Wearable Devices For Single Cell Sensing And Transfection,
2019
Beihang University, Beijing
Wearable Devices For Single Cell Sensing And Transfection, Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan
Department of Mechanical and Materials Engineering: Faculty Publications
Transdermal drug delivery systems have been successful for decades. Now these devices can be further scaled down, and their applications have been extended to wide selections of cargo, ranging from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles and vaccines). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, …
Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy,
2019
University of Nebraska-Lincoln
Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang
Department of Mechanical and Materials Engineering: Faculty Publications
Solute segregation at dislocations can impede the motion of dislocations, strengthening materials. Here, we study the formation and role of solute segregation at dislocations in CrFeCoNiMo high-entropy alloys (HEAs) by high-angle annular dark-field scanning transmission electron microscopy imaging and mechanical testing both deformed and annealed samples. Mo atoms exhibit pronounced segregation into the planar-extended core of dislocations, i.e. stacking faults, causing the increase in the yield strength while the loss of the ductility. This work suggests that mechanical properties of HEAs can be tailored by alloying additional elements that are in favor of segregation into dislocations.
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy,
2019
Michigan State University
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
Department of Mechanical and Materials Engineering: Faculty Publications
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry. Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets. Here, we report developments of methods to increase the signal-to-noise ratio (SNR) for screening protein-protein interactions using atomic force microscopy (AFM) force spectroscopy. We have demonstrated the effectiveness of these developments on detecting the binding process between focal adhesion kinases (FAK) with protein kinase B (Akt1), which is a target for potential cancer drugs. These developments …
Local Control Robotic Surgical Devices And Related Methods,
2019
Ravenna, NE
Local Control Robotic Surgical Devices And Related Methods, Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Michael Farritor
Department of Mechanical and Materials Engineering: Faculty Publications
The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices.
Medical Inflation, Attachment And Delivery Devices And Related Methods,
2019
Boulder, CO
Medical Inflation, Attachment And Delivery Devices And Related Methods, Mark Rentschler, Shane Michael Farritor
Department of Mechanical and Materials Engineering: Faculty Publications
The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.
Nebraska Summary: S1179 Fendt 936,
2019
University of Nebraska-Lincoln
Nebraska Summary: S1179 Fendt 936, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Nebraska Summary: S1178 Fendt 933,
2019
University of Nebraska-Lincoln
Nebraska Summary: S1178 Fendt 933, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Nebraska Summary: S1177 Fendt 930,
2019
University of Nebraska-Lincoln
Nebraska Summary: S1177 Fendt 930, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Nebraska Summary: S1181 Fendt 942,
2019
University of Nebraska-Lincoln
Nebraska Summary: S1181 Fendt 942, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Nebraska Summary: S1157 John Deere 5125ml,
2019
University of Nebraska-Lincoln
Nebraska Summary: S1157 John Deere 5125ml, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2214: Kubota M7-132,
2019
University of Nebraska-Lincoln
Test 2214: Kubota M7-132, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2208a: New Holland Workmaster 60,
2019
University of Nebraska-Lincoln
Test 2208a: New Holland Workmaster 60, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2209: Case Ih Farmall 70a,
2019
University of Nebraska-Lincoln
Test 2209: Case Ih Farmall 70a, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2208: Case Ih Farmall 60a,
2019
University of Nebraska-Lincoln
Test 2208: Case Ih Farmall 60a, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Test 2216: Kubota M7-172,
2019
University of Nebraska-Lincoln
Test 2216: Kubota M7-172, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Development Of Physics Based Machine Learning Algorithms,
2019
Bucknell University
Development Of Physics Based Machine Learning Algorithms, Rob Jennings
Master’s Theses
In this study, a baseball pitch was examined to try to understand its behavior, and make a predictive model of it. A baseball pitch was tested experimentally with a wind tunnel and modeled computationally with COMSOL CFD software. Five input variables (spin rate, sting angle, seam orientation: Y axis, seam orientation: Z axis, and air velocity) were controlled, with force in three axes recorded as outputs. The experimental and computational results were examined and seen to be interdependent for all input variables. Experimental and computational data were both insufficient for predicting system behavior. Experimental data collection would have required an …
Analysis And Control Of Fiber-Reinforced Elastomeric Enclosures (Frees),
2019
Bucknell University
Analysis And Control Of Fiber-Reinforced Elastomeric Enclosures (Frees), Soheil Habibian
Master’s Theses
While rigid robots are extensively used in various applications, they are limited in the tasks they can perform and can be unsafe in close human-robot interactions. Soft robots on the other hand surpass the capabilities of rigid robots in several ways, such as compatibility with the work environments, degrees of freedom, manufacturing costs, and safe interactions with the environment. This thesis studies the behavior of Fiber-Reinforced Elastomeric Enclosures (FREEs) as a particular type of soft pneumatic actuator that can be used in soft manipulators. A dynamic lumped-parameter model is created to simulate the motion of a single FREE under various …
Influence Of Micro-Nucleate Boiling On Annular Flow Regime Heat Transfer Coefficient Values And Flow Parameters – For High Heat-Flux Flow Boiling Of Water,
2019
Michigan Technological University
Influence Of Micro-Nucleate Boiling On Annular Flow Regime Heat Transfer Coefficient Values And Flow Parameters – For High Heat-Flux Flow Boiling Of Water, Soroush Sepahyar
Dissertations, Master's Theses and Master's Reports
Analysis of results from steady and steady-in-the-mean high heat-flux (15 - 70 W/cm2, with water as working fluid) shear driven annular flow-boiling experiments presented here - and low heat-flux (0.1- 1 W/cm2, with FC-72 as working fluid) experiments presented elsewhere – together lead to a key conclusion. The conclusion is that heat carrying nucleation rates go often undetected by the typically used visualization approaches for flow boiling – as such flows often involve µm- to sub- µm scale bubble diameters in millimeter-scale ducts. These nucleation rates play a significant role in most of the so-called convective …
Experimental Characterization Of Hydraulic System Sound,
2019
Michigan Technological University
Experimental Characterization Of Hydraulic System Sound, Ben Kolb
Dissertations, Master's Theses and Master's Reports
The purpose of this research was to establish test methods for characterizing the interaction between the hydraulic fluid and hydraulic hose at clipping points in mobile heavy equipment hydraulic systems. A simple hydraulic circuit test bench was developed and the laboratory axial piston pump was characterized using ISO 10767-1. A direct relationship between the fluidborne noise and structureborne noise present at each hose clip location was observed for a specific operating condition using operating deflection shapes and structureborne noise measurements. This result shows that optimal hose clip placement can be a viable solution to structureborne noise reduction. Additionally, a modal …
Development Of A Fused Deposition 3d Printed Buoy And Method For Quantifying Wave Tank Reflections,
2019
Michigan Technological University
Development Of A Fused Deposition 3d Printed Buoy And Method For Quantifying Wave Tank Reflections, Samantha G. Swartzmiller
Dissertations, Master's Theses and Master's Reports
Testing model scale prototypes is integral to the development of wave energy converter (WEC) technology. Model scale WECs are tested in wave tanks where they are subjected to repeatable wave fields. Their presence in water creates radiated waves that eventually reflect off tank walls disrupting the intended wave field. Fabrication of model scale WECs is another developing aspect of tank testing. Often model WECs are built of foam. Additive manufacturing is a promising alternative although the most common method, fused deposition modeling (FDM) 3D printing, does not typically produce waterproof parts. The goals of this work were 1) develop a …
