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Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar 2017 University of Kentucky

Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar

Radiation Medicine Faculty Publications

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling

Susan Elizabeth Starling

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy

Peter Lynwood Surguy

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen

Susan Mardis Allen

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman

Sara Friedman

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie

Steven Lee Christie

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock 2017 U.S. Military Academy

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock

Robert John Kock

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu 2017 Colorado Technical University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu

Su-Mei Chen Liu

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin

Yusif Yamin

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban

Thomas Orban

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari 2017 Morgan State University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari

Sakina Aleemah Ansari

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes 2017 Rosemont College

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes

Victoria Lee Vannes

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas

Russell Phillip Callas

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones

Susan Jones

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad

Rolando Baptista Piedad

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade

Tom Charles Slade

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susanne Wasmus 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susanne Wasmus

Susanne Kathrin Wasmus

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


The Role Of Inflammasomes In Asbestos-Induced Mesothelial To Fibroblastic Transition, Joyce K. Thompson 2017 University of Vermont

The Role Of Inflammasomes In Asbestos-Induced Mesothelial To Fibroblastic Transition, Joyce K. Thompson

Graduate College Dissertations and Theses

Malignant Mesothelioma (MM) is a fatal disease with a low median survival between 8 to 12 months after diagnosis. MM has a long latency period (10-60 years), is causally related to asbestos exposure, and is refractory to all available modes of therapy. Despite the causal association between asbestos exposure and MM however, the mechanisms by which asbestos induces this deadly disease remain unclear. Chronic inflammation due to the presence of asbestos fibers is believed to play an important role in all aspects of MM pathogenesis, from development to progression and resistance. Chronic inflammation has been shown to promote dysregulated wound ...


Evaluation Of Pro-Inflammatory Cytokines Expression In Mouse Splenocytes After Co-Incubation With The Biofield Energy Treated Formulation: Impact Of The Trivedi Effect®, James Mcleran, Mahendra Kumar Trivedi 2016 Trivedi Global Inc.

Evaluation Of Pro-Inflammatory Cytokines Expression In Mouse Splenocytes After Co-Incubation With The Biofield Energy Treated Formulation: Impact Of The Trivedi Effect®, James Mcleran, Mahendra Kumar Trivedi

James Jay McLeran

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral test formulation using mice splenocytes. The test formulation was divided into two parts. One part was the control without the Biofield Treatment. The other part was labelled the Biofield Treated sample, which received the Biofield Energy Healing Treatment remotely from twenty renowned Biofield Energy Healers. The splenocyte cells were exposed with the ...


Evaluation Of Pro-Inflammatory Cytokines Expression In Mouse Splenocytes After Co-Incubation With The Biofield Energy Treated Formulation: Impact Of The Trivedi Effect®, Joseph Foty, Mahendra Kumar Trivedi 2016 Trivedi Global inc.

Evaluation Of Pro-Inflammatory Cytokines Expression In Mouse Splenocytes After Co-Incubation With The Biofield Energy Treated Formulation: Impact Of The Trivedi Effect®, Joseph Foty, Mahendra Kumar Trivedi

Joseph Foty

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral test formulation using mice splenocytes. The test formulation was divided into two parts. One part was the control without the Biofield Treatment. The other part was labelled the Biofield Treated sample, which received the Biofield Energy Healing Treatment remotely from twenty renowned Biofield Energy Healers. The splenocyte cells were exposed with the ...


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