Medicine and Health Sciences Commons^™

The Lived Experience Of Retention And Progression Of Black/African American Nursing Students, India Mylon Medley

Loma Linda University Electronic Theses, Dissertations & Projects

Despite recent strides to increase workforce diversity, nurses continue to inadequately reflect the ethnic composition of the population they serve. To effectively answer the national calls for increased diversity in the nursing workforce, there must be a greater representation of minority students studying nursing. However, minority nursing students, especially those of Black/African American descent, have less access to nursing education, poorer retention and progression rates in nursing programs, and are more likely to withdraw from programs. The existence of an increasingly diverse nursing workforce depends upon the recruitment, retention, progression, and graduation of minority students. Whereas Historically Black Colleges and …

Prenatal Undernutrition, Metyrapone, And The Cerebrovasculature, Lara Durrant

Loma Linda University Electronic Theses, Dissertations & Projects

The link between intrauterine environmental conditions and adult cardiovascular system is well established. Independent of lifestyle factors such as poor diet and exercise habits, individuals who have been exposed to stressful conditions in utero show an increased risk of health problems such as hypertension, stroke, and type II diabetes. In support of the Fetal Origin of Adult Disease hypothesis, many labs have reported permanent anatomical and physiological changes associated with fetal stress and nutrient deficiency, with a focus on organ systems such as the kidney and heart. One key idea proposed by many of these studies is the glucocorticoid hypothesis, …

Targeting Ledgf/P75 To Sensitize Chemoresistant Prostate Cancer Cells To Taxanes, Leslimar Rios-Colón

Loma Linda University Electronic Theses, Dissertations & Projects

Prostate cancer (PCa) is the second most diagnosed cancer in males. This disease disproportionately affects African American men, with a higher incidence and mortality compared to other ethnic/racial groups. An aging male population and the complexity of addressing the health disparities associated with this disease puts PCa into the spotlight due to its serious public health implications and the imminent fiscal challenge over the next decades. Chronic prostate inflammation resulting in activation of stress and prosurvival pathways contribute to disease progression and the development of chemoresistance. Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival …

Pas Signaling Mechanisms In Aer And Aer2, Darysbel Garcia

Loma Linda University Electronic Theses, Dissertations & Projects

PAS domains are widespread signal sensors that share a conserved three-dimensional αβ fold that consists of a central β-sheet flanked by several α- helices. The aerotaxis receptor Aer from Escherichia coli and the Aer2 chemoreceptor from Pseudomonas aeruginosa both contain PAS domains. Aer senses oxygen (O2) indirectly via an FAD cofactor bound to its PAS domain, while Aer2 directly binds O2 to its PAS b-type heme cofactor. The Aer and Aer2 PAS domains both interact with a signal transduction domain known as a HAMP domain. The PAS-HAMP arrangement differs between Aer and Aer2, with Aer- PAS residing adjacent to its …

Organizational, Nurse, And Patient Empowerment At A Magnet And Non-Magnet Hospital, Mai Yaseen

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose/Aims: To explore the relationships between organizational, nurse, and patient empowerment at a Magnet designated hospital versus a non-Magnet designated hospital. There are three aims to the study. Aim 1 examines the relationship between level of organizational empowerment and individual nurse self-empowerment (Self-efficacy). Aim 2 examines the relationship between individual nurse self-empowerment and patient empowerment. Aim 3 investigates if there are any differences in empowerment levels between a Magnet and non-Magnet designated hospital. Background: Patients must feel empowered to make decisions and participate in their care however; it is the healthcare provider’s role to prepare patients to make these decisions. …

Association Of Hypercapnia On Admission With Increased Length Of Hospital Stay And Severity In Patients Admitted With Community-Acquired Pneumonia: A Prospective Observational Study From Pakistan., Nousheen Iqbal, Muhammad Irfan, Ali Bin Sarwar Zubairi, Safia Awan, Javaid Khan

Department of Medicine

Objectives: To determine whether the presence of hypercapnia on admission in adult patients admitted to a university-based hospital in Karachi, Pakistan with community-acquired pneumonia (CAP) correlates with an increased length of hospital stay and severity compared with no hypercapnia on admission.

Study Design: A prospective observational study.

Settings: Tertiary care hospital in Karachi, Pakistan.

Methods: Patients who met the inclusion criteria were enrolled in the study. The severity of pneumonia was assessed by CURB-65 and PSI scores. An arterial blood gas analysis was obtained within 24 hours of admission. Based on arterial PaCO₂ levels, patients were divided into three …

Opioid Prescription And Use After Laparoscopic Cholecystectomy, Valynn Christina Haslam

Theses and Dissertations

Background: Opioid abuse has become a serious public health issue. While adequate pain management is an ethical responsibility for health care providers, responsible stewardship of controlled substances is of equal concern. Opioids are often prescribed for treatment of acute pain post-operatively. The purpose of this study is to examine opioid prescription practices and use of opioids after laparoscopic cholecystectomy. Methods: A convenience sample of 42 patients scheduled for laparoscopic cholecystectomy were enrolled in the study. Using a descriptive study design, patients were interviewed by phone 6-10 days post-operatively using a scripted questionnaire. The average number of excess prescribed opioid medication …

Parents Advising Parents: Raising A Child With Type 1 Diabetes, Becky Jean Rasmuson

Theses and Dissertations

Background and Purpose: Children diagnosed with Type 1 Diabetes face significant challenges in the day to day management of their disease. Parents play an important role in supporting children at every stage of their lives and helping them transition to independence in the management of T1D. The purpose of this study was to learn from parents who have raised their children with T1D to adulthood and identify strategies for parents who are currently raising a child with T1D. Methods: Using a biographical method, a qualitative design, two in-depth interviews with open-ended prompts were completed with purposively selected parents of children …

Ultra-Filtration Of Human Serum For Improved Quantitative Analysis Of Low Molecular Weight Biomarkers Using Atr-Ir Spectroscopy, Franck Bonnier, Luis Felipe Cs. Carvalho, Matthew J. Baker, Hugh Byrne, Igor Chourpa

Articles

Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique. Using glucose as a model spike in human serum, …

Extraoral Maxillofacial Prosthesis Implant Retention Systems: A Critical Review., Hugh Byrne, Marina L. Pimentel

Articles

Objectives: The purpose of this literature review is to provide information on the different available techniques for implant-supported prosthetic retention, which are bar-clip, o-ring or magnets. Through presenting the practitioner preferences reported in literature, although limited from strict comparison due to the heterogeneity of methodologies and studied individuals, this review aims to identify the choices for maxillofacial prosthesis implant retention systems, regarding patient comfort and good aesthetic outcome, as an aid to surgical and prosthetic planning for implant-supported extraoral maxillofacial prosthetics. With proper knowledge of each implant retention system, a practitioner can design a treatment plan which allows for a …

White Blood Cell Subtypes Are Associated With A Greater Long-Term Risk Of Death After Acute Myocardial Infarction, Arthur Shiyovich, Harel Gilutz, Ygal Plakht

The Texas Heart Institute Journal

We evaluated the association between white blood cell counts and long-term mortality rates in 2,129 patients (mean age, 65.3 ± 13.5 yr; 69% men) who had survived acute myocardial infarction. We obtained white blood cell counts and differential counts of white blood cell subtypes within the first 72 hours of hospital admission. The primary outcome was all-cause death at 1, 5, and 10 years after acute myocardial infarction.

In regard to death in the long term, we found significant negative linear associations (lymphocytes), positive linear associations (neutrophils and the neutrophil-to-lymphocyte ratio), and nonlinear U-shaped associations (basophils, eosinophils, monocytes, and total …

Expanding The Genotypic Spectrum Of Bathing Suit Ichthyosis., Nareh V. Marukian, Rong-Hua Hu, Brittany G. Craiglow, Leonard M. Milstone, Jing Zhou, Amy Theos, Hande Kaymakcalan, Deniz A. Akkaya, Jouni J. Uitto, Hassan Vahidnezhad, Leila Youssefian, Susan J. Bayliss, Amy S. Paller, Lynn M. Boyden, Keith A. Choate

Department of Dermatology and Cutaneous Biology Faculty Papers

Importance: Bathing suit ichthyosis (BSI) is a rare congenital disorder of keratinization characterized by restriction of scale to sites of relatively higher temperature such as the trunk, with cooler areas remaining unaffected. Fewer than 40 cases have been reported in the literature. Bathing suit ichthyosis is caused by recessive, temperature-sensitive mutations in the transglutaminase-1 gene (TGM1). Clear genotype-phenotype correlations have been difficult to establish because several of the same TGM1 mutations have been reported in BSI and other forms of congenital ichthyosis. We identify novel and recurrent mutations in 16 participants with BSI.

Objective: To expand the genotypic spectrum of …

Comprehensive Review Of The Evidence Regarding The Effectiveness Of Community-Based Primary Health Care In Improving Maternal, Neonatal And Child Health: 8. Summary And Recommendations Of The Expert Panel, Robert E. Black, Carl E. Taylor, Shobha Arole, Abhay Bang, Zulfiqar Ahmed Bhutta, A Mushtaque R. Chowdhury, Betty R. Kirkwood, Nazo Kureshy, Claudio F. Lanata, James F. Phillips

Department of Paediatrics and Child Health

Background: The contributions that community-based primary health care (CBPHC) and engaging with communities as valued partners can make to the improvement of maternal, neonatal and child health (MNCH) is not widely appreciated. This unfortunate reality is one of the reasons why so few priority countries failed to achieve the health-related Millennium Development Goals by 2015. This article provides a summary of a series of articles about the effectiveness of CBPHC in improving MNCH and offers recommendations from an Expert Panel for strengthening CBPHC that were formulated in 2008 and have been updated on the basis of more recent evidence.
Methods: …

Setting Health Research Priorities Using The Chnri Method: Vii. A Review Of The First 50 Applications Of The Chnri Method, Igor Rudan, Sachiyo Yoshida, Kit Yee Chan, Devi Sridhar, Kerri Wazny, Harish Nair, Aziz Sheikh, Mark Tomlinson, Joy E. Lawn, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Several recent reviews of the methods used to set research priorities have identified the CHNRI method (acronym derived from the "Child Health and Nutrition Research Initiative") as an approach that clearly became popular and widely used over the past decade. In this paper we review the first 50 examples of application of the CHNRI method, published between 2007 and 2016, and summarize the most important messages that emerged from those experiences.
Methods: We conducted a literature review to identify the first 50 examples of application of the CHNRI method in chronological order. We searched Google Scholar, PubMed and so-called …

The Two Anomalies Of Wilhelm Ebstein, Magdalena Mazurak, Jacek Kusa

The Texas Heart Institute Journal

The year 2016 was the 180th anniversary of Wilhelm Ebstein's birth and the 150th anniversary of his description of the congenital tricuspid valve malformation that came to be known as Ebstein anomaly. We present a brief history of the life and work of Dr. Wilhelm Ebstein. Despite his distinguished career, he is seemingly forgotten in his own birthplace. We include a review of the relevant historical medical literature.

Evaluation Of Chest Pain After Implantable Cardioverter-Defibrillator Placement, Amir Gahremanpour, Mohammad Saeed, Yochai Birnbaum

The Texas Heart Institute Journal

No abstract provided.

Transcatheter Tricuspid Valve-In-Valve Replacement With An Edwards Sapien 3 Valve, Pranav Loyalka, Angelo Nascimbene, Benjamin Metz, Igor D Gregoric, Ajay Sundara Raman, Biswajit Kar

The Texas Heart Institute Journal

A few case reports and case series have documented the outcomes in patients with tricuspid bioprosthetic valvular degeneration who underwent transcatheter implantation of the Medtronic Melody and the Edwards Sapien XT and Sapien 3 valves. In this report, we describe the case of a 49-year-old woman with severe bioprosthetic tricuspid valvular stenosis and multiple comorbidities who underwent transcatheter tricuspid valve replacement with a Sapien 3 valve.

Unproven Stem Cell-Based Interventions: Advancing Policy Through Stakeholder Collaboration, Kirstin R W Matthews, Ana S Iltis

The Texas Heart Institute Journal

No abstract provided.

Incremental Validity Of The Pid-5 In Relation To The Five Factor Model And Traditional Polythetic Personality Criteria Of The Dsm-5, J Christopher Fowler, Michelle A Patriquin, Alok Madan, Jon G Allen, B Christopher Frueh, John M Oldham

Staff and Researcher Publications

Background: This study assessed the incremental validity of the Personality Inventory for DSM-5 (PID-5) beyond the impact of demographic, burden of illness, five-factor model of personality, and DSM-5 personality disorder criteria with respect to associations with admission psychiatric symptoms and functional disability.

Methods: Psychiatric inpatients (N = 927) were administered the Big Five Inventory, PID-5, and personality disorder criteria counts. Prior treatment utilization, as well as baseline depression, anxiety, emotion regulation, and functional disability were administered within two days of the personality measures. Hierarchical regression models were used to explore the association of personality functioning with symptom functioning, emotion regulation …

The Exerrt Trial: "Exercise To Regadenoson In Recovery Trial": A Phase 3b, Open-Label, Parallel Group, Randomized, Multicenter Study To Assess Regadenoson Administration Following An Inadequate Exercise Stress Test As Compared To Regadenoson Without Exercise For Myocardial Perfusion Imaging Using A Spect Protocol, G Thomas, S Cullom, T Kitt, K Feaheny, K Ananthasubramaniam, R Gropler, Diwakar Jain, R Thompson

NYMC Faculty Publications

BACKGROUND: This study assessed the non-inferiority and safety of regadenoson administration during recovery from inadequate exercise compared with administration without exercise. METHODS: Patients unable to achieve adequate exercise stress were randomized to regadenoson 0.4 mg either during recovery (Ex-Reg) or 1 hour after inadequate exercise (Regadenoson) (MPI1). All patients also underwent non-exercise regadenoson MPI 1-14 days later (MPI2). The number of segments with reversible perfusion defects (RPDs) detected using single photon emission computerized tomography imaging was categorized. The primary analysis evaluated the majority agreement rate between Ex-Reg and Regadenoson groups. RESULTS: 1,147 patients were randomized. The lower bound of the …

Piperacillin-Tazobactam Versus Other Antibacterial Agents For Treatment Of Bloodstream Infections Due To Ampc Β-Lactamase-Producing Enterobacteriaceae, L Cheng, B Nelson, M Giddins, Qiuhu Shi, S Whittier, A Gomez-Simmonds, A Uhlemann

NYMC Faculty Publications

In vivo induction of AmpC beta-lactamases produces high-level resistance to many beta-lactam antibiotics in Enterobacteriaceae, often resulting in the need to use carbapenems or cefepime (FEP). The clinical effectiveness of piperacillin-tazobactam (TZP), a weak inducer of AmpC beta-lactamases, is poorly understood. Here, we conducted a case-control study of adult inpatients with bloodstream infections (BSIs) due to Enterobacter, Serratia, or Citrobacter species from 2009 to 2015 to assess outcomes following treatment with TZP compared to FEP or meropenem (MEM). We collected clinical data and screened all isolates for the presence of ampC alleles by PCR. Primary study outcomes were 30-day mortality …

Study Of Testicular Immunolocalization Of Inhibin Subunits And Epididymal Histological Structures Among Different Antler Status In Rusa Deer (Rusa Timorensis), Apichaya Sudsukh, Kazuyoshi Taya, Gen Watanabe, Kentaro Nagaoka, Worawidh Wajjwalku, Nikorn Thongtip

The Thai Journal of Veterinary Medicine

The number of rusa deer (Rusa timorensis) raising farms has highly increased in Thailand. Basic data on the reproduction of rusa deer are essential for improvement in deer farming reproduction and the assisted reproductive technologies (ARTs) of endangered deer species. This study aimed to determine the relation of antler changes to testicular and epididymis histological structure and cellular source of testicular inhibin subunits in rusa deer. Eighteen rusa deer testes and epididymis were collected from a slaughterhouse located in Kamphaeng Saen, Nakhon Pathom, Thailand. The male rusa deer used in this study were separated into three groups depending on antler …

Streptococcus Agalactiae Serotype Ib, An Emerging Pathogen Affecting Climbing Perch (Anabas Testudineus) And Günther’S Walking Catfish (Clarias Macrocephalus) Polycultured In Southern Thailand, Chutima Klingklib, Naraid Suanyuk

The Thai Journal of Veterinary Medicine

Streptococcus agalactiae (Group B Streptococcus; GBS) causes serious damage to fish aquaculture worldwide. The present study reports S. agalactiae infection in climbing perch (Anabas testudineus) and Günther’s walking catfish (Clarias macrocephalus) polycultured in southern Thailand between 2011 and 2015. During the disease outbreak, a mortality rate of 10-40% was observed, affecting climbing perch and Günther’s walking catfish weighing from 60-150 g and 30-90 g, respectively. The infected fish exhibited a variety of symptoms typical of streptococcosis, including lethargy, exophthalmia, corneal opacity, ascites, haemorrhage and erratic swimming. One hundred and twenty six isolates from the infected fish were identified as S. …

Comparative In Vitro Killing Activities Of Enrofloxacin When Used Alone And In Combination With Doxycycline Against E. Coli Isolates From Dogs And Cats, Supapatt Kireewan, Nipattra Suanpairintr

The Thai Journal of Veterinary Medicine

Enrofloxacin (ENR) exhibits bactericidal activity while doxycycline (DOX), a drug of choice for Ehrlichia canis (E. canis), demonstrates bacteriostatic effect. When Gram-negative bacteria and E. canis co-infection occurs, using enrofloxacin concurrently with doxycycline is inevitable. The objectives of this study were to compare in vitro killing activities and killing times of enrofloxacin when used alone with those of its combination with doxycycline against ten Escherichia coli (E. coli) isolates from dogs and cats using time-kill curves. The combination treatment was administered either simultaneously (ENR+DOX at t=0 hr) or separately (DOX at t=0 followed by ENR at t=12 hr). The best …

Evaluation Of Antimicrobial Peptide K9cath In A Murine Model Of Mastitis, Alberto Barreras-Serrano, Alma Rossana Tamayo-Sosa, Víctor Manuel Del Villar-Pérez, Alma Angelina Castellanos-Félix, Gilberto López-Valencia, Luis Tinoco-Gracia, Rogelio Hernández-Pando, Tonatiuh Melgarejo

The Thai Journal of Veterinary Medicine

In the present study the effect of antimicrobial peptide K9CATH was evaluated in a murine model of mastitis by Staphylococcus aureus. Mastitis was induced with a clinical isolate of S. aureus in 20 female Balb/c mice at 7 to 10 days of lactation. Ten mice (treatment group) received daily intramammary infusions of 32 μg/50 μL K9CATH peptide, for 3 consecutive days, and 10 other mice (control group) received only 50 μL of saline solution. Results showed a significant reduction (P<0.01) in S. aureus CFU counts in the treatment group compared to the control group. These data suggest that the K9CATH peptide could be a potential candidate for the treatment of bovine mastitis.

Temporohyoid Osteoarthropathy In A Mare With Unilateral Facial Paralysis And Vestibular Signs, Hamid Tavanaeimanesh, Majid Masoudifard, Seyyed Hosein Moaddab

The Thai Journal of Veterinary Medicine

The aim of this case report was to present clinical signs and radiographic features of one of the most important peripheral vestibular diseases in horse, and also present the treatment for this disease. Temporohyoid osteoarthropathy (THO) is caused by proliferation of the proximal stylohyoid bone and petrous temporal bone which finally results in ankylosis of the temporohyoid joint. Any sudden movement may result in damage to the joint and also structures in its vicinity. Some peripheral nerves especially cranial nerve VII and VIII may be affected and THO manifestation appears. The mare presented in this report was referred with unilateral …

Surgical Treatment Of Spontaneous Pneumothorax Associated With Lobal Emphysema In A Dog, Yawon Hwang, Seungwon Yoo, Gonhyung Kim

The Thai Journal of Veterinary Medicine

A 3-year-old female Maltese dog was admitted with cough, dyspnea, and gasping. There was no sign of trauma in history taking. It was speculated that pneumothorax occurred in the right pleural space after X-ray examination. Thoracocentesis and chest tube were applied for 5 days. The symptoms of dyspnea and cough were, however, not relieved or recurred. Exploratory thoracotomy was considered to be the most appropriate approach. Spongiform and air-containing tissue was identified in the whole parenchyma in the right middle lobe. Total lobectomy was performed and then a chest tube was inserted. Atrophy of the right cranial lobe and collapse …

Effect Of A Prebiotic, Probiotic And Symbiotic On Performance Of Broilers Under Clostridium Perfringens Challenge, Ahmed Abdulaziz Al-Sagan, Alaeldein Mahmoud Abudabos

The Thai Journal of Veterinary Medicine

The risk of developing antibiotic-resistant pathogenic bacteria is a major concern in poultry production. The aim of this paper was to evaluate a number of commercially available products as alternatives to antimicrobial growth promoters (AGPs) in broiler’s feed. Six experimental treatments [T1 = unmediated feed (negative control, NC); T2 = unmediated feed plus bacterial challenge (positive control, PC); T3 = feed plus antibiotic (NEOX); T4 = feed plus probiotic (GALI); T5 = feed plus prebiotic (TECHNO); and T6 = feed plus probiotic and prebiotic (SYM)] were used in this study. A total of 240 one-day-old chicks were utilized in the …

The Lipidome In Major Depressive Disorder: Shared Genetic Influence For Ether-Phosphatidylcholines, A Plasma-Based Phenotype Related To Inflammation, And Disease Risk, Emma E. M. Knowles, Kevin Huynh, Peter J. Meikle, Harald H. H. Goring, Rene L. Olvera, Samuel R. Mathias, Ravi Duggirala, Laura Almasy, John Blangero, Joanne E. Curran, David C. Glahn

School of Medicine Publications

Background

The lipidome is rapidly garnering interest in the field of psychiatry. Recent studies have implicated lipidomic changes across numerous psychiatric disorders. In particular there is growing evidence that the concentrations of several classes of lipids are altered in those diagnosed with MDD. However, for lipidomic abnormalities to be considered potential treatment targets for MDD (rather than secondary manifestations of the disease), a shared etiology between lipid concentrations and MDD should be demonstrated.

Methods

In a sample of 567 individuals from 37 extended pedigrees (average size 13.57 people, range = 3–80), we used mass-spectrometry lipidomic measures to evaluate the genetic …

Birth Record Analysis Of Gestational Diabetes: Applications For Intervention Planning, Elizabeth L. Macquillan

Dissertations

Gestational diabetes (GDM) rates in the U.S. and in Michigan have increased over the past several decades, along with the increases in Type 2 Diabetes Mellitus and obesity. GDM is associated with adverse health outcomes for mothers and their offspring. Many current maternal-infant health (MIH) programs in Michigan do not target women with GDM. This study aims to assess state-level rates of GDM in pregnancy with a combination of statistical and spatial analyses using Geographic Information Systems (GIS) for the purpose of informing content and location of public health interventions.

Existing data from 2013 Michigan birth records (107,743 births) were …