In-Vivo Testing Of Vertically Aligned Nanowire Implantable Titanium Electrodes In The Rattus Norvegicus Hippocampus,
2010
University of Arkansas, Fayetteville
In-Vivo Testing Of Vertically Aligned Nanowire Implantable Titanium Electrodes In The Rattus Norvegicus Hippocampus, Lauren Kegley
Inquiry: The University of Arkansas Undergraduate Research Journal
Miniaturized multielectrode arrays are MEMS devices that have found use as neural prosthetics (Neuro-MEMS). As implants, they can interface with neurons as sensors or actuators and help compensate for loss of sensory input, motor control, or cognitive functions. The microelectrodes studied here were developed in-house. They have a vertically aligned gold nanowire array and are mounted on a sturdy titanium needle with a fine gauge. Hence, the bill of materials and design characteristics encourage their use as a neural probe. For this study, a probe was tested in vivo for signal acquisition in the hippocampus of a Rattus Norvegicus (Sprague …
Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression,
2010
Old Dominion University
Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, R. Heller
Bioelectrics Publications
Gene therapy is an attractive method for the treatment of cardiovascular disease. However, using current strategies, induction of gene expression at therapeutic levels is often inefficient. In this study, we show a novel electroporation (EP) method to enhance the delivery of a plasmid expressing an angiogenic growth factor (vascular endothelial growth factor, VEGF), which is a molecule previously documented to stimulate revascularization in coronary artery disease. DNA expression plasmids were delivered in vivo to the porcine heart with or without coadministered EP to determine the potential effect of electrically mediated delivery. The results showed that plasmid delivery through EP significantly …
