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Articles 1 - 30 of 282
Full-Text Articles in Medicine and Health Sciences
The Knowledge And High Seroprevalence Of Hepatitis A In A High-Risk Group(Agricultural Reproductive-Aged Women) In The Southeastern Region Of Turkey, Nebi̇ye Yentür Doni̇, Zeynep Şi̇mşek, Gülcan Gürses, Fadi̇le Yildiz Zeyrek, Muhsi̇n Akbaba
The Knowledge And High Seroprevalence Of Hepatitis A In A High-Risk Group(Agricultural Reproductive-Aged Women) In The Southeastern Region Of Turkey, Nebi̇ye Yentür Doni̇, Zeynep Şi̇mşek, Gülcan Gürses, Fadi̇le Yildiz Zeyrek, Muhsi̇n Akbaba
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the seroprevalence of antihepatitis A virus (HAV), risk factors, and the knowledge of female farm workers living in the Southeastern Anatolia Region (SAR) of Turkey. Materials and methods: This representative cross-sectional survey was conducted between January and April of 2013 in the SAR. A total of 705 reproductive-aged women were randomly selected by clustering method using Epi Info software. The sera were analyzed for anti-HAV antibodies using ELISA. Sociodemographic information and the knowledge of female farm workers regarding hepatitis A were collected using a questionnaire. Results: Of the female farm workers, …
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Turkish Journal of Medical Sciences
Background/aim: Intracranial stenosis (ICS) is identified in 2.2%?70.4% of patients with ischemic stroke and transient ischemic attack. This study aimed to determine the prevalence of ICS in a single center registry from Turkey. Materials and methods: We reviewed the charts of 619 patients with acute ischemic stroke. ICS was defined as any ICS > 50% on cerebrovascular imaging. The demographic data, risk factors, NIHSS scores and C reactive protein level at admission, mortality in hospital, recurrent stroke, and mRS in the follow-up period were recorded. Results: A total of 72 (11.6%) patients with ICS (45 males (62.5%); mean age 68.3 ± …
Decreased Oxidative Stress May Contribute To The Disease Process In Placenta Accreta, Efser Öztaş, Si̇bel Özler, Merve Ergi̇n, Özcan Erel, Başak Güler, Ali̇ Turhan Çağlar, Aykan Yücel, Di̇lek Uygur, Ahmet Nuri̇ Danişman
Decreased Oxidative Stress May Contribute To The Disease Process In Placenta Accreta, Efser Öztaş, Si̇bel Özler, Merve Ergi̇n, Özcan Erel, Başak Güler, Ali̇ Turhan Çağlar, Aykan Yücel, Di̇lek Uygur, Ahmet Nuri̇ Danişman
Turkish Journal of Medical Sciences
Background/aim: The main aim of this study was to investigate serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase levels in pregnant women with placenta accreta and to compare those with age-matched healthy pregnant women. Materials and methods: A total of 27 pregnant women who had clinically and pathologically proven placenta accreta and 30 age- and BMI- matched healthy pregnant women were enrolled in this case control study. Maternal serum TOS, TAS, OSI, and arylesterase levels were evaluated using logistic regression analysis to determine if there was an association with abnormal placental invasion or …
The Prevalence Of Abdominal Obesity Is Remarkable For Underweightand Normal Weight Adolescent Girls, Ni̇lüfer Tek, Nevi̇n Şanlier, Duygu Türközü
The Prevalence Of Abdominal Obesity Is Remarkable For Underweightand Normal Weight Adolescent Girls, Ni̇lüfer Tek, Nevi̇n Şanlier, Duygu Türközü
Turkish Journal of Medical Sciences
Background/aim: Obesity is a global public health challenge. This study was carried out in order to determine the prevalence of obesity and abdominal obesity in Turkish adolescent girls. Materials and methods: A cross-sectional study was conducted in a total of 1111 adolescent girls aged 12?18 years. The subjects were classified into four groups: underweight, normal, overweight, and obese. Abdominal obesity was defined according to waist circumference (WC) $\geq$ 90th percentile for Turkish adolescent population references (12-17 years) and waist-to-height ratio (WHtR) $\geq$ 0.5. Results: The prevalence of underweight was 17.4%, normal weight 68.5%, overweight 12.1%, and obese 2.0%. A total …
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay. DNA was extracted from fecal samples of about 200 mg using the QIAamp Fast DNA Stool Mini Kit (QIAGEN, Hilden, …
Pooled Analysis Of 899 Nosocomial Meningitis Episodes From Turkey, Oğuz Reşat Si̇pahi̇, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bi̇lgi̇n Arda, Tansu Yamazhan, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Pooled Analysis Of 899 Nosocomial Meningitis Episodes From Turkey, Oğuz Reşat Si̇pahi̇, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bi̇lgi̇n Arda, Tansu Yamazhan, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Turkish Journal of Medical Sciences
Background/aim: Healthcare-associated meningitis (HCAM) is a relatively rare entity with significant morbidity and mortality. The aim of this study was to systematically review the Turkish medical literature for acute nosocomial meningitis. Materials and methods: One national (ULAKBİM) and two international (www.scopus.com and www.pubmed.com) databases were searched. In addition, abstracts of four national congresses held between 2004 and 2013 were searched for reports for HCAM meningitis. Results: Data for 899 HCAM meningitis episodes were obtained from 24 reports. In terms of clinical findings, 177 of 216 (81.9%) had fever (>38 °C), 55 of 64 (85.9%) had high CRP levels, 105 …
Potential Drug-Drug Interactions Among Prescriptionsfor Elderly Patients In Primary Health Care, Zafer Gören, Mahluga J. Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi̇ İdri̇z Oğlu
Potential Drug-Drug Interactions Among Prescriptionsfor Elderly Patients In Primary Health Care, Zafer Gören, Mahluga J. Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi̇ İdri̇z Oğlu
Turkish Journal of Medical Sciences
Background/aim: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic. Materials and methods: Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database. Results: Of the 5059 prescriptions, 33% were found to have DDIs. We detected 29 (0.9%) A, 380 (11.8%) B, 2494 (77.7%) C, 289 (9%) D, and 18 (0.6%) X risk rating category DDIs among the prescriptions. Prescriptions of female patients and …
A Functional Tool Demonstrating The Physical Function Decline Independentof Age In Patients With Predialysis Chronic Kidney Disease, Özlem Taşoğlu, Nergi̇z Bayrakci, Di̇dem Sezgi̇n Özcan, Ni̇hal Özkayar, İrfan Taşoğlu, Neşe Özgi̇rgi̇n
A Functional Tool Demonstrating The Physical Function Decline Independentof Age In Patients With Predialysis Chronic Kidney Disease, Özlem Taşoğlu, Nergi̇z Bayrakci, Di̇dem Sezgi̇n Özcan, Ni̇hal Özkayar, İrfan Taşoğlu, Neşe Özgi̇rgi̇n
Turkish Journal of Medical Sciences
Background/aim: Physical function decline in chronic kidney disease (CKD) patients has been a popular area of investigation in the last decade. It has been shown that lower levels of physical function in CKD results in poor outcomes. Nevertheless, nephrology practice does not include routine assessment of physical function. The aim of the present study is to elucidate which physical function assessment tool is better in CKD. Materials and methods: A total of 148 predialysis CKD patients and 40 healthy controls were included in this cross-sectional single-blind study. CKD patients were further divided into two groups as stage 3 and stage …
Attitudes And Behaviors Of Physicians In Dealing With Difficult Patientsand Relatives: A Cross-Sectional Study In Two Training And Research Hospitals, Kamuran Bahar Sandikci, Yusuf Üstü, Mert Muhi̇tti̇n Sandikci, Burcu Kayhan Teti̇k, Derya Işik, Mehmet Uğurlu
Attitudes And Behaviors Of Physicians In Dealing With Difficult Patientsand Relatives: A Cross-Sectional Study In Two Training And Research Hospitals, Kamuran Bahar Sandikci, Yusuf Üstü, Mert Muhi̇tti̇n Sandikci, Burcu Kayhan Teti̇k, Derya Işik, Mehmet Uğurlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to examine the reasons constituting the definition of 'difficult patient' and to evaluate attitudes and behaviors of physicians in coping with these patients and their relatives. Materials and methods: This cross-sectional study was conducted in May and June 2013 with 400 randomly selected physicians from different specialties working in two training and research hospitals in Ankara. A questionnaire was created by reviewing the relevant literature, by family medicine clinic, and delivered to the physicians following a pilot study. Results: In our study 92.8% of the physicians participating had experienced a negative contact with …
The Genicular Nerve: Radiofrequency Lesion Application For Chronic Knee Pain, Paki̇ze Kirdemi̇r, Serdar Çatav, Fi̇li̇z Alkaya Solmaz
The Genicular Nerve: Radiofrequency Lesion Application For Chronic Knee Pain, Paki̇ze Kirdemi̇r, Serdar Çatav, Fi̇li̇z Alkaya Solmaz
Turkish Journal of Medical Sciences
Background/aim: We investigated the short- and medium-term effectiveness of genicular nerve radiofrequency (RF) applied in patients with chronic knee pain due to osteoarthritis. Materials and methods: Radiofrequency was performed in 49 patients with a diagnosis of knee osteoarthritis. VAS and WOMAC were measured at baseline and at 1, 4, and 12 weeks postprocedure. Under fluoroscopic guidance, the cannula was advanced percutaneously towards the area connecting the shaft to the epicondyle. The RF electrode was inserted through the cannula and the electrode tip temperature was raised to 80 °C for 90 s. One RF lesion was made for each genicular nerve. …
Can Ischemia-Modified Albumin Be Used To Differentiate Between Generalized Seizures And Pseudoseizures?, Tülay Kamaşak, Süleyman Türedi̇, Hepsen Mi̇ne Seri̇n, Ahmet Menteşe, Abdülkadi̇r Gündüz, Ahmet Alver, Ali̇ Cansu
Can Ischemia-Modified Albumin Be Used To Differentiate Between Generalized Seizures And Pseudoseizures?, Tülay Kamaşak, Süleyman Türedi̇, Hepsen Mi̇ne Seri̇n, Ahmet Menteşe, Abdülkadi̇r Gündüz, Ahmet Alver, Ali̇ Cansu
Turkish Journal of Medical Sciences
Background/aim: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures. Materials and methods: A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group. The patients' IMA, albumin, and IMA/albumin values at hours 0 and 1 following …
Identification Of The Cysteine-Rich 61 (Cyr61) Gene Variations In Osteosarcoma Patients, Syed Rizwan Hussain, Sabir Ali, Ajai Singh, Vineet Kumar, Nazia Rizivi, Manish Yadav, Mohammad Kaleem Ahmad, Vijay Kumar, Abbas Ali Mahdi
Identification Of The Cysteine-Rich 61 (Cyr61) Gene Variations In Osteosarcoma Patients, Syed Rizwan Hussain, Sabir Ali, Ajai Singh, Vineet Kumar, Nazia Rizivi, Manish Yadav, Mohammad Kaleem Ahmad, Vijay Kumar, Abbas Ali Mahdi
Turkish Journal of Medical Sciences
Background/aim: Osteosarcoma requires an angiogenesis process. CYR61 is one of the extracellular signaling molecules that promote angiogenesis, tumor growth, and the malignancy of osteosarcoma. In the present study, we investigate the CYR61 gene variations in osteosarcoma and their correlations with clinicopathological findings. Materials and methods: We performed variation analysis of the CYR61 gene in 58 patients with osteosarcoma. With an aim to ascertain the variety of variations in exons 2, 3, 4, and 5 of the CYR61 gene in osteosarcoma, we did a PCR-SSCP followed by DNA sequencing. Results: In osteosarcoma the CYR61 gene variations found were 18.96% (11/58) in …
Dysregulation Of The Dkk1 Gene In Pediatric B-Cell Acute Lymphoblastic Leukemia, Si̇nem Firtina, Özden Hatirnaz Ng, Yücel Erbi̇lgi̇n, Uğur Özbek, Müge Sayi̇toğlu
Dysregulation Of The Dkk1 Gene In Pediatric B-Cell Acute Lymphoblastic Leukemia, Si̇nem Firtina, Özden Hatirnaz Ng, Yücel Erbi̇lgi̇n, Uğur Özbek, Müge Sayi̇toğlu
Turkish Journal of Medical Sciences
Background/aim: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the β-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6. Materials and methods: We studied DKK1 gene promoter methylation and investigated DKK1, β-catenin, LRP5, and LRP6 mRNA levels in B-cell acute lymphoblastic leukemia …
Analysis Of Fancc Gene Mutations (Ivs4+4a>T, Del322g, And R548x)In Patients With Fanconi Anemia In Pakistan, Iram Aftab, Saima Iram, Saba Khaliq, Muhammad Israr, Nadir Ali, Shah Jahan, Shabbir Hussain, Shagufta Khaliq, Shahida Mohsin
Analysis Of Fancc Gene Mutations (Ivs4+4a>T, Del322g, And R548x)In Patients With Fanconi Anemia In Pakistan, Iram Aftab, Saima Iram, Saba Khaliq, Muhammad Israr, Nadir Ali, Shah Jahan, Shabbir Hussain, Shagufta Khaliq, Shahida Mohsin
Turkish Journal of Medical Sciences
Background/aim: Fanconi anemia (FA) is an autosomal recessive disease determined by mutations in at least 16 genes, with distinct distributions in different populations. To the best of our knowledge, there are no reports regarding the molecular basis of the disease in FA patients in Pakistan. The current study aimed to determine the frequency of FANCC gene mutations, i.e. IVS4+4A>T, del322G, and R548X, in FA patients. Materials and methods: Genomic DNA was obtained from 36 FA patients. All samples were analyzed by polymerase chain reaction and restriction fragment length polymorphism techniques. Results: Mutation IVS4+4A>T was identified in 26 (72.2%) …
Effect Of Transfusion Of Washed Red Blood Cells On Serumpotassium Level In Hemodialysis Patients, Refi̇k Demi̇rtunç, Emel Üstün, Cumali̇ Karatoprak, Kadi̇r Kayataş, Fuat Çeti̇nkaya, Uğur Özensoy, Rümeyza Kazancioğlu
Effect Of Transfusion Of Washed Red Blood Cells On Serumpotassium Level In Hemodialysis Patients, Refi̇k Demi̇rtunç, Emel Üstün, Cumali̇ Karatoprak, Kadi̇r Kayataş, Fuat Çeti̇nkaya, Uğur Özensoy, Rümeyza Kazancioğlu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare washed red blood cell (WRBC) transfusion versus nonwashed RBC (NWRBC) transfusion in terms of posttransfusion potassium levels in dialysis patients on a day when the patient did not receive dialysis. Materials and methods: The patients were randomly assigned into two groups, i.e. those receiving WRBCs (n = 21) and those receiving NWRBCs (n = 17). Both groups received one unit of RBCs. Serum potassium and sodium levels were measured before and at the 1st, 2nd, 3rd, 4th, and 6th hours after transfusion. Results: In the WRBC group, the changes in the serum potassium levels …
Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker
Associations Between Obesity And The Radiographic Phenotype In Knee Osteoarthritis, Mehmet Derya Demi̇rağ, Seçi̇l Özkan, Şemi̇nur Haznedaroğlu, Evi̇n Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Goker
Turkish Journal of Medical Sciences
Background/aim: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. Materials and methods: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal. Results: Obese patients had a significantly more frequent osteophyte-dominant pattern compared to nonobese subjects (74.5% and 38%, respectively, P < 0.001). Logistic regression analysis demonstrated that obesity had a stronger association with an osteophytedominant pattern compared to a JSN-dominant pattern (OR and 95% CI = 7.16 (3.15-16.26) and 1.63 (0.96-2.78), respectively). Age had a very weak effect on the distinction to an osteophyte-dominant pattern and no effect on JSN dominance (OR and 95% CI = 1.1 (1.06-1.15) and 1.02 (0.99-1.05), respectively). Conclusion: There might be an association between obesity and the radiographic phenotype in patients with knee osteoarthritis. The findings suggest that the association between obesity and the osteophyte formation is stronger than that of JSN.
The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç
The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç
Turkish Journal of Medical Sciences
Background/aim: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. Materials and methods: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement. Fall assessment included falling risk (Berg Balance Scale), dynamic balance (Time Up and …
Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
Turkish Journal of Medical Sciences
Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 …
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a crosssectional study. Materials and methods: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. Results: There were 98 infants, with mean birth weight (BW) 1517.4 ± 486.5 g and GA 30.8 ± 2.9 weeks. The frequencies of wheezing, asthma, and bronchopulmonary dysplasia (BPD) were 32.7%, 16.3%, and 14.3%, respectively. Skin-prick tests were positive for 11 subjects, with allergy to cereals for 7 infants, egg for 3, and peanut for 1. Wheezing was related to GA, BW, respiratory distress syndrome, mechanical ventilation, sepsis, asphyxia, smoking, antenatal steroid, BA, palivizumab prophylaxis, number of people in the household, and duration of hospitalization (P < 0.05). Wheezing was negatively correlated to GA. Family history of BA, smoking, and number of people in the household were linked to BA (P < 0.05). Conclusion: Wheezing was related to degree of premature birth, but BA was linked to BA in the family and smoking. Increased gestation should improve the infant's respiratory health up to 2 years of age.
The Efficacy Of Microphototherapy With A Medlight Cupcubegrimed Device In Psoriatic Patients With Localized Lesions, Nesli̇han Yildirim, Gül Erki̇n
The Efficacy Of Microphototherapy With A Medlight Cupcubegrimed Device In Psoriatic Patients With Localized Lesions, Nesli̇han Yildirim, Gül Erki̇n
Turkish Journal of Medical Sciences
Background/aim: Psoriasis is a chronic skin disease. To reduce side effects associated with current treatment modalities, new treatment methods are required. Some clinicians have begun to use microphototherapy to treat psoriatic patients with a limited number of lesions (lesions affecting <10% of the body surface area). Materials and methods: Microphototherapy is indicated in patients whose lesions persist despite systemic and topical treatment or when such treatment is contraindicated. Our study aimed to evaluate the efficacy of microphototherapy in psoriasis patients with localized lesions. Patients in this unblinded and prospective study were treated three times a week for 50 sessions using a MedLight CupCUBE Grimed microphototherapy device that emits an ultraviolet B (UVB) spectrum. Results: Forty-five lesions in 23 psoriatic patients were treated. Treatment outcome was evaluated based on the Psoriasis Severity Index (PSI). PSI scores decreased significantly during the treatment. Conclusion: The MedLight CupCUBE Grimed microphototherapy device was effective for the treatment of psoriasis patients with localized lesions. The device can administer UVB radiation to involved regions while protecting uninvolved regions and minimizing radiation dose. However, having to be administered by experienced technicians and the long time required for each treatment session are disadvantages of the technique.
Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Turkish Journal of Medical Sciences
Background/aim: Central line-associated bloodstream infections (CLABSIs) are associated with substantial morbidity and mortality and the infection rates vary in a wide range (high: 62.5%; low: 20%) in developing countries. We aimed to investigate the characteristics and the risk factors for mortality in patients with CLABSIs in intensive care units (ICUs) and provide the relevant data. Materials and methods: The electronic medical records database and file records obtained through active surveillance by an infection control committee of a hospital were screened to identify patients with CLABSIs hospitalized from January 2008 through July 2013. Results: A total of 166 CLABSI episodes in …
Combination Therapy With Dendritic Cell-Based Vaccine And Anti-Cd69 Antibodyenhances Antitumor Efficacy In Renal Cell Carcinoma-Bearing Mice, Si Ming Wei, Hang Li Pan, Li Wang, Guo Li Yin, Kai Zhong, Ya Zhou, Shu Jiao Yang, Zhao Liang Xin
Combination Therapy With Dendritic Cell-Based Vaccine And Anti-Cd69 Antibodyenhances Antitumor Efficacy In Renal Cell Carcinoma-Bearing Mice, Si Ming Wei, Hang Li Pan, Li Wang, Guo Li Yin, Kai Zhong, Ya Zhou, Shu Jiao Yang, Zhao Liang Xin
Turkish Journal of Medical Sciences
Background/aim: Dendritic cell-based vaccine therapy for renal cell carcinoma is effective but requires improvement. Here we explored whether combination therapy with dendritic cell-based vaccine and anti-CD69 antibody can enhance antitumor efficacy in renal cell carcinoma-bearing mice. Materials and methods: Balb/c mice were challenged subcutaneously with murine renal cell carcinoma (Renca) cells. On day 3 after tumor cell inoculation, tumor-bearing mice either were left untreated or were treated with Renca tumor lysate-pulsed dendritic cells (i.e. dendritic cell-based vaccine), anti-CD69 antibody, or a combination of Renca tumor lysate-pulsed dendritic cells with anti-CD69 antibody. The mice were sacrificed on day 28. Tumor volume …
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Background/aim: The effects of chronic ethanol consumption on male sexual function are debateable, and its effects on the Rho/ Rho-kinase pathway are unknown. Therefore, we investigated smooth muscle reactivity and Rho/Rho-kinase signalling in the corpus cavernosum of ethanol-fed mice. Materials and methods: Ethanol was added to drinking water at 5% concentration in the first 2 days with 5% increment every subsequent 2 days, up to a final concentration of 20% for 45 days. Corpora cavernosa were isolated and a cumulative dose-response curve to phenylephrine was obtained. Acetylcholine (10-6 M), electrical field stimulation (EFS, 40 V, 8-16 Hz) and Y-27632 (10-6-10-5 …
Molecular Characteristics And Antibiotic Resistance Of Acinetobacter Baumanniibeta-Lactamase-Producing Isolates, A Predominance Of Intrinsic Blaoxa-51, And Detection Oftem And Ctx-M Genes, Amir Ibrahimagic, Farah Kamberovic, Selma Uzunovic, Branka Bedenic, Emina Idrizovic
Molecular Characteristics And Antibiotic Resistance Of Acinetobacter Baumanniibeta-Lactamase-Producing Isolates, A Predominance Of Intrinsic Blaoxa-51, And Detection Oftem And Ctx-M Genes, Amir Ibrahimagic, Farah Kamberovic, Selma Uzunovic, Branka Bedenic, Emina Idrizovic
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the molecular characteristics and antibiotic resistance of 13 (10 inpatient and three outpatient) Acinetobacter baumannii beta-lactamase-producing isolates collected in Bosnia and Herzegovina between December 2009 and May 2010. Materials and methods: Susceptibility testing was performed by disk diffusion and broth microdilution methods. The modified Hodge and combined disk test with EDTA/phenylboronic acid was used to screen for carbapenemase production. Production of extended spectrum beta-lactamases (ESBLs) was determined by double-disk synergy test. PCR was used to detect blaESBL/blacarb genes. Results: Ten (22.2%) inpatient and three (13.6%) outpatient isolates produced beta-lactamases, ESBLs, or …
Evaluation And Comparison Of Radiologic-Pathologic Findings In Invasive Cribriform Carcinoma Of The Breast, Pinar Balci, Işil Başara Akin, Nevi̇n Köremezli̇, Meri̇h Güray Durak, Canan Altay, Naci̇ye Si̇nem Gezer, Ali̇ İbrahi̇m Sevi̇nç
Evaluation And Comparison Of Radiologic-Pathologic Findings In Invasive Cribriform Carcinoma Of The Breast, Pinar Balci, Işil Başara Akin, Nevi̇n Köremezli̇, Meri̇h Güray Durak, Canan Altay, Naci̇ye Si̇nem Gezer, Ali̇ İbrahi̇m Sevi̇nç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to report invasive cribriform carcinoma (ICC) with radiological and histopathologic correlations. Materials and methods: Seventy patients with ICC were classified into two groups; pure ICC patients and patients with >50% cribriform carcinoma component were included in group 1, while patients with <50% cribriform carcinoma component were included in group 2. All patients were reviewed according to American College of Radiology (ACR) breast imaging reporting and data system (BI-RADS) lexicon of mammography (MG), ultrasonography (US), and magnetic resonance imaging (MRI). One-way analysis of variance tests and t-tests were used for analysis. P < 0.05 was accepted as statistically significant. Results: Eighteen patients were in group 1 and 52 were in group 2. All patients had MG and US, while 24 patients needed MRI. According to MG ACR BI-RADS lexicon evaluation, irregular shape, spiculated margin and indistinct margin, and high density were statistically significantly higher in group 2 than the other group (respectively P = 0.001, P = 0.001, and P= 0.04). Equal density was statistically significantly higher in group 1 than the other group (P = 0.008). According to US ACR BI-RADS lexicon evaluation, irregular shape, spiculated margins, angular margins, microlobulated margins, and nonparallel orientation were more common US findings in group 2 than the other group (respectively P = 0.001, P = 0.001, P = 0.003, P = 0.04, and P = 0.04). The rate of parallel orientation was higher in group 1 than the other group (P = 0.02). Conclusion: Few cases showed benign characteristics and most ICCs appear with typical features of malignancy. Radiologic features of ICC could be better understood and would be helpful for radiologists in diagnosing this rare type of malignancy.
Performing Icsi With Commercial Microinjection Pipettes Enhanced Pregnancy Rates, Mohammad Ali Khalili, Iman Halvaei, Shahin Ghazali, Mohammad Hossein Razi
Performing Icsi With Commercial Microinjection Pipettes Enhanced Pregnancy Rates, Mohammad Ali Khalili, Iman Halvaei, Shahin Ghazali, Mohammad Hossein Razi
Turkish Journal of Medical Sciences
Background/aim: Many technical factors can affect intracytoplasmic sperm injection (ICSI) outcomes. The role of the injection micropipette could be of vital importance in ICSI programs. The main goal was to compare ICSI pregnancy outcomes between commercial and home-made injection micropipettes in a large population with male factor infertility. Materials and methods: Five-hundred and eleven ICSI cycles with severe male factor were included in this retrospective study. ICSI cycles were divided into two groups: A (home-made micropipettes, n = 267) and B (commercial micropipettes, n = 244). Rates of fertilization, embryo formation, and chemical and clinical pregnancies were compared between the …
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Turkish Journal of Medical Sciences
Background/aim: Understanding the causes of under-five deaths is key to realizing sustainable developmental goals. The aim of this descriptive study was to investigate the causes of under-five mortality in İstanbul during 2011 and compare the findings to those of 1988 and 2000. Materials and methods: All burial records of İstanbul were evaluated, and cemetery records of 1494 children, who died at under five years of age and were buried in İstanbul Metropolitan Municipality Cemeteries between 1 January and 31 December 2011, were analyzed. Several sociodemographic characteristics and causes of death were compared with the results of studies carried out in …
Risk Factors Associated With Poor Outcome In Diabetic Foot Ulcer Patients, Saira Saleem, Nazim Hayat, Irshad Ahmad, Tanvir Ahmad, Abdulgaffar Rehan
Risk Factors Associated With Poor Outcome In Diabetic Foot Ulcer Patients, Saira Saleem, Nazim Hayat, Irshad Ahmad, Tanvir Ahmad, Abdulgaffar Rehan
Turkish Journal of Medical Sciences
Background/aim: Diabetic foot ulcers and related complications are a major cause of morbidity and hospital admissions. Our aim was to evaluate the risk factors associated with poor outcome in diabetic foot ulcers. Materials and methods: A prospective study was conducted on patients with diabetic foot ulceration attending the Madinah Teaching Hospital from June 2014 to December 2015. Potential risk factors and laboratory test results at presentation were recorded and their association with outcome (healing vs. amputation) was analyzed using IBM SPSS Statistics for Windows, Version 22.0. Results: In total, 112 patients were studied during our study period. The majority of …
Routine Assessment Of Occupational Exposure And Its Relation To Semen Quality In Infertile Men: A Cross-Sectional Study, Salima Daoud, Afifa Sellami, Mehdi Bouassida, Sahbi Kebaili, Leila Ammar Keskes, Tarek Rebai, Nozha Chakroun Feki
Routine Assessment Of Occupational Exposure And Its Relation To Semen Quality In Infertile Men: A Cross-Sectional Study, Salima Daoud, Afifa Sellami, Mehdi Bouassida, Sahbi Kebaili, Leila Ammar Keskes, Tarek Rebai, Nozha Chakroun Feki
Turkish Journal of Medical Sciences
Background/aim: Concerns about the detrimental effects of occupational and environmental exposure on male reproductive function have been raised by reports of declining sperm quality over the last decades. The aim of this study was to investigate the association between altered semen parameters and exposure to occupational risk factors as assessed by questionnaire. Materials and methods: We conducted a cross-sectional questionnaire-based study among a population of 2122 men who underwent andrological investigation for couple infertility. All participants were interviewed and their semen samples were analyzed. Information about medical history and occupational exposure was used to classify participants into exposed and unexposed …
Rational Design Of Rabies Vaccine Formulation For Enhanced Stability, Veysel Kayser, Alain Francon, Herve Pinton, Jean-Francois Saluzzo, Bernhardt L. Trout
Rational Design Of Rabies Vaccine Formulation For Enhanced Stability, Veysel Kayser, Alain Francon, Herve Pinton, Jean-Francois Saluzzo, Bernhardt L. Trout
Turkish Journal of Medical Sciences
Background/aim: Vaccines are often lyophilized in order to retain their stability and efficacy for a longer period of time. However, the same lyophilization process may also cause a major degradation of the vaccine, especially during early phases of manufacturing, leading to a loss of potency of the product. Many viral diseases, such as rabies, are acute and fatal unless the vaccine is administered prior to exposure or the onset of symptoms in the case of postexposure treatment. Materials and methods: We investigated the effect of lyophilization on the stability of the virus structure during rabies vaccine manufacturing using dynamic light …