Impact Of Ionizable Lipid Variation On The Immunogenicity Of Lipid Nanoparticles,
2025
DePauw University
Impact Of Ionizable Lipid Variation On The Immunogenicity Of Lipid Nanoparticles, Chloe M. Krueger, Abbey L. Stokes, Shilpi Agrawl, Christopher E. Nelson
Annual Student Research Poster Session
Lipid nanoparticles (LNPs) are a leading nonviral delivery system for nucleic acid therapeutics due to their scalability and efficiency. However, certain formulations may trigger undesired immune responses. This study aimed to assess the inflammatory potential of LNPs formulated with different ionizable lipids using a murine macrophage reporter cell line (RAW-IRCs). RAW-IRCs express GFP upon successful mRNA delivery and mRFP1 upon activation of inflammatory pathways. A library of LNPs was synthesized via vortex mixing and characterized for hydrodynamic diameter, polydispersity index, and encapsulation efficiency. Treated RAW-IRCs were analyzed by flow cytometry to evaluate GFP and mRFP1 expression. Our results highlight seven …
Characterization Of The Fatigue Threshold Behavior Of Uhmwpe,
2025
University of California - Berkeley
Characterization Of The Fatigue Threshold Behavior Of Uhmwpe, Bethany B. Smith, Anurag Roy, Robert O. Ritchie, Lisa A. Pruitt
Faculty Journal Articles
Ultra-high-molecular-weight-polyethylene (UHMWPE) has been the material of choice for bearings in total joint replacements (TJRs) for decades as a result of its excellent wear resistance, chemical inertness, energetic toughness, low friction, and biocompatibility. Utilization of this polymer in orthopedic devices requires oxidation, wear, and fatigue resistance. Balancing these important properties by tailoring processing techniques and modulating microstructural features has been an ongoing endeavor in the field. Research into the clinical applications of UHMWPE has primarily focused on the challenges of wear and oxidation while studies into the realm of fatigue have been more limited. Literature gaps exist in fully understanding …
Comparison Of Peening Effect Between Additive Manufacutred And Drawing Titanium Alloy,
2025
Tohoku University
Comparison Of Peening Effect Between Additive Manufacutred And Drawing Titanium Alloy, Hitoshi Soyama
15th International Conference on Shot Peening
Although additively manufactured (AM) metals are attractive materials, their remarkable weak fatigue properties are an obstacle to their practical application. Thus, post-processing to improve their fatigue properties is required. In the present study, powder bed fusion using laser sintering titanium alloy, i.e., PBF-LS/Ti6Al4V was treated by shot peening (SP), submerged laser peening (SLP), cavitation peening (CP), and fine particle bombarding (FPB), then the fatigue properties were investigated by a torsional fatigue test, comparing with drawing Ti6Al4V. It was revealed that the fatigue strength at 107 was 446 ± 5 MPa for PBF-LS/Ti6Al4V treated by FPB+CP, 359 ± 9 MPa …
Nonlinear Analytical Models Of The Seismically Isolated ``Frame-Boiler'' System With Cantilever-Type Hysteresis Dampers,
2025
CKTI-VIBROSEISM Co. Ltd., Saint-Petersburg, Gzhatskaya str., 9, 195251, Russian Federation
Nonlinear Analytical Models Of The Seismically Isolated ``Frame-Boiler'' System With Cantilever-Type Hysteresis Dampers, Aleksandr Mikhailovich Anushchenko, Dmitrii Evgenievich Bondarev, Aleksandr Yurievich Schukin
Journal of Sustainable Construction Materials and Technologies
This study shows results of development of the ``frame-boiler'' system with hysteresis dampers analytical model. Hysteresis dampers are used as boiler antiseismic bracing. It is noted that simplified analytical models are necessary at the stage of preliminary iterative calculations, when a CAE-modeling is impractical due to significant time costs. The authors have proposed 2 options of analytical models: 2-mass model and 3-mass model. The differential equations of motion for each model are written below. The results of the calculation for seismic impacts are compared with the finite element model. It is shown that 3-mass model gives good match of results …
Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development,
2025
Assistant Professor, Department of Engineering & Sustainable Technologies, Frostburg State University, Frostburg, MD, USA
Advancing Sustainable Structural Solutions: Hemp Fiber-Reinforced Polymer (Hfrp) Reinforcement Bars For Concrete Applications Through Material Selection, Simulation, And Pathways For Future Development, Thomas Cadenazzi, Busra Keles
Journal of Sustainable Construction Materials and Technologies
This paper investigates innovative Hemp Fiber-Reinforced Polymer (HFRP) rebars as a sustainable alternative to conventional Carbon Steel (CS) and Glass Fiber-Reinforced Polymer (GFRP) rebars used as reinforcement in concrete structures. The feasibility of HFRP rebars is assessed, focusing on mechanical properties and sustainability advantages. A virtual tensile test on a modeled M19 HFRP rebar, conducted using Autodesk's Fusion 360, demonstrates tensile strength comparable to CS 235 and greater environmental sustainability than GFRP, despite a slight reduction in stiffness. The study also considers the potential of graphene fiber integration to enhance mechanical properties, underscoring HFRP's adaptability. Findings suggest that HFRP rebars, …
Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings,
2025
Bursa Uludağ AND University, Graduate School of Natural and Applied Sciences, Department of Architecture, Görükle, Nilüfer, Bursa, Türkiye
Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings, Sadık Akşar, Gökçe Tuna
Journal of Sustainable Construction Materials and Technologies
Wood has long been used as a primary building material, but with the Industrial Revolution and the spread of multi-story structures, its structural limitations became evident. In the 21st century, engineered timber products have reintroduced wood as a sustainable alternative, offering advantages such as lightness, rapid assembly, and recyclability. At the same time, buildings are responsible for significant environmental impacts, making assessment methods essential. Life Cycle Assessment (LCA) is one of the most widely used tools for evaluating these impacts across all stages of a building’s life cycle. This study applies LCA to timber construction systems, focusing on both traditional …
Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties,
2025
Department of Physics, IPB University, Bogor 16680, Indonesia AND Surfactant and Bioenergy Research Center (SBRC), IPB University Baranangsiang Campus, Jl Raya Pajajaran Bogor 16153
Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties, Siti Nikmatin, Allen Kurniawan, Heriansyah Putra, Rima Fitria Adiati, Riawan Ma’Ruf, Dwi Arso Yedi Irwanto
Journal of Sustainable Construction Materials and Technologies
This study investigated the potential use of rejected coal as a fine aggregate filler in paving block production. Comprehensive characterization of the rejected coal was conducted, including toxicity, physical, chemical, and mineralogical analyses of the coal. The results showed that the rejected coal met environmental safety standards (TCLP) and had suitable properties as an aggregate. Paving blocks were produced by incorporating different proportions of rejected coal fillers and were tested for compressive strength, water absorption, and density. The optimal mix with 35% rejected coal filler as a replacement of stone ash achieved a compressive strength of 14.61 MPa, water absorption …
Numerical Comparative Study Of The Thermal Performance And Load-Bearing Capacity Of Hollow Clay Bricks Used In Construction In Libya,
2025
Sabratha University, Faculty of Engineering, Department of Mechanical Engineering, Sabratha 26.27.151, Libya
Numerical Comparative Study Of The Thermal Performance And Load-Bearing Capacity Of Hollow Clay Bricks Used In Construction In Libya, Osama Lawej, Mahmoud Ahmed, Ismael Ehtiwesh
Journal of Sustainable Construction Materials and Technologies
The optimization of structural and thermal performance in building components is a key challenge in sustainable construction, particularly in hot climate regions like Libya. Hollow clay bricks are widely used due to their local availability and affordability; however, their internal geometry is often not optimized for thermal resistance or mechanical integrity. This study addresses this gap by numerically investigating the effect of cavity geometry on the load-bearing capacity and thermal insulation performance of hollow clay bricks. Three configurations were analyzed, including two commercial designs from the Libyan market and a newly proposed arched cavity design. Finite Element Method (FEM) simulations …
Developing A Modular Circular Wall Over-Clad System For Facade Thermal Upgrade In Deep Energy Retrofit,
2025
Principle Investigator/Author Drive 0 Project Ireland AND School of Architecture and Built Environment, Technical University of Dublin, Ireland
Developing A Modular Circular Wall Over-Clad System For Facade Thermal Upgrade In Deep Energy Retrofit, Patrick Daly
Journal of Sustainable Construction Materials and Technologies
The EU has implemented several policy and legislative initiatives aimed at decarbonisation and circularity transition of the Built Environment including a strategy for large scale renovation of the building / housing stock. Modularised construction solutions are argued to be a potential acceleration pathway toward this objective. Yet there remains issues and challenges in implementing such strategies in a complex and heterogeneous stock and sector. This research investigates this decarbonisation pathway, examining the feasibility and potential of applying a modularised construction over-clad system, based on advanced circularity, in the deep energy retrofit of social housing. The research is based on a …
Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments,
2025
The British University in Egypt
Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments, Samar A. Salim, Abdullah Elbadry, Eman Gomaa, Mennatullah Faisal, Elbadawy A. Kamoun
Nanotechnology Research Centre
The development of advanced wound dressings capable of accelerating healing and achieving effective hemostasis remains a critical challenge in managing traumatic and surgical wounds. This study reports the fabrication and comprehensive evaluation of a novel multilayered, sandwich-structured nanofiber scaffold composed of Tranexamic acid (TXA), chitosan (CS), polyvinyl alcohol (PVA), L-arginine, and polylactic acid (PLA) for biodegradable wound dressing applications. Using sequential electrospinning, a four-layered scaffold was developed as a smart wound dressing, comprising an immediate-release TXA-CS-PVA layer for rapid clotting, a hydrophobic PLA barrier layer for protection, a sustained-release L-arginine-PVA layer to promote tissue regeneration, and a final PLA protective …
Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation,
2025
The British University in Egypt
Coumarin/Nitrogen-Bearing Heterocyclic Hybridloaded Electrospun Pmma/Pvp Nanofibrous Scaffolds For Accelerating Topical Wound Healing Rates: Synthesis And In Vitro Bio-Evaluation, Samar A. Salim, Mohamed Ali, Tasneem Abed, El Badawy Kamoun
Nanotechnology Research Centre
Coumarin-nitrogen heterocyclic compounds (e.g. quinoline, acridine, and phthalazine) were synthesized by facile reactions and elucidated by FTIR, 1H, and 13C-NMR analyses, which showed consistency with the expected structures. Coumarin-quinoline (drug A)- and coumarin-acridine (drug B)-loaded electrospun PMMA/PVP nanofibrous scaffolds were fabricated using electrospinning techniques. Results showed a successful PMMA/PVP blend, which formed the matrix that was used as the main scaffold for drug loading/release. The drugs (A and B) were encapsulated within the matrix as verified by IR and SEM results. Bio-evaluation through cytotoxicity and anticancer screening was conducted using the MTT assay against lung fibroblast (Wi-38), colon carcinoma (Caco-2), …
Predicting The Response Of Tendon-Driven Prosthetic Finger With Hyperelastic Joints,
2025
University of Nevada, Las Vegas
Predicting The Response Of Tendon-Driven Prosthetic Finger With Hyperelastic Joints, Lucas Gallup, Mohamed Trabia, Brendan O'Toole
Mechanical Engineering Faculty Research
Properly designed prosthetics hands can enhance the quality of life for those suffering from limb loss. Recently, 3D-printed prosthetic hands are becoming common. In these prostheses, fingers flex through the tendons that are activated by motion of the wrist. To provide spring action, thermoplastic polyurethane (TPU) hyperelastic joints are used to connect digits to each other as well as to the wrist. While these designs are common, no model for the relationship between tendon tension and joint flexion is available. This work has developed a quasi-static virtual work-based model to predict the relationship between tendon forces and the flexion of …
Ceramic Waste As Sustainable Material In Self-Compacting Concrete: Experimental Study And Ann Predictive Modeling,
2025
Faculty of Technology, Laboratory of Construction Engineering and Architecture (LGCA), University of Bejaia, 06000 Bejaia, Algeria
Ceramic Waste As Sustainable Material In Self-Compacting Concrete: Experimental Study And Ann Predictive Modeling, Abderrezak Bouziane, Houssam Slimanou, Mohamed Amin Bouzidi, Nedjima Bouzidi
Journal of Sustainable Construction Materials and Technologies
Recycling of ceramic waste in the construction sector is a promising option for reducing the environmental impacts of the concrete industry. The main objective of this study is the elaboration of a solid predictive model for ceramic waste based self-compacting (SCC) concrete properties, using artificial neural networks (ANN). This further, reduces its environmental impact without compromising satisfactory performance. An experimental approach was adopted with different substitution ratios: 0 to 30 wt% and particle sizes ranging from 3-8 mm and 8-15 mm. Tested properties of modified SCC as compressive strength at 7 and 28 days (fc7, fc28), spread (L), sieve stability …
Comparative Study On The Performance Of Ggbs, Uggbs, And Rha-Incorporated Cement Mortar Mixes,
2025
Research Scholar, School of Construction, NICMAR University, Pune-411025, Maharashtra, India
Comparative Study On The Performance Of Ggbs, Uggbs, And Rha-Incorporated Cement Mortar Mixes, Devansh Goel, Sudarshan D. Kore
Journal of Sustainable Construction Materials and Technologies
The environmental footprint of cement production has accelerated the pursuit of sustainable alternatives in the construction industry. Supplementary cementitious materials (SCMs), particularly those derived from industrial and agricultural waste, offer a promising approach to reducing cement consumption while maintaining performance. This study evaluates the fresh and mechanical behavior of binary, ternary, and quaternary cementitious mortar blends incorporating ground granulated blast-furnace slag (GGBS), ultrafine GGBS (UGGBS), and rice husk ash (RHA) as partial replacements for cement. A total of 32 mortar mixes were designed with water-to-binder (w/b) ratios ranging from 0.3 to 0.5 and varied replacement levels of RHA (0-20%), GGBS …
Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses,
2025
Clemson University
Crevice Corrosion Mechanisms Of Cocrmo Alloys In Orthopedic Implants: Retrieval Analysis, Nano-Tribocorrosion And Cellular Responses, Hwaran Lee
All Dissertations
Mechanically assisted corrosion and non-mechanically (chemically) driven corrosion in modular junctions of orthopedic implants using cobalt-chromium-molybdenum (CoCrMo) alloys remain clinical concerns and may contribute to implant failure. The underlying corrosion mechanisms are not yet fully understood, leaving a critical research gap. We hypothesized that corrosion in modular junctions may be driven by aggressive local environments, including fretting, metal ion release (cobalt ion, Co2+), low pH and reactive oxygen species (ROS). This dissertation aims to (1) analyze corrosion modes and potential causes in modular junctions; (2) identify chemically driven corrosion modes on CoCrMo alloys using simulated inflammatory modular taper …
Development And Characterization Of Pmma/Pvp Nanofiber-Loaded Bioactive Agents With Enhanced Breast Cancer Activity,
2025
The British University in Egypt
Development And Characterization Of Pmma/Pvp Nanofiber-Loaded Bioactive Agents With Enhanced Breast Cancer Activity, Samar A. Salim, The British University In Egypt, Esraa Abdelazim, Marwa Abdel Aleem
Nanotechnology Research Centre
Breast cancer remains a leading cause of cancer-related mortality globally, driving the need for novel effective and less toxic therapeutic agents. This study explores the synthesis and characterization of bioactive compounds: 1-(4-methoxyphenyl)-N- (p-tolyl)methanimine (MPTI), N-(4-methylphenyl)benzamide (MPB), and 4-methyl-N-(p-tolyl)benzenesulfonamide (MTS), and their incorporation into a PMMA/PVP polymer matrix for potential anticancer applications. Morphological analysis of the PMMA/PVP-loaded agents via SEM depicts structural modifications in the PMMA/PVP nanofibrous matrix upon incorporation of the bioactive agents. The FTIR analysis of the synthesized compounds before and after loading into the 7PMMA:3PVP nanofibers reveals successful incorporation of MPTI, MPB, and MTS, with characteristic absorption bands …
Harnessing Environmentally Healthy Approaches For Plastic Degradation: A Review And Future Perspectives,
2025
Embry-Riddle Aeronautical University
Harnessing Environmentally Healthy Approaches For Plastic Degradation: A Review And Future Perspectives, Marc Chojnacki
Beyond: Undergraduate Research Journal
In the face of escalating plastic pollution, innovative degradation strategies, such as enzymatic degradation, smokeless incineration technology, and biodegradable plastics, are gaining traction. This paper collates comprehensive research on these methods, assessing their environmental impact and operational feasibility. A special focus is placed on the role of technology and its capacity to spark advancements in these degradation strategies as well as to draw on specific research to understand the economic implications of these methods. At the core of this study is the exploration of potential new, inventive degradation methodologies. Through examining methods of green plastic degradation, the study aims to …
Characterization Of Lactobacilli-Containing Catheter Segments Developed By Using Selective Laser Sintered Mold.,
2025
University of Louisville
Characterization Of Lactobacilli-Containing Catheter Segments Developed By Using Selective Laser Sintered Mold., Caden Maners
Master of Engineering Theses
Catheter-associated urinary tract infections (CAUTIs) are a major healthcare burden with current prevention strategies offering limited success. This study presents a novel, self-coating biomaterial approach using a silicone-based bioink embedded with thermally sensitive probiotic strains (L. crispatus, L. rhamnosus, and L. reuteri). Catheter segments were fabricated via bio-injection molding using 3D-printed CAD molds. These Lactobacilli, selected for their probiotic and antimicrobial potential, serve as a non- antibiotic strategy to reduce infection risk. These segments were evaluated for mechanical strength (Shore A hardness), thermal stability (TGA/DSC), porosity and bacterial presence (SEM), biofilm formation (crystal-violet assay), as well as mass retention in …
A Wearable-Based Approach To Spinal Posture Tracking And Assessment,
2025
California Polytechnic State University, San Luis Obispo
A Wearable-Based Approach To Spinal Posture Tracking And Assessment, Sydney Marie Sherman, Noah Jeffery
Biomedical Engineering: Graduate Reports and Projects
This paper describes the design, manufacturing, and testing of a novel spinal posture tracking wearable device with embedded sensors. Currently on the market, most of the spinal posture tracking devices only focus on one segment of the spine and therefore do not track the entirety of human posture. The objective for this project was to create a wearable device in the form of a “smart shirt” that offers insights into posture trends throughout the day by tracking the entire spine. To begin the project, multiple designs were developed for the sensor array and wearable materials. These concepts were compared against …
The Utilization Of Basic Oxygen Furnace Slag As Fine Aggregates In Concrete: Physical, Mechanical, And Durability Properties,
2025
Betâo Liz SA, Avenida Almirante Gago Coutinho, Portela 2710-418 Sintra, Portugal
The Utilization Of Basic Oxygen Furnace Slag As Fine Aggregates In Concrete: Physical, Mechanical, And Durability Properties, Hakan Ozkan
Journal of Sustainable Construction Materials and Technologies
This study examines the feasibility of using basic oxygen furnace slag (BOFS) as an alternative to fine crushed limestone aggregate in concrete. BOFS is sourced from two steel production facilities in Türkiye, designated as I-BOFS and E-BOFS. The experimental results showed that as the E-BOFS aggregate replacement ratio increased, the water-to-cement (w/c) ratio increased to maintain the target workability. The concrete mixtures incorporating E-BOFS exhibited consistent reductions in the compressive strength with an increase in the BOFS ratio. At the same time, I-BOFS maintained higher compressive strength, with only minor losses up to 80% of the substitution ratio. Flexural strength …
