Techniques To Stimulate And Interrogate Cell–Cell Adhesion Mechanics,
2018
University of Nebraska-Lincoln
Techniques To Stimulate And Interrogate Cell–Cell Adhesion Mechanics, Ruiguo Yang, Joshua A. Broussard, Kathleen J. Green, Horacio D. Espinosa
Department of Mechanical and Materials Engineering: Faculty Publications
Cell–cell adhesions maintain the mechanical integrity of multicellular tissues and have recently been found to act as mechanotransducers, translating mechanical cues into biochemical signals. Mechanotransduction studies have primarily focused on focal adhesions, sites of cell-substrate attachment. These studies leverage technical advances in devices and systems interfacing with living cells through cell–extracellular matrix adhesions. As reports of aberrant signal transduction originating from mutations in cell–cell adhesion molecules are being increasingly associated with disease states, growing attention is being paid to this intercellular signaling hub. Along with this renewed focus, new requirements arise for the interrogation and stimulation of cell–cell adhesive junctions. …
Molecular Dynamics Studies On Nanoscale Confined Liquids,
2018
Southern Methodist University
Molecular Dynamics Studies On Nanoscale Confined Liquids, Alper Celebi
Mechanical Engineering Research Theses and Dissertations
Liquid transport in nanochannels have been attracting great interests, especially for last two decades, owing to its potential applicability in various fields including biochemistry, medical science and engineering. For exploring and generating new ideas in the field of nanofluidics, molecular simulation techniques have become an ideal way due to the experimental challenges impeding the field of nanofluidics in fabrication and measurements.
In this dissertation, we perform molecular dynamics simulations to investigate liquid transport behavior in nanoscale channels. The expanse of this dissertation concerns several fundamental topics in nanoscale liquid transport phenomena such as liquid properties in nanoscale confinements, interfacial flows …
Strong And Tough Continuous Nanofibers,
2018
Lincoln, NE
Strong And Tough Continuous Nanofibers, Yuris Dzenis
Department of Mechanical and Materials Engineering: Faculty Publications
Amethod of fabricating a continuous nanofiber is described . The method includes preparing a solution of one or more polymers and one or more solvents and electrospinning the solution by discharging the solution through one or more liquid jets into an electric field to yield one or more continuous nanofibers . The electrospinning process ( i ) highly orients one or more polymer chains in the one or more continuous nanofibers along a fiber axis of the one or more continuous nanofibers , and ( ii ) suppresses polymer crystallization in the one or more continuous nanofibers . The one …
Predict The Failure Of Hydraulic Pumps By Different Machine Learning Algorithms,
2018
School of Agricultural & Biological Engineering, Purdue University
Predict The Failure Of Hydraulic Pumps By Different Machine Learning Algorithms, Yifei Zhou, Monika Ivantysynova, Nathan Keller
The Summer Undergraduate Research Fellowship (SURF) Symposium
Pump failure is a general concerned problem in the hydraulic field. Once happening, it will cause a huge property loss and even the life loss. The common methods to prevent the occurrence of pump failure is by preventative maintenance and breakdown maintenance, however, both of them have significant drawbacks. This research focuses on the axial piston pump and provides a new solution by the prognostic of pump failure using the classification of machine learning. Different kinds of sensors (temperature, acceleration and etc.) were installed into a good condition pump and three different kinds of damaged pumps to measure 10 of …
Design Survey Of Laminated Composite I-Beam,
2018
Utah State University
Design Survey Of Laminated Composite I-Beam, Mrinmoy Saha
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Composite I-beams are popular for high-strength low-weight applications. Learning the macro-mechanics and designing the composite I-beam properly are necessary. In this report, a design overview of the composite I-beam is discussed which is based on classical lamination theory where it includes the homogenization approach, the plane stress assumption and the Kirchhoff hypothesis. Using these assumptions, a method was developed to come up with the effective material properties of a beam. Formulas to calculate maximum deflection and maximum bending stress and shear stress and the stress concentration at the connection of web-flange are discussed which describe ways for designing and manufacturing …
Temperature Effects On Helium Filled Soap Bubble Particle Tracking Velocimetry.,
2018
University of Louisville
Temperature Effects On Helium Filled Soap Bubble Particle Tracking Velocimetry., Michael C. Blum
Electronic Theses and Dissertations
Helium Filled Soap Bubble (HFSB) Particle Tracking Velocimetry (PTV) methods are becoming increasingly popular as they provide a low cost, safe option for reliable flow visualization. Several studies have been conducted to understand the accuracy of such systems under normal temperatures and pressures; however, no such studies to date have examined accuracy of HFSB PTV at high temperatures. The goal of this study is to characterize the capability of HFSB PTV methods to visualize air flow through a rectangular duct at elevated temperature. A heated wind tunnel was designed to heat up to 150 m3/h of 25 °C …
Material-Process-Property Relationships Of 17-4 Stainless Steel Fabricated By Laser-Powder Bed Fusion Followed By Hot Isostatic Pressing.,
2018
University of Louisville
Material-Process-Property Relationships Of 17-4 Stainless Steel Fabricated By Laser-Powder Bed Fusion Followed By Hot Isostatic Pressing., Harish Irrinki
Electronic Theses and Dissertations
17-4 PH stainless steel is commonly used in medical, tooling, automotive, chemical and aerospace industries due to its excellent strength and corrosion properties. Additive manufacturing processes such as laser-powder bed fusion (L-PBF) have gained attention and importance due to the potential to produce complex-shaped three-dimensional parts for various industries. In order to manufacture three-dimensional components from 17-4 PH stainless steel powder using L-PBF, it is critical for design and manufacturing engineers to have an awareness of various material options and corresponding processing and post-processing conditions to obtain useful mechanical properties from the process. The goal of this dissertation is to …
Modeling And Validations Of Control Parameters For Material Extrusion-Based Additive Manufacturing Of Thixotropic Aluminum Alloys.,
2018
University of Louisville
Modeling And Validations Of Control Parameters For Material Extrusion-Based Additive Manufacturing Of Thixotropic Aluminum Alloys., Lars Herhold
Electronic Theses and Dissertations
Additive Manufacturing (AM) with metals has been accomplished mainly through powder bed fusion processes. Initial experiments and simulations using Material Extrusion Additive Manufacturing (MEAM) have been performed by various researchers especially using low melting alloys. Recently Stratasys Inc. submitted a patent application for the use of their Material Extrusion technology also called Fused Deposition Modeling (FDM) where they describe the process using thixotropic semi-solid alloys. Currently this process using semi-solid, engineering type alloys such as A356 or THIXALLOY 540 aluminum have not been researched to evaluate the control parameters. This research combines the in-depth knowledge of applying thixotropic semi-solid aluminum …
Impact Of Extended Sintering Times On Mechanical Properties In Pa-12 Parts Produced By Powderbed Fusion Processes,
2018
University of South Florida
Impact Of Extended Sintering Times On Mechanical Properties In Pa-12 Parts Produced By Powderbed Fusion Processes, Garrett Craft, Justin Nussbaum, Nathan B. Crane, J. P. Harmon
Faculty Publications
Additive Manufacturing provides many advantages in reduced lead times and increased geometric freedom compared to traditional manufacturing methods, but material properties are often reduced. This paper considers powder bed fusion of polyamide 12 (PA12, Nylon 12) produced by three different processes: laser sintering (LS), multijet fusion (MJF)/high speed sintering (HSS), and large area projection sintering (LAPS). While all utilize similar PA12 materials, they are found to differ significantly in mechanical properties especially in elongation to break. The slower heating methods (MJF/HSS and LAPS) produce large elongation at break with the LAPS process showing 10x elongation and MJF/HSS exhibiting 2.5x the …
Experimental And Theoretical Investigation Of Mechanical Response Of Laser-Sintered Diamond Lattice Structures,
2018
University of South Florida
Experimental And Theoretical Investigation Of Mechanical Response Of Laser-Sintered Diamond Lattice Structures, Clayton Neff, Neil Hopkinson, Nathan B. Crane
Faculty Publications
Typically additive manufacturing (AM) processes are limited to a single material per part while many products benefit from the integration of multiple materials with varied properties. To achieve the benefits of multiple materials, the geometric freedom of AM could be used to build internal structures that emulate a range of different material properties such as stiffness, Poisson’s ratio, and elastic limit using only one build material. This paper examines the range of properties that can be simulated using diamond lattice structures manufactured from Nylon 12 with a commercial laser sintering process. Diamond lattices were fabricated with a unit cell length …
Near-Field Heat Transfer Enabled Nanothermomechanical Memory And Logic Devices,
2018
University of Nebraska-Lincoln
Near-Field Heat Transfer Enabled Nanothermomechanical Memory And Logic Devices, Sidy Ndao, Mahmoud Elzouka
Department of Mechanical and Materials Engineering: Faculty Publications
A thermomechanical memory / logic device is disclosed . In embodiments , the thermomechanical device includes a first thermally controlled terminal ( e . g . , hot terminal ) ; a second thermally controlled terminal ( e . g . , cool terminal / base ) ; a stem or other structure that can be thermally expanded connected to the cool terminal ; and a thermal conductive head coupled to the stem . The head can exchange heat with the hot terminal . The stem and head are between the first thermally controlled terminal and the second thermally controlled …
Design For Maintainability In Developing Communities—A Case Study On The Uros Islands,
2018
Brigham Young University
Design For Maintainability In Developing Communities—A Case Study On The Uros Islands, Thomas Barlow
Undergraduate Honors Theses
Designing products for developing communities has exposed many of the underlying assumptions that engineers from developed nations have during the design process. There has been much written about these underlying assumptions in order to create a better framework for designing for developing communities. One unexplored, yet important area is the universality of common maintainability principles used in developed countries when designing products used in developing communities. Such principles include: simplicity, diagnosability, standardization of parts, modular subassemblies, minimizing assembly and disassembly parts, labeling components, increased life of moving parts, manuals, and simplifying tools needed for repairs [1]–[3]. The purpose of this …
Prevascularization Of 3d Printed Bone Scaffolds By Bioactive
Hydrogels And Cell Co-Culture,
2018
University of Nebraska Medical Center
Prevascularization Of 3d Printed Bone Scaffolds By Bioactive Hydrogels And Cell Co-Culture, Mitchell Kuss, Shaohua Wu, Ying Wang, Jason B. Untrauer, Wenlong Li, Jung Yul Lim, Bin Duan
Department of Mechanical and Materials Engineering: Faculty Publications
Vascularization is a fundamental prerequisite for large bone construct development and remains one of the main challenges of bone tissue engineering. Our current study presents the combination of 3D printing technique with a hydrogel-based prevascularization strategy to generate prevascularized bone constructs. Human adipose derived mesenchymal stem cells (ADMSC) and human umbilical vein endothelial cells (HUVEC) were encapsulated within our bioactive hydrogels, and the effects of culture conditions on in vitro vascularization were determined. We further generated composite constructs by forming 3D printed polycaprolactone/hydroxyapatite scaffolds coated with cell-laden hydrogels and determined how the co-culture affected vascularization and osteogenesis. It was demonstrated …
Smart Bandage For Monitoring And Treatment Of Chronic Wounds,
2018
Harvard Medical School
Smart Bandage For Monitoring And Treatment Of Chronic Wounds, Pooria Mostafalu, Ali Tamayol, Rahim Rahimi, Manuel Ochoa, Akbar Khalilpour, Gita Kiaee, Iman K. Yazdi, Sara Bagherifard, Mehmet R. Dokmeci, Babak Ziaie, Sameer R. Sonkusale, Ali Khademhosseini
Department of Mechanical and Materials Engineering: Faculty Publications
Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to …
Migration Resistance Of Esophageal Stents: The Role Of Stent Design,
2018
University of Nebraska-Lincoln
Migration Resistance Of Esophageal Stents: The Role Of Stent Design, Hozhabr Mozafari, Pengfei Dong, Shijia Zhao, Yonghua Bi, Xinwei Han, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
Objective: Stenting is one of the major treatments for malignant esophageal cancer. However, stent migration compromises clinical outcomes. A flared end design of the stent diminishes its migration. The goal of this work is to quantitatively characterize stent migration to develop new strategies for better clinical outcomes.
Methods: An esophageal stent with flared ends and a straight counterpart were virtually deployed in an esophagus with asymmetric stricture using the finite element method. The resulted esophagus shape, wall stress, and migration resistance force of the stent were quantified and compared.
Results: The lumen gain for both the flared stent and the …
Evaluation Of Processing Variables In Polymer Projection Sintering,
2018
University of South Florida, Tampa
Evaluation Of Processing Variables In Polymer Projection Sintering, Justin Nussbaum, Nathan B. Crane
Faculty Publications
Purpose – Projection sintering, a system for selectively sintering large areas of polymer powder simultaneously with a high power projector is introduced. The paper evaluates the suitability of laser sintering process parameters for projection sintering as it uses substantially lower intensities, longer exposure times, and larger areas than conventional laser sintering (LS).
Design/methodology/approach – The tradeoffs in sintering outcomes are evaluated by creating single layer components with varied exposure times and optical intensities. Some of these components were cross-sectioned and evaluated for degree of densification while the single layer thickness and the maximum tensile force was measured for the rest. …
Efficient Adjacency Queries And Dynamic Refinement For Meshfree Methods With Applications To Explicit Fracture Modeling,
2018
University of South Florida
Efficient Adjacency Queries And Dynamic Refinement For Meshfree Methods With Applications To Explicit Fracture Modeling, James Olliff
USF Tampa Graduate Theses and Dissertations
Meshfree methods provide a more practical approach to solving problems involving large deformation and modeling fracture compared to the Finite Element Method (FEM). However meshfree methods are more computationally intensive compared to FEM, which can limit their practicality in engineering. Meshfree methods also lack a clear boundary definition, restricting available visualization techniques. Determining particle locations and attributes such that a consistent approximation is ensured can be challenging in meshfree methods, especially when employing h-refinement. The primary objective of this work is to address the limitations associated with computational efficiency, meshfree domain discretization, and h-refinement, including both placement of particles as …
Transient Heat Storage Systems,
2018
California Polytechnic State University, San Luis Obispo
Transient Heat Storage Systems, Ian M. Sweeney, Brock M. Johnson, Todd K. Lundberg
Mechanical Engineering
Phase change materials (PCM) have many applications in transient cooling systems, including those with high transient heat loads and low duty cycles. These materials allow a system to remain within a narrow temperature range with a relatively low weight compared to conventional heat sinks or high-power cooling systems. This senior capstone project includes the design of a PCM based thermal energy storage system to integrate into an existing cooling loop, as well as a determination of viable PCM’s for the application. This report contains the necessary information to build the test apparatus.
Theatrical Turntable,
2018
California Polytechnic State University, San Luis Obispo
Theatrical Turntable, Liam R. Martinez, Isaac Becker, Robert R. Reed, Caroline A. Whelan
Mechanical Engineering
No abstract provided.
Retractable Hammock,
2018
California Polytechnic State University, San Luis Obispo
Retractable Hammock, Collin J. Richardson, Jesse Bryn Mandell, Owen Alle Guenther
Mechanical Engineering
This Final Design Review will recap the objectives, background, design ideation, and concept development of the Retractable Hammock senior capstone project and continue to report on the final design and manufacturing that resulted in the final iteration of the Retractable Hammock.
