Engineering Commons^™

Size-Dependent Inhibitory Effects Of Antibiotic Nanocarriers On Filamentation Of E. Coli, Preeyaporn Songkiatisak, Feng Ding, Pavan Kumar Cherukuri, Xiao-Hong Nancy Xu

Chemistry & Biochemistry Faculty Publications

Multidrug membrane transporters exist in both prokaryotic and eukaryotic cells and cause multidrug resistance (MDR), which results in an urgent need for new and more effective therapeutic agents. In this study, we used three different sized antibiotic nanocarriers to study their mode of action and their size-dependent inhibitory effects against Escherichia coli (E. coli). Antibiotic nanocarriers (AgMUNH–Oflx NPs) with 8.6 × 10², 9.4 × 10³ and 6.5 × 10⁵ Oflx molecules per nanoparticle (NP) were prepared by functionalizing Ag NPs (2.4 ± 0.7, 13.0 ± 3.1 and 92.6 ± 4.4 nm) with a monolayer …

Loading Orientation Dependence On The Compressive Response Of Ice-Templated Ceramic-Polymer Composites, Sashanka Akurati, Justine Marin, Dipankar Ghosh

College of Engineering & Technology (Batten) Posters

Natural materials are made from weak constituents, yet exhibit an excellent synergy of high stiffness, strength, and damage-tolerance. They consist of alternate layers of the hard and soft phases with a complex hierarchical structural organization. The ice-templating technique provides an approach to fabricate multilayered architectures for engineering applications. In this technique, an aqueous ceramic suspension is solidified unidirectionally leading to phase separation into alternating layers of ice-crystals and ceramic particles. Ice-crystals are sublimated by freeze-drying process and resultant ceramic foams are sintered to impart strength. The fabricated sintered ceramic foams contain alternate layers of oriented ceramic lamella walls and pores. …

Illuminator, Volume 3, Issue 8, Batten College Of Engineering & Technology, Old Dominion University

College of Engineering & Technology Newsletter

April 2020 issue of Illuminator, a monthly publication of ODU's Batten College of Engineering and Technology.

Comprehensive Designs Of Innovate Secure Hardware Devices Against Machine Learning Attacks And Power Analysis Attacks, Yiming Wen

Electrical & Computer Engineering Theses & Dissertations

Hardware security is an innovate subject oriented from growing demands of cybersecurity and new information vulnerabilities from physical leakages on hardware devices. However, the mainstream of hardware manufacturing industry is still taking benefits of products and the performance of chips as priority, restricting the design of hardware secure countermeasures under a compromise to a finite expense of overheads. Consider the development trend of hardware industries and state-of-the-art researches of architecture designs, this dissertation proposes some new physical unclonable function (PUF) designs as countermeasures to side-channel attacks (SCA) and machine learning (ML) attacks simultaneously. Except for the joint consideration of hardware …

Engineering Management Competencies: A Framework For Present And Future Engineering Environments, Christopher Vaughn Barrett

Engineering Management & Systems Engineering Theses & Dissertations

Managing and directing engineering requires engineering management competencies. Although perspectives may differ concerning competencies for engineering management, identifying competencies can direct and improve management. The purpose of this research is to develop a framework of competencies for engineering managers using an inductive research design. Development of this engineering management competency framework involves an exploration of three primary research questions. The first question is ‘What are the current competencies for engineering managers?’ The response to this question provides a basis for the current state of competencies for engineering managers. The second research question, ‘What are future engineering management competencies based on …

Lateral-Torsional Instability And Biaxial Flexure Of Continuous Gfrp Beams Including Warping And Shear Deformations, Waverly G. Hampton

Civil & Environmental Engineering Theses & Dissertations

This dissertation presents an experimental and theoretical study of the lateral-torsional instability and biaxial flexure of Glass Fiber Reinforced Polymer (GFRP) beams including warping and shear deformation effects. The theoretical analysis is based on three simultaneous differential equations of equilibrium with new terms added to account for shear deformation effects. To solve these equations, algorithms based upon a central finite-difference approach are then developed. The experimental study is conducted on a series of single- and multi-span beams subjected to concentrated loads. The predicted beam behavior agreed well with that observed experimentally. The investigation revealed that the ASCE-LRFD Prestandard for pultruded …

Virtual Satcom, Long Range Broadband Digital Communications, Dennis George Watson

Electrical & Computer Engineering Theses & Dissertations

The current naval strategy is based on a distributed force, networked together with high-speed communications that enable operations as an intelligent, fast maneuvering force. Satellites, the existing network connector, are weak and vulnerable to attack. HF is an alternative, but it does not have the information throughput to meet the distributed warfighting need. The US Navy does not have a solution to reduce dependency on space-based communication systems while providing the warfighter with the required information speed.

Virtual SATCOM is a solution that can match satellite communications (SATCOM) data speed without the vulnerable satellite. It is wireless communication on a …

Deep Cellular Recurrent Neural Architecture For Efficient Multidimensional Time-Series Data Processing, Lasitha S. Vidyaratne

Electrical & Computer Engineering Theses & Dissertations

Efficient processing of time series data is a fundamental yet challenging problem in pattern recognition. Though recent developments in machine learning and deep learning have enabled remarkable improvements in processing large scale datasets in many application domains, most are designed and regulated to handle inputs that are static in time. Many real-world data, such as in biomedical, surveillance and security, financial, manufacturing and engineering applications, are rarely static in time, and demand models able to recognize patterns in both space and time. Current machine learning (ML) and deep learning (DL) models adapted for time series processing tend to grow in …

Longitudinal Brain Tumor Tracking, Tumor Grading, And Patient Survival Prediction Using Mri, Linmin Pei

Electrical & Computer Engineering Theses & Dissertations

This work aims to develop novel methods for brain tumor classification, longitudinal brain tumor tracking, and patient survival prediction. Consequently, this dissertation proposes three tasks. First, we develop a framework for brain tumor segmentation prediction in longitudinal multimodal magnetic resonance imaging (mMRI) scans, comprising two methods: feature fusion and joint label fusion (JLF). The first method fuses stochastic multi-resolution texture features with tumor cell density features, in order to obtain tumor segmentation predictions in follow-up scans from a baseline pre-operative timepoint. The second method utilizes JLF to combine segmentation labels obtained from (i) the stochastic texture feature-based and Random Forest …

Dod Mission Engineering And Integration Explorative-Exploitative Architecture For Technology Innovation, Jose L. Bricio-Neto

Engineering Management & Systems Engineering Theses & Dissertations

The ability of U.S. Department of Defense to achieve timely innovation in support of U.S. National Defense and Military Strategies continues to increase in significance. The growing challenges in U.S. Department of Defense (DoD) technological innovation in a context of global security and rapid pace of global competitiveness continue to reveal many shortcomings in current weapon systems development and acquisition practice. As the pace of technological innovation is accelerating, the DoD faces the challenge that the same disruptive technological advances are also being made available to or developed by its adversaries. Based on literature review, no innovation system theory exists …

Nonlinearity Index Aircraft Spin Motion Analysis With Dynamic Inversion Spin Recovery Controller Design, Jeffry Walker

Mechanical & Aerospace Engineering Theses & Dissertations

The aim of this thesis research is to extend the previous work of Tapolcai utilizing nonlinearity index theory to quantitatively analyze nonlinearities in an aircraft model and to augment these undesirable nonlinear characteristics with feedback control. In his work Tapolcai utilized a simplified rotational three degree of freedom model to analyze spin conditions of the F-18 High Angle-of-Attack Research Vehicle model. Through the application of nonlinearity index theory, regions of severe nonlinearity were uncovered exhibiting chaotic non-periodic behavior, periodic limit cycling, and instability. If these conditions were encountered during flight, the aircraft would exhibit undesirable response characteristics thereby requiring augmented …

Role Of Anisometric Particles In Ice-Templated Porous Ceramic Structure And Mechanical Properties, Mahesh Banda

Mechanical & Aerospace Engineering Theses & Dissertations

Open-cell macroporous ceramics have a significant impact on advancing various engineering endeavors such as bone-tissue engineering, lithium-ion batteries, filtration, thermal insulation, impact protection, etc. While pore orientation in conventional open-cell foams is random, in recent years, significant interest has grown in utilizing directionally porous ceramics in these applications to enhance performance. Ice-templating has emerged as a versatile technique that can synthesize directionally macroporous ceramics with low pore tortuosity. Although the fabrication is relatively straightforward, the challenge is that there are numerous variables associated with this technique, which can have significant effects on the final structure and macroscopic properties. As a …

A Rule Based Control Algorithm For On-Ramp Merge With Connected And Automated Vehicles, Ehsan Beheshtitabar

Civil & Environmental Engineering Theses & Dissertations

One of the designs for future highways with the flow of Connected Automated Vehicles (CAVs) cars will be a dedicated lane for the CAVs to form platoons and travel with higher speeds and lower headways. The connectivity will enable the formation of platoons of CAVs traveling beside non-platoon lanes. The advent of connectivity between vehicles and the infrastructure will enable advanced control strategies ̶ improving the performance of the traffic ̶ to be incorporated in the traffic system. The merge area in a multilane highway with CAVs is one of the sections which can be enhanced by the operation of …

Through-Thickness Reinforcement And Repair Of Carbon Fiber Based Honeycomb Structures Under Flexure And Tension Of Adhesively Bonded Joints, Aleric Alden Sanders

Mechanical & Aerospace Engineering Theses & Dissertations

Repair and reinforcement of composite honeycomb structures is an area of concern as higher demands are being placed on high strength, lightweight structural materials, such as carbon fiber reinforced plastics and corresponding honeycomb structures. A common issue with these structures is when a delamination in the facesheet may form and spread, leading to a failure scenario. An investigation of adding a through thickness reinforcement (TTR) to these structures at the sample level that undergo four-point-bending, tension, and joining methods is conducted throughout this thesis. The embedding of pultruded carbon fiber rods is found to be an ideal addition to composite …

A Study Of The Aeroacoustics Of Swept Propellers For Small Unmanned Aerial Vehicles, Arthur David Wiedemann

Mechanical & Aerospace Engineering Theses & Dissertations

In recent years, small unmanned aerial vehicles (UAVs) have increased in availability and use in both public and commercial sectors. This increased use of small UAVs or “drones” has the unfortunate consequence of introducing excessive noise into communities where they operate. Implementation of noise reduction methods is necessary if we wish to see expanded use of drones in public areas. With electric propulsion, the primary source of noise is the rotor/propeller used in contemporary multi-rotor configurations. In this thesis, the aerodynamics and acoustic behavior of various swept propellers is examined with computational and experimental methods.

A family of propeller geometries …

Deposition And Characterization Of Indium Nitride And Aluminum Nitride Thin Films By Reactive Sputtering, Sushma Swaraj Atluri

Electrical & Computer Engineering Theses & Dissertations

Intensive research has been carried out on III-V semiconductors for over a century due to their various applications in the field of Microelectronics, Optics, and Photonics. Among III-V materials, the III-nitrides, for example Aluminum Nitride, Indium Nitride, Gallium Nitride and their ternary alloys are known for their unique properties. All the III-Nitride Compounds are direct bandgap semiconductors with a bandgap ranging from 0.7 eV to 6.2 eV covering the entire visible region and extending to the UV region as well. Despite having many applications, fabricating good quality thin films without defects is quite a challenge. They are typically grown using …

Topology Control, Scheduling, And Spectrum Sensing In 5g Networks, Prosanta Paul

Electrical & Computer Engineering Theses & Dissertations

The proliferation of intelligent wireless devices is remarkable. To address phenomenal traffic growth, a key objective of next-generation wireless networks such as 5G is to provide significantly larger bandwidth. To this end, the millimeter wave (mmWave) band (20 GHz -300 GHz) has been identified as a promising candidate for 5G and WiFi networks to support user data rates of multi-gigabits per second. However, path loss at mmWave is significantly higher than today's cellular bands. Fortunately, this higher path loss can be compensated through the antenna beamforming technique-a transmitter focuses a signal towards a specific direction to achieve high signal gain …

Compaction And Residual Stress Modeling In Composite Manufactured With Automated Fiber Placement, Von Clyde Jamora

Mechanical & Aerospace Engineering Theses & Dissertations

Automated fiber placement is a state-of-the-art manufacturing process that allows for complex layup patterns and can quickly place, cut, and restart composite tows. However, with this type of manufacturing process layup defects are inevitable, and manufacturing defects propagate after curing. Process modeling is the considered approach for exploring the defect prediction. Two different but related works were conducted, which are the thermochemical and hyperelastic model and the residual deformation model. For the model before cooling, a hyperelastic model and a thermo-chemical were made to simulate the compaction and heat transfer. Temperature dependent properties that are a function of degree of …

Effects Of Transparency And Haze On Trust And Performance During A Full Motion Video Analysis Task, Sarah C. Leibner

Psychology Theses & Dissertations

Automation is pervasive across all task domains, but its adoption poses unique challenges within the intelligence, surveillance, and reconnaissance (ISR) domain. When users are unable to establish optimal levels of trust in the automation, task accuracy, speed, and automation usage suffer (Chung & Wark, 2016). Degraded visual environments (DVEs) are a particular problem in ISR; however, their specific effects on trust and task performance are still open to investigation (Narayanaswami, Gandhe, & Mehra, 2010). Research suggests that transparency of automation is necessary for users to accurately calibrate trust levels (Lyons et al., 2017). Chen et al. (2014) proposed three levels …

Thermal Contact Resistance Measurement And Related Uncertainties, Amanda Elizabeth Stark

Mechanical & Aerospace Engineering Theses & Dissertations

Thermal contact resistance is an important parameter in detailed thermal analysis and design of aerospace systems. The ability to determine thermal contact resistance reliably can have a significant impact on the fidelity of thermal models—particularly for space applications. The 2004 NASA Langley Research Center thermal contact resistance test apparatus has been employed to evaluate two methods for inferring estimated interface surface temperatures so that thermal contact resistance can be calculated more accurately. The traditional method of extrapolation is a steady-state approach, while the new method utilizes inverse heat transfer techniques to account for inherent unsteadiness in these quasi-steady-state measurements. The …

Application Of Theory Of Constraints (Toc) In Managing Project Information Constraints, Ferdinand Z. Prantl

EMSE Doctoral Projects

The scope of this doctoral project is the non-traditional application of Drum-Buffer-Rope (DBR) from the area of Theory of Constraints (ToC) in mitigating disruption in distribution facilities during phased upgrades caused by information constraint. The relevance of this project is that industrial equipment upgrades pose a significant risk of disrupting the operation of automated distribution facilities. It is partly due to a very high expected availability rate, as well as tight coupling with other upstream and downstream elements of the larger supply chain network. As a consequence of disruption in this scenario, losses incurred not only within the facility being …

Rotorcraft Blade Angle Calibration Methods, Brian David Calvert Jr.

Mechanical & Aerospace Engineering Theses & Dissertations

The most vital system of a rotorcraft is the rotor system due to its effects on the overall flight quality of the vehicle. Therefore, it is of importance to be able to accurately determine blade position during flight so that fine adjustments can be made to ensure a safe and efficient flight. In this study, a current calibration method focusing on the pitch, flap, and lead-lag blade angles is analyzed and found to have larger than acceptable error associated with the sensor calibrations. A literature review is conducted which reveals four novel methods that can potentially increase the accuracy of …

Cfd Simulations Of A Propeller-Wing Interaction, Asim Oktay Akdeniz

Mechanical & Aerospace Engineering Theses & Dissertations

In this study, 3-D turbulent flows around a propeller driven aircraft model placed in a subsonic wind tunnel were computationally simulated for qualitative investigation of near field wakes. The geometry of the model was created using commercial mesh generation software, GRIDGEN, and then simulations were performed using a commercial finite volume Reynolds-Averaged Navier-Stokes (RANS) solver FLUENT.

Initial runs were performed to validate the boundary conditions and setup of the problem where a hybrid mesh consisting of multi-blocks was in use. Sliding mesh concept used in the computations. Laminar flow simulation have been utilized and tested besides Spalart-Allmaras and k-ω SST …

Biphasic Gene Electrotransfer Enhances Gene Delivery In Vitro, John Bui

Biomedical Engineering Theses & Dissertations

The application of short, pulsed electric fields to eukaryotic cells and tissues has been shown to permeabilize cells. This phenomenon has been used for clinical applications for irreversible electroporation of cancer cells or for molecule delivery for drug or gene therapies. Typically, a monophasic (monopolar) pulse train is used; however, recent studies have explored the possibility of using biphasic (often referred to as bipolar) pulses, primarily for irreversible electroporation (IRE), which report reduced muscle contraction during pulse train application compared to monophasic pulses. Additional studies show improved transfection efficiency using biphasic pulses, conversely, with low cell viability. The purpose of …

Validation Risk Across Hierarchical Models, John B. Young

Computational Modeling & Simulation Engineering Theses & Dissertations

Modeling and simulation are applied in a great many methods across a variety of topics. Model developers and users alike have a professional duty to understand the complexities of the tools and methods they are used. Oftentimes, models that have been independently constructed and executed are used to inform one another for an analytic purpose and the compatibility of the models is not always addressed. In the literature, great attention has been paid to model validation. When using models constructively with one another, analysts must understand the bounds of model validity and ensure that the combination of models does not …

Lignin: A Likely Precursor Of A Significant Fraction Of Humic Substances Via Oxidative Transformations, Seyyedhadi Khatami

Chemistry & Biochemistry Theses & Dissertations

Lignin is a major component of decaying terrestrial vegetation in soils and has been arguably reported to contribute substantially to the formation of soil carbon humus, and natural dissolved organic matter (DOM). To better understand the process by which this humification occurs, lignin and lignin-derived monomers were subjected to both biotic and abiotic oxidation processes. Two well-known oxidative transformation strategies were employed. The first involved the fungal degradation of brown-rot degraded wood subjected to a white-rot fungus (Phanerochaete chrysosporium) whose enzymes are particularly effective in lignin degradation via enzymatic oxidation. This enzymatic attack was monitored by ultrahigh resolution …

Highly Transmissive Scalable Colored Coatings For Architectural Photovoltaic Panels, Akbar Ali Syed

Electrical & Computer Engineering Theses & Dissertations

Highly transmissive coatings were developed by fabricating thin films using SiO₂ and SiO₂/TiO₂ core/shell nanoparticles on glass substrates and on the photovoltaic cell glass covers. This coating is to maintain an attractive color appearance of the exterior surface for architecturally integrated photovoltaics and can be coated on fabricated photovoltaic panels. The color and optical properties of the nanoparticle coating was investigated for different nanoparticle diameters of 200-400 nm for SiO₂ nanoparticles and core/shell nanoparticles having SiO₂/TiO₂ structure with 300 ± 11 nm diameter, and SiO₂/TiO₂/SiO₂ structure with …

A Post-Impact Behavior Of Platelet-Based Composites Produced By Compression Molding, Christopher Eugene Ervin Volle

Mechanical & Aerospace Engineering Theses & Dissertations

Prepreg-based Platelet Molded Compounds (PPMCs) are quickly becoming a widely used method for creating structural components in the aerospace and automotive industries. The discontinuous nature of the platelets used allow good formability of both complex and basic structural components; from seats on commercial airplanes to outer panels of vehicles.

This thesis will look at an important research question of these composites: how PPMCs behave under dynamic loading, e.g. impact and post-impact behavior. Impact is analyzed using recorded force and velocity data to find the absorbed energy. Digital image correlation is used with compression after impact testing to study the propagation …

Flexible Electrochemical Lactate Sensor, Peyton Miesse

Biomedical Engineering Theses & Dissertations

Lactic acid is a vital indicator for shock, trauma, stress, and exercise intolerance. It is a key biomarker for increases in stress levels and is the primary metabolically produced acid responsible for tissue acidosis that can lead to muscle fatigue and weakness. During intensive exercise, the muscles go through anerobic metabolism to produce energy. This leads to decreases in the blood flow of nutrients and oxygen to the muscles and increases in lactate production, which in turn cause lactic acidosis. Currently, changes in blood lactate concentrations are monitored by sensors that can be invasive via blood or wearable based sensors …

Truck Trailer Classification Using Side-Fire Light Detection And Ranging (Lidar) Data, Olcay Sahin

Civil & Environmental Engineering Theses & Dissertations

Classification of vehicles into distinct groups is critical for many applications, including freight and commodity flow modeling, pavement management and design, tolling, air quality monitoring, and intelligent transportation systems. The Federal Highway Administration (FHWA) developed a standardized 13-category vehicle classification ruleset, which meets the needs of many traffic data user applications. However, some applications need high-resolution data for modeling and analysis. For example, the type of commodity being carried must be known in the freight modeling framework. Unfortunately, this information is not available at the state or metropolitan level, or it is expensive to obtain from current resources.

Nevertheless, using …