Modification And Characterization Of Chloro-Sugar Derivatives As Anti-Bacterial Agents, 2019 Rowan University
Modification And Characterization Of Chloro-Sugar Derivatives As Anti-Bacterial Agents, Mansi Jani
Theses and Dissertations
Sucralose is an artificial sugar substitute which is most commonly used sweetener among other artificial sweeteners. It is derived from sucrose through a complex chemical process that selectively substitutes three atoms of chlorine for three hydroxyl groups on sucrose molecule, which have shown some inhibition of bacterial growth in gut. The goal of the project was to substitute halide in sucralose in a way that it sustains potential anti-bacterial activity along with sweetening effect, which can be then incorporated into mouthwash formulation. Sucralose is very stable molecule and it also has other physico-chemical advantages which are suitable for our anticipated …
Effect Of Hyperoxia On Type-1 Diabetic Mouse Model, 2019 University of South Florida
Effect Of Hyperoxia On Type-1 Diabetic Mouse Model, Samuel Ignatious Bolleddu
USF Tampa Graduate Theses and Dissertations
Administration of Hyperoxia (>90 % oxygen) is a pervasive intervention to supplement respiratory needs in patients admitted in ICU/critical care units. Current literature suggests that prolonged use of Hyperoxia therapy is directly associated with in-hospital mortality. The exact reason for this high mortality under Hyperoxia is unknown. Recent explorations in Dr. Panguluri lab identified that dysregulation of Kv channels plays a vital role in the pathophysiology of Hyperoxia-induced pulmonary and cardiac complications using animal models. The proposed research will focus on the part of Hyperoxia in generating cardiotoxicity and ventricular remodeling in the type-1 diabetes patients using the Akita, …
An In Silico Study Of G Protein-Coupled-Receptor Activation, Specifically In The Corticotropin Releasing Factor Receptor And The Glucagon-Like Peptide Receptor, 2019 Rowan University
An In Silico Study Of G Protein-Coupled-Receptor Activation, Specifically In The Corticotropin Releasing Factor Receptor And The Glucagon-Like Peptide Receptor, Nicolas Angelo Scorese
Theses and Dissertations
The drug discovery process is an extremely long and expensive process that modern computational methods help to alleviate. Through the use of computational methods, we provide information and insight into the activation methods of class B GPCRs so that future drugs can be developed to have less side effects. The first study focuses on the corticotropin releasing factor receptor, which is a good drug target for anxiety and depression. A mechanism of activation was theorized which focuses less on molecular switches (as has been the focus of several papers) and more on large scale conformation at the intracellular region of …
A Systematic Review Of The Evidence Behind Use Of Reduced Doses Of Acetaminophen In Chronic Liver Disease, 2019 St. John Fisher University
A Systematic Review Of The Evidence Behind Use Of Reduced Doses Of Acetaminophen In Chronic Liver Disease, Anne Schweighardt, Katherine Juba
Pharmacy Faculty/Staff Publications
Acetaminophen is among the most commonly used nonopioid analgesics, but significant variation exists in its prescribing practices for cirrhosis patients. Our primary objective was to describe the quality of evidence supporting or refuting the use of acetaminophen in patients with hepatic dysfunction. A comprehensive literature review of PubMed, Cochrane Library, Web of Science, and International Pharmaceutical Abstracts using the search terms “acetaminophen,” “paracetamol,” “chronic liver disease,” “cirrhosis,” and “hepatic disease” for studies describing changes in acetaminophen metabolism in patients with hepatic dysfunction was conducted. Twelve studies and four abstracts were included. Ten studies and three abstracts were pharmacokinetic studies. Two …
June 2019, 2019 Southwestern Oklahoma State University
June 2019, Randy Curry, Cindy Brooks
RURAL ROCKS
Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy
A Rapid Viability And Drug‑Susceptibility Assay Utilizing Mycobacteriophage As An Indicator Of Drug Susceptibilities Of Anti‑Tb Drugs Against Mycobacterium Smegmatis Mc2 155, 2019 Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland
A Rapid Viability And Drug‑Susceptibility Assay Utilizing Mycobacteriophage As An Indicator Of Drug Susceptibilities Of Anti‑Tb Drugs Against Mycobacterium Smegmatis Mc2 155, Gillian Catherine Crowley, Jim O'Mahony, Aidan Coffey, Riona G. Sayers, Paul D. Cotter
Department of Biological Sciences Publications
Background: A rapid in-house TM4 mycobacteriophage-based assay, to identify multidrug resistance against various anti-tuberculosis drugs, using the fast-growing Mycobacterium smegmatis mc2 155 in a microtiter plate format was evaluated, based on phage viability assays. Methods: A variety of parameters were optimized before the study including the minimum incubation time for the drugs, phage and M. smegmatis mc2 155 to be in contact. An increase in phage numbers over 2 h was indicative that M. smegmatis mc2 155 is resistant to the drugs under investigation, however when phage numbers remained static, M. smegmatis mc2 155 found to …
Patient And Student Experience On An Interprofessional Hotspotting Team, 2019 Thomas Jefferson University
Patient And Student Experience On An Interprofessional Hotspotting Team, Steven Elsesser, Md, Elizabeth Feeney, Bsn, Katherine Petty, Spt, Kevin Shaloo, Spt, Nancy Tang, Pharmd
JCIPE Posters
The purpose of the Student Hotspotting initiative is to identify these individuals, understand their barriers and intervene by:
- Connecting them with community resources
- Improving coordination and communication between both providers and the patient
- Empowering these individuals to better manage their health
Our patient (DW) lives in a close-knit, 4-generation household that just welcomed their newest member: a black-and-white kitten
DW is a 61 year-old female who recently received orthotopic heart transplant. Her comorbidities include sleep apnea, GERD, OA, chronic pain syndrome, COPD and a history of a CVA
We identified 3 main barriers to address with DW
- Transportation difficulties
- Management …
Preclinical Evaluation Of An Unconventional Ruthenium‐Gold‐ Based Chemotherapeutic: Rance‐1, In Clear Cell Renal Cell Carcinoma, 2019 CUNY Brooklyn College
Preclinical Evaluation Of An Unconventional Ruthenium‐Gold‐ Based Chemotherapeutic: Rance‐1, In Clear Cell Renal Cell Carcinoma, Benelita Elie, Karen Hubbard, Yuriy Pechenyy, Buddhadev Layek, Swayam Prabha, Maria Contel
Publications and Research
Background: There are few effective treatments for patients with advanced clear cell renal cell carcinoma (CCRCC). Recent findings indicate that ruthenium‐gold containing compounds exhibit significant antitumor efficacy against CCRCC in vitro affecting cell viability as well as angiogenesis and markers driving those 2 phenomena. However, no in vivo preclinical evaluation of this class of compounds has been reported.
Methods: Following the dose‐finding pharmacokinetic determination, NOD. CB17‐Prkdc SCID/J mice bearing xenograft CCRCC Caki‐1 tumors were treated in an intervention trial for 21 days at 10 mg/kg/72h of RANCE‐1. At the end of the trial, tumor samples were analyzed for histopathological and …
“Smoking Evolved?” Perceptions And Use Of Juul Products Amongst College Students, 2019 Massachusetts College of Pharmacy & Health Science
“Smoking Evolved?” Perceptions And Use Of Juul Products Amongst College Students, Ty Meka
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
Small‐Molecule Activators Of Glucose‐6‐Phosephate Dehydrogenase (G6pd) Bridging The Dimer Interface, 2019 Stanford University
Small‐Molecule Activators Of Glucose‐6‐Phosephate Dehydrogenase (G6pd) Bridging The Dimer Interface, Andrew G. Raub, Sunhee Hwang, Naoki Horikoshi, Anna D. Cunningham, Simin Rahighi, Soichi Wakatsuki, Daria Mochly-Rosen
Pharmacy Faculty Articles and Research
We have recently identified AG1, a small-molecule activator that functions by promoting oligomerization of glucose-6- phosphate dehydrogenase (G6PD) to the catalytically competent forms. Biochemical experiments indicate activation of G6PD by the original hit molecule (AG1) is noncovalent and that one C2-symmetric region of the G6PD homodimer is important for ligand function. Consequently, the disulfide in AG1 is not required for activation of G6PD and a number of analogs were prepared without this reactive moiety. Our Study supports a mechanism of action whereby AG1 bridges the dimer interface at the structural nicotinamide adenine dinucleotide phosphate (NADP+)-binding sites of two interacting G6PD …
A Multivalent Kaposi Sarcoma-Associated Herpesvirus-Like Particle Vaccine Capable Of Eliciting High Titers Of Neutralizing Antibodies In Immunized Rabbits, 2019 Beckman Research Institute of City of Hope
A Multivalent Kaposi Sarcoma-Associated Herpesvirus-Like Particle Vaccine Capable Of Eliciting High Titers Of Neutralizing Antibodies In Immunized Rabbits, David H. Mulama, Lorraine Z. Mustvunguma, Jennifer Totonchy, Peng Ye, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Ramina Nabiee, Murali Muniraju, Felix Wussow, Anne K. Barasa, Javier Gordon Ogembo
Pharmacy Faculty Articles and Research
Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and the causative agent of multiple cancers in immunocompromised patients. To date, there is no licensed prophylactic KSHV vaccine. In this study, we generated a novel subunit vaccine that incorporates four key KSHV envelope glycoproteins required for viral entry in diverse cell types (gpK8.1, gB, and gH/gL) into a single multivalent KSHV-like particle (KSHV-LP). Purified KSHV-LPs were similar in size, shape, and morphology to KSHV virions. Vaccination of rabbits with adjuvanted KSHV-LPs generated strong glycoprotein-specific antibody responses, and purified immunoglobulins from KSHV-LP-immunized rabbits neutralized KSHV infection in epithelial, endothelial, fibroblast, and B …
Diagnosis, Treatment And Follow Up Of Acute Pulmonary Embolism: Consensus Practice From The Pert Consortium, 2019 University of Pittsburgh
Diagnosis, Treatment And Follow Up Of Acute Pulmonary Embolism: Consensus Practice From The Pert Consortium, Belinda Rivera-Lebron, Michael Mcdaniel, Kamran Ahrar, Abdulah Alrifai, David M. Dudzinski, Christina Fanola, Danielle Blais, David Janicke, Roman Melamed, Kerry Mohrien, Elizabeth Rozycki, Charles B. Ross, Andrew J. Klein, Parth Rali, Nicholas R. Teman, Leoara Yarboro, Eugene Ichinose, Aditya M. Sharma, Jason A. Bartos, Mahir Elder, Brent Keeling, Harold Palevsky, Soophia Naydenov, Parijat Sen, Nancy Amoroso, Josanna M. Rodriguez-Lopez, George A. Davis, Rachel Rosovsky, Kenneth Rosenfield, Christopher Kabrhel, James Horowitz, Jay S. Giri, Victor Tapson, Richard Channick, Pert Consortium
Pharmacy Practice and Science Faculty Publications
Pulmonary embolism (PE) is a life-threatening condition and a leading cause of morbidity and mortality. There have been many advances in the field of PE in the last few years, requiring a careful assessment of their impact on patient care. However, variations in recommendations by different clinical guidelines, as well as lack of robust clinical trials, make clinical decisions challenging. The Pulmonary Embolism Response Team Consortium is an international association created to advance the diagnosis, treatment, and outcomes of patients with PE. In this consensus practice document, we provide a comprehensive review of the diagnosis, treatment, and follow-up of acute …
A Pilot Process To Identify And Switch High-Risk Warfarin Patients To Direct Oral Anticoagulants, 2019 Selected Works
A Pilot Process To Identify And Switch High-Risk Warfarin Patients To Direct Oral Anticoagulants, S. Lee, J. B. Groce, J. Kim
James Groce
No abstract provided.
Torsades De Pointes And Qt Prolongation Associations With Antibiotics: A Pharmacovigilance Study Of The Fda Adverse Event Reporting System, 2019 University of South Carolina
Torsades De Pointes And Qt Prolongation Associations With Antibiotics: A Pharmacovigilance Study Of The Fda Adverse Event Reporting System, Chengwen Teng Pharm.D., Ph.D., Elizabeth A. Walter, Daryl Kevin S. Gaspar, Obiageri O. Obodozie-Ofoegbu, Christopher R. Frei
Faculty Publications
Introduction: Macrolides, linezolid, imipenem-cilastatin, fluoroquinolones, penicillin combinations, and ceftriaxone are known to be associated with Torsades de pointes/QT prolongation (TdP/QTP). Other antibiotics may also lead to TdP/QTP, but no study has systemically compared TdP/QTP associations for many available antibiotics.
Objectives: The objective of this study was to evaluate the association between TdP/QTP and many available antibiotics using the FDA Adverse Event Report System (FAERS).
Methods: FAERS reports from January 1, 2015 to December 31, 2017 were analyzed. The Medical Dictionary for Regulatory Activities (MedDRA) was used to identify TdP/QTP cases. We calculated the Reporting Odds Ratios (RORs) …
Building A Rotation Syllabus Using Legos: Learning Experience Goals & Objectives, 2019 Baptist Hospital of Miami
Building A Rotation Syllabus Using Legos: Learning Experience Goals & Objectives, Radhan Gopalani
All Publications
No abstract provided.
Impact Of High Volume Energy Drink Consumption On Electrocardiographic And Blood Pressure Parameters: A Randomized Trial, 2019 University of the Pacific
Impact Of High Volume Energy Drink Consumption On Electrocardiographic And Blood Pressure Parameters: A Randomized Trial, Sachin A. Shah, Andy H. Szeto, Raechel Farewell, Allen Shek, Dorothy Fan, Kathy N. Quach, Mouchumi Bhattacharyya, Jasmine Elmiari, Winny Chan, Kate O'Dell, Nancy Nguyen, Tracey J. Mcgaughey, Javed M. Nasir, Sanjay Kaul
School of Pharmacy Faculty Articles
Background Energy drinks have been linked to an increase in emergency room visits and deaths. We aim to determine the impact of energy drinks on electrocardiographic and hemodynamic parameters in young healthy volunteers. Methods and Results A randomized, double-masked, placebo-controlled, crossover study was conducted in healthy volunteers. Participants consumed 32 oz of either energy drink A, energy drink B, or placebo within 60 minutes on 3 study days with a 6-day washout period in between. The primary end point of QT c interval and secondary end points of QT interval, PR interval, QRS duration, heart rate, and brachial and central …
A Community Pharmacy Elective Course Utilizing A Service Development Project To Foster Innovation And Creative Thinking, 2019 Thomas Jefferson University
A Community Pharmacy Elective Course Utilizing A Service Development Project To Foster Innovation And Creative Thinking, Danielle Mayer, Pharmd, Bcacp
College of Pharmacy Posters
Course Description
Innovations in Community Pharmacy Practice is a 2-credit hour course offered to pharmacy students in the spring of the third professional year.
Teaching methods
- Group discussions
- Case study activity
- Self-reflection
- Group project
The focus of this course is the evolving role of the community pharmacist in delivering direct patient care services. Students learn the basics of creating a business plan and utilize these principles to create their own business plan for a new or enhanced service that could be implemented at a community pharmacy site. This is a hands-on, project- based course, designed to foster innovation, entrepreneurship, and …
Investigating Trail Sensitivity In Platinum-Resistant Ovarian Cancer, 2019 College of Saint Benedict/Saint John's University
Investigating Trail Sensitivity In Platinum-Resistant Ovarian Cancer, Nicholas Pathoulas
All College Thesis Program, 2016-2019
Ovarian cancer is the deadliest gynecologic malignancy in the United States. While these tumors may have a promising initial response to platinum-based chemotherapies, the patient’s prognosis is commonly hindered by the development of platinum resistant cancer. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been implicated as a potential treatment for many cancers based on its tumor selective nature. Combination therapies with TRAIL and platinum drugs have been shown to increase apoptosis and have been used in a variety of clinical trials, which have thus far failed to pass phase II.1 Researchers have not yet elucidated the complex mechanism(s) of TRAIL …
Impact Of A Co-Curricular Program On Students’ Perceptions Of Personal And Professional Growth, 2019 Cedarville University
Impact Of A Co-Curricular Program On Students’ Perceptions Of Personal And Professional Growth, Brenda Pahl, Jeffrey A. Bates, Zach Jenkins, Aleda Chen
Pharmacy Practice Faculty Publications
No abstract provided.
Commencement Program 2019, 2019 Loma Linda University
Commencement Program 2019, Loma Linda University
Commencement Programs
CONTENTS
1 | Message from the President
3 | 2019 Events of Commencement
5 | The Academic Procession
7 | Significance of Academic Regalia
9 | The Good Samaritan
10 | University History Highlights
12 | Loma Linda University Song - "Healing Love"
13 | Criteria for Institutional Awards—Loma Linda University and Loma Linda University Health
15 | Loma Linda University Health and Loma Linda University Honorees
34 | The Programs, The School Honorees, and The Speakers
- School of Medicine, 35
- School of Pharmacy, 66
- School of Dentistry, 79
- School of Allied Health Professions - Allied Health Studies, Cardiopulmonary Sciences, …