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Full-Text Articles in Endocrinology

Role Of Berry Bioactive Compounds On Lipids And Lipoproteins In Diabetes And Metabolic Syndrome, Arpita Basu Aug 2019

Role Of Berry Bioactive Compounds On Lipids And Lipoproteins In Diabetes And Metabolic Syndrome, Arpita Basu

Kinesiology and Nutrition Sciences Faculty Research

Blood lipids are an important biomarker of cardiovascular health and disease. Among the lipid biomarkers that have been widely used to monitor and predict cardiovascular diseases (CVD), elevated LDL and low HDL cholesterol (C), as well as elevated triglyceride-rich lipoproteins, deserve special attention in their predictive abilities, and thus have been the targets of several therapeutic and dietary approaches to improving lipid profiles. Among natural foods and nutraceuticals, dietary berries are a rich source of nutrients, fiber, and various types of phytochemicals. Berries as whole fruits, juices, and purified extracts have been shown to lower total and LDL-C, and increase …


Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes, Arpita Basu Phd, Ionut Bebu Phd, Alicia J. Jenkins Md, Julie A. Stoner Phd, Ying Zhang Md; Phd, Richard L. Klein Phd, Maria F. Lopes-Virella Md; Phd, W. Timothy Garvey Md, Matthew J. Budoff Md, Peter Alaupovic Phd, Timothy J. Lyons Md Jun 2019

Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes, Arpita Basu Phd, Ionut Bebu Phd, Alicia J. Jenkins Md, Julie A. Stoner Phd, Ying Zhang Md; Phd, Richard L. Klein Phd, Maria F. Lopes-Virella Md; Phd, W. Timothy Garvey Md, Matthew J. Budoff Md, Peter Alaupovic Phd, Timothy J. Lyons Md

Kinesiology and Nutrition Sciences Faculty Research

Apolipoproteins and apolipoprotein-defined lipoprotein subclasses have been associated with dyslipidemia and cardiovascular disease (CVD). Our main objective was to define associations of serum apolipoproteins and ADLS with any CVD and major atherosclerotic cardiovascular events (MACE) in a prospective study of T1D. Serum apolipoproteins and ADLS (14 biomarkers in total) were measured in sera (obtained 1997-2000) from a subset (n=465) of the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort. Prospective associations of any CVD (myocardial infarction, stroke, confirmed angina, silent MI, revascularization, or congestive heart failure) and MACE (fatal or nonfatal myocardial infarction or stroke), over 5942 and 6180 patient-years …


Apolipoprotein-Defined Lipoprotein Subclasses, Serum Apolipoproteins, And Carotid Intima-Media Thickness In T1d, Arpita Basu, Alicia J. Jenkins, Julie A. Stoner, Ying Zhang, Richrd L. Klein Mar 2018

Apolipoprotein-Defined Lipoprotein Subclasses, Serum Apolipoproteins, And Carotid Intima-Media Thickness In T1d, Arpita Basu, Alicia J. Jenkins, Julie A. Stoner, Ying Zhang, Richrd L. Klein

Kinesiology and Nutrition Sciences Faculty Research

Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickness (IMT) measured contemporaneously and 6 years later in 417 T1D participants [men: n = 269, age 42 +/- 6 y (mean +/- SD); women: n = 148, age 39 +/- 8 y] in the Epidemiology of Diabetes Interventions and Complications study, the follow-up of the Diabetes Control and Complications Trial (DCCT). Date were analyzed by multiple linear regression stratified by sex, and …