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Natural Products Chemistry and Pharmacognosy Commons

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The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson 2016 Cedarville University

The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson

Samson Amos, R.Ph., Ph.D.

Glioblastoma multiforme (GBM) is widely recognized as the most common and lethal of the malignant gliomas. Few effective therapeutic treatments are available as five-year survival rates of diagnosed individuals are less than five percent. Luteolin, a common flavonoid found in a variety of fruits and vegetables, has demonstrated significant promise in combating cancers of the breast, colon, liver, lung, and bone. In this study, we investigated the effects of luteolin on glioblastoma multiforme cell lines U-251, U-87, and U-1242. Cell viability was assessed using cell count with trypan blue exclusion and MTT assays. Results revealed that luteolin reduces GBM cell ...


The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson 2016 Cedarville University

The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson

Samson Amos, R.Ph., Ph.D.

Glioblastoma multiforme (GBM) is a WHO grade IV brain tumor. These tumors are highly proliferative, infiltrative, necrotic, angiogenic, and resistant to apoptosis. One major characteristic of GBM is the overexpression of epidermal growth factor receptor (EGFR), which leads to cell growth and proliferation when activated. GBM is very difficult to treat due to its location, heterogeneity, and invasiveness; an effective treatment is therefore needed. The use of flavonoids, which are natural compounds found in many fruits and vegetables, has been studied in the treatment of many different tumor types. Apigenin is a specific flavonoid that has previously been shown to ...


Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, MD, Thomas Melvin, Brandon Merritt, Charles Bishop, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation ...


Current Therapeutic Role And Medicinal Potential Of Scutellaria Barbata In Traditional Chinese Medicine And Western Research, Geyang Tao, Marcy J. Balunas 2016 University of Connecticut - Storrs

Current Therapeutic Role And Medicinal Potential Of Scutellaria Barbata In Traditional Chinese Medicine And Western Research, Geyang Tao, Marcy J. Balunas

Honors Scholar Theses

ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria barbata is a common herb in Traditional Chinese Medicine (TCM) most often used to treat cancer. S. barbata has been found to exhibit efficacy both in vitro and in vivo on a variety of cancer types. Similarly encouraging results have been shown in patients with metastatic breast cancer from Phase Ia and Ib clinical trials. This study aims to elucidate the current use of S. barbata by TCM practitioners and in current Western research.

MATERIALS AND METHODS: Semi-structured interviews were conducted with fifteen TCM practitioners in Beijing and Nanjing, China to understand their clinical use of ...


Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer H. Shannon, Nissreen Abu-Ghannam 2016 Dublin Institute of Technology

Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer H. Shannon, Nissreen Abu-Ghannam

Articles

The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved to survive the high concentrations of infectious and surface-fouling bacteria that are indigenous to ocean waters. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion. The resistance of pathogenic bacteria to existing antibiotics has become a global epidemic. Marine algae derivatives have shown promise as candidates in novel, antibacterial drug discovery. The efficacy of these compounds, their mechanism of action, applications as antibiotics, disinfectants, and ...


The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson 2016 Cedarville University

The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson

The Research and Scholarship Symposium

Glioblastoma multiforme (GBM) is widely recognized as the most common and lethal of the malignant gliomas. Few effective therapeutic treatments are available as five-year survival rates of diagnosed individuals are less than five percent. Luteolin, a common flavonoid found in a variety of fruits and vegetables, has demonstrated significant promise in combating cancers of the breast, colon, liver, lung, and bone. In this study, we investigated the effects of luteolin on glioblastoma multiforme cell lines U-251, U-87, and U-1242. Cell viability was assessed using cell count with trypan blue exclusion and MTT assays. Results revealed that luteolin reduces GBM cell ...


The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson 2016 Cedarville University

The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson

The Research and Scholarship Symposium

Glioblastoma multiforme (GBM) is a WHO grade IV brain tumor. These tumors are highly proliferative, infiltrative, necrotic, angiogenic, and resistant to apoptosis. One major characteristic of GBM is the overexpression of epidermal growth factor receptor (EGFR), which leads to cell growth and proliferation when activated. GBM is very difficult to treat due to its location, heterogeneity, and invasiveness; an effective treatment is therefore needed. The use of flavonoids, which are natural compounds found in many fruits and vegetables, has been studied in the treatment of many different tumor types. Apigenin is a specific flavonoid that has previously been shown to ...


The Influence Of Safety, Efficacy, And Medical Condition Severity On Natural V. Synthetic Drug Preference, Brian P. Meier, Courtney M. Lappas 2016 Gettysburg College

The Influence Of Safety, Efficacy, And Medical Condition Severity On Natural V. Synthetic Drug Preference, Brian P. Meier, Courtney M. Lappas

Psychology Faculty Publications

Research indicates that there is a preference for natural v. synthetic products, but the influence of this preference on drug choice in the medical domain is largely unknown. We present 5 studies in which participants were asked to consider a hypothetical situation in which they had a medical issue requiring pharmacological therapy. Participants ( N = 1223) were asked to select a natural, plant-derived, or synthetic drug. In studies 1a and 1b, approximately 79% of participants selected the natural v. synthetic drug, even though the safety and efficacy of the drugs were identical. Furthermore, participants rated the natural drug as safer than ...


The Antioxidant Activity And Their Major Antioxidant Compounds From Acanthopanax Senticosus And A. Koreanum, Young-Hyun Kim, Myoung Lae Cho, Dan-Bi Kim, Gi-Hae Shin, Jin-Ha Lee, Jong Seok Lee, Sun-Ok Park, Sang-Jong Lee, Hyun Mu Shin, Ok-Hwan Lee 2015 Kangwon National University

The Antioxidant Activity And Their Major Antioxidant Compounds From Acanthopanax Senticosus And A. Koreanum, Young-Hyun Kim, Myoung Lae Cho, Dan-Bi Kim, Gi-Hae Shin, Jin-Ha Lee, Jong Seok Lee, Sun-Ok Park, Sang-Jong Lee, Hyun Mu Shin, Ok-Hwan Lee

Open Access Articles

The antioxidant activity and chlorogenic acid and caffeic acid contents were investigated from different parts of Acanthopanax senticosus and A. koreanum. Antioxidant activity was assessed by various in vitro assays such as DPPH, ABTS, FRAP, reducing power assays and ORAC, and the chlorogenic acid and caffeic acid were validated by HPLC chromatography. Among the various extracts, the fruit extracts of A. senticosus and A. koreanum exhibited strongest antioxidant activities including ABTS, FRAP, reducing power and ORAC, however, strongest DPPH radical scavenging activity was observed from the leaf extract of A. senticosus. In addition, the antioxidant activities of various extracts were ...


Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro 2015 Marshall University

Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro

Zijian Xie

Background

Left ventricular hypertrophy commonly complicates chronic renal failure. We have observed that at least one pathway of left ventricular hypertrophy appears to involve signaling through reactive oxygen species (ROS). Green tea is a substance that appears to have substantial antioxidant activity, yet is safe and is currently widely used. We, therefore, studied whether green tea supplementation could attenuate the development of left ventricular hypertrophy in an animal model of chronic renal failure.

Methods

Male Sprague-Dawley rats were subjected to sham or remnant kidney surgery and given green tea extract (0.1% and 0.25%) or plain drinking water for ...


Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro 2015 Marshall University

Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro

Joseph I Shapiro MD

Background

Left ventricular hypertrophy commonly complicates chronic renal failure. We have observed that at least one pathway of left ventricular hypertrophy appears to involve signaling through reactive oxygen species (ROS). Green tea is a substance that appears to have substantial antioxidant activity, yet is safe and is currently widely used. We, therefore, studied whether green tea supplementation could attenuate the development of left ventricular hypertrophy in an animal model of chronic renal failure.

Methods

Male Sprague-Dawley rats were subjected to sham or remnant kidney surgery and given green tea extract (0.1% and 0.25%) or plain drinking water for ...


Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro 2015 Marshall University

Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro

Jiang Liu

Background

Left ventricular hypertrophy commonly complicates chronic renal failure. We have observed that at least one pathway of left ventricular hypertrophy appears to involve signaling through reactive oxygen species (ROS). Green tea is a substance that appears to have substantial antioxidant activity, yet is safe and is currently widely used. We, therefore, studied whether green tea supplementation could attenuate the development of left ventricular hypertrophy in an animal model of chronic renal failure.

Methods

Male Sprague-Dawley rats were subjected to sham or remnant kidney surgery and given green tea extract (0.1% and 0.25%) or plain drinking water for ...


Milking The Information: Resources On Herbal Lactation Aids, Erica Rosalle 2015 Philadelphia College of Osteopathic Medicine

Milking The Information: Resources On Herbal Lactation Aids, Erica Rosalle

PCOM Scholarly Papers

This article provides information for the layperson on herbs commonly used as galactagogues (lactation aids), their effectiveness, and risks according to existing scientific literature. In addition, resources for further research on herbal lactation aids are listed.


The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., Emily Martell 2015 University of Rhode ISland

The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., Emily Martell

Senior Honors Projects

Natural product extracts and chemicals isolated from natural products (e.g. plants, berries, seeds) have been commonly used in various types of traditional medicines. In addition, some drugs on the market today have been derived from natural product sources. The purpose of our study was to evaluate two natural products, Rhein and Thymoquinone, for as potential anti-diabetic and anti–obesity agents. According to the Center for Disease Control (CDC), the number of people in the US diagnosed with diabetes has increase from 11.9 million people in the year 2000 to 20.8 million people in the year 2011. Rhein ...


Anti-Neoplastic Effects Of Extracts From Gnaphalium Gracile On Colon, Pancreatic, And Prostate Cancer Cells, Joshua R. Canter 2015 East Tennessee State University

Anti-Neoplastic Effects Of Extracts From Gnaphalium Gracile On Colon, Pancreatic, And Prostate Cancer Cells, Joshua R. Canter

Undergraduate Honors Theses

Over 4,000 flavonoids have been identified, and among these, many of them are known to possess cardioprotective, anti-inflammatory, antimicrobial, and antitumor effects. However, most of these properties have yet to be fully understood. In this study, extracts from Gnaphalium gracile, thought to possess a mixture of flavonoids, have been tested for cytotoxic activity on pancreatic (MiaPaca, Panc28), colon (HCT-116, Caco-2), and prostate (PC3, LNCaP), cancer cell lines. Polar extracts from the leaves of G. gracile have the most cytotoxic effect on these cancer cell lines, particularly the prostate cancer cell lines PC3 and LNCaP. Evidence suggests the extracts have ...


Evaluating Antioxidant Activity Of Selected Plant Species Native To Cedarville, Ohio, Daniel A. Benson, Alexander P. Treide, David Woodfield, Joshua A. Sitler, Denise S. Simpson, Robert L. Paris 2015 Cedarville University

Evaluating Antioxidant Activity Of Selected Plant Species Native To Cedarville, Ohio, Daniel A. Benson, Alexander P. Treide, David Woodfield, Joshua A. Sitler, Denise S. Simpson, Robert L. Paris

The Research and Scholarship Symposium

Over the past several decades, there has been an increase in the number of synthetic drug molecules developed and utilized to treat various conditions. Although these synthetic drugs have proven useful, there has been growing public concern regarding the potentially negative long-term effects of synthetic agents on the body. As a result, there has been an increased interest in identifying and utilizing plant extracts and purified compounds since they are perceived to be a more natural alternative to synthetic drugs. The goal of this study was to evaluate the specific antioxidant properties of alsike clover Trifolum hybridum when produced under ...


Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo 2015 Virginia Commonwealth University

Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo

Undergraduate Research Posters

Cancer is the second leading cause of death in the U.S. and millions of novel cancer cases are being diagnosed each year. While chemotherapy and ionizing radiation are effective treatments against these malignant tumors, the adverse effects that accompany such treatments are devastating. In order to find alternative treatment methods with less side effects, we turn to Eastern herbal medicine. Recent scientific research has found that Tripterygium wilfordii, an herbal medicine traditionally used to treat inflammation in China, contains compounds (triptolide and celastrol) that prevent the growth of solid tumors, induce apoptosis, and prevent metastasis of developed tumors. Investigations ...


Target-Directed Biosynthetic Evolution: Redirecting Plant Evolution To Genomically Optimize A Plant’S Pharmacological Profile, Dustin Paul Brown 2015 University of Kentucky

Target-Directed Biosynthetic Evolution: Redirecting Plant Evolution To Genomically Optimize A Plant’S Pharmacological Profile, Dustin Paul Brown

Theses and Dissertations--Anatomy and Neurobiology

The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a native Lobelia species toward metabolites with greater activity ...


Design, Synthesis, And Pharmacological Evaluation Of Three Series Of Lobelane Analogs As Inhibitors Of The Vesicular Monoamine Transporter (Vmat2), John P. Culver 2015 University of Kentucky

Design, Synthesis, And Pharmacological Evaluation Of Three Series Of Lobelane Analogs As Inhibitors Of The Vesicular Monoamine Transporter (Vmat2), John P. Culver

Theses and Dissertations--Pharmacy

Methamphetamine (METH) abuse is a serious problem in the United States and worldwide. The reward experienced by METH users is due to the increase in extracellular dopamine (DA) concentrations caused by an interaction between METH and the DA transporter (DAT) as well as the Vesicular Monoamine Transporter-2 (VMAT2). The reward felt by users of METH leads to further use of the drug and subsequent abuse. The current project examined the ability of three novel series of lobelane analogs to interact with a binding site on the Vesicular Monoamine Transporter-2 (VMAT2) in an attempt to inhibit the effects of METH. Lobelane ...


Chemoenzymatic Studies To Enhance The Chemical Space Of Natural Products, Jhong-Min Chen 2015 University of Kentucky

Chemoenzymatic Studies To Enhance The Chemical Space Of Natural Products, Jhong-Min Chen

Theses and Dissertations--Pharmacy

Natural products provide some of the most potent anticancer agents and offer a template for new drug design or improvement with the advantage of an enormous chemical space. The overall goal of this thesis research is to enhance the chemical space of two natural products in order to generate novel drugs with better in vivo bioactivities than the original natural products.

Polycarcin V (PV) is a gilvocarcin-type antitumor agent with similar structure and comparable bioactivity with the principle compound of this group, gilvocarcin V (GV). Modest modifications of the polyketide-derived tetracyclic core of GV had been accomplished, but the most ...


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