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Schizophrenia And Its Effects On An American Family: A Call To Action For The 21st Century, Cynthia Newton Captain 2017 Dominican University of California

Schizophrenia And Its Effects On An American Family: A Call To Action For The 21st Century, Cynthia Newton Captain

Senior Theses and Capstone Projects

Our country’s healthcare system is at a moral crossroads. The way we treat those whom we call “the homeless” is deplorable. The majority of the homeless are mentally ill and need treatment. Our country needs to treat those with the severe brain diseases of schizophrenia, schizo-affective disorder, and bi-polar disorder just as we would Alzheimer’s disease and Parkinson’s disease. Those with severe mental illness, who have no insight into their illness, should not be allowed to dictate their own treatment. If a homeless person is brought to San Francisco General Hospital and is found to be a ...


Diet And Cognition: Data, Theory, And Some Solutions From The Playbook Of Psychology, Aaron P. Blaisdell 2017 University of California, Los Angeles

Diet And Cognition: Data, Theory, And Some Solutions From The Playbook Of Psychology, Aaron P. Blaisdell

Journal of Evolution and Health

No abstract provided.


Eating Disorders: Identifying, Assessing, And Treatment, Valerie M. Miranda 2017 Eating Disorders Recovery Center of Athens

Eating Disorders: Identifying, Assessing, And Treatment, Valerie M. Miranda

National Youth-At-Risk Conference Savannah

This presentation will address DSM-V criteria for feeding and eating disorders, demographics for eating disorders, long-term medical issues associated with eating disorders, assessment measures for feeding and eating disorders, and resources for the community. Being able to identify, assess, and treat eating disorders within the children and adolescent population is crucial in their long-term physical development and mental health as eating disorders typically begin in mid-adolescence.


Rumination Is Associated With Diminished Performance Monitoring, Ema Tanovic, Greg Hajack, Charles A. Sanislow 2017 Yale University

Rumination Is Associated With Diminished Performance Monitoring, Ema Tanovic, Greg Hajack, Charles A. Sanislow

Charles A. Sanislow

Rumination is a construct that cuts across a variety of disorders, including anxiety and depression. It has been associated with deficits in cognitive control thought to confer risk for psychopathology. One aspect of cognitive control that is especially relevant to the content of ruminative thoughts is error processing. We examined the relation of rumination and 2 electrophysiological indices of error processing, error related negativity (ERN), an early index of error detection, and error positivity (Pe), a later index of error awareness. Consistent with prior work, ERN was negatively correlated with anxiety (i.e., more anxious individuals were characterized by larger ...


Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl 2017 University of New Mexico

Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl

Gina M. Vincent

Adult psychopathic offenders show an increased propensity towards violence, impulsivity, and recidivism. A subsample of youth with elevated psychopathic traits represent a particularly severe subgroup characterized by extreme behavioral problems and comparable neurocognitive deficits as their adult counterparts, including perseveration deficits. Here, we investigate response-locked event-related potential (ERP) components (the error-related negativity [ERN/Ne] related to early error-monitoring processing and the error-related positivity [Pe] involved in later error-related processing) in a sample of incarcerated juvenile male offenders (n=100) who performed a response inhibition Go/NoGo task. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV ...


An Examination Into The Relationship Between Iron Deficiency And Postpartum Depression, Sara A. Burroughs 2016 Liberty University

An Examination Into The Relationship Between Iron Deficiency And Postpartum Depression, Sara A. Burroughs

Senior Honors Theses

Postpartum depression is recognized as the most common complication of childbearing; however, its etiology remains fairly undetermined. Many different influences have been hypothesized as to what may cause postpartum depression, including changes in levels of various hormones (such as estrogen and progesterone), a decrease in serotonin, low levels of vitamin D, social factors, and iron deficiency. The lack of strong evidence for one specific cause makes it fairly clear that there are many factors that play a role in the development of postpartum depression. Iron deficiency is one issue that is thought to contribute to the development of postpartum depression ...


Improving Mental Health Of Elementary School Children, Alexa Proctor 2016 Purdue University

Improving Mental Health Of Elementary School Children, Alexa Proctor

Purdue Journal of Service-Learning and International Engagement

Alexa Proctor is an advanced practice student on clinical rotations with the Purdue University College of Pharmacy. In this article, she describes her experience working with Mental Health America (MHA) of Tippecanoe County and third grade children, in addition to her passion to help improve mental health in students of all ages.


Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot 2016 The Graduate Center, City University of New York

Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Empathy, the ability to both experientially share in and understand others’ thoughts, behaviors, and feelings, is vital for human adaptation. Deficits in empathy development have implications across the lifespan for the development of prosocial behavior, social functioning, mental health disorders, and risk for antisocial behavior (e.g., Guajardo, Snyder, & Petersen, 2009; Moreno, Klute & Robinson, 2008). In light of these societal and individual burdens, it is imperative to foster and strengthen the development of this ability early in life to prevent or ameliorate such negative outcomes. This type of prevention can take a variety of forms, but parent and child verbal exchanges and modeling are often the most direct methods after two years of age (e.g., Moreno et al., 2008). The aim of this research was to inform the development of a system to naturalistically assess empathy development via home-based observation of mothers and their children’s verbal exchanges.

The proposed system, iEAR-Empathy in Parent-Child Interactions (iEAR-EPIC), is a verbal coding system to code for verbal behaviors empirically demonstrated to foster empathy development, as well as behaviors found to indicate empathy development. The development of the iEPIC was theoretically informed by Preston and de Waal’s (2002) Perception Action Mechanism (PAM) model of empathy, a neurocognitive-emotional model of empathy. This model demonstrates empathy as a maturing system in which emotional and cognitive understanding develop in tandem through brain-environment interactions. However, the iEPIC also accounts for the interplay between parents and neurocognitive emotional processes, and thus captures the parallel, increasingly interactive, development of cognitive and emotional abilities from infancy onward in the context of a parent-child dyad.

To develop and test the iEPIC, an ethnically diverse subsample of 84 mothers and their 2 to 6-year-old children were recruited from a large, northeastern, urban, public university. After consenting, mother-child dyads were recorded for a 4-hour period during the dyad’s evening routine (5-9p.m.), using a two-minutes on, 10 seconds off protocol, resulting in 28 2-minute clips (56 minutes total) per dyad. Recordings were transcribed and reviewed, and then 4 pairs of coders were trained in the iEPIC coding system, and then coded the dyad recordings for behaviors comprising the proposed iEPIC assessment system.

The iEPIC observational assessment system consists of 5 codes for each parent and child: Reflection (R), Exploring Emotion and State (EES), Emotion and State Description (ESD), and Empathic Understanding and Concern (EUC), as well as Neutral verbalizations (N; non-study-related verbalizations). The EES, ESD, and EUC each have levels of complexity, with higher levels expected to occur more frequently in older children (e.g., 4 years and older).

There were several purposes of the current study: 1) assess inter-rater reliability for the iEPIC coding system 2) determine if ...


Object Relations In Children's Projective Testing: Applying The Mutuality Of Autonomy Scale To The Thematic Apperception Test, Lily A. Thom 2016 The Graduate Center, City University of New York

Object Relations In Children's Projective Testing: Applying The Mutuality Of Autonomy Scale To The Thematic Apperception Test, Lily A. Thom

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Psychodynamic assessment of object relations on projective tests has consistently been shown to contribute to a better understanding of children’s psychological functioning and to guide therapeutic interventions (Tuber, 1992). This research examines the enhanced utility of applying a psychodynamically-derived scale of children’s object relations to a commonly used projective assessment tool, the Thematic Apperception Test (TAT) (Morgan & Murray, 1935; Murray, 1943). The current study investigates the adaptation and application of the Mutuality of Autonomy Scale (MOA) (Urist, 1977; Urist & Shill, 1982), commonly used as a Rorschach Inkblot Method object relations scale, to examine verbal narratives on the TAT. It was hypothesized that findings from the proposed study would demonstrate that the MOA is a readily employable scale for examining children’s object relational paradigms on TAT responses. A second aim of the study was to demonstrate concurrent validity between MOA scores and the Defense Mechanisms Manual (DMM), a well-validated tool for assessing developmental level of defenses on the TAT (Cramer, 1991). In addition, this work contributes to the need for empirically-validated, systematic approaches to interpreting TAT data (Rossini & Moretti, 1997; Cramer, 2004). The findings showed several expected, significant relationships between level of defense and object relations that confirmed the study’s ...


The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică 2016 Valparaiso University, Department of Psychology

The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică

Journal of Mind and Medical Sciences

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”

Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...


Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao 2016 University of Massachusetts Medical School

Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao

Open Access Articles

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cortical neurons differentiated from these and other published iPSC lines, we found that MAPT mutations do not affect neuronal differentiation but increase the 4R/3R tau ratio. Patient neurons had significantly higher levels of MMP-9 and MMP-2 and were more sensitive to stress-induced cell death. Inhibitors of MMP-9/MMP-2 protected patient neurons from stress-induced cell death and recombinant MMP-9 ...


Neuroethics: Neurolaw, Stephen J. Morse 2016 University of Pennsylvania Law School

Neuroethics: Neurolaw, Stephen J. Morse

Faculty Scholarship

This is a pre-copyedited version of a chapter in the Oxford Handbooks Online (Philosophy) edited by Sandy Goldberg. In altered form, it was published online in February, 2017 and can be found at the Oxford Handbooks Online website. The entry discusses whether the findings of the new neuroscience based largely on functional brain imaging raise new normative questions and entail normative conclusions for ethical and legal theory and practice. After reviewing the source of optimism about neuroscientific contributions and the current scientific status of neuroscience, it addresses a radical challenge neuroscience allegedly presents: whether neuroscience proves persons do not have ...


Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori 2016 Humana, Inc.

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori

Amy B. Wachholtz

BACKGROUND: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

METHODS: We used multi-state Medicaid data (2000-2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for ...


Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad 2016 The University of Western Ontario

Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad

Electronic Thesis and Dissertation Repository

PDZ (PSD95/Disc Large/Zona Occludens) domain-containing proteins are scaffolding proteins that play important roles in regulating the activity of G protein-coupled receptors. Corticotropin Releasing Factor Receptor 1 (CRFR1) and Serotonin 2A Receptor (5-HT2AR) are two GPCRs that are commonly associated with mental disorders. Both receptors also contain a class I PDZ-binding motif at the carboxyl terminal tail. In the first chapter, we investigate the effects of CAL (CFTR-associated ligand) on regulating the trafficking and signaling of CRFR1. We demonstrate a role for CAL in inhibiting CRFR1 endocytosis, cell surface expression, and CRF-mediated ERK1/2 signaling via the ...


Implementing Change To Decrease The Emergency Department Visits For Pediatric Clients Referred To Mental Health Services, Diane Sandoval 2016 University of San Francisco

Implementing Change To Decrease The Emergency Department Visits For Pediatric Clients Referred To Mental Health Services, Diane Sandoval

Master's Projects

The purpose of this clinical nurse leader (CNL) internship project is to implement an improvement intervention to decrease emergency department visits or psychiatric emergency services visit rates for pediatric clients receiving mental health services through the ambulatory clinic. The goal is to increase client safety by preventing harm to themselves or others and improving quality of care provided through timely nursing telephone triage. The project is taking place in a county run pediatric ambulatory clinic. We will participate in a shared leadership team to make recommendations for improvement at the microsystem level. Team members include the charge nurse, clinic manager ...


Association Of Common Mental Disorder Symptoms With Health And Healthcare Factors Among Women In Rural Western India: Results Of A Cross-Sectional Survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, Somashekhar Nimbalkar 2016 University of Massachusetts Medical School

Association Of Common Mental Disorder Symptoms With Health And Healthcare Factors Among Women In Rural Western India: Results Of A Cross-Sectional Survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, Somashekhar Nimbalkar

Nancy Byatt

OBJECTIVES: Information about common mental disorders (CMD) is needed to guide policy and clinical interventions in low-income and middle-income countries. This study's purpose was to characterise the association of CMD symptoms with 3 inter-related health and healthcare factors among women from rural western India based on a representative, cross-sectional survey.

SETTING: Surveys were conducted in the waiting area of various outpatient clinics at a tertiary care hospital and in 16 rural villages in the Anand district of Gujarat, India.

PARTICIPANTS: 700 Gujarati-speaking women between the ages of 18-45 years who resided in the Anand district of Gujarat, India, were ...


Evaluation Of Tobacco Use On Chinese Population Through Attoc Model: A Cross-Sectional Survey On Hospitalized Psychiatric Patients, Xue Wang, Zugui Peng, Douglas M. Ziedonis, Chaomin Wang, Bo Yu, Tao Li 2016 Sichuan University

Evaluation Of Tobacco Use On Chinese Population Through Attoc Model: A Cross-Sectional Survey On Hospitalized Psychiatric Patients, Xue Wang, Zugui Peng, Douglas M. Ziedonis, Chaomin Wang, Bo Yu, Tao Li

Douglas M. Ziedonis

OBJECTIVES: To evaluate the feasibility of Addressing Tobaccos through Organizational Change (ATTOC) intervention to Chinese psychiatric patients, and to better address tobacco use through the ATTOC intervention model in the context of China.

METHODS: The study was conducted in Mental Health Center of West China Hospital in 2010. A total of 100 hospitalized psychiatric patients were recruited to carry out ATTOC intervention. Subjects suffers from mental illness were diagnosed by professional psychiatrists according to the International Statistical Classification of Diseases (ICD-10) criteria.

RESULTS: The prevalence of tobacco use in hospitalized psychiatric patients were closely correlated with the type of mental ...


Linezolid Induced Delirium In The Absence Of Serotonin Syndrome: A Psychiatric Consultation/Liaison Case Report, Hani Nazha, MD, Nathan T. Harrington, MD 2016 WVU

Linezolid Induced Delirium In The Absence Of Serotonin Syndrome: A Psychiatric Consultation/Liaison Case Report, Hani Nazha, Md, Nathan T. Harrington, Md

Marshall Journal of Medicine

Delirium is one of the most common mental illnesses that can affect elderly patients and patients with advanced medical problems. Because these patients are frequently on multiple medications and/or are more sensitive to medications secondary to their age, interactions with current medications, or existing medical problems; medication toxicity is frequently the etiology behind their delirium. This is a case report of a patient admitted for cellulitis that developed delirium from Linezolid however did not develop any other signs or symptoms of Serotonin Syndrome; a known side effect of Linezolid. This distinctive case highlights the importance of a careful analysis ...


Effects Of Autism Spectrum Disorder Insurance Mandates On The Treated Prevalence Of Autism Spectrum Disorder, David S. Mandell, Colleen L. Barry, Steven C. Marcus, Ming Xie, Kathleen Shea, Katherine Mullan, Andrew J Epstein 2016 University of Pennsylvania

Effects Of Autism Spectrum Disorder Insurance Mandates On The Treated Prevalence Of Autism Spectrum Disorder, David S. Mandell, Colleen L. Barry, Steven C. Marcus, Ming Xie, Kathleen Shea, Katherine Mullan, Andrew J Epstein

Research Briefs

Key Findings: State mandates requiring commercial health plans to cover services for children with autism spectrum disorder increased the number of children diagnosed with the disorder. However, diagnosis rates remain much lower than community estimates, suggesting that many commercially insured children with ASD remain undiagnosed or are insured through public plans.


Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori 2016 Humana, Inc.

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori

Open Access Articles

BACKGROUND: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

METHODS: We used multi-state Medicaid data (2000-2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for ...


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