Medicine and Health Sciences Commons^™

Expression Of Mir-29a And Ifn-Γ In Pigs Vaccinated With Modified Live Prrs Vaccine, Sunaree Nantakhruea, Nuntawan Aunjangwang, Orawan Limsivilai, Win Surachetpong

The Thai Journal of Veterinary Medicine

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the important RNA viruses that affects swine production worldwide. To better improve vaccine efficacy, understanding the molecular mechanisms and viral-host interaction is important to increase the knowledge of vaccine response. The objective of this study was to investigate the expression levels of miR-29a and IFN-γ in pigs that received modified live PRRSV vaccine. The study revealed that both miR-29a and IFN-γ transcript levels increased in vivo early, at day 3 post vaccination, whereas levels of miR-29a and IFN-γ mRNA were not different at day 7 post vaccination. Our study is …

Effects Of Proportion Of Cassava And Lactic Acid-Treated Cassava In Rations On Rumen Ph And Plasma Lipopolysaccharide-Binding Protein In Beef Cattle, Rittichai Pilachai, Weerachai Thongdee, Yauvapol Chumpol, Suvaluk Seesupa, Jan Thomas Schonewille

The Thai Journal of Veterinary Medicine

The objectives of this study were to investigate the effect of the proportion of cassava and lactic acid (LA)-treated cassava in rations on rumen fermentation parameters and plasma lipopolysaccharide-binding protein (LBP) in beef cattle. Four, rumen cannulated, beef cattle were randomly assigned to four experimental rations in a study with a 2 × 2 factorial arrangement in a 4 × 4 Latin square with a 16-day adaptation period, followed by a 5-day experimental period. During the 5 days of experimental period, the cattle were subjected to 4 experimental treatments, i.e. rations that contained either a high proportion or a low …

Seroprevalence Of Bluetongue Virus Infection And Associated Risk Factors In Domestic Ruminants In The South Of Iran, Mohsen Manavian, Majid Hashemi, Davood Nikoo, Farhang Tavan, Seyed Mohammad Hossein Hosseini, Mehran Bakhshesh, Mohammad Hossein Marhamatizade

The Thai Journal of Veterinary Medicine

A cross-sectional study was designed and 3,872 blood samples were collected from apparently healthy sheep, goats and cows in Fars province, the south of Iran. The sera were screened for detection of bluetongue virus (BTV) antibodies using a commercially competitive enzyme-linked immunosorbent assay kit. Overall prevalence rate of BTV antibodies among the domestic ruminants was 57.64% (70.93%, 55.70% and 19.77% for sheep, goat and cow, respectively). Associations between each independent variable, including ruminant type, age, sex, region, farming system and breed, and BTV infection were statistically significant (p<0.05). Females were 1.32 times more likely to exhibit seropositivity. Odds ratio for BTV infection was higher in older animals and traditional farming. The results revealed a wide spread of BTV infection in the domestic ruminants, especially in sheep and goat. Further studies of the distribution of Culicoides vectors in the region, virus isolation and genome sequencing of the isolated viruses are suggested.

New Methods To Differentiate Cardiac And Non-Cardiac Disease Cats From Thoracic Radiographs, Pakapol Fucharoen, Wannisa Pankham, Siwakorn Thong-In, Sirapop Juengthanasomboon, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

The objective of this study was to distinguish between cats with cardiac disease and non-cardiac disease by using parameters obtained from thoracic radiographs. This study was performed in 49 cats with a mean age of 7.7±4.79 years. Weight, sex and breed of all cats were randomly chosen. Echocardiography was used as a gold standard to diagnose cardiac disease and separate the cats into two groups, cardiac disease (n=31) and non-cardiac disease (n=18). Five parameters were measured from the right lateral radiographs including 1) the cardiac length (L), 2) the cardiac width (W), 3) the width of the caudal vena cava …

Seroprevalence And Molecular Investigation Of Brucellosis In Camels Of Selected Districts Of Punjab, Pakistan, Asim Shahzad, Ahrar Khan, Muhammad Zargham Khan, Muhammad Saqib

The Thai Journal of Veterinary Medicine

Camels still play an important role in providing food security in several developing countries, especially in the arid zones. As brucellosis has zoonotic importance, thereby diseased camels can infect humans chiefly via milk. In spite of its vital importance, limited studies are available of brucellosis in camels in Pakistan. Keeping in view the fact, this study was designed and executed. For this purpose, serum samples (n=761) from various herds of camel with history of abortion from different locations of Punjab province, Pakistan were collected. Initial screening was done using Rose Bengal plate test (RBPT). To avoid improper judgment of the …

In Vivo Bone Regeneration Of Thai Silk Fibroin Scaffolds With Gelatin, Hydroxyapatite And Hyaluronic Acid, Tonporn Lamlerd, Kumpanart Soontornvipart, Sawang Kesdangsakonwut, Sorada Kanokpanont, Siriporn Damrongsakkul

The Thai Journal of Veterinary Medicine

Three-dimensional Thai silk fibroin-based scaffolds have been developed and reported in our previous study on their appropriate morphology, physical properties and, in particular, promising potential to promote the growth of bone cells in vitro. Moreover, our previous study found that they were non-toxic to cells in vivo. In this work, three types of Thai silk fibroin-based scaffolds, including conjugated gelatin/Thai silk fibroin scaffold (CGSF), hydroxyapatite/conjugated gelatin/Thai silk fibroin scaffold (CGSF4) and hyaluronic acid/Thai silk fibroin scaffold (HSF), were investigated for their in vivo osteogenic potential in rat model. Each Thai silk fibroin-based scaffold was implanted in the bone defect (6 …

Ophthalmology Snapshot, Nalinee Tuntivanich

The Thai Journal of Veterinary Medicine

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Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi

Research Collection School of Social Sciences

This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound …

Maternal Serum Markers Of Lipid Metabolism In Relation To Neonatal Anthropometry, Nansi S. Boghossian, Pauline Mendola, Aiyi Liu, Candace Robledo, Edwina H. Yeung

School of Medicine Publications

Objective: The objective of this study is to examine associations between lipids (high-density lipoprotein, low-density lipoprotein, total cholesterol, triglycerides and lipoprotein (a)) measured on average three time points during pregnancy and neonatal anthropometrics.

Study design: Stored samples from a preeclampsia trial measured as part of a case-control study from five US centers (1992 to 1995) were used. The sample included women without pregnancy complications (n=136) and cases of gestational diabetes (n=93), abnormal glucose tolerance (AGT; n=76), gestational hypertension (n=170) and preeclampsia (n=177). Linear regression and linear mixed-effects models estimated adjusted associations between lipids and birth weight z-score, ponderal index (PI), …

Molecular-Based Recursive Partitioning Analysis Model For Glioblastoma In The Temozolomide Era: A Correlative Analysis Based On Nrg Oncology Rtog 0525., Erica Hlavin Bell, Stephanie L Pugh, Joseph P. Mcelroy, Mark R. Gilbert, Minesh Mehta, Alexander C Klimowicz, Anthony Magliocco, Markus Bredel, Pierre Robe, Anca L. Grosu, Roger Stupp, Walter Curran, Aline P. Becker, Andrea L. Salavaggione, Jill S. Barnholtz-Sloan, Kenneth Aldape, Deborah T. Blumenthal, Paul D. Brown, Jon Glass, Luis Souhami, R. Jeffrey Lee, David Brachman, John Flickinger, Minhee Won, Arnab Chakravarti

Department of Neurosurgery Faculty Papers

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era.

Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables.

Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation. Prognostic significance of each protein was examined by single-marker and multimarker Cox regression analyses. To reclassify the prognostic risk groups, significant protein biomarkers on single-marker analysis were incorporated into an RPA model …

Correlation Of Tp53 Overexpression And Clinical Parameters With Five-Year Survival In Oral Squamous Cell Carcinoma Patients, Syed A. Ali, Hamza A Khan, Omar Irfan, Adeel Samad, Yamna Mirza, Mohammad Sohail Awan

Section of Otolaryngology, Head & Neck Surgery

Abstract

Introduction TP53 mutation and overexpression have been correlated with poor survival in many cancers including oral squamous cell carcinoma (OSCC). We aim to understand the role of TP53 overexpression in OSCC in our population and correlate it with five-year survival to test its viability as a prognostic marker for OSCC patients. Materials and methods Patients with biopsy proven OSCC at Aga Khan University Hospital from January 2000 to January 2008 were recruited. Immunohistochemistry was used to establish TP53 status and the results were published. Following up on these patients, five-year data were collected and correlated with TP53 status and …

Upgrading A Social Media Strategy To Increase Twitter Engagement During The Spring Annual Meeting Of The American Society Of Regional Anesthesia And Pain Medicine., Eric S. Schwenk, Kellie M. Jaremko, Rajnish K. Gupta, Ankeet D. Udani, Colin J J.L. Mccartney, Anne Snively, Edward R. Mariano

Department of Anesthesiology Faculty Papers

Microblogs known as "tweets" are a rapid, effective method of information dissemination in health care. Although several medical specialties have described their Twitter conference experiences, Twitter-related data in the fields of anesthesiology and pain medicine are sparse. We therefore analyzed the Twitter content of 2 consecutive spring meetings of the American Society of Regional Anesthesia and Pain Medicine using publicly available online transcripts. We also examined the potential contribution of a targeted social media campaign on Twitter engagement during the conferences. The original Twitter meeting content was largely scientific in nature and created by meeting attendees, the majority of whom …

June 2017, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

No abstract provided.

Empirical Assessment Of The Role Of Technology-Related Factors And Organization-Related Factors In Electronic Medical Records Implementation Success, Rangarajan Parthasarathy

College of Computing and Digital Media Dissertations

The objective of this research was to investigate if certain technology-related and organization-related factors that have most often been associated with successful IT/MIS implementations in other information technology and information science domains are also associated with successful Electronic Medical Records (EMR) implementations. This research uncovered a unique set of technology-related factors and organization-related factors associated with successful EMR implementations from the perspective of healthcare enablers and healthcare providers. Specific technology-related factors considered in this research were the innovativeness of EMR (measured with respect to the relative advantage, compatibility and complexity of EMR), privacy and security attributes of EMR, and usefulness …

E-Cigarettes: A Hazy Hazard, Cheryl (Cheri) L. Marcham, John (Jack) P. Springston

Publications

• Electronic cigarettes (e-cigarettes or e-cigs) are battery-powered devices that deliver vaporized nicotine and other substances, such as flavorings, to users without smoke or combustion. They are commonly marketed as smoking cessation tools and, as such, are promoted as being a healthier alternative to smoking.

• A common misperception is that that e-cigarettes only release water vapor. In reality, though, these devices release nicotine and other chemicals in a vapor form that can expose both the user (a.k.a., the vaper), as well as those in the immediate vicinity, to those contaminants. While the health risks of e-cigarettes compared to regular …

An Isogenic Stem Cell Model Of Alzheimer's Disease: Direct Expression Of Amyloid-Beta, Teresa Marie Ubina

Electronic Theses, Projects, and Dissertations

Alzheimer’s disease (AD), identified over 100 years ago and intensively studied since the 1970s, has no effective treatments or mechanistic understanding of the underlying neurodegenerative process. Most investigators believe accumulation or aggregation of amyloid beta (Ab) proteins plays a causative role. Aβ peptides (~39-43 residues) are generated by proteolysis of the transmembrane protein APP. One reason we know so little about AD is an incomplete understanding of the cellular mechanisms responsible for Ab proteotoxicity. Human ES and iPSC models of AD are recent additions to many other models used to investigate these mechanisms. AD, however is a chronic progressive condition …

A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot

Electronic Theses, Projects, and Dissertations

As gerontologists may know, there are a great deal of studies and a variety of academic literature on the misuse of alcohol and prescription medication amongst the elderly population. While there is a plethora of information on alcohol and prescription misuse, there is little reported data about the prevalence of other substance misuse experienced by this population. This study aims to help to fill that gap in the data by using quantitative methods to describe the scope of substance abuse of individuals 55-years or older. This study utilizes data from the Treatment Data Set Admission (TEDS-A). The TEDS-A is a …

Prioritizing Research For Integrated Implementation Of Early Childhood Development And Maternal, Newborn, Child And Adolescent Health And Nutrition Platforms, Renee Sharma, Michelle F. Gaffey, Harold Alderman, Diego G. Bassani, Kimber Bogard, Gary L. Darmstadt, Jai K. Das, Joseph E De Graft–Johnson, Jena D. Hamadani, Susan Horton

Department of Paediatrics and Child Health

Background: Existing health and nutrition services present potential platforms for scaling up delivery of early childhood development (ECD) interventions within sensitive windows across the life course, especially in the first 1000 days from conception to age 2 years. However, there is insufficient knowledge on how to optimize implementation for such strategies in an integrated manner. In light of this knowledge gap, we aimed to systematically identify a set of integrated implementation research priorities for health, nutrition and early child development within the 2015 to 2030 timeframe of the Sustainable Development Goals (SDGs).
Methods: We applied the Child Health and Nutrition …

Idiopathic Hypogonadotropic Hypogonadism Reversal After Testosterone Replacement In A 34-Year-Old Male, Owais Rashid, Nanik Ram, Saad Farooq, Zareen Kiran,

Section of Diabetes, Endocrinology and Metabolism

A 34-year-old male presented to the endocrinology clinic with the complaint of the absence of facial, axillary and pubic hairs. Further history revealed absent ejaculations and decreased early morning erections. The patient had no history of headaches, visual problems or anosmia. On physical examination, there were sparse facial, axillary and pubic hairs, bilateral gynaecomastia, stretch penile length of 5 cm and bilateral testicular volume of 10 mL. Laboratory investigations showed low luteinising hormone, follicular stimulating hormone and testosterone with normal prolactin and thyroid profile. MRI of the pituitary gland showed no evidence of pituitary microadenoma or macroadenoma. The patient was …

Response To Comment On Ahsan Ali Syed Et Al (J Pak Med Assoc 2017; 67: 400-404 Frequency Of Worsening Liver Function In Severe Dengue Hepatitis Patients Receiving Paracetamol: A Retrospective Analysis Of Hospital Data, Syed Ahsan Ali

Section of Gastroenterology

No abstract provided.

Could Titin Have A Role In Strain-Induced Injuries?, Craig Perrin, Kazunori Nosaka, James Steele

Research outputs 2014 to 2021

It has been known for some time that strain injuries occur through the excessive lengthening of a muscle. However, the precise mechanism for strain injury remains elusive and has been the subject of recent debate in the Journal of Sport and Health Science, but it seems sensible to consider mechanisms at the level of the muscle fiber. It was previously believed that damage was the result of non-uniform stretching of sarcomeres on the descending limb of the length–tension curve, with the weakest sarcomeres undergoing the greatest deformation and ultimately damaging the myofibril. This non-uniform lengthening was also believed to …

Implementation Of Quality Measures In Site-Specific Multidisciplinary Tumour Boards, Ahmed Nadeem Abbasi, Huriye Senay Kiziltan

Department of Radiation Oncology

No abstract provided.

Whisper Or Shout Study: Protocol Of A Cluster-Randomised Controlled Trial Assessing Mhealth Sexual Reproductive Health And Nutrition Interventions Among Female Sex Workers In Mombasa, Kenya, Frances H. Ampt, Collins Mudogo, Peter Gichangi, Megan S. C. Lim, Griffins Manguro, Matthew Chersich, Walter Jaoko, Marleen Temmerman, Marilyn Laini, Stanley Luchters

Population Health, East Africa

Introduction New interventions are required to reduce unintended pregnancies among female sex workers (FSWs) in low- and middle-income countries and to improve their nutritional health. Given sex workers’ high mobile phone usage, repeated exposure to short messaging service (SMS) messages could address individual and interpersonal barriers to contraceptive uptake and better nutrition.

Methods In this two-arm cluster randomised trial, each arm constitutes an equal-attention control group for the other. SMS messages were developed systematically, participatory and theory-driven and cover either sexual and reproductive health (WHISPER) or nutrition (SHOUT). Messages are sent to participants 2–3 times/week for 12 months and include …

Clara's Final Christmas Gift, Gus W Krucke

Faculty, Staff and Student Publications

No abstract provided.

Innovative Running Related Researches, Li Li

Health Sciences & Kinesiology: Faculty Publications

There was a surge in published research related to barefoot running in the past 2 decades, and especially in the past 5 years. For example, the number of returns for “barefoot running” in Google Scholar increased dramatically relative to the search returns for “running” (Fig. 1). “Running” related returns started at about 220,000 in 1997 and peaked at about 376,000 in 2007 (a 0.7 times increase) and gradually decreased to less than 70,000 in 2016. In contrast, “barefoot running” related returns started at 945 in 1997 and peaked at 5010 in 2012 (a 4.3 times increase). Between 2007 and 2012, …

Parallel And Cross-Sectional Hamstring Injuries In Sprint Running, Li Li, Donghai Wang

Health Sciences & Kinesiology: Faculty Publications

This issue of Journal of Sport and Health Science contains a point-counterpoint discussion of hamstring injuries in sprint running by the groups of Drs. Liu and Yu.^1–4 They propose different mechanisms of muscle injuries in general, and hamstring injuries in sprint running specifically. Yu et al.^2,4 present evidence suggesting that hamstring injuries are primarily caused by excessive muscle strain during eccentric contraction. In maximal effort sprint running, excessive muscle strains occur at the end of the swing phase. In contrast, Liu et al.^1,3 point out that, in addition to excessive hamstring strain, high stresses in the late …

Serious Fungal Infections In Pakistan, Kauser Jabeen, Joveria Farooqi, Sajjad Mirza, D Denning, Afia Zafar

Department of Pathology and Laboratory Medicine

The true burden of fungal infection in Pakistan is unknown. High-risk populations for fungal infections [tuberculosis (TB), diabetes, chronic respiratory diseases, asthma, cancer, transplant and human immunodeficiency virus (HIV) infection] are numerous. Here, we estimate the burden of fungal infections to highlight their public health significance. Whole and at-risk population estimates were obtained from the WHO (TB), BREATHE study (COPD), UNAIDS (HIV), GLOBOCAN (cancer) and Heartfile (diabetes). Published data from Pakistan reporting fungal infections rates in general and specific populations were reviewed and used when applicable. Estimates were made for the whole population or specific populations at risk, as previously …

Molecular Detection Of Tick-Borne Pathogen Diversities In Ticks From Livestock And Reptiles Along The Shores And Adjacent Islands Of Lake Victoria And Lake Baringo, Kenya, David Omondi, Daniel K. Masiga, Burtram C. Fielding, Edward Kariuki, Yvonne Ukamaka Ajamma, Micky M. Mwamuye, Daniel O. Ouso, Jandouwe Villinger

All Peer-Reviewed Publications

Although diverse tick-borne pathogens (TBPs) are endemic to East Africa, with recognized impact on human and livestock health, their diversity and specific interactions with tick and vertebrate host species remain poorly understood in the region. In particular, the role of reptiles in TBP epidemiology remains unknown, despite having been implicated with TBPs of livestock among exported tortoises and lizards. Understanding TBP ecologies, and the potential role of common reptiles, is critical for the development of targeted transmission control strategies for these neglected tropical disease agents. During the wet months (April-May; October-December) of 2012-2013, we surveyed TBP diversity among 4,126 ticks …

(Re)Defining Race: Addressing The Consequences Of The Law's Failure To Define Race, Destiny Peery

Cardozo Law Review

Modern lawmakers and courts have consistently avoided discussing how to define race for legal purposes even in areas of law tasked regularly with making decisions that require them. This failure to define what race is in legal contexts specifically requiring such determinations, and in the law more broadly, creates problems for multiple actors in the legal system, from plaintiffs deciding whether to pursue claims of discrimination, lawyers deciding how to argue cases, and legal decision-makers deciding cases where race is not only relevant but often central to the legal question at hand. This Article considers the hesitance to engage with …

Frequency Of Nonalcoholic Fatty Liver Disease And Subclinical Atherosclerosis Among Young Mexican Americans, Clarence Gill, Kristina Vatcheva, Jen-Jung Pan, Beverly Smulevitz, David D. Mcpherson, Michael Fallon, Joseph B. Mccormick, Susan P. Fisher-Hoch, Susan T. Laing

School of Mathematical & Statistical Sciences Faculty Publications

Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome, whose criteria are risk factors for atherosclerotic cardiovascular disease. We aimed to evaluate the prevalence of NAFLD, its association with subclinical atherosclerosis, and factors that may account for this association in Mexican Americans. In a population based cross-sectional sample drawn from the Cameron County Hispanic Cohort in Texas, carotid intima media thickness (cIMT), an indicator of subclinical atherosclerosis, was measured. Abnormal carotid ultrasound study was defined as mean cIMT >75th percentile for age and gender and/or plaque presence. NAFLD was defined as steatosis by ultrasound in …