Dynamic, Reconfigurable, And Hierarchical Biosynthetic Composites Via Collagen Self-Assembly Within Highly Crowded Microgel Pastes,
2025
Chapman University
Dynamic, Reconfigurable, And Hierarchical Biosynthetic Composites Via Collagen Self-Assembly Within Highly Crowded Microgel Pastes, Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E. Daniel Cárdenas-Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy, Marco Bisoffi, L. Andrew Lyon
Engineering Faculty Articles and Research
The fabrication of a new class of biomimetic biomaterials is reported using nanostructured microgel pastes formed from “overpacked” assemblies of ultrasoft poly(N-isopropyl acrylamide-co-acrylic acid) microgels and their composites with collagen. Despite the solid-like nature of microgel pastes, collagen fibrillogenesis is robust and rapid, with a 3D collagen network forming throughout the paste volume. Structural organization within the composite is interrogated via a suite of microscopy methods, while rheological characterization provides insight into the static and dynamic mechanical properties of the materials. Long-range fibrillogenesis is enabled by local crowding, dynamics, and spatial reconfigurability of pastes at the …
Degradation Of Cobalt Chrome Molybdenum Hip And Knee Implants In Vivo And In Vitro,
2025
Clemson University
Degradation Of Cobalt Chrome Molybdenum Hip And Knee Implants In Vivo And In Vitro, Peter William Kurtz
All Dissertations
Cobalt Chrome Molybdenum (CoCrMo) remains a popular material choice for femoral condyles in total knee arthroplasty and for acetabular liners in dual mobility total hip designs. CoCrMo has been phased out of conventional THA designs due to its correlation with adverse effects such as ALTR and ALVAL. It is less understood if the mechanisms (i.e. abrasive wear to the surface of the implant) that release metal ions into the surrounding tissue occur at similar rates as seen in conventional THA. Additionally, it is unknown what effect the secondary damage modes such as electrocautery damage and adhesive wear have on these …
Scientific Characterization Of Historic Mortars Dating From The 15th-Century Of A Historical Building In Algeria: A Case Study,
2025
University of Science and Technology Houari Boumedienne, USTHB, Algiers, Algeria
Scientific Characterization Of Historic Mortars Dating From The 15th-Century Of A Historical Building In Algeria: A Case Study, M. E. Belgacem, N. Rabahi-Touloum, R. Neves, Y. Ouldkhaoua
Journal of Sustainable Construction Materials and Technologies
This research investigates the historic mortars (Aggregate/Binder (A/B) ratio) of a historical patrimony building, dating from the 15th century, in Algeria, for restoration purposes. It is well known that thorough characterization is essential for successful restoration. To this end, several techniques, including Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), and X-ray Fluorescence (XRF), optical microscope were used to characterize the historic mortars. A mechanical test was used to characterize the compressive strength of a historic mortar. For a comprehensive characterization, A/B ratios were estimated using both Digital Image Analyses (DIA) and chemical analyses. The results obtained provided clear information on …
Stress-Relaxation And Failure Properties Of Spinal Ligaments In Pigs With And Without Scoliosis-Like Deformity,
2025
Thomas Jefferson University
Stress-Relaxation And Failure Properties Of Spinal Ligaments In Pigs With And Without Scoliosis-Like Deformity, Christian D'Andrea, Mattan Orbach, Dogerno Norceide, Madeline Boyes, Axel Moore, Jacob Jordan, Thomas Schaer, Anita Singh, Patrick Cahill, Edward Vresilovic, Brian Snyder, Sriram Balasubramanian
Student Papers, Posters & Projects
This study addresses the need for accurate tissue material properties in computational models of the spine. Fundamental to functional spinal unit (FSU) biomechanics are the stress-relaxation and failure properties of the interspinous and intertransverse ligaments (ISL and ITL, respectively). These were measured and compared in normative and scoliotic spines using a Yorkshire pig model. Skeletally immature female pig spines were posterolaterally tethered to induce scoliosis. 23 ISLs and 17 ITLs excised from normative and scoliotic spine segments underwent stress-relaxation and failure tests. Group comparisons tested the effects of scoliosis (magnitude, convexity versus concavity), spinal level (thoracic, lumbar), and pig age. …
Evaluation Of An In Situ Forming Composite Hydrogel Based On Gelatin–Sodium Alginate– Polyethylene Oxide For Biomedical Applications: Effect Of Incorporated Sophora Japonica On Hydrogel Performance,
2025
The British University in Egypt
Evaluation Of An In Situ Forming Composite Hydrogel Based On Gelatin–Sodium Alginate– Polyethylene Oxide For Biomedical Applications: Effect Of Incorporated Sophora Japonica On Hydrogel Performance, Samar A. Salim
Nanotechnology Research Centre
Hydrogels are ideal candidates for biomedical applications such as wound healing, tissue engineering, and bone regeneration due to their porosity and similarity to the extracellular matrix of humans. A gelatin/ sodium alginate (SA) hydrogel with the inclusion of polyethylene oxide (PEO) was utilized to achieve enhanced mechanical strength. Hydrogels were prepared at different ratios of polymer solutions to select the hydrogel that exhibited an optimal gelation time. Sophora japonica, a plant leaf extract (SJLE) rich in flavonoids and isoflavonoids, was added to the hydrogel to enhance tissue repair. The developed hydrogels were extensively characterized for their morphology, porosity, and swelling …
Impact Of Ionizable Lipid Variation On The Immunogenicity Of Lipid Nanoparticles,
2025
DePauw University
Impact Of Ionizable Lipid Variation On The Immunogenicity Of Lipid Nanoparticles, Chloe M. Krueger, Abbey L. Stokes, Shilpi Agrawl, Christopher E. Nelson
Annual Student Research Poster Session
Lipid nanoparticles (LNPs) are a leading nonviral delivery system for nucleic acid therapeutics due to their scalability and efficiency. However, certain formulations may trigger undesired immune responses. This study aimed to assess the inflammatory potential of LNPs formulated with different ionizable lipids using a murine macrophage reporter cell line (RAW-IRCs). RAW-IRCs express GFP upon successful mRNA delivery and mRFP1 upon activation of inflammatory pathways. A library of LNPs was synthesized via vortex mixing and characterized for hydrodynamic diameter, polydispersity index, and encapsulation efficiency. Treated RAW-IRCs were analyzed by flow cytometry to evaluate GFP and mRFP1 expression. Our results highlight seven …
Characterization Of The Fatigue Threshold Behavior Of Uhmwpe,
2025
University of California - Berkeley
Characterization Of The Fatigue Threshold Behavior Of Uhmwpe, Bethany B. Smith, Anurag Roy, Robert O. Ritchie, Lisa A. Pruitt
Faculty Journal Articles
Ultra-high-molecular-weight-polyethylene (UHMWPE) has been the material of choice for bearings in total joint replacements (TJRs) for decades as a result of its excellent wear resistance, chemical inertness, energetic toughness, low friction, and biocompatibility. Utilization of this polymer in orthopedic devices requires oxidation, wear, and fatigue resistance. Balancing these important properties by tailoring processing techniques and modulating microstructural features has been an ongoing endeavor in the field. Research into the clinical applications of UHMWPE has primarily focused on the challenges of wear and oxidation while studies into the realm of fatigue have been more limited. Literature gaps exist in fully understanding …
Comparison Of Peening Effect Between Additive Manufacutred And Drawing Titanium Alloy,
2025
Tohoku University
Comparison Of Peening Effect Between Additive Manufacutred And Drawing Titanium Alloy, Hitoshi Soyama
15th International Conference on Shot Peening
Although additively manufactured (AM) metals are attractive materials, their remarkable weak fatigue properties are an obstacle to their practical application. Thus, post-processing to improve their fatigue properties is required. In the present study, powder bed fusion using laser sintering titanium alloy, i.e., PBF-LS/Ti6Al4V was treated by shot peening (SP), submerged laser peening (SLP), cavitation peening (CP), and fine particle bombarding (FPB), then the fatigue properties were investigated by a torsional fatigue test, comparing with drawing Ti6Al4V. It was revealed that the fatigue strength at 107 was 446 ± 5 MPa for PBF-LS/Ti6Al4V treated by FPB+CP, 359 ± 9 MPa …
Nonlinear Analytical Models Of The Seismically Isolated ``Frame-Boiler'' System With Cantilever-Type Hysteresis Dampers,
2025
CKTI-VIBROSEISM Co. Ltd., Saint-Petersburg, Gzhatskaya str., 9, 195251, Russian Federation
Nonlinear Analytical Models Of The Seismically Isolated ``Frame-Boiler'' System With Cantilever-Type Hysteresis Dampers, Aleksandr Mikhailovich Anushchenko, Dmitrii Evgenievich Bondarev, Aleksandr Yurievich Schukin
Journal of Sustainable Construction Materials and Technologies
This study shows results of development of the ``frame-boiler'' system with hysteresis dampers analytical model. Hysteresis dampers are used as boiler antiseismic bracing. It is noted that simplified analytical models are necessary at the stage of preliminary iterative calculations, when a CAE-modeling is impractical due to significant time costs. The authors have proposed 2 options of analytical models: 2-mass model and 3-mass model. The differential equations of motion for each model are written below. The results of the calculation for seismic impacts are compared with the finite element model. It is shown that 3-mass model gives good match of results …
Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development,
2025
Assistant Professor, Department of Engineering & Sustainable Technologies, Frostburg State University, Frostburg, MD, USA
Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development, Thomas Cadenazzi, Busra Keles
Journal of Sustainable Construction Materials and Technologies
This paper investigates innovative Hemp Fiber-Reinforced Polymer (HFRP) rebars as a sustainable alternative to conventional Carbon Steel (CS) and Glass Fiber-Reinforced Polymer (GFRP) rebars used as reinforcement in concrete structures. The feasibility of HFRP rebars is assessed, focusing on mechanical properties and sustainability advantages. A virtual tensile test on a modeled M19 HFRP rebar, conducted using Autodesk's Fusion 360, demonstrates tensile strength comparable to CS 235 and greater environmental sustainability than GFRP, despite a slight reduction in stiffness. The study also considers the potential of graphene fiber integration to enhance mechanical properties, underscoring HFRP's adaptability. Findings suggest that HFRP rebars, …
Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings,
2025
Bursa Uludağ AND University, Graduate School of Natural and Applied Sciences, Department of Architecture, Görükle, Nilüfer, Bursa, Türkiye
Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings, Sadık Akşar, Gökçe Tuna
Journal of Sustainable Construction Materials and Technologies
Wood has long been used as a primary building material, but with the Industrial Revolution and the spread of multi-story structures, its structural limitations became evident. In the 21st century, engineered timber products have reintroduced wood as a sustainable alternative, offering advantages such as lightness, rapid assembly, and recyclability. At the same time, buildings are responsible for significant environmental impacts, making assessment methods essential. Life Cycle Assessment (LCA) is one of the most widely used tools for evaluating these impacts across all stages of a building’s life cycle. This study applies LCA to timber construction systems, focusing on both traditional …
Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties,
2025
Department of Physics, IPB University, Bogor 16680, Indonesia AND Surfactant and Bioenergy Research Center (SBRC), IPB University Baranangsiang Campus, Jl Raya Pajajaran Bogor 16153
Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties, Siti Nikmatin, Allen Kurniawan, Heriansyah Putra, Rima Fitria Adiati, Riawan Ma’Ruf, Dwi Arso Yedi Irwanto
Journal of Sustainable Construction Materials and Technologies
This study investigated the potential use of rejected coal as a fine aggregate filler in paving block production. Comprehensive characterization of the rejected coal was conducted, including toxicity, physical, chemical, and mineralogical analyses of the coal. The results showed that the rejected coal met environmental safety standards (TCLP) and had suitable properties as an aggregate. Paving blocks were produced by incorporating different proportions of rejected coal fillers and were tested for compressive strength, water absorption, and density. The optimal mix with 35% rejected coal filler as a replacement of stone ash achieved a compressive strength of 14.61 MPa, water absorption …
Numerical Comparative Study Of The Thermal Performance And Load-Bearing Capacity Of Hollow Clay Bricks Used In Construction In Libya,
2025
Sabratha University, Faculty of Engineering, Department of Mechanical Engineering, Sabratha 26.27.151, Libya
Numerical Comparative Study Of The Thermal Performance And Load-Bearing Capacity Of Hollow Clay Bricks Used In Construction In Libya, Osama Lawej, Mahmoud Ahmed, Ismael Ehtiwesh
Journal of Sustainable Construction Materials and Technologies
The optimization of structural and thermal performance in building components is a key challenge in sustainable construction, particularly in hot climate regions like Libya. Hollow clay bricks are widely used due to their local availability and affordability; however, their internal geometry is often not optimized for thermal resistance or mechanical integrity. This study addresses this gap by numerically investigating the effect of cavity geometry on the load-bearing capacity and thermal insulation performance of hollow clay bricks. Three configurations were analyzed, including two commercial designs from the Libyan market and a newly proposed arched cavity design. Finite Element Method (FEM) simulations …
Developing A Modular Circular Wall Over-Clad System For Facade Thermal Upgrade In Deep Energy Retrofit,
2025
Principle Investigator/Author Drive 0 Project Ireland AND School of Architecture and Built Environment, Technical University of Dublin, Ireland
Developing A Modular Circular Wall Over-Clad System For Facade Thermal Upgrade In Deep Energy Retrofit, Patrick Daly
Journal of Sustainable Construction Materials and Technologies
The EU has implemented several policy and legislative initiatives aimed at decarbonisation and circularity transition of the Built Environment including a strategy for large scale renovation of the building / housing stock. Modularised construction solutions are argued to be a potential acceleration pathway toward this objective. Yet there remains issues and challenges in implementing such strategies in a complex and heterogeneous stock and sector. This research investigates this decarbonisation pathway, examining the feasibility and potential of applying a modularised construction over-clad system, based on advanced circularity, in the deep energy retrofit of social housing. The research is based on a …
Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments,
2025
The British University in Egypt
Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments, Samar A. Salim, Abdullah Elbadry, Eman Gomaa, Mennatullah Faisal, Elbadawy A. Kamoun
Nanotechnology Research Centre
The development of advanced wound dressings capable of accelerating healing and achieving effective hemostasis remains a critical challenge in managing traumatic and surgical wounds. This study reports the fabrication and comprehensive evaluation of a novel multilayered, sandwich-structured nanofiber scaffold composed of Tranexamic acid (TXA), chitosan (CS), polyvinyl alcohol (PVA), L-arginine, and polylactic acid (PLA) for biodegradable wound dressing applications. Using sequential electrospinning, a four-layered scaffold was developed as a smart wound dressing, comprising an immediate-release TXA-CS-PVA layer for rapid clotting, a hydrophobic PLA barrier layer for protection, a sustained-release L-arginine-PVA layer to promote tissue regeneration, and a final PLA protective …
Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation,
2025
The British University in Egypt
Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation, Samar A. Salim, Mohamed Ali, Tasneem Abed, El Badawy Kamoun
Nanotechnology Research Centre
Coumarin-nitrogen heterocyclic compounds (e.g. quinoline, acridine, and phthalazine) were synthesized by facile reactions and elucidated by FTIR, 1H, and 13C-NMR analyses, which showed consistency with the expected structures. Coumarin-quinoline (drug A)- and coumarin-acridine (drug B)-loaded electrospun PMMA/PVP nanofibrous scaffolds were fabricated using electrospinning techniques. Results showed a successful PMMA/PVP blend, which formed the matrix that was used as the main scaffold for drug loading/release. The drugs (A and B) were encapsulated within the matrix as verified by IR and SEM results. Bio-evaluation through cytotoxicity and anticancer screening was conducted using the MTT assay against lung fibroblast (Wi-38), colon carcinoma (Caco-2), …
Predicting The Response Of Tendon-Driven Prosthetic Finger With Hyperelastic Joints,
2025
University of Nevada, Las Vegas
Predicting The Response Of Tendon-Driven Prosthetic Finger With Hyperelastic Joints, Lucas Gallup, Mohamed Trabia, Brendan O'Toole
Mechanical Engineering Faculty Research
Properly designed prosthetics hands can enhance the quality of life for those suffering from limb loss. Recently, 3D-printed prosthetic hands are becoming common. In these prostheses, fingers flex through the tendons that are activated by motion of the wrist. To provide spring action, thermoplastic polyurethane (TPU) hyperelastic joints are used to connect digits to each other as well as to the wrist. While these designs are common, no model for the relationship between tendon tension and joint flexion is available. This work has developed a quasi-static virtual work-based model to predict the relationship between tendon forces and the flexion of …
Ceramic Waste As Sustainable Material In Self-Compacting Concrete: Experimental Study And Ann Predictive Modeling,
2025
Faculty of Technology, Laboratory of Construction Engineering and Architecture (LGCA), University of Bejaia, 06000 Bejaia, Algeria
Ceramic Waste As Sustainable Material In Self-Compacting Concrete: Experimental Study And Ann Predictive Modeling, Abderrezak Bouziane, Houssam Slimanou, Mohamed Amin Bouzidi, Nedjima Bouzidi
Journal of Sustainable Construction Materials and Technologies
Recycling of ceramic waste in the construction sector is a promising option for reducing the environmental impacts of the concrete industry. The main objective of this study is the elaboration of a solid predictive model for ceramic waste based self-compacting (SCC) concrete properties, using artificial neural networks (ANN). This further, reduces its environmental impact without compromising satisfactory performance. An experimental approach was adopted with different substitution ratios: 0 to 30 wt% and particle sizes ranging from 3-8 mm and 8-15 mm. Tested properties of modified SCC as compressive strength at 7 and 28 days (fc7, fc28), spread (L), sieve stability …
Comparative Study On The Performance Of Ggbs, Uggbs, And Rha-Incorporated Cement Mortar Mixes,
2025
Research Scholar, School of Construction, NICMAR University, Pune-411025, Maharashtra, India
Comparative Study On The Performance Of Ggbs, Uggbs, And Rha-Incorporated Cement Mortar Mixes, Devansh Goel, Sudarshan D. Kore
Journal of Sustainable Construction Materials and Technologies
The environmental footprint of cement production has accelerated the pursuit of sustainable alternatives in the construction industry. Supplementary cementitious materials (SCMs), particularly those derived from industrial and agricultural waste, offer a promising approach to reducing cement consumption while maintaining performance. This study evaluates the fresh and mechanical behavior of binary, ternary, and quaternary cementitious mortar blends incorporating ground granulated blast-furnace slag (GGBS), ultrafine GGBS (UGGBS), and rice husk ash (RHA) as partial replacements for cement. A total of 32 mortar mixes were designed with water-to-binder (w/b) ratios ranging from 0.3 to 0.5 and varied replacement levels of RHA (0-20%), GGBS …
Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses,
2025
Clemson University
Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses, Hwaran Lee
All Dissertations
Mechanically assisted corrosion and non-mechanically (chemically) driven corrosion in modular junctions of orthopedic implants using cobalt-chromium-molybdenum (CoCrMo) alloys remain clinical concerns and may contribute to implant failure. The underlying corrosion mechanisms are not yet fully understood, leaving a critical research gap. We hypothesized that corrosion in modular junctions may be driven by aggressive local environments, including fretting, metal ion release (cobalt ion, Co2+), low pH and reactive oxygen species (ROS). This dissertation aims to (1) analyze corrosion modes and potential causes in modular junctions; (2) identify chemically driven corrosion modes on CoCrMo alloys using simulated inflammatory modular taper …
