9 Institutions 13 Full-Text Articles 42 Authors 5,863 Downloads
Recent Articles in Natural Products Chemistry and Pharmacognosy
Isolation And Partial Characterization Of Bioactive Fucoxanthin From Himanthalia Elongata Brown Seaweed: A Tlc-Based Approach, Gaurav Rajauria, Nissreen Abu-Ghannam Dublin Institute of Technology
Isolation And Partial Characterization Of Bioactive Fucoxanthin From Himanthalia Elongata Brown Seaweed: A Tlc-Based Approach, Gaurav Rajauria, Nissreen Abu-Ghannam
Seaweeds are important sources of carotenoids, and numerous studies have shown the beneficial effects of these pigments on human health. In the present study, Himanthalia elongata brown seaweed was extracted with a mixture of low polarity solvents, and the crude extract was separated using analytical thin-layer chromatography (TLC).The separated compounds were tested for their potential antioxidant capacity and antimicrobial activity against Listeria monocytogenes bacteria using TLC bioautography approach. For bio-autography, the coloured band on TLC chromatogram was visualized after spraying with DPPH and triphenyltetrazolium chloride reagents which screen antioxidant and antimicrobial compounds, respectively, and only one active compound was ...
Investigating Key Post-Pks Enzymes From Gilvocarcin Biosynthetic Pathway, Nidhi Tibrewal University of Kentucky
Investigating Key Post-Pks Enzymes From Gilvocarcin Biosynthetic Pathway, Nidhi Tibrewal
Theses and Dissertations--Pharmacy
Gilvocarcin V (GV) belongs to the angucycline class of antibiotics that possesses remarkable anticancer and antibacterial activities with low toxicity. Gilvocarcin exhibits its light induced anticancer activity by mediating crosslinking between DNA and histone H3. When photo-activated by near-UV light, the C8 vinyl group forms a [2+2] cycloadduct with thymine residues of double stranded DNA. D-fucofuranose is considered essential for histone H3 interactions. However, the poor water solubility has rendered it difficult to develop gilvocarcin as a drug. We aim to design novel gilvocarcin analogues with improved pharmaceutical properties through chemo-enzymatic synthesis and mutasynthesis. Previous studies have characterized ...
North American Bioactive Plants For Human Health And Performance, Maria Pontes Ferreira, Fidji Gendron, Katrina C. McClure, Kelly Kindscher Wayne State University
North American Bioactive Plants For Human Health And Performance, Maria Pontes Ferreira, Fidji Gendron, Katrina C. Mcclure, Kelly Kindscher
Nutrition and Food Science Faculty Research Publications
Native and naturalized bioactive plants of the Canadian and American temperate biome are examined for their health and performance enhancement properties. Some of these plants are now being used as natural health products, and many have a long history as traditional foods and/or medicines with indigenous groups. This paper reviews the medicinal/cultural uses and bioactive properties of selected plant families: the Holly family (Aquifoliaceae) as stimulants, the Celery family (Apiaceae) as normoglycemic aids and analgesics, the Ginseng family (Araliaceae) as energy- boosting aids, the Sunflower family (Compositae) as anti-inflammatory aids, and the Legume family (Fabaceae) and Nightshade family ...
Pharmacy Professor Collaborates In Valuable Drug Research, Nathan Pilling Cedarville University
Pharmacy Professor Collaborates In Valuable Drug Research, Nathan Pilling
Natural products make up a sizable portion of the drugs Americans use every day. What makes these products effective? Are there other plants we haven’t discovered yet that could help us control diseases such as cancer and malaria? These are the questions Denise Simpson, Ph.D., is focused on answering through her research.
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North American Bioactive Plants For Human Health And Performance, Maria Pontes Ferreira
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