Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells,
2019
Technological University Dublin
Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick Cullen, James Curtin
Articles
Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma …
Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi,
2019
Mzuzu University
Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi, Jazimoni Lazaro, Fanuel Kapute, Rochelle H. Holm
Faculty Scholarship
In sub-Saharan Africa, informal markets account for more than 80% of the total food selling. Fish is a major protein source for households in Malawi and is commonly purchased from individual vendors. The aim of this study was to review national acts and policies and local regulations focused on fresh fish sold at open-air markets or by mobile vendors and to further examine the water, sanitation, and hygiene environment that may impact food safety in Mzuzu City, Malawi. The study used interviews, an observational checklist, and sampling of water and fish skin. In general, there was limited oversight of food …
Developing A Dissociative Nanocontainer For Peptide Drug Delivery,
2019
The Graduate Center, City University of New York
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Dissertations, Theses, and Capstone Projects
The potency and specificity of bioactive peptides have propelled these agents to the forefront of pharmacological research. However, delivery of peptides to their molecular target in cells is a major obstacle to their widespread application. A Trojan Horse strategy of packaging a bioactive peptide within a modified protein cage to protect it during transport, and releasing it at the target site, is a promising delivery method. Recent work has demonstrated that the viral capsid of the P22 bacteriophage can be loaded with an arbitrary, genetically-encoded peptide, and externally decorated with a cell-penetrating peptide, such as HIV-Tat, to translocate across in …
Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification,
2019
University of Nevada, Las Vegas
Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification, Micajah Daniels, Courtney Coughenour
McNair Poster Presentations
This project is intended to use Black Feminist Health Studies as an interdisciplinary approach to analyze the holisitc impacts of community gardens on nutrition behaviors. The implementation of green spaces such as community gardens have been correlated to both benefits and unintended consequences which this study demonstrates through the Socio-Ecological Wellness Wheel. An empirical and systematic way of measuring garden quality through an audit tool using Black Feminist Health Studies could help measure the nutrition environment of the community gardens and how they may influence fruit and vegetable consumption of food insecure populations. The need for this study is highlighted …
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition.,
2019
University of Manitoba
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami
Center for Translational Medicine Faculty Papers
Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. We found that simvastatin significantly reduced cell viability in C2C12 cells compared to RH30 cells. However, simvastatin induced greater apoptosis in RH30 compared to C2C12 cells. Simvastatin-induced cell death is dependent on geranylgeranyl pyrophosphate (GGPP) in C2C12 cells, while in RH30 cells it is dependent on both farnesyl pyrophosphate (FPP) and GGPP. Simvastatin inhibited …
Our Envirome, Spring/Summer 2019, Issue 40,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.3,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.3
Sustain Magazine
No abstract provided.
Plastic Pollution, Fall/Winter 2019, Issue 39.2,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.2
Sustain Magazine
No abstract provided.
Plastic Pollution, Fall/Winter 2019, Issue 39,
2019
University of Louisville
Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System,
2019
Purdue University
Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner
The Journal of Purdue Undergraduate Research
No abstract provided.
Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes,
2019
Purdue University
Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad
The Journal of Purdue Undergraduate Research
No abstract provided.
Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes,
2019
Purdue University
Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis
The Journal of Purdue Undergraduate Research
No abstract provided.
Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine,
2019
Purdue University
Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski
The Journal of Purdue Undergraduate Research
No abstract provided.
Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri,
2019
Purdue University
Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer
The Journal of Purdue Undergraduate Research
No abstract provided.
Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ,
2019
Tianjin University
Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang
Peer Reviewed Articles
Natural killer (NK) cells play an irreplaceable role in the development of colon cancer, in which antitumor function of NK cells was impaired. Astragaloside III is a natural compound from Astragalus that has been shown to have immunomodulatory effects in various systems. However, few studies have evaluated the antitumor effects of Astragaloside III through stimulating systemic immunity and regulating NK cells. In this study, flow cytometry, immunohistochemical analysis, and immunofunctional assays were performed to elucidate the functions of Astragaloside III in restoring antitumor function of NK cells. We demonstrated that Astragaloside III significantly elevated the expression of natural killer group …
Dual Inhibition Of The Pi3k/Akt And Mek5/Erk5 Pathways For The Treatment Of Breast Cancer,
2019
Duquesne University
Dual Inhibition Of The Pi3k/Akt And Mek5/Erk5 Pathways For The Treatment Of Breast Cancer, Thomas Douglas Wright
Electronic Theses and Dissertations
Breast cancer is a heterogeneous disease state with several challenging frontiers. In particular, aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK) pathways have been linked to increased breast cancer proliferation and survival. It has been proposed that these survival characteristics are enhanced through compensatory signaling and crosstalk mechanisms. New evidence suggests that MEK5/ERK5, a member of the MAPK family, is a crucial component in the proliferation and survival of several aggressive cancers. We hypothesize that inhibiting both PI3K/Akt and MEK5/ERK5 pathways will decrease cell viability while maintaining limited collateral toxicity. In this study, we examined the effects …
Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1,
2019
Indian Institute of Packaging, Mumbai
Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms
Journal of Applied Packaging Research
Biodegradable polymers (especially those derived from plant sources) begin their lifecycle as renewable resources, usually in the form of starch or cellulose. In this paper, the evaluation of biodegradability of cellulose-based polymer film under controlled composting conditions as per the guidelines of IS/ISO 14855 (Part-1) standard has been described. Microcrystalline cellulose (MCC) powder was taken as positive-control polymer. The apparatus used to analyse the degree and rate of biodegradation was developed indigenously. The validation of the biodegradability testing apparatus was also performed as per the prescribed test method given in IS/ISO 14855-1.
Investigation Of Riluzole’S Synaptic Protection Mechanism Through Hsf1-Bdnf Axis,
2019
University of Tennessee Health Science Center
Investigation Of Riluzole’S Synaptic Protection Mechanism Through Hsf1-Bdnf Axis, Yi Zhang
Theses and Dissertations (ETD)
The FDA-approved amyotrophic lateral sclerosis (ALS) drug Riluzole has great potential in treating Alzheimer’s disease (AD) based on promising animal data as well as its known action on modulating synaptic transmission. However, its detailed mechanism of action is not fully understood. Here, we proposed work aiming to address this aspect via focus- ing on the Heat Shock Factor 1 (HSF1)-dependent mechanisms. We found that Riluzole could increase HSF1 and BDNF (Brain-Derived Neurotrophic Factor) expression both at transcriptional and translational levels. CA1 (Cornu Ammonia, the first region in the hip- pocampal circuit), is its main target. We also demonstrated a protective …
Molecular Responses To Deepwater Horizon Oil Spill Contaminants In Estuarine Fish,
2019
University of Southern Mississippi
Molecular Responses To Deepwater Horizon Oil Spill Contaminants In Estuarine Fish, Elizabeth Jones
Dissertations
The 2010 Deepwater Horizon (DWH) oil spill resulted in the oiling of approximately 2100 km of shoreline. During that time, resident organisms had to contend with the effects of multiple contaminants and suboptimal environmental conditions. This research examines the molecular effects of DWH oil spill contaminants in estuarine fish (CyprinodonvariegatusandFundulusgrandis) across multiple life stages, contaminant concentrations, and in conjunction with environmental stressors.
Our results indicate that:
1. Oil elicits substantial transcriptional effects across life stages in C. variegatus. In adults, exposure to low concentrations of oil and dispersant results in transcriptional effects related …
Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status,
2019
University of Alberta
Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas
Office of the Provost
In addition to small for gestational age (SGA) and low birth weight at term (LBWT), critically ill cases of SGA/LBWT are significant events from outcomes and economic perspectives that require further understanding of risk factors. We aimed to assess the spatiotemporal distribution of locations where there were consistently higher numbers of critically ill SGA/LBWT (hot spots) in comparison with all SGA/LBWT and all births. We focused on Edmonton (2008-2010) and Calgary (2006-2010), Alberta, and used a geographical information system to apply emerging hot spot analysis, as a new approach for understanding SGA, LBWT, and the critically ill counterparts (ciSGA or …
