Psychiatry and Psychology Commons^™

Methamphetamine-Associated Psychosis, Kathleen M. Grant, Tricia D. Le Van, Sandra M. Wells, Ming Li, Scott F. Stoltenberg, Howard E. Gendelman, Gustavo Carlo, Rick A. Bevins

Scott F. Stoltenberg

Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and …

Serotonergic Agents And Alcoholism Treatment: A Simulation, Scott F. Stoltenberg

Scott F. Stoltenberg

Background: Those with early-onset alcoholism may better respond to ondansetron (a 5-HT3 receptor antagonist) than to selective serotonin reuptake inhibitor (SSRI) treatment, whereas those with late-onset alcoholism may present the reverse response pattern. Johnson and colleagues proposed a model that attempts to explain the observed treatment response patterns of those with early and late alcoholism onset by focusing on the influence of a common genetic variant in the serotonin transporter regulatory region (5-HTTLPR) on serotonin (5-HT) and dopamine (DA) system function. Methods: The present study formalizes and extends Johnson’s descriptive model into a computer simulation consisting of differential equations. For …

Antisocial Alcoholism And Serotonin-Related Polymorphisms: Association Tests, Elizabeth M. Hill, Scott F. Stoltenberg, Katherine Harris Bullard, Sheng Li, Robert A. Zucker, Marget Burmeister

Scott F. Stoltenberg

Central serotonin dysfunction appears to be related to a subtype of alcoholism with antisocial impulsive features (type II; antisocial alcoholism). The serotonergic deficit may be associated with greater impulsivity, which in turn facilitates both alcohol dependence and antisocial behavior. The present study tested association of antisocial impulsive alcoholism with candidate genes related to serotonergic neurotransmission, using families. Eight markers were assayed using polymerase chain reaction: tryptophan hydroxylase (intron 7), the serotonin transporter SLC6A4 (VNTR 9/12), HTTLPR, the three serotonin receptor types HTR1B (G861C), HTR2A (T102C) and HTR2C (Cys23Ser), monoamine oxidase A (T1460C), and (CA)n. Eligible probands had early age of …

Gender Differences In The Relationships Among Ses, Family History Of Alcohol Disorders And Alcohol Dependence, Geoffrey M. Curran, Scott F. Stoltenberg, Elizabeth M. Hill, Sharon A. Mudd, Frederic C. Blow, Robert A. Zucker

Scott F. Stoltenberg

Objective: Potential moderator and mediator roles of several measures of socioeconomic status (SES) were investigated for the relationship between a family history of alcoholism( FH) and alcohol dependence symptoms in adulthood. Method: These analyses were performed with a sample of 931 men and 385 women participating in studies at the Alcohol Research Center, University of Michigan. Hierarchical multiple regression equations were used to assess whether SES mediated and moderated relationships between FH and alcohol dependence symptoms. Results: In general, measures of SES (education, occupation, personal and household income) were more important predictors of alcohol dependence symptoms among men, while FH …

Serotonin Transporter Promoter Polymorphism, Peripheral Indexes Of Serotonin Function, And Personality Measures In Families With Alcoholism, Scott F. Stoltenberg, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Hiram E. Fitzgerald, Robert A. Zucker, Karley Y. Little

Scott F. Stoltenberg

A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) is considered to be a plausible candidate gene for anxiety-related personality traits and for alcoholism. Empirical support for the association between 5-HTTLPR and psychological traits has been somewhat inconsistent; however, observations of the functional dominance of the low-activity s-allele over the l-allele have been more consistent. When studying the influence of particular genes on psychological traits, it seems useful also to assess more biological intermediate traits that may mediate the effects of those genes on the traits of interest. The present study examined relationships between 5-HTTLPR genotype, …

Serotonin Transporter And Gaba(A) Alpha 6 Receptor Variants Are Associated With Neuroticism, Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeister

Scott F. Stoltenberg

Background: A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with inconclusive results. A GABA(A) receptor α6 subunit variant (Pro385Ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression. Methods: A total of 384 subjects who completed the NEO-PI were genotyped …

A Bdnf Coding Variant Is Associated With The Neo Personality Inventory Domain Neuroticism, A Risk Factor For Depression, Srijan Sen, Randolph M. Nesse, Scott F. Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B. Weber, Margit Burmeister

Scott F. Stoltenberg

Genetic factors influence vulnerability to depression (Sullivan et al, 2000), but no specific genes have been definitively implicated. One promising approach is to determine whether variations in specific (candidate) genes are associated not with disease per se, but with traits, such as personality factors, that are themselves associated with risk for the disorder (Lander and Schork, 1994; Stoltenberg and Burmeister, 2000). Often such traits have a higher heritability than the disease status (Almasy and Blangero, 2001). Neuroticism, as measured by the NEO personality inventory (NEO-PI) (Costa and McCrae, 1997), a psychometrically sound and widely used instrument, is one such trait. …

Possible Association Between Response Inhibition And A Variant In The Brain-Expressed Tryptophan Hydroxylase-2 Gene, Scott Stoltenberg, Jennifer Glass, Steven Chermack, Heather Flynn, Sheng Li, Margaret Weston, Margit Burmeister

Scott F. Stoltenberg

The ability to inhibit a response is an important component of normal behavioral control and is an aspect of psychopathology when diminished. Converging evidence implicates the serotonergic neurotransmitter system in response inhibition circuitry. Objectives — The present study examined potential associations between serotonergic genetic markers and response inhibition as indexed by Stop Task performance. Methods — College-age participants (N= 199) completed self-report questionnaires, the computerized Stop Task, and donated buccal cells for genetic analyses. Statistics were analyzed by ANOVA. Results — Stop Signal reaction time was not associated with allelic variation at a monoamine oxidase A promoter length polymorphism or …

Description And Validation Of A Dynamical Systems Model Of Presynaptic Serotonin Function: Genetic Variation, Brain Activation And Impulsivity, Scott F. Stoltenberg, Parthasarathi Nag

Scott F. Stoltenberg

Despite more than a decade of empirical work on the role of genetic polymorphisms in the serotonin system on behavior, the details across levels of analysis are not well understood. We describe a mathematical model of the genetic control of presynaptic serotonergic function that is based on control theory, implemented using systems of differential equations, and focused on better characterizing pathways from genes to behavior. We present the results of model validation tests that include the comparison of simulation outcomes with empirical data on genetic effects on brain response to affective stimuli and on impulsivity. Patterns of simulated neural firing …

Exploring Separable Components Of Institutional Confidence, Joseph A. Hamm, Lisa M. Pytlik Zillig, Alan Tomkins, Mitchel Herian, Brian H. Bornstein, Elizabeth Neeley

Joseph A Hamm

Despite its contemporary and theoretical importance in numerous social scientific disciplines, institutional confidence research is limited by a lack of consensus regarding the distinctions and relationships among related constructs (e.g., trust, confidence, legitimacy, distrust, etc.). This study examined four confidence-related constructs that have been used in studies of trust/confidence in the courts: dispositional trust, trust in institutions, obligation to obey the law, and cynicism. First, the separability of the four constructs was examined by exploratory factor analyses. Relationships among the constructs were also assessed. Next, multiple regression analyses were used to explore each construct’s independent contribution to confidence in the …

Help-Negation For Suicidal Thoughts In Sub-Clinical Samples Of Young People, Coralie Joy Wilson

Coralie J Wilson

Across the popular and academic literature, it is widely recognised that young people with persistent suicidal thoughts are at high risk for suicide completion. It is also accepted that seeking and receiving appropriate help offers protection against the development of acute forms of suicidality, along with suicide completion. Yet, as promising as appropriate help-seeking appears for suicide prevention, a growing number of studies suggest that suicidal ideation itself may impede the help-seeking process. There is evidence that acutely suicidal samples will negate or avoid available help, and there are indications that the help-negation process may occur in samples before levels …

Staff Perceptions Of Risk For Prison Rape Perpetration And Victimization, Valerie M. Gonsalves, Kate Walsh, Mario J. Scalora

Department of Psychology: Faculty Publications

Copyright © 2012 SAGE Publications, http://tpj.sagepub.com Used by permission.

Communication-Based Assessment Of Developmental Age For Young Children With Developmental Disabilities, Shari L. Deveney, Lesa Hoffman, Cynthia J. Cress

Department of Psychology: Faculty Publications

Purpose: In this study, the authors compared a multiple-domain strategy for assessing developmental age of young children with developmental disabilities who were at risk for long-term reliance on augmentative and alternative communication (AAC) with a communication-based strategy composed of receptive language and communication indices that may be less affected by physically challenging tasks than traditional developmental age scores.

Method: Participants were 42 children (age 9–27 months) with developmental disabilities and who were at risk for long-term reliance on AAC. Children were assessed longitudinally in their homes at 3 occasions over 18 months using multiple-domain and communication-based measures. Confirmatory factor analysis …

Linking Outcomes From Peabody Picture Vocabulary Test Forms Using Item Response Models, Lesa Hoffman, Jonathan Templin, Mabel L. Rice

Department of Psychology: Faculty Publications

Purpose: The present work describes how vocabulary ability as assessed by 3 different forms of the Peabody Picture Vocabulary Test (PPVT; Dunn & Dunn, 1997) can be placed on a common latent metric through item response theory (IRT) modeling, by which valid comparisons of ability between samples or over time can then be made.

Method: Responses from 2,625 cases in a longitudinal study of 697 persons for 459 unique PPVT items (175 items from Peabody Picture Vocabulary Test—Revised [PPVT–R] Form M [Dunn & Dunn, 1981], 201 items from Peabody Picture Vocabulary Test—3 [PPVT–3] Form A [Dunn & Dunn, 1997], and …

Narrative Health Communication And Behavior Change: The Influence Of Exemplars In The News On Intention To Quit Smoking., Hyun Suk Kim, Cabral A. Bigman, Amy E. Leader, Caryn Lerman, Joseph N. Cappella

Department of Medical Oncology Faculty Papers

This study investigated psychological mechanisms underlying the effect of narrative health communication on behavioral intention. Specifically, the study examined how exemplification in news about successful smoking cessation affects recipients' narrative engagement, thereby changing their intention to quit smoking. Nationally representative samples of U.S. adult smokers participated in 2 experiments. The results from the 2 experiments consistently showed that smokers reading a news article with an exemplar experienced greater narrative engagement compared to those reading an article without an exemplar. Those who reported more engagement were in turn more likely to report greater smoking cessation intentions.

Stress, Coping And Suicide Ideation In Chinese College Students, Xiaoyun Zhang, Haiping Wang, Yan Ruth Xia, Xiaohong Liu, Eunju Jung

Department of Child, Youth, and Family Studies: Faculty Publications

The study was to examine 1) whether stress and coping styles could significantly predict the probability of suicide ideation; 2) and whether coping styles were mediators or moderators on the association between life stress and suicide ideation. The survey was conducted in a sample of 671 Chinese college students. Approximately twenty percent students reported having suicide ideation. Life stress, active coping styles, and passive coping styles all had independent effect on the probability of suicide ideation. Passive coping styles, especially fantasizing, mediated the relation between life stress and suicide ideation. Moderation hypotheses were not supported. Implications of the findings and …

Research Brief: "Employment Outcomes And Ptsd Symptom Severity", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study investigates how the severity of PTSD symptoms relates to employment and earnings. It found that veterans with more severe symptoms of PTSD were more likely to work part-time or not at all rather than have full-time work. In practice, treating PTSD, even if some symptoms remain, could result in better employment outcomes for veterans. In policy, policymakers should consider providing previously successful programs focused on veterans with PTSD for individuals with other mental health conditions. Suggestions for future research include a large, controlled, longitudinal survey that would allow researchers to investigate more thoroughly how PTSD symptoms relate to …

An Evaluation Of The Revised Hierarchical Model (Rhm): How Quickly Do We Learn To Associate Clock With Uhr?, Sierra Fuller

Honors Theses

The goal of the current study was to examine the Revised Hierarchical Model of bilingual language representation proposed by Kroll and Stewart (1994) by exploring the connection between the lexicon for one’s native language (L1) and the lexicon for one’s second language (L2) in novice bilinguals. Forty-three participants were taught 30 German words and then given a Translation Recognition Task to conjecture which pathways of the RHM were being utilized in the language acquisition process. The results supported our hypothesis, showing that there was greater interference for the monolinguals from the orthographically similar translations than the unrelated translations. The discovery …

Can The Survival Processing Effect Be Replicated In Non-Ancestral Survival Scenarios?, Ciro Griffiths

Honors Theses

When primed to think about one’s survival, participants experience an increase in recall for a set of words. This result called the ‘survival processing effect’ was initially found for participants primed to think about their survival in an ancestral environment. The present study was designed to access whether the effect could be replicated in non-ancestral scenarios. Analyses showed that the effect could be replicated and that non-ancestral scenarios even led to a slightly higher level of recall than the traditional ancestral scenario. Various characteristics of the modern scenarios are believed to have been responsible for this finding including an increase …

Does Personality Moderate Reciprocity?, Arianna Groveman

Honors Theses

I completed this experiment in order to better understand how personality moderates reciprocity. Reciprocity is a compliance strategy that involves giving or doing something for someone in exchange for something in return (Cialdini, 1993). I originally predicted that high self-monitors would show greater reciprocity than low self-monitors. Also, I predicted people with high need for cognition will show more reciprocity than people with a low need for cognition. In addition, I hypothesized that people with a low need to evaluate will show more reciprocity than people with a high need to evaluate. Participants were randomly assigned to either a “Soft …