Why Do Family Members Reject Ai In Health Care? Competing Effects Of Emotions, 2022 Old Dominion University
Why Do Family Members Reject Ai In Health Care? Competing Effects Of Emotions, Eun Hee Park, Karl Werder, Lan Cao, Balasubramaniam Ramesh
Information Technology & Decision Sciences Faculty Publications
Artificial intelligence (AI) enables continuous monitoring of patients’ health, thus improving the quality of their health care. However, prior studies suggest that individuals resist such innovative technology. In contrast to prior studies that investigate individuals’ decisions for themselves, we focus on family members’ rejection of AI monitoring, as family members play a significant role in health care decisions. Our research investigates competing effects of emotions toward the rejection of AI monitoring for health care. Based on two scenario-based experiments, our study reveals that emotions play a decisive role in family members’ decision making on behalf of their parents. We find …
Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, 2022 West Virginia University
Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, Justin Edward Markel
Graduate Theses, Dissertations, and Problem Reports
Osteosarcoma (OS) is a complex tumor with no effective targeted therapies due to its genomic heterogeneity and pleomorphism. The immune response it creates, particularly against metastatic lesions, is considerable; however, various suppressive mechanisms induced by the tumor prohibit its effectiveness. The presence of infiltrating lymphocytes suggests that therapeutic disinhibition through checkpoint blockade could increase antitumor immunity, though none have been successful in clinical trials. The complexities of the immune response to OS tumors have yet to be unraveled; however, there is evidence to suggest that cell-mediated immunity (CMI, specifically T cells, Natural Killer [NK] cells, and myeloid-lineage cells [MLCs]) plays …
Pulsed Chronopotentiometry With Polymer-Based Potassium-Selective Electrodes, 2021 Northern Kentucky University
Pulsed Chronopotentiometry With Polymer-Based Potassium-Selective Electrodes, Roland A. Long, Kebede L. Gemene Dr.
Posters-at-the-Capitol
This research aimed to develop ion-selective electrodes selective to potassium for use in measuring potassium concentration in blood. Potassium is an important electrolyte within the body, orchestrating nerve excitation, muscular function, and heart rate. Excessive or insufficient potassium levels can cause breakdowns in these systems difficult to differentiate from other potential causes. Isolating potassium concentration as the sole cause necessitates selective measurement. Pulsed Chronopotentiometry with polymer-based membrane electrodes offered a versatile route of interrogation: membrane composition and magnitude of applied current can be altered to assess selectivity in a fast and controlled manner. All potential measurements recorded corresponded to known …
Developing Deep-Learning Methods For Diagnosis And Prognosis Of Pediatric Progressive Diseases Using Modern Imaging Techniques, 2021 University of Tennessee Health Science Center
Developing Deep-Learning Methods For Diagnosis And Prognosis Of Pediatric Progressive Diseases Using Modern Imaging Techniques, Mahdieh Shabanian
Theses and Dissertations (ETD)
Purpose and Rationale. Central nervous system manifestations form a significant burden of disease in young children. There have been efforts to correlate the neurological disease state in tuberous sclerosis complex (TSC) neurological disease state with imaging findings is a standard part of patient care. However, such analysis of neuroimaging is time- and labor-intensive. Automated approaches to these tasks are needed to improve speed, accuracy, and availability. Automated medical image analysis tools based on 3D/2D deep learning algorithms can help improve the quality and consistency of image diagnosis and interpretation for cognitive disorders in infants. We propose to automate neuroimaging analysis …
Examination Of Antiviral Resistance In Venezuelan Equine Encephalitis Virus, 2021 University of Tennessee Health Science Center
Examination Of Antiviral Resistance In Venezuelan Equine Encephalitis Virus, Jasper Lee
Theses and Dissertations (ETD)
Venezuelan equine encephalitis virus (VEEV) is a New World Alphavirus that causes Venezuelan equine encephalitis (VEE), which is characterized by a febrile illness that can progress to neurological disease and death. While no major outbreaks of VEE have occurred since 1995, VEEV is a virus of concern as, in addition to its spread through mosquitos, it can be aerosolized and used as a bioweapon. Unfortunately, there are currently no FDA-approved vaccines or antivirals against VEEV. Efforts have been made to discover small molecules with an inhibitory effect on VEEV, but the potential for emergence of antiviral resistance to these compounds …
Identifying The Molecular Cause Of Extreme Endoplasmic Reticulum Dilation In Pediatric Osteosarcoma And Its Relationship To The Disease, 2021 University of Tennessee Health Science Center
Identifying The Molecular Cause Of Extreme Endoplasmic Reticulum Dilation In Pediatric Osteosarcoma And Its Relationship To The Disease, Rachael Wood
Theses and Dissertations (ETD)
Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the majority of 108 patient tumor samples, PDXs and osteosarcoma cell lines. These tumors exhibit reduced expression of four critical COPII vesicle proteins that has resulted in the accumulation of procollagen-I protein within ‘hallmark’ dilated ER. Using CRISPR activation technology, increased expression of only SAR1A and SEC24D to physiologically normal levels was sufficient to restore both collagen-I secretion and resolve dilated ER morphology …
Determining States Of Movement In Humans Using Minimally Processed Eeg Signals And Various Classification Methods, 2021 Clemson University
Determining States Of Movement In Humans Using Minimally Processed Eeg Signals And Various Classification Methods, Maurice Barnett
All Theses
Electroencephalography (EEG) is a non-invasive technique used in both clinical and research settings to record neuronal signaling in the brain. The location of an EEG signal as well as the frequencies at which its neuronal constituents fire correlate with behavioral tasks, including discrete states of motor activity. Due to the number of channels and fine temporal resolution of EEG, a dense, high-dimensional dataset is collected. Transcranial direct current stimulation (tDCS) is a treatment that has been suggested to improve motor functions of Parkinson’s disease and chronic stroke patients when stimulation occurs during a motor task. tDCS is commonly administered without …
Ecology Of Hantaviruses In Rodent Reservoirs And Their Early Innate Immune Responses In Human Model Systems, 2021 University of Tennessee Health Science Center
Ecology Of Hantaviruses In Rodent Reservoirs And Their Early Innate Immune Responses In Human Model Systems, Evan Peter Williams
Theses and Dissertations (ETD)
The spillover of zoonotic RNA viruses is responsible for a great deal of the disease outbreaks in human populations. These spillover events are set to continue due to anthropogenic and environmental changes that impact the distribution of these viruses. The viruses in the family Hantaviridae are classified as one of these emerging zoonotic RNA viruses. The spillover of the viruses in this family are responsible for two severe human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). These viruses are distributed across the globe and are responsible for a large number of human disease cases with …
Evaluation Of Root-End Resection With Conventional And Ultrasonic Methods: A Single-Blind, Randomized In-Vitro Study, 2021 Graduate Student, Faculty of Dentistry, Beirut Arab University, Beirut, Lebanon
Evaluation Of Root-End Resection With Conventional And Ultrasonic Methods: A Single-Blind, Randomized In-Vitro Study, Mohammad Al Shammaa, Roula S. Abiad, Nayer Abo Elsaad
BAU Journal - Creative Sustainable Development
The root-end resection is considered critical endodontic surgical procedure. Three millimeters of the root tip is resected and root-end cavity with parallel walls and comparable depth is cut to receive a root-end filling. The literature discussed dentinal cracks after root canal instrumentation and/or root dentine cutting. The aim of the present study was to assess cracks at root ends after resection with conventional versus ultrasonic techniques. Material and Methodology: Thirty-two extracted human lower premolar teeth with single root were used. Their root canals were prepared and received gutta-percha. Sixteen roots Group 1 were resected using tungsten carbide fissure burs, while …
Impact Of Central Line Bundle Care On Reduction Of Central Line Associated-Infections: A Scoping Review, 2021 University of Tennessee Health Science Center
Impact Of Central Line Bundle Care On Reduction Of Central Line Associated-Infections: A Scoping Review, Alisha James-Scott Msn, Fnp-C, Rachel Savoy Msn, Fnp-Bc, Donna Lynch-Smith Dnp, Acnp-Bc, Apn, Ne-Bc, Cnl, Tracy Mcclinton Dnp, Ag-Acnp-Bc, Apn
Doctor of Nursing Practice Projects
Purpose/Background Central venous catheters (CVC) are typical for critically ill patients in the intensive care unit (ICU). Due to the invasiveness of this procedure, there is a high risk for central line-associated bloodstream infection (CLABSI). These infections have been known to increase mortality and morbidity, medical costs, and reduce hospital reimbursements. Evidenced-based interventions were grouped to assemble a central line bundle to decrease the number of CLABSIs and improve patient outcomes. This scoping review will evaluate the literature and examine the association between reduced CLABSI rates and central line bundle care implementation or current use.
Methods A literature review was …
Medicated-Assisted Treatment And 12-Step Programs: Evaluating The Referral Process, 2021 University of Tennessee Health Science Center
Medicated-Assisted Treatment And 12-Step Programs: Evaluating The Referral Process, Candace S. Brown, Chudney Williams, Ryan E. Stephens, Jacqueline Sharp, Bobby Bellflower, Martinus T. Zeeman
Doctor of Nursing Practice Projects
Purpose/Background Overdose deaths in the U.S. from opioids have dramatically increased since the COVID-19 pandemic. Although medicated-assisted treatment (MAT) programs are widely available for sufferers of opiate addiction, many drop out of treatment prematurely. Twelve-step programs are considered a valuable part of treatment, but few studies have examined the effect of combining these approaches. We aimed to compare abstinence rates among patients receiving MAT who were referred to 12-step programs to those only receiving MAT.
Methods In this prospective study, a cohort of participants from a MAT clinic agreeing to attend a 12-step program was compared to 15 controls selected …
Geriatric Emergency Medicine Fellowship Journal Club: Frailty, 2021 Beaumont Royal Oak
Geriatric Emergency Medicine Fellowship Journal Club: Frailty, Sarah Keene, Rebecca Fisher, Lauren Cameron-Comasco
Journal of Geriatric Emergency Medicine
No abstract provided.
Aptamer-Based Voltammetric Biosensing For The Detection Of Codeine And Fentanyl In Sweat And Saliva, 2021 Florida International University
Aptamer-Based Voltammetric Biosensing For The Detection Of Codeine And Fentanyl In Sweat And Saliva, Rosa Lashantez Cromartie
FIU Electronic Theses and Dissertations
Despite the many governmental and medicinal restrictions created to combat the opioid epidemic in the United States, opioid abuse and overdose rates continue to rise. The development of an aptamer-based voltammetric sensor and biosensor is described in this dissertation. The aim was to develop a low-cost, sensitive, and specific aptamer-based sensor for on-site, label-free determination of codeine and fentanyl in biological fluids. To do this, the surfaces of screen-printed carbon electrodes (SPCE) were modified with gold nanoparticles (AuNPs), followed by the addition of single-stranded DNA aptamers. These were covalently bound to the electrode surface. Operations of the sensors were collected …
Responding To The Pandemic: A Multicountry Study On Social-Political Factors And Health Outcomes Of Covid-19, 2021 University of Tennessee Health Science Center
Responding To The Pandemic: A Multicountry Study On Social-Political Factors And Health Outcomes Of Covid-19, Lan Yao
Theses and Dissertations (ETD)
Introduction. Coronavirus Disease 2019 (COVID-19) poses a major global threat to human beings, which has caused devastating consequences of population health, political, and economic crises in many countries. This dissertation was composed of three research activities to study the following aims: (1) review the existing literature focusing on political factors and health outcomes of COVID-19; (2) assess the relationship between democracy and case fatality rate of COVID-19 by controlling for the effect of age, comorbidity, health expenditure, healthcare workforce, and population density; and (3) identify the trajectory pattern cases peak days, deaths peak days, and peak periods.
Methods. We accessed …
Evaluation And Feasibility Of A Head Positioning Intervention In Patients With Intraparenchymal Hemorrhage, 2021 University of Tennessee Health Science Center
Evaluation And Feasibility Of A Head Positioning Intervention In Patients With Intraparenchymal Hemorrhage, Wendy L. Dusenbury
Theses and Dissertations (ETD)
Stroke caused by intraparenchymal hemorrhage (IPH) is most commonly the result of hypertension-induced blood vessel rupture in the brain and is associated with devastating disability and high rates of death. To date, no intervention has improved outcomes in IPH stroke patients; however, head elevation may be one of the most important first steps to promote clinical stability in the hyperacute stage of IPH stroke because of the risk of increased intracranial pressure (ICP) in these patients. Nursing research completed in the late 1970s and early 1980s in patients with increased ICP due to traumatic brain injury showed that elevating the …
Flag State Performance As A Crucial Element Of Human Factor Analysis And Classification System (Hfacs) On Marine Casualty Investigations, 2021 World Maritime University
Flag State Performance As A Crucial Element Of Human Factor Analysis And Classification System (Hfacs) On Marine Casualty Investigations, Panagiotis Vangelatos
World Maritime University Dissertations
No abstract provided.
Effect Of Different Irrigation Regimens On Enterococcus Faecalis Elimination From Infected Root Canals (An In-Vitro Comparative Study), 2021 PHD program Resident, Division of Endodontology, Department of Restorative Sciences, Faculty of Dentistry, Beirut Arab University, Beirut, Lebanon
Effect Of Different Irrigation Regimens On Enterococcus Faecalis Elimination From Infected Root Canals (An In-Vitro Comparative Study), Fadl Khaled, Roula Abiad, Khaled Abd El Galil, Essam Osman
BAU Journal - Health and Wellbeing
Microorganisms harbored in the complexities of root canal systems might lead to endodontic failures and development of apical periodontitis. Enterococcus faecalis is the most common isolated bacteria in these cases. Aim: This study was conducted to compare the efficiency of four irrigation regimens on the elimination of an inoculated strain of E. faecalis. Materials and Methods: Forty single rooted extracted premolars were inoculated with a standard strain of Enterococcus faecalis (ATCC 29212) and incubated at 37˚C for two weeks to allow infection of the dentinal tubules. The bacterial suspension was replaced with a new one every 48 hours. The teeth …
Validation Of Arterial Spin Labeling For Longitudinal Monitoring And Differential Diagnosis Of Frontotemporal Dementia, 2021 The University of Western Ontario
Validation Of Arterial Spin Labeling For Longitudinal Monitoring And Differential Diagnosis Of Frontotemporal Dementia, Tracy Ssali
Electronic Thesis and Dissertation Repository
Frontotemporal dementia (FTD) is a devastating neurodegenerative disease characterized by a rapid decline in behavioural, language, and motor abilities. Advances in the understanding of FTD genetics and pathophysiology, and the subsequent development of novel disease modifying treatments have highlighted the need for tools to assess their efficacy. While structural magnetic resonance imaging (MRI) and functional imaging with 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) are used for clinical diagnosis, structural changes are subtle at the early stages and PET imaging is expensive and access limited. Given the coupling of cerebral blood flow (CBF) to energy metabolism, an attractive alternative is …
Retrospective Review Of Efficacy Of Repeated Radiofrequency Ablation For Cervicaland Lumbosacral Facet Pain, 2021 LSU Health Sciences Center- New Orleans
Retrospective Review Of Efficacy Of Repeated Radiofrequency Ablation For Cervicaland Lumbosacral Facet Pain, Andrew Carbajal, Robert Mipro, Liz Mortazavi, Casey Murphy
Medical Research Day
Objectives: Neck and low back pain are two common complaints that can significantly reduce quality of life, resulting in interference with daily activities.1 It is estimated that 84% of adults have had low back pain at some time in their lives, with 25% of adults reporting low back pain in the last three months.2-4 Some studies estimated that the 1 year incidence of neck pain is between 10.4% and 21.3%,5 with an annual prevalence rate exceeding 30% among adults in the United States.6 One of the most common pain generators for axial neck and back pain is the facet joint. …
Refining A Postpandemic Approach To Cancer Screening, 2021 Advocate Aurora Health
Refining A Postpandemic Approach To Cancer Screening, Michael A. Thompson
Journal of Patient-Centered Research and Reviews
In introducing Volume 8, Issue 4 of Journal of Patient-Centered Research and Reviews — a specially themed issue comprised of several works focused on improving cancer screening processes in clinical practice — JPCRR editor and hematologist/oncologist Michael Thompson reflects on the current state of various screening modalities and how the pandemic has already begun to shape ongoing research in this area. A delicate balance must be struck between avoiding overtesting or overdiagnosis and identifying the presence of malignant tumors early enough to allow for successful treatment.