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Recent Articles in Other Pharmacy and Pharmaceutical Sciences
Cross-Validation For Nonlinear Mixed Effects Models, Emily Colby, Eric Bair 
COBRA
Cross-Validation For Nonlinear Mixed Effects Models, Emily Colby, Eric Bair
The University of North Carolina at Chapel Hill Department of Biostatistics Technical Report Series
Cross-validation is frequently used for model selection in a variety of applications. However, it is difficult to apply cross-validation to mixed effects models (including the nonlinear mixed effects models) due to the fact that cross-validation requires “out-of-sample” predictions of the outcome variable, which cannot be easily calculated when random effects are present.We describe two novel variants of cross-validation that can be applied to nonlinear mixed effects models. One variant, where out-of-sample predictions are based on post hoc estimates of the random effects, can be used to select the overall structural model. Another variant, where cross-validation seeks to minimize the ...
High Dose Simvastatin As A Potential Anticancer Therapy In Leukemia Patients, Tamer Ahmed 
University of Kentucky
High Dose Simvastatin As A Potential Anticancer Therapy In Leukemia Patients, Tamer Ahmed
Theses and Dissertations--Pharmacy
Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that is used for the treatment of hyperlipidemia. Simvastatin has recently been studied for its potential use in cancer therapy. In-vitro studies have shown that simvastatin displays anticancer activity, but at concentrations unlikely to be achieved in patients being receiving typical antihyperlipidemic treatment doses. Thus, several clinical trials were conducted to study the tolerability of high dose statins in cancer patients. The maximum tolerated dose of simvastatin was determined to be 15 mg/kg/day, 25-fold higher than a typical dose. However, it is not known if simvastatin plasma concentrations can ...
Popular Institutions
Popular Authors
Prianka Chaudhari
University of North Texas Health Science Center
Christin Hollis
University of Kentucky
Tamer Ahmed
University of Kentucky
Violeta Hennessey
Texas Medical Center Library
Kenneth Kennedy
University of Kentucky
Eric Bair
COBRA
Emily Colby
COBRA
Matthew Varga
University of Tennessee, Knoxville
Alex Mejia
Thomas Jefferson University
Scott Waldman
Thomas Jefferson University
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Popular Articles
Overview Of Study Start Up Activities For A Clinical Trial At An Investigative Site, Prianka Chaudhari
Nanocrystals Of Chemotherapeutic Agents For Cancer Theranostics: Development And In Vitro And In Vivo Evaluation, Christin Hollis
High Dose Simvastatin As A Potential Anticancer Therapy In Leukemia Patients, Tamer Ahmed
A Bayesian Approach To Dose-Response Assessment And Drug-Drug Interaction Analysis: Application To In Vitro Studies, Violeta Hennessey
Influence Of Oncotype Dx® On Chemotherapy Prescribing In Early Stage Breast Cancer Patients: A Claims-Based Evaluation Of Utilization In The Real World, Kenneth Kennedy
Cross-Validation For Nonlinear Mixed Effects Models, Eric Bair, Emily Colby
Prescription Stimulant Use By Graduate Students, Matthew Varga
Investigation Of A Metal Complexing Route To Arene Trans-Dihydrodiols
Molecular Staging Individualizing Cancer Management, Scott Waldman, Stephanie Schulz, Terry Hyslop, Alex Mejia
Over The Counter (Otc) Analgesics: A Knowledge And Usage Assessment In College Students, Nicole Patel
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