Endocrinology Commons^™

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Selected Works Temporary Series

No abstract provided.

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Arshad Khan, Alan Watts

Selected Works Temporary Series

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts

Departmental Papers (Biology)

No abstract provided.

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive And Express Katp Channels, Nurhadi Ibrahim, Martha A. Bosch, James L. Smart, Jian Qiu, Marcelo Rubinstein, Oline K. Rønnekleiv, Malcolm J. Low, Martin J. Kelly

Faculty Publications - Department of Biological & Molecular Science

Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in the mammal. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced green fluorescent protein to perform visualized, whole-cell patch recordings from prepubertal female hypothalamic slices. The mouse POMC-enhanced green fluorescent protein neurons expressed the same endogenous conductances (a transient outward K current and a hyperpolarization-activated, cation current) that have been described for guinea pig POMC neurons. In addition, the selective -opioid receptor agonist DAMGO induced an outward current (maximum of 12.8 1.2 pA), which reversed at K equilibrium potential (EK), in the majority …

The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is A Nonspecific Neuronal Activator, Kanji A. Takahashi, James L. Smart, Hongyan Liu, Roger D. Cone

Faculty Publications - Department of Biological & Molecular Science

C75, a recently derived compound that potently suppresses feeding and induces weight loss, has been proposed to act mainly by inhibiting fatty acid synthase (FAS) in central neurons that control feeding. For example, normal, fasting- associated, hypothalamic increases in neuropeptide Y (NPY)/Agouti-related protein (AGRP) expression and decreases in proopiomelanocortin (POMC)/cocaine and amphetamine regulated transcript (CART) expression were reported to be blocked by C75. Using loose-patch extracellular recording in acute slices, we tested the effect of C75 on anorexigenic POMC neurons and orexigenic NPY neurons of the hypothalamic arcuate nucleus, which were identified by promoter-driven GFP expression, as well as on …

Il-1Α And Tnf-Α Down-Regulate Crh Receptor-2 Mrna Expression In The Mouse Heart, Sarah C. Coste, Kurt A. Heldwein, Susan L. Stevens, Eric Tobar-Dupres, Mary P. Stenzel-Poore

Faculty Publications

Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysaccharide, a model of systemic immune activation, and inflammation. We postulated that inflammatory cytokines may regulate CRH receptor type 2. We show that systemic IL-1α administration significantly down-regulates CRH receptor type 2 mRNA in mouse heart. In addition, TNFα treatment also reduces CRH receptor type 2 mRNA expression, although the effect was not as marked as with …

Spontaneous And Induced Genetic Mutations Of The Pomc System, James L. Smart, Malcolm J. Low

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley

Selected Works Temporary Series

No abstract provided.

The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley

Selected Works Temporary Series

No abstract provided.

Effects Of Xenoestrogens And Cytochrome P450 Aromatase Inhibitors On Sexual Differentiation In Medaka (Oryzias Latipes), John Stewart Gilman Edmunds

MUSC Theses and Dissertations

Several classes of environmental contaminants have been demonstrated to disrupt reproductive function in wild populations and laboratory animals through interactions with endocrine pathways. Primary targets for these endocrine active contaminants are steroid hormone receptors and steroidogenic enzymes. The first study tests the hypothesis that aromatase represents a major target for environmental contaminants which disrupt reproductive function. The results indicate that the biosynthesis of estrogens can be inhibited by certain pesticides and that aromatase represents a target for contaminants disrupting reproductive function. The second study develops an estrogen sensitive and specific reporter gene assay responsive to steroid hormones and several estrogenic …

Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley

Departmental Papers (Biology)

No abstract provided.

A Study Of The Human Longevity Potential And Its Manifestation In Longevous Individuals, Corliss White

Theses

This study examines the present state of aging and longevity research as it applies to longevous elderly, those who reach their 10th and 11th decade of life. Their numbers, if not percentages, have risen considerably in the growing elderly population, The difference between the longevous and other elderly persons is not just one of degree, but of kind. Each of them is a living biological prototype of the human potential to live an extended life span without significant loss of vitality.

Many past studies of longevous population have been marred by inaccurate claims based on unreliable data. Beyond that, researchers …

The Magnetic Separation Of Rat Anterior Pituitary Cells, Jodi Flaws

Master's Theses

No abstract provided.

The Effects Of A Four-Day Treatment With Prophylthiouracil (Ptu) On Thyroid Histology And Serum Levels Of Thyroxine (T₄) And Triiodothyronine (T₃) In The Diabetic Mouse C57bl/Ksj (D̲B̲/D̲B̲), Sterling Roulette

Theses Digitization Project

No abstract provided.

The Effect Of Intraperitoneally Administered Thyroxine, Thiidothyronine And Iopanoic Acid On The In Vivo And In Vitro Oxygen Consumption Rates Of Normal (C57bl/Ksj Db/M) And Diabetic (C57bl/Ksj Db/Db) Mice, A. Kay. Kalousek

Theses Digitization Project

No abstract provided.

The Reduction Of The Diabetic Syndrome In The C57bl/Ksj (Db/Db) Diabetic Mouse By Diet-Restriction And Exercise, Horst R. Rudrich

Theses Digitization Project

No abstract provided.

Extrathyroidal Human Biochemistry Of Monoiodotyrosine, Stanley Andrew Tan

Loma Linda University Electronic Theses, Dissertations & Projects

The existence of extrathyroidal monoiodotyrosine (MIT) has been debated because of uncertain results from measuring serum MIT. The reason is that the isotopic and chromatographic assays used have not been sensitive enough. This investigation undertook to establish the existence of MIT in serum utilizing a radioimmunoassay (RIA), to study the physiology of serum MIT, and to discover the pharmacologic effects of exogenous MIT.

MIT-binding antibody was raised in rabbits by immunization with an MIT-porcine thyroglobulin conjugate. The antiserum bound 40% of the labeled MIT at a final dilution of 1:1000. Incubation of 100 µ1 antiserum with 50 pg [^{125 …}

Comparison Of Lipid And Lipoprotein Levels In Diabetic And Non-Diabetic Juveniles Of Eastern Kentucky, Louise Mccall Isaacs

Morehead State Theses and Dissertations

A thesis presented to the faculty of the School of Science and Mathematics at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Biology by Louise McCall Isaacs on February 27, 1981.

The Effect Of Ketamine Hydrochloride On The Rat's Adrenal-Pituitary System, Dwight Douglas Gallo

Theses Digitization Project

No abstract provided.

The Histology Of The Pineal Gland In Odocoileus Virginianus, Terry Michael De Villiers

Masters Theses

A total of 26 pineal glands from the white-tailed deer were histologically examined. Five different stains were utilized to determine various cell types present in pineal tissue. Connective tissue septa divide the pineal gland into incompletely separated lobules which are supplied by a very extensive vascular system. The pinealocyte is the most numerous cell in the gland and is most easily recognized by a prominent nucleus approximately 6-8 microns in diameter. The pinealocyte cytoplasm contains many minute granules. A distinct difference was noted in the histology of the oldest age deer pineal (age 7 years) when globular granules were observed …

The Effects Of Crowding On The Diurnal Ascorbic Acid Levels Of Albino Rats, Mary Jo Barr

Masters Theses

The adrenal physiology of the albino rat was studied through the measurement of adrenal ascorbic acid levels. A cyclic phenomenon was observed which follows the diel periodicity of the animal. Ascorbic acid values were found to be characteristically higher in males than in females. A similar difference was also seen in populations divided into young animals (body weight less than 175 grams) and old animals (body weight greater than 175 grams). Crowding, induced by manipulating the area of cage space per gram of body weight, was observed to be a definite stressor and caused the adrenal ascorbic acid levels to …

The Effects Of Acute Stress On Adrenal Ascorbic Acid Levels, Robert Joseph Collier

Masters Theses

The diurnal rhythm of adrenal ascorbic acid (DAR) displays an inverse relationship to the diurnal rhythm of circulating levels of plasma corticosteroids. Alloxan monohydrate, 175 mg/kg body weight was given subcutaneously to albino rats to determine the effect of the diabetic state on the DAR. A total of 200 female albino rats were divided into two study groups. Study Group I was composed of 150 animals divided into populations of 15, each including 3 controls. Study Group II was composed of populations of 5, each group containing all controls or all alloxinated rats. The populations of 15 were sacrificed at …

Phosphate Applications Affect The Coumestrol Level Of Medics, T Marshall, R. J. Parkin

Journal of the Department of Agriculture, Western Australia, Series 4

Western Australia has a million acres of medics including various cultivars of barrel medic, Medicago truncatula, and strand medic, M. littoralis. Both species contain coumestrol, a chemical thought to have caused delayed conception and reduced twinning rates among grazing ewes in New Zealand.

No infertility has been reported among ewes grazing medic pastures in Western Australia, but coumestrol levels in both species have often been high enough to suggest the possibility of oestrogenic responses among sheep grazing them.

Superphosphate Deficiency Raises Pasture Oestrogens, H G. Neil, T. Marshall

Journal of the Department of Agriculture, Western Australia, Series 4

A recent field experiment on established pastures at Esperance Downs Research Station has demonstrated a relationship between superphosphate application, pasture oestrogens and oestrogenic response in sheep.

Results of the experiment indicate that on phosphate deficient soils carrying oestrogenic clovers, the levels of oestrogenic materials in the pasture are increased if superphosphate applications are below those recommended for healthy pasture growth.

Control Of Clover Infertility In Sheep, H G. Neil, H. E. Fels, C. M. Francis

Journal of the Department of Agriculture, Western Australia, Series 4

A summary of practices recommended for the control of infertility caused by subterranean clover in West Australian sheep.

PROLONGED grazing of green subterranean clover pastures often reduces ewe fertility. In more extreme cases, obvious signs of clover disease occur.

Oestrogen Free Subterranean Clovers : Their Development And Prospects, C M. Francis

Journal of the Department of Agriculture, Western Australia, Series 4

SELDOM have plants received more publicity than the "oestrogen free" subterranean clovers developed by the University of Western Australia's Institute of Agriculture.

The production of oestrogen free clovers has attracted great popular interest, particularly among farmers in the southern sheep raising districts.

Damage Caused By Hormone-Like Herbicides, G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

THE discovery of the selective action of herbicides such as 2,4-D and MCPA resulted in a rapid expansion in the use of these chemicals for agricultural purposes, particularly for the control of weeds in cereal crops.

Clover Disease Of Sheep In Western Australia, A B. Beck, M. R. Gardiner

Journal of the Department of Agriculture, Western Australia, Series 4

DURING the past five years there has been a marked increase in the incidence of breeding abnormalities of sheep associated with the grazing of subterranean clover pastures.

This complex of diseases first became a major problem in Western Australia in the years following 1940 and eventually became known as "clover disease".