Epi-Pens: Honors Capstone Enhancement, 2020 Ohio Northern University
Epi-Pens: Honors Capstone Enhancement, Chelsey Boecker
Honors Capstone Enhancement Presentations
No abstract provided.
Discrepancies In Written Versus Calculated Durations In Opioid Prescriptions: Pre-Post Study., 2020 Thomas Jefferson University
Discrepancies In Written Versus Calculated Durations In Opioid Prescriptions: Pre-Post Study., Benjamin H. Slovis, John Kairys, Bracken Babula, Melanie Girondo, Cara Martino, Lindsey M. Roke, Jeffrey Riggio
Department of Medicine Faculty Papers
BACKGROUND: The United States is in the midst of an opioid epidemic. Long-term use of opioid medications is associated with an increased risk of dependence. The US Centers for Disease Control and Prevention makes specific recommendations regarding opioid prescribing, including that prescription quantities should not exceed the intended duration of treatment.
OBJECTIVE: The purpose of this study was to determine if opioid prescription quantities written at our institution exceed intended duration of treatment and whether enhancements to our electronic health record system improved any discrepancies.
METHODS: We examined the opioid prescriptions written at our institution for a 22-month period. We …
Research News. Publications, 2020. Volume 1, 2020 University of Mississippi
Research News. Publications, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period January 1 through March 31, 2020
A Novel Elvitegravir Nanoformulation For Drug Delivery Across The Blood-Brain Barrier To Suppress Hiv-1 In Macrophages And Microglia, 2020 University of Tennessee Health Science Center
A Novel Elvitegravir Nanoformulation For Drug Delivery Across The Blood-Brain Barrier To Suppress Hiv-1 In Macrophages And Microglia, Yuqing Gong
Theses and Dissertations (ETD)
Over the last two decades, the use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection. However, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The appearance and persistence of HAND are partially due to the entry of HIV-1-infected monocytes into the brain. Within the central nervous system (CNS), HIV-1-infected macrophages and microglia serve as the major viral reservoirs and provide active viral replication even when systemic viral suppression has been achieved by ART. Efficient viral suppression of CNS macrophages and microglia is important for an effective HIV-1 treatment in the brain. The primary …
Using Medical Claims Database To Develop A Population Disease Progression Model For Leuprorelin-Treated Subjects With Hormone-Sensitive Prostate Cancer, 2020 University of Kentucky
Using Medical Claims Database To Develop A Population Disease Progression Model For Leuprorelin-Treated Subjects With Hormone-Sensitive Prostate Cancer, Yixuan Zou, Fei Tang, Jeffery C. Talbert, Chee M. Ng
Pharmacy Practice and Science Faculty Publications
Androgen deprivation therapy (ADT) is a widely used treatment for patients with hormone-sensitive prostate cancer (PCa). However, duration of treatment response varies, and most patients eventually experience disease progression despite treatment. Leuprorelin is a luteinizing hormone-releasing hormone (LHRH) agonist, a commonly used form of ADT. Prostate-specific antigen (PSA) is a biomarker for monitoring disease progression and predicting treatment response and survival in PCa. However, time-dependent profile of tumor regression and growth in patients with hormone-sensitive PCa on ADT has never been fully characterized. In this analysis, nationwide medical claims database provided by Humana from 2007 to 2011 was used to …
Method And System For Diterpene Production Platforms In Yeast, 2020 University of Kentucky
Method And System For Diterpene Production Platforms In Yeast, Joseph Chappell, Xun Zhuang, Shuiqin Wu
Pharmaceutical Sciences Faculty Patents
A method is provided for modifying yeast to express mutant avian farnesyl disphospate synthase and the resulting modified yeast. The yeast advantageously includes additional mutants including but not limited to having ergosterol dependent growth and being erg-. The modified yeast are beneficial for the production of various terpenes including diterpenes.
The Incidence And Severity Of Drug Interactions Before And After Switching Antiretroviral Therapy To Bictegravir/Emtricitabine/Tenofovir Alafenamide In Treatment Experienced Patients, 2020 Thomas Jefferson University
The Incidence And Severity Of Drug Interactions Before And After Switching Antiretroviral Therapy To Bictegravir/Emtricitabine/Tenofovir Alafenamide In Treatment Experienced Patients, Ciara Walshe, Pharmd Candidate, Jason J. Schafer, Pharmd, Mph, Bcps-Aq Id, Bcidp, Aahivp
College of Pharmacy Posters
Objective
- The primary outcome was to measure the proportion of patients experiencing DIs before and after the ART switch.
- The secondary outcome was to measure changes in DI scores before and after the ART switch.
How Do Pharmacies Evaluate Cleanroom Automation Systems?, 2020 Marshall University
How Do Pharmacies Evaluate Cleanroom Automation Systems?, Kenneth Maxik, Craig Kimble, Alberto Coustasse, Chris Booth
Pharmacy Practice & Administration
Many pharmacies have implemented or considered implementing cleanroom automation or compounding systems. Intravenous (IV) admixture automation is one of the newest areas of technology that has been applied to pharmacy workflow. Manufacturers tout systems for reducing errors reaching patients. Clinical literature supports that cleanroom technology can aid in patient safety.
Diabetes Debunked: What You Need To Know, 2020 University of Nebraska - Lincoln
Diabetes Debunked: What You Need To Know, Maggie Hutson
Honors Theses
The goal of this Honors creative project is to encourage health literacy in populations who are curious about Type 2 Diabetes or have Type 2 Diabetes. From personal experience, I have seen noncompliance in diabetics and wondered why since it is a serious, progressive disease. After researching, I found that some diabetics do not understand the scope of their disease, especially since many of the dangerous complications that arise from Type 2 Diabetes do not present until later in the disease when it is too late. For my senior project, I decided to write an educational paper as a supplement …
Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, 2020 University of Oklahoma Health Sciences Center
Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka
Department of Pharmacology and Experimental Therapeutics Faculty Papers
Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45+ immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …
The Use Of Urine Drug Testing For Risk Stratification And Efficacious Drug Monitoring In Pain Management Settings, 2020 Wayne State University
The Use Of Urine Drug Testing For Risk Stratification And Efficacious Drug Monitoring In Pain Management Settings, Ahmad I. Hasan, Kareem Elhage, Brendan Farley, Khaled J. Saleh
Medical Student Research Symposium
Objective: To understand the current landscape of urine drug testing (UDT) guidelines as part of risk assessment for opioid abuse, and to offer recommendations towards adopting universal screening guidelines.
Background: There has been an opioid epidemic within the United States, and the role of prescription opioids has been well established. Despite proposed recommendations, there has yet to be a published universal screening guideline on the use of UDT in the setting of opioid abuse risk stratification as well as postoperative drug monitoring.
Methods: We explored current guidelines for UDT on two levels. First, we explore general indications for UDT within …
February/March 2020, 2020 Southwestern Oklahoma State University
February/March 2020, Randy Curry, Cindy Brooks
RURAL ROCKS
Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy
Assessing The Dyadic Relationship Between Sleep And Health-Related Quality Of Life In Pd Patients And Their Caregivers Using The Actor-Partner Interdependence Model (Apim), 2020 University of Mississippi
Assessing The Dyadic Relationship Between Sleep And Health-Related Quality Of Life In Pd Patients And Their Caregivers Using The Actor-Partner Interdependence Model (Apim), Sushmitha Inguva
Graduate Student Council Research Grants
Overview: My name is Sushmitha Inguva. I am a 4th year doctoral student in the Department of Pharmacy Administration in the School of Pharmacy. My primary area of interest is in Health Economics and Outcomes Research. For my dissertation, I am focusing on sleep disorders and their impact on health-related quality of life (HRQoL) in Parkinson’s disease (PD) patients and caregivers.
Intellectual Merit: PD is caused by loss of dopaminergic neurons in the brain. PD patients experience motor and non-motor symptoms (NMS). Among NMS, sleep disorders are the most common, occurring in about 60-90% of patients. Sleep disorders in patients …
Flavonoids And Other Polyphenols Act As Epigenetic Modifiers In Breast Cancer., 2020 Thomas Jefferson University
Flavonoids And Other Polyphenols Act As Epigenetic Modifiers In Breast Cancer., Priyanga Selvakumar, Aja Badgeley, Paige Murphy, Hina Anwar, Urvashi Sharma, Katharine Lawrence, Ashakumary Lakshmikuttyamma
College of Pharmacy Faculty Papers
Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are present in plants, as secondary metabolites has been a major topic of research for many years. Our review analysis demonstrates that flavonoids exhibit anti-cancer activity against breast cancer occurring in different ethnic populations. Breast cancer subtype and menopausal status are the key factors in inducing the flavonoid's anti-cancer action in breast cancer. The dose is another key …
Incorporation Of Agouti-Related Protein (Agrp) Human Single Nucleotide Polymorphisms (Snps) In The Agrp-Derived Macrocyclic Scaffold C[Pro-Arg-Phe-Phe-Asn-Ala-Phe-Dpro] Decreases Melanocortin-4 Receptor Antagonist Potency And Results In The Discovery Of Melanocortin-5 Receptor Antagonists, Zoe M. Koerperich, Mark D. Ericson, Katie T. Freeman, Robert C. Speth, Irina D. Pogozheva, Henry I. Mosberg, Carrie Haskell-Luevano
HPD Articles
While the melanocortin receptors (MCRs) are known to be involved in numerous biological pathways, the potential roles of the MC5R have not been clearly elucidated in humans. Agouti-related protein (AgRP), an MC3R/MC4R antagonist and MC4R inverse agonist, contains an exposed β-hairpin loop composed of six residues (Arg-Phe-Phe-Asn-Ala-Phe) that is imperative for binding and function. Within this active loop of AgRP, four human missense polymorphisms were deposited into the NIH Variation Viewer database. These polymorphisms, Arg111Cys, Arg111His, Phe112Tyr, and Ala115Val (AgRP full-length numbering), were incorporated into the peptide macrocycles c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-dPro], where Xaa was Dap or Asn, to explore the functional effects …
Rna Nanoparticles For Brain Tumor Treatment, 2020 The Ohio State University
Rna Nanoparticles For Brain Tumor Treatment, Peixuan Guo, Carlo M. Croce, Tae Jin Lee, Farzin Haque, Hui Li
Pharmaceutical Sciences Faculty Patents
The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.
“Why Wouldn’T I Use It?”: Purdue Pharmaceutical’S Push Of Pills, 2020 College of DuPage
“Why Wouldn’T I Use It?”: Purdue Pharmaceutical’S Push Of Pills, Gillian Fletcher
English Student Scholarship
Throughout the early 1940’s to mid 1960’s, the popular habit of smoking cigarettes was not only condoned, but advertised by doctors and lawmakers. With the support of medical professionals and non-restrictive advertisement laws, the widespread use of this deadly product exploded. The ‘Big Tobacco’ industry and the federal government made enormous amounts in profit and tax revenue. Numerous similarities can be found between the advertising of cigarettes and the prescription opioid, OxyContin. ‘Big Tobacco’ and the producer of OxyContin, Purdue Pharma (Hoffman and Williams Walsh), employed incredibly similar tactics to encourage the public to use their lethal products. By controlling …
Pharmacist-Prescribed Birth Control: A Policy Analysis, 2020 University of Nebraska at Omaha
Pharmacist-Prescribed Birth Control: A Policy Analysis, Brianna Full
UNO Student Research and Creative Activity Fair
Although unintended pregnancy in the United States has steadily decreased from 2008, rates are still unacceptably high as almost half (42%) of all pregnancies are not wanted or timed correctly (Finer & Zolna). In 2011, 2.8 million of the 6.1 million pregnancies in the United States each year were unintended. Public health professionals are worried about unintended pregnancy because research shows that unwanted or mistimed pregnancies come with associations to adverse maternal and child health outcomes, such as delayed prenatal care, premature birth, and negative physical and mental health effects for children (Frost, Frohwirth & Zolna, 2016). Also, two-thirds (68%) …
Cannabis Chemistry And Pharmacognosy, 2020 University of Rhode Island
Cannabis Chemistry And Pharmacognosy, Joanna Burkhardt
Library Impact Statements
No abstract provided.
Caqnnabis Studies Certificate, 2020 University of Rhode Island
Caqnnabis Studies Certificate, Joanna Burkhardt
Library Impact Statements
No abstract provided.