Engineering Commons^™

Adaptation Of Nirtrifiers And Heterotrophs To Low Dissolved Oxygen In An Activated Sludge Biological Nutrient Removal Pilot Plant, Shashank Khatiwada

Civil & Environmental Engineering Theses & Dissertations

Low dissolved oxygen (DO) operation is one of the innovative technologies in biological nutrient removal (BNR) processes that is being investigated due to the potential to reduce aeration requirements, reduce a treatment plant’s carbon footprint, and to lower costs associated with chemical addition to promote denitrification. These benefits are achieved through development of micro-zones, within aerated basins where simultaneous nitrification and denitrification (SND) can occur. In this study, an activated sludge BNR pilot was run in an anerobic/aerobic (A/O) configuration at a controlled temperature and constant flow to observe microorganism-driven transformations of nitrogen and phosphorus at varying low DO conditions. …

Synthesis And Characterization Of Cobalt(Iii) Complexes And A Vanadium(Iv) Complex With Flavonoids As Ligands, Ethan Schroeder

Chemistry & Biochemistry Theses & Dissertations

For many years now, transition metal complexes have been used as favorable additional chemotherapeutic approaches to medicine that were previously unexplored in the literature. One well-known chemotherapeutic drug, cisplatin, has been applied, but is limited in use due to its toxicity to the cells and its undesirable side effects to humans. Newly developed cobalt-based complexes with ligands known as flavonoids are being used to fight cancer. Flavonoids, compounds mainly found in fruits and vegetables, are shown to have antioxidative and anticancer properties. Use of flavonoids as ligands in transition metal complexes, e.g., those with a Ru(II) metal center, have been …

Experimental And Computational Aerodynamic Studies Of Axially-Oriented Low-Fineness-Ratio Cylinders, Forrest Miller

Mechanical & Aerospace Engineering Theses & Dissertations

For the successful completion of atmospheric entry, descent, and landing (EDL) missions, a body geometry must be selected which provides favorable dynamic aerodynamic properties. The types of experimental facilities capable of collecting information on these properties are limited; however, their numbers are growing thanks to the continued work by the aerodynamics community. NASA Langley Research Center (LaRC) is conducting dynamic aerodynamic testing using a subsonic magnetic suspension and balance system (MSBS), with the end goal of implementing a supersonic MSBS facility at NASA Glenn Research Center. MSBSs are also currently used at the Institute of Fluid Science (IFS) at Tohoku …

A Unit-Load Approach For Reliability-Based Design Optimization Of Linear Structures Under Random Loads And Boundary Conditions, Robert James Haupin, Gene Jean-Win Hou

Mechanical & Aerospace Engineering Faculty Publications

The low order Taylor’s series expansion was employed in this study to estimate the reliability indices of the failure criteria for reliability-based design optimization of a linear static structure subjected to random loads and boundary conditions. By taking the advantage of the linear superposition principle, only a few analyses of the structure subjected to unit-loads are needed through the entire optimization process to produce acceptable results. Two structural examples are presented in this study to illustrate the effectiveness of the proposed approach for reliability-based design optimization: one deals with a truss structure subjected to random multiple point constraints, and the …

Data-Driven Predictive Modeling To Enhance Search Efficiency Of Glowworm-Inspired Robotic Swarms In Multiple Emission Source Localization Tasks, Payal Nandi

Mechanical & Aerospace Engineering Theses & Dissertations

In time-sensitive search and rescue applications, a team of multiple mobile robots broadens the scope of operational capabilities. Scaling multi-robot systems (< 10 agents) to larger robot teams (10 – 100 agents) using centralized coordination schemes becomes computationally intractable during runtime. One solution to this problem is inspired by swarm intelligence principles found in nature, offering the benefits of decentralized control, fault tolerance to individual failures, and self-organizing adaptability. Glowworm swarm optimization (GSO) is unique among swarm-based algorithms as it simultaneously focuses on searching for multiple targets. This thesis presents GPR-GSO—a modification to the GSO algorithm that incorporates Gaussian Process Regression (GPR) based data-driven predictive modeling—to improve the search efficiency of robotic swarms in multiple emission source localization tasks. The problem formulation and methods are presented, followed by numerical simulations to illustrate the working of the algorithm. Results from a comparative analysis show that the GPR-GSO algorithm exceeds the performance of the benchmark GSO algorithm on evaluation metrics of swarm size, search completion time, and travel distance.

Ultrasensitive Tapered Optical Fiber Refractive Index Glucose Sensor, Erem Ujah

Biomedical Engineering Theses & Dissertations

Refractive index (RI) sensors are of great interest for label-free optical biosensing. A tapered optical fiber (TOF) RI sensor with micron-sized waist diameters can dramatically enhance sensor sensitivity by reducing the mode volume over a long distance. Here, a simple and fast method is used to fabricate extremely sensitive refractive index sensors based on localized surface plasmon resonance (LSPR). Two TOFs (l = 5 mm) with waist diameters of 5 µm and 12 µm demonstrated sensitivity enhancement at λ = 1559 nm for glucose sensing (5–45 wt%) at room temperature. The optical power transmission decreased with increasing glucose concentration due …

Evaluating Direct Filtration As An Alternative To Conventional Carbon-Based Advanced Treatment For Indirect Potable Reuse, Savannah M. Flemmer

Civil & Environmental Engineering Theses & Dissertations

Hampton Roads Sanitation District (HRSD) is recharging purified wastewater into the Potomac Aquifer via the Sustainable Water Initiative for Tomorrow (SWIFT) project. Conventional SWIFT treatment applies coagulation, flocculation, sedimentation, ozonation, biofiltration, granular activated carbon (GAC) adsorption, and ultraviolet disinfection to secondary effluent to produce water that meets drinking water standards for managed aquifer recharge. HRSD is considering implementing direct filtration as an alternative to conventional treatment for two additional SWIFT facilities. Direct filtration presents an opportunity for significant cost savings by eliminating sedimentation, shortening flocculation detention time, and reducing coagulant usage. Without upstream removal of solids and organics, however, biofilters …

Study Of Microphonic Effects On The C100 Cryomodule For High Energy Electron Beam Accelerators, Caleb James Hull

Mechanical & Aerospace Engineering Theses & Dissertations

The Continuous Electron Beam Accelerator Facility (CEBAF) at Thomas Jefferson National Laboratory (JLab) is a particle accelerator which can accelerate an electron beam to relativistic speeds and apply the beam onto target samples. The C100 superconducting radio frequency (SRF) cavity is the primary accelerating structure of the C100 cryomodule, one of the many cryomodules which compose the CEBAF linear accelerator. SRF cavities are particularly sensitive to internal and external vibrations that can result in a phenomenon called microphonics which degrade the operational stability of a cryomodule.

The purpose of this thesis is to investigate the significance of mechanical disturbances on …

An Advanced Simulation Architecture For Testing Autonomous And Connected Vehicles Enabled By Virtual Reality, Defu Cui

Electrical & Computer Engineering Theses & Dissertations

With the advancement of intelligent transportation systems, autonomous driving and connected driving are seen as potential solutions to alleviate traffic congestion, enhance traffic safety, and improve efficiency. Extensive testing and validation of autonomous vehicles (AVs) and connected vehicles (CVs) including connected autonomous vehicles are crucial to ensure their safety and reliability. However, testing and validating AVs and CVs on public roads faces challenges such as high costs, inadequate support from transportation infrastructure with communication technologies, and safety concerns, among others. Simulations have become essential tools for testing autonomous driving and connected driving. As mixed traffic involves multiple domains including traffic …

Biocrude Production From Lignin In Hydrothermal Medium: Effect Of Rapid Heating And Short Residence Time, Kyoko Hirayama

Civil & Environmental Engineering Theses & Dissertations

This study aims to address knowledge gaps in the production of valuable products from waste streams generated during lignocellulosic biofuel production. The primary objective is to develop a process that converts lignin, a byproduct of bioethanol refineries, into a sustainable biolubricant.

The first chapter examines recent advancements in synthesizing biolubricants and investigates their scalability. It explores innovative materials, catalysts, chemical modification approaches, and additives that have emerged in the field. A particular hurdle is the oxidative stability of biolubricants derived from plant oils, which are prone to autooxidation due to their C=C bonds. To overcome this, the study aims to …

A Dynamical Systems Approach To Characterizing Brain–Body Interactions During Movement: Challenges, Interpretations, And Recommendations, Derek C. Monroe, Nathaniel T. Berry, Peter C. Fino, Christopher K. Rhea

Rehabilitation Sciences Faculty Publications

Brain–body interactions (BBIs) have been the focus of intense scrutiny since the inception of the scientific method, playing a foundational role in the earliest debates over the philosophy of science. Contemporary investigations of BBIs to elucidate the neural principles of motor control have benefited from advances in neuroimaging, device engineering, and signal processing. However, these studies generally suffer from two major limitations. First, they rely on interpretations of ‘brain’ activity that are behavioral in nature, rather than neuroanatomical or biophysical. Second, they employ methodological approaches that are inconsistent with a dynamical systems approach to neuromotor control. These limitations represent a …

Control Of The Electroporation Efficiency Of Nanosecond Pulses By Swinging The Electric Field Vector Direction, Vitalii Kim, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Ruben M. L. Colunga Biancatelli, Andrei G. Pakhomov

Bioelectrics Publications

Reversing the pulse polarity, i.e., changing the electric field direction by 180°, inhibits electroporation and electrostimulation by nanosecond electric pulses (nsEPs). This feature, known as “bipolar cancellation,” enables selective remote targeting with nsEPs and reduces the neuromuscular side effects of ablation therapies. We analyzed the biophysical mechanisms and measured how cancellation weakens and is replaced by facilitation when nsEPs are applied from different directions at angles from 0 to 180°. Monolayers of endothelial cells were electroporated by a train of five pulses (600 ns) or five paired pulses (600 + 600 ns) applied at 1 Hz or 833 kHz. Reversing …

Gradient-Based Trade-Off Design For Engineering Applications, Lena A. Royster, Gene Hou

Mechanical & Aerospace Engineering Faculty Publications

The goal of the trade-off design method presented in this study is to achieve newly targeted performance requirements by modifying the current values of the design variables. The trade-off design problem is formulated in the framework of Sequential Quadratic Programming. The method is computationally efficient as it is gradient-based, which, however, requires the performance functions to be differentiable. A new equation to calculate the scale factor to control the size of the design variables is introduced in this study, which can ensure the new design achieves the targeted performance objective. Three formal approaches are developed in this study for trade-off …

Optimal Domain-Partitioning Algorithm For Real-Life Transportation Networks And Finite Element Meshes, Jimesh Bhagatji, Sharanabasaweshwara Asundi, Eric Thompson, Duc T. Nguyen

Civil & Environmental Engineering Faculty Publications

For large-scale engineering problems, it has been generally accepted that domain-partitioning algorithms are highly desirable for general-purpose finite element analysis (FEA). This paper presents a heuristic numerical algorithm that can efficiently partition any transportation network (or any finite element mesh) into a specified number of subdomains (usually depending on the number of parallel processors available on a computer), which will result in “minimising the total number of system BOUNDARY nodes” (as a primary criterion) and achieve “balancing work loads” amongst the subdomains (as a secondary criterion). The proposed seven-step heuristic algorithm (with enhancement features) is based on engineering common sense …

Measurements Of Magnetic Field Penetration Of Materials For Superconducting Radiofrequency Cavities, Iresha Harshani Senevirathne

Physics Theses & Dissertations

Superconducting Radio Frequency (SRF) cavities used in particle accelerators are typically formed from or coated with superconducting materials. Currently high purity niobium is the material of choice for SRF cavities which have been optimized to operate near their theoretical field limits. This brings about the need for significant R&D efforts to develop next generation superconducting materials which could outperform Nb and keep up with the demands of new accelerator facilities. To achieve high quality factors and accelerating gradients, the cavity material should be able to remain in the superconducting Meissner state under high RF magnetic field without penetration of quantized …

Systemic Risk Analysis Of Human Factors In Phishing, Mark Guilford

Engineering Management & Systems Engineering Theses & Dissertations

The scope of this study is the systemic risk of the role of humans in the risk of phishing. The relevance to engineering managers and systems engineers of the risks of phishing attacks is the theft of data which has significantly increased in the past couple of years. Phishing has become a systemic persistent threat to all internet users. Understanding the role of humans in phishing from a systemic perspective is a critical objective towards creating a strong defense against complex and manipulative phishing attacks. The systemic view of phishing concentrates on how phishing affects the entire organizational system, not …

E-Cadherin Force Transmission And Stiffness Sensing, Mazen Mezher

Mechanical & Aerospace Engineering Theses & Dissertations

E-cadherin is the chief mediator of cell-cell adhesion between epithelial cells and is a known mechanosensor. Force transmission and stiffness sensing are two crucial aspects of E-cadherin mechanobiology.

E-cadherin has an extracellular adhesive region, a transmembrane region and an intracellular region that binds to adhesion-associated proteins. Here, we assessed how different factors affect the level of force transmission (i) from inside the cell such as adhesion-associated proteins, (ii) on the cell membrane, such as growth factor receptors and (iii) outside the cell, such as different binding partners in adhesion. To study the level of force transmission inside the cell, we …

Human Psychology Factors Influencing Agile Team Autonomy In Post-Pandemic Remote Software Organizations, Ravikiran Kalluri

Engineering Management & Systems Engineering Theses & Dissertations

Agile project management methods are gaining in popularity in the software industry as software development teams are being asked to be adaptive to market needs and resilient to change and uncertainty. With increasing market uncertainty, global competition, and time-to-market pressure, it is becoming a challenge to develop an innovative product and deliver it on-time without the opportunity that comes from team autonomy to experiment and learn from failures in a remote workplace. To resolve this challenge, it is critical to understand the myriad human psychological factors in play that influence Agile team autonomy in a remote work environment.

The role …

Nb3Sn Coating Of Twin Axis Cavity And Other Complex Srf Cavity Structures, Jayendrika Kumari Tiskumara

Physics Theses & Dissertations

In the field of Accelerator Science, for the low cost and increased quality factor, thin films coated niobium cavities are used in the modern SRF research. Within the potential substances, Nb₃Sn has shown higher critical temperature than niobium. Here the tin vapor diffusion method is used as the preferred technique to coat niobium cavities. So far, only elliptical cavities have been coated with Nb₃Sn and this technique has not yet been applied to cavities with complex geometries, which are also helpful in the accelerator science field. The Half-wave resonator could provide us data across frequencies of …

Validation Of Meta Motion Imu Sensors Through Measurement Of Knee Angles During Gait, Kerri Caruso

Biomedical Engineering Theses & Dissertations

The implementation of inertial measurement units (IMU) in the biomechanical field has become increasingly popular due to their robustness, simplicity, accuracy, and the ability to move research out of a lab and into the real world. In this study, the MetaMotion IMU sensors are assessed for validity against a dynamometer and the Vicon motion capture system. Both systems have proven their measuring accuracies in the biomechanics world and are used as the truth source for this validation study. In the first part of this study, the sensors are assessed for various common sensor errors. Individual sensor components of the IMU, …

Fusion Bonding Behavior Of 3d Printed Pa6/Cf Composites Via Post Fabrication Compaction, Gonzalo Fernandez Mediavilla

Mechanical & Aerospace Engineering Theses & Dissertations

Additive manufacturing (AM) is becoming a robust production technology for aerospace, healthcare, and construction industries among others. Fused Deposition Modelling (FDM) is one of the methods most used to 3D print products. FDM has limitation due to interlayer adhesion and restriction imposed by the printing direction. Specially with AM composites, as reinforced nylon PA6 with short fibers, parts show more strength along the direction of the filament due to the alignment of the carbon fibers, but weaker in other directions. The proposed method to solve this issue is to print parts separately and join them together by fusion bonding. PA6/CF …

Fabrication Of Solid Oxide Fuel Cell Components Using Stereolithography 3d Printing, Hannah Dyer

Mechanical & Aerospace Engineering Theses & Dissertations

Transitioning from fossil fuel supplied energy to renewable technology must meet cost efficient parameters throughout the manufacturing process while possessing the characteristics of a functioning and reliable power source. With a significant demand in renewable energy products, developmental techniques require adaptive approaches and procedures for novel materials in the manufacturing phase. This report proposes how a solid oxide fuel cell (SOFC), a renewable energy system, can employ additive manufacturing for directly 3D printing its components by utilizing stereolithography (SLA) 3D printing techniques. Fabrication of the printed components from the mixtures were first mixed with varying concentrations of ceramic powder and …

Cardiac Ablation And Stimulation With Nanosecond Pulsed Electric Fields (Nspefs), Federica Serra

Biomedical Engineering Theses & Dissertations

Surgical ablation of cardiac tissue is the definitive treatment for the most common arrhythmia, atrial fibrillation. In current medical practice, myocardial tissue is often ablated by the application of radiofrequency (RF) currents which are delivered through an electrode to create lesions that block the electrical pathways that sustain reentrant arrhythmias and restore the normal heart rhythm. An alternative to RF is cryoablation, during which the endocardial or epicardial tissue is brought in contact with a cryoprobe. Both RF ablation and cryoablation have significant limitations. In RF ablation, tissue is heated in order to ablate it, but it is an open …

Iot Health Devices: Exploring Security Risks In The Connected Landscape, Abasi-Amefon Obot Affia, Hilary Finch, Woosub Jung, Issah Abubakari Samori, Lucas Potter, Xavier-Lewis Palmer

School of Cybersecurity Faculty Publications

The concept of the Internet of Things (IoT) spans decades, and the same can be said for its inclusion in healthcare. The IoT is an attractive target in medicine; it offers considerable potential in expanding care. However, the application of the IoT in healthcare is fraught with an array of challenges, and also, through it, numerous vulnerabilities that translate to wider attack surfaces and deeper degrees of damage possible to both consumers and their confidence within health systems, as a result of patient-specific data being available to access. Further, when IoT health devices (IoTHDs) are developed, a diverse range of …

Generation Of Plasma With A Rotating Electric Field, Franklin Price Mosely

Electrical & Computer Engineering Theses & Dissertations

Nonthermal plasma generation is an important area of research that has many applications ranging from semiconductor production to medical applications including the treatment of cancers and sterilization of surfaces. Specific radicals and excited species and discharge powers are critical for the successful completion of these processes. It is important that these excited species are shown to be achievable for a given discharge system without leading to instabilities such as arcing.

The present thesis details the design, fabrication, testing, and analysis of a novel plasma generation system based on multiphase excitation. As predicted by theory, the experimental results demonstrate that a …

Electric Vehicle Routing Problem – Models And Algorithms, Hesamoddin Tahami

Engineering Management & Systems Engineering Theses & Dissertations

The transportation sector is a major greenhouse gas emitter that is heavily regulated to reduce its dependence on oil. These regulations along with the growing customer awareness of global warming have led to the investigation of new transportation problems that consider using eco-friendly vehicle fleets. Promising alternatives to traditional fleets include alternative fuel vehicles (AFVs) and electric vehicles (EVs). These twenty-first-century vehicles offer an appealing advantage of consistently reducing their environmental impact, but due to the current technology, they exhibit bothersome limitations. The short driving range along with limited charging infrastructure may consequently cause issues related to range anxiety, i.e., …

Opensim-Based Musculoskeletal Modeling: Foundation For Interactive Obstetric Simulator, Bahador Dodge

Electrical & Computer Engineering Theses & Dissertations

The use of mathematical and computational models to understand complex biological systems, such as the human birth process, is a rapidly growing field in medicine. These models can be used to optimize and personalize medical treatments for individual patients, enhance training, and aid in educational efforts. While recent advancements in healthcare, particularly in obstetrics, have improved care for mothers and babies, studies and government reports indicate a rising rate of maternal mortality in the United States.

Despite this rising trend, there is a lack of detailed studies concerning the use of modeling and simulation to develop an interactive obstetrics simulator …

Sealion Cubesat Mission Architecture Using Model Based Systems Engineering With A Docs As Code Approach, Kevin Yi-Tzu Chiu

Mechanical & Aerospace Engineering Theses & Dissertations

CubeSats are a growing population within the space industry. Every year, universities launch numerous amounts of CubeSats due to their inexpensive cost of development, launch, and deployment. However, this comes with numerous challenges. As the number of university-CubeSats grow, so too do the numbers that fail. With development teams consisting mainly of students with little to no training, proper and yet easy to use tools or methods should be implemented to help ensure mission success. Especially in the critical stages of planning before and during development, a technical approach to quickly track life cycle development of a CubeSat is needed. …

Roboretrieve--In A Dual Role As A Hand-Held Surgical Robot And A Collaborative Robot End-Effector To Perform Spillage-Free Specimen Retrieval In Laparoscopy, Siqin Dong

Mechanical & Aerospace Engineering Theses & Dissertations

Recent advances in surgical robotics attempt to overcome limitations of manual surgery by augmenting the surgeon’s capabilities while performing suturing, incision, retraction, and retrieval tasks. This dissertation presents novel approaches for spillage-free specimen retrieval in confined spaces, targeted toward the surgical domain of minimally invasive robotic surgery. The retrieval task involves extraction of a resected specimen, residing in the abdominal cavity, completely outside of the patient’s body. A major challenge in this context is the spillage of content being retrieved, which may cause dissemination of malignancy. To address this challenge, this dissertation develops RoboRetrieve, a portable hand-held robot that …

Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter

Biomedical Engineering Theses & Dissertations

Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and pulse duration of milliseconds is used for biomedical treatment to induce pores in the plasma membrane of cells. Nanosecond Pulsed Electric Fields (nsPEFs)– an extension of electroporation, uses waveforms with pulse durations on the order of 10-900 nanoseconds. nsPEF treatment has demonstrated intracellular effects for potential biomedical applications. In this work, nsPEF treatment is used to demonstrate changes that affect viability, plasma membrane permeability ROS (Reactive Oxygen Species) in the …