connection to baseball pitchers. This research focused on GIRD and its possible connection to football quarterbacks because of the repetitive overhead motion. GIRD is often connected to baseball pitchers due to the extensive research done with baseball pitchers. There are several …

Production Of Putative Enhanced Oral Cholera Vaccine Strains That Express Toxin-Coregulated Pilus, Caitlyn A. Hauke, Ronald K. Taylor

Dartmouth Scholarship

The use of whole cell killed (WCK) oral cholera vaccines is an important strategy for cholera prevention in endemic areas. To overcome current vaccine limitations, we engineered strains of V. cholerae to be non-toxigenic and to express the protective protein colonization factor, toxin-coregulated pilus (TCP), under scale-up conditions potentially amenable to vaccine production. Two V. cholerae clinical strains were selected and their cholera toxin genes deleted. The tcp operon was placed under control of a rhamnose-inducible promoter. Production and stability of TCP were assessed under various conditions. The strains lack detectable cholera toxin production. The addition of 0.1% …

Quality Of Life And Medication Adherence Of Independently Living Older Adults Enrolled In A Pharmacist-Based Medication Management Program, Christopher Harlow, Catherine Hanna, Lynne Eckmann, Yevgeniya Gokun, Faika Zanjani, Karen Blumenschein, Holly Divine

Pharmacy Practice and Science Faculty Publications

This study sought to understand the medication adherence and quality of life (QOL) of recipients of a pharmacist-based medication management program among independently living older adults. Using a cross-sectional, quasi-experimental study design, we compared older adults enrolled in the program to older adults not enrolled in the program. Data were collected via face-to-face interviews in independent-living facilities and in participants’ homes. Independently living older adults who were enrolled in the medication management program (n = 38) were compared to older adults not enrolled in the program (control group (n = 41)). All participants were asked to complete questionnaires …

Gastrointestinal Stromal Tumor Induced Hypercalcemia, Aram Barbaryan, Stefania Bailuc, Padma Poddutoori, Aida Richardson, Aibek E. Mirrakhimov

Internal Medicine Faculty Publications

Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D₃ mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D₃. We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our …

Plasma Cross-Gestational Sphingolipidomic Analyses Reveal Potential First Trimester Biomarkers Of Preeclampsia, Aneta Dobierzewska, Sony Soman, Sebastian E Illanes, Andrew J. Morris

Saha Cardiovascular Research Center Faculty Publications

Introduction

Preeclampsia (PE) is a gestational disorder, manifested in the second half of pregnancy by maternal hypertension, proteinuria and generalized edema. PE is a major cause of maternal and fetal morbidity and mortality, accounting for nearly 40% of all premature births worldwide. Bioactive sphingolipids are emerging as key molecules involved in etiopathogenesis of PE, characterized by maternal angiogenic imbalance and symptoms of metabolic syndrome. The aim of this study was to compare the cross-gestational profile of circulating bioactive sphingolipids in maternal plasma from preeclamptic (PE) versus normotensive control (CTL) subjects with the goal of identifying sphingolipids as candidate first trimester …

Effect Of Social Support And Marital Status On Perceived Surgical Effectiveness And 30-Day Hospital Readmission, Owoicho Adogwa, Aladine A. Elsamadicy, Victoria D. Vuong, Ankit I. Mehta, Raul A. Vasquez, Joseph Cheng, Carlos A. Bagley, Isaac O. Karikari

Neurosurgery Faculty Publications

Study Design: Retrospective cohort review.

Objective: To determine whether higher levels of social support are associated with improved surgical outcomes after elective spine surgery.

Methods: The medical records of 430 patients (married, n = 313; divorced/separated/widowed, n = 71; single, n = 46) undergoing elective spine surgery at a major academic medical center were reviewed. Patients were categorized by their marital status at the time of surgery. Patient demographics, comorbidities, and postoperative complication rates were collected. All patients had prospectively collected outcomes measures and a minimum of 1-year follow-up. Patient reported outcomes instruments (Oswestry Disability Index, Short Form-36, and visual …

Alterations In Erythrocyte Fatty Acid Composition In Preclinical Alzheimer's Disease, Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R. Sohrabi, Prita R. Ash, Preeti Dave, Bethany Ball, Candice Manyan, Kevin Taddei, Roger Chung, Manohar L. Garg, Ralph Martins

Research outputs 2014 to 2021

Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65 – 90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand ¹⁸F-Florbetaben, was employed to categorise participants as low NAL (standard uptake value ratio; SUVR < 1.35, N = 65) and high NAL or preclinical AD (SUVR ≥ 1.35, N = 35) wherein, linear models were employed to compare FA compositions between the two groups. Increased arachidonic acid (AA, p < 0.05) and decreased docosapentaenoic acid (DPA, p < 0.05) were observed in high NAL. To differentiate low from high NAL, the area under the curve (AUC) generated from a ‘base model’ comprising age, gender, APOEε4 and education (AUC = 0.794) was outperformed by base model + AA:DPA (AUC = 0.836). Our …

General Aviation Hypoxia And Reporting Statistics, Timothy B. Holt, Jacqueline Luedtke, Claire Schindler

Publications

“All too often, pilots tell me they don't need physiological training because they don't fly that high. The statement points out the general feelings of a large majority of the aviation population. I suppose then the burning question is ‘why do we still have aircraft accidents?’” (Boshers, 2015). To this day there are no statistics on how often general aviation pilots experience hypoxia during everyday operations. General aviation pilots (i.e. non-commercial operations) were chosen for this study because:

• Little regulation regarding flight physiology training
• General attitude of invulnerability towards hypoxia
• No requirement to report hypoxia or similar events

Acetaminophen Associated Neurotoxicity And Its Relevance To Neurodevelopmental Disorders, Seol-Hee Kim

USF Tampa Graduate Theses and Dissertations

Autism is a lifelong neurodevelopmental disorder. The etiology of autism still remains unclear due to the heterogeneous and complex nature of the disorder, however synergistic actions between genetic components and environmental factors have been suggested. Acetaminophen (APAP) is one of the most popular over-the-counter drugs that possess antipyretic and analgesic effects. It is considered a relatively safe and effective within therapeutic doses. Recently, early exposure to APAP has been suggested to be one of the underlying cause of autism. Children are often prescribed APAP to lessen fever or irritability after vaccination during the first year, and APAP may adversely affect …

Parent Involvement Factors From The Perspectives Of Academically Successful Black Male College Students, Vernon Leo Stanley Smith

USF Tampa Graduate Theses and Dissertations

During the past two decades, concerns about Black males’ academic achievement have been a major theme in the literature devoted to education and social sciences. Despite over two decades of studies focused specifically on Black males and their academic underachievement, the achievement gap persists. According to the National Center for Educational Statistic (2006), African-American males were reported as being disproportionally negatively represented in regards to academic achievement. Some researchers suggested Black children’s underachievement might be due to the lack of parental involvement. Other studies have highlighted statements of Black males who indicated parental involvement factors that contributed to their academic …

Scheduling, Heather Ann Paine 2481430

Student Scholar Showcase

Problem:

Self scheduling via paper sign-up sheets can lead to missed staffing needs for the Operating Room. Paper scheduling lacks the ability to run quick analysis of staffing needs as well as ensure each shift is staffed properly.

Evidence:

Electronic scheduling will improve scheduling efficiency, cost savings, as well as improve moral and staff engagement.

Strategy:

This project will use design and plan, do, study, and act to implement and evaluate project. This project is being conducted take place at Lynchburg General Hospital Operating Room with the current five members of the cardiothoracic team as a pilot, based on post …

Air Pollution: An Emerging Concern On The Cardiovascular System, Lauren Martin, Husnia Akrami

Student Scholar Showcase

No abstract provided.

Difference Between Regular Season And Postseason Impacts Of Women’S Soccer, Elizabeth R. Oden, Debbie Bradney, Katie Breedwood, Tom G. Bowman

Student Scholar Showcase

Context: Subconcussive head impacts receive increased attention for brain health. It remains unknown if game type affects frequency or magnitude of head impacts. Objective: Examine relationship between magnitude and frequency of head impacts during regular and postseason soccer games. Setting: Collegiate soccer fields. Participants: 17 women’s soccer athletes (height=163.68±4.99 cm, age=19.88±1.05 years, mass=61.12±5.00 kg) participated in 19 regular and 9 postseason games during 2014 season. Main Outcome Measures: Game type. XPatch sensor (Seattle, WA) collected linear (g) and rotational (deg/sec2) accelerations, Incidence rates (IR) and incidence rate ratios (IRRs) with corresponding 95% confidence intervals (CIs) determining frequency differences. Mann-Whitney U …

Subanesthetic Ketamine For Pain Management In Hospitalized Children, Adolescents, And Young Adults: A Single-Center Cohort Study, K A. Sheehy, C Lippoid, A L. Rice, R Nobrega, Julia C. Finkel, Zenaide Quezado

Anesthesiology and Critical Care Medicine Faculty Publications

¹Division of Anesthesiology, Pain, and Perioperative Medicine, The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s Research Institute, Children’s National Health System, George Washington University School of Medicine and Health Sciences, ²Center for Neuroscience Research, Children’s Research Institute, Children’s National Health System, Washington, DC, USA *These authors contributed equally to this work Background: Subanesthetic doses of ketamine, an N-methyl-D-aspartate receptor antagonist used as an adjuvant to opioid for the treatment of pain in adults with acute and chronic pain, have been shown, in some instances, to improve pain intensity and to decrease opioid intake. However, less is …

An Analysis Of Correlation Between Agrichemical Contaminated Wells And Birth Defects In Nebraska, Moses New-Aaron, Martha Rhoades, Jane L. Meza, Jeff Wallman

Posters and Presentations: College of Public Health

Background:

Evidences that agrichemicals might be associated with the incidence of birth defects are inconsistent.

Objectives:

• Examine whether Triazine, Acetanilide, Carbamothioate, Nitrate, Trifluralin and Uracil present in well-water are associated with birth defect rates in Nebraska Counties
• Identify the well types contaminated with these pesticides.

Methods:

Birth defects data obtained from Nebraska Department of Human and Health Services were merged with data on wells tested for agrichemicals obtained from Quality-Assessed Agrichemical Contaminant Database for Nebraska Ground Water. The 33 contaminants sampled from the wells were sub classified into 6 predictors and expressed as percentages for analysis in a multiple regression …

Recurrent Urinary Tract Infections In Adult Women, Ayaan Mohamed

Nursing Capstones

No abstract provided.

Noninvasive Monitoring Intracranial Pressure - A Review Of Available Modalities, Marium Naveed Khan, Hussain Shallwani, Muhammad Ulusyar Khan, Muhammad Shahzad Shamim

Section of Neurosurgery

Background: Intracranial pressure (ICP) monitoring is important in many neurosurgical and neurological patients. The gold standard for monitoring ICP, however, is via an invasive procedure resulting in the placement of an intraventricular catheter, which is associated with many risks. Several noninvasive ICP monitoring techniques have been examined with the hope to replace the invasive techniques. The goal of this paper is to provide an overview of all modalities that have been used for noninvasive ICP monitoring to date.
Methods: A thorough literature search was conducted on PubMed, selected articles were reviewed in completion, and pertinent data was included in the …

The Increased Risk Of Osteoporosis With Selective Serotonin Reuptake Inhibitor Use And The Need For Adjusted Screening Methods, Kelsey A. Adams

Nursing Capstones

No abstract provided.

Retention Of Normal Glia Function By An Isoform-Selective Protein Kinase Inhibitor Drug Candidate That Modulates Cytokine Production And Cognitive Outcomes, Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

Background: Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacological strategy via inhibiting the same activated target in both glia and neurons, thereby enhancing the possibility for efficacy. The highly selective, brain-penetrant p38αMAPK inhibitor MW150 attenuates cognitive dysfunction in two distinct Alzheimer's disease (AD)-relevant models and avoids the problems encountered with previous mixed-kinase inhibitor drug candidates. Therefore, it is essential that the glial effects of this CNS-active kinase inhibitor be addressed in order to anticipate future use in clinical investigations.

Methods: …

Mindfulness Interventions For Preventing And Treating Eating Disorders In Adolescent And Young Adult Females, Amanda P. Graves, Jane Lassetter

Student Works

Purpose: The portrayal of women in the mass media is increasingly sexualized. An accumulation of negative media exposure can cause adolescent girls to fall prey to self-objectification. Repeated experiences of self-objectification can result in body shame, which consequently may lead to dietary restraint and binge eating to achieve the idealized thin body. The goals of a mindfulness intervention are to change how one feels in response to external cues and to develop healthier coping skills. The purpose of this literature review is to compare and contrast recent studies on mindfulness measures aimed at preventing or treating disordered eating behaviors in …

Improving Diagnostic Accuracy In Health Care, Melissa Devries

Nursing Capstones

No abstract provided.

A Historical Look At New Mexico’S Public Health, Laura J. Hall

Posters and Presentations

The poster A Historical Look at New Mexico’s Public Health, presented by Laura J. Hall, MFA, at the New Mexico Public Health Association Annual Meeting, April 5-6, 2017, examined the evolution of public health in New Mexico from statehood in 1912 to the mid-20th century. The poster highlighted key public health milestones, such as the establishment of the New Mexico Public Health Association in 1917, efforts to improve sanitation and healthcare access, and significant reductions in communicable diseases and mortality rates. It emphasized how public health initiatives contributed to longer, healthier lives for New Mexicans.

Perioperative Steroids For Lumbar Disc Surgery: A Meta-Analysis Of Randomized Controlled Trials, Muhammad Waqas, Hussain Shallwani, Muhammad Shahzad Shamim, Khabir Ahmed

Department of Surgery Docs

Background: Our review question was "Does perioperative steroids administration, in comparison with other treatments or placebo, improve either postoperative pain control, length of hospital stay, or return to work in patients undergoing lumbar disc surgery?"
Methods: We searched PubMed, CINAHL PLUS, and Cochrane databases for randomized control trials (RCTs) studying the role of steroids for lumbar disc surgery. Studies that compared perioperative steroids with other treatments or placebo were included. Study outcomes included postoperative back pain, leg pain, length of hospital stay, and return to work. Data was extracted through a proforma. Means and mean differences were calculated for continuous …

Web-Based Interventions Alone Or Supplemented With Peer-Led Support Or Professional Email Counseling For Weight Loss And Weight Maintenance In Women From Rural Communities: Results Of A Clinical Trial., Patricia A. Hageman, Carol H. Pullen, Melody A. Hertzog, Bunny J. Pozehl, C Eisenhauer, Linda S. Boeckner

Journal Articles: Physical Therapy

Objective. This trial compared the effectiveness of a web-based only (WO) intervention with web-based supplemented by peer-led discussion (WD) or professional email counseling (WE) across 3 phases to achieve weight loss and weight maintenance in women from underserved rural communities. Methods. 301 women (BMI of 28-45 kg/m(2)) randomly assigned to groups participated in guided weight loss (baseline to 6 months), guided weight loss and maintenance (6 to 18 months), and self-managed weight maintenance (18 to 30 months). Results. Retention was 88.7%, 76.5%, and 71.8% at 6, 18, and 30 months, respectively. Intent-to-treat analyses demonstrated no group differences in change in …

Challenges And Strategies For Prevention Of Multidrug-Resistant Organism Transmission In Nursing Homes, Christopher J. Crnich, Robin L.P. Jump

Faculty Scholarship

Purpose of Review: Nursing home residents are at high risk for colonization and infection with bacterial pathogens that are multidrug-resistant organisms (MDROs). We discuss challenges and potential solutions to support implementing effective infection prevention and control practices in nursing homes. Recent Findings: Challenges include a paucity of evidence that addresses MDRO transmission during the care of nursing home residents, limited staff resources in nursing homes, insufficient infection prevention education in nursing homes, and perceptions by nursing home staff that isolation and contact precautions negatively influence the well being of their residents. Summary: A small number of studies provide evidence that …

Severe Maternal Morbidity In Florida: Risk Factors And Determinants Of The Increasing Rate, Lindsay Shively Womack

USF Tampa Graduate Theses and Dissertations

Severe maternal morbidity generally refers to the most severe complications of pregnancy and includes: hemorrhage, embolism, acute renal failure, stroke, acute myocardial infarction, and other complications. These complications affect more than 50,000 women in the United States every year, with rates significantly increasing from 1998 to 2011. In an effort to reduce these increasing complication rates, clinicians and researchers have emphasized the need to identify potential modifiable risk factors for severe maternal morbidity, and the need to study the relationships between these risk factors and severe maternal morbidity. The overall goal of this study is to improve the understanding of …