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Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley 2017 George Washington University

Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley

Integrative Systems Biology Faculty Publications

Most nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from the ER to mitochondria and clusters at the outer mitochondrial membrane (OMM). Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and clusters at the OMM. By disruption of phosphofurin acidic cluster sorting protein 2 (PACS-2), mitofusins (Mfn1/2), and dynamin related protein 1 ...


Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D. 2017 Brigham Young University - Provo

Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.

Biomedical Engineering Western Regional Conference

Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.


Mt1-Mmp Mediates The Migratory And Tumourigenic Potential Of Breast Cancer Cells Via Non-Proteolytic Mechanisms, Mario Cepeda 2017 The University of Western Ontario

Mt1-Mmp Mediates The Migratory And Tumourigenic Potential Of Breast Cancer Cells Via Non-Proteolytic Mechanisms, Mario Cepeda

Electronic Thesis and Dissertation Repository

Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease that affects cell function via proteolytic and non-proteolytic mechanisms such as promoting degradation of the extracellular matrix (ECM) or augmentation of cell migration and viability, respectively. MT1-MMP has been implicated in metastatic progression ostensibly due to its ability to degrade ECM components and to allow migration of cells through the basement membrane. Despite in vitro studies demonstrating this principle, this knowledge has not translated into the use of MMP inhibitors (MMPi) that inhibit substrate catalysis as effective cancer therapeutics, or been corroborated by evidence of in vivo ECM degradation mediated by ...


Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar 2017 University of Kentucky

Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar

Radiation Medicine Faculty Publications

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings ...


Caf-1 P150 And Ki-67 Regulate Nuclear Structure Throughout The Human Cell Cycle, Timothy D. Matheson 2017 University of Massachusetts Medical School

Caf-1 P150 And Ki-67 Regulate Nuclear Structure Throughout The Human Cell Cycle, Timothy D. Matheson

GSBS Dissertations and Theses

The three-dimensional organization of the human genome is non-random in interphase cells. Heterochromatin is highly clustered at the nuclear periphery, adjacent to nucleoli, and near centromeres. These localizations are reshuffled during mitosis when the chromosomes are condensed, nucleoli disassembled, and the nuclear envelope broken down. After cytokinesis, heterochromatin is re-localized to the domains described above. However, the mechanisms by which this localization is coordinated are not well understood. This dissertation will present evidence showing that both CAF-1 p150 and Ki-67 regulate nuclear structure throughout the human cell cycle.

Chromatin Assembly Factor 1 (CAF-1) is a highly conserved three-subunit protein complex ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling

Susan Elizabeth Starling

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy

Peter Lynwood Surguy

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen

Susan Mardis Allen

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman

Sara Friedman

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie

Steven Lee Christie

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock 2017 U.S. Military Academy

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock

Robert John Kock

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu 2017 Colorado Technical University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu

Su-Mei Chen Liu

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin

Yusif Yamin

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban

Thomas Orban

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari 2017 Morgan State University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari

Sakina Aleemah Ansari

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes 2017 Rosemont College

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes

Victoria Lee Vannes

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas

Russell Phillip Callas

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones

Susan Jones

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad

Rolando Baptista Piedad

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade

Tom Charles Slade

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


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