Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

2017

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1 - 30 of 592

Full-Text Articles in Biomedical Engineering and Bioengineering

Carbon Fiber Electrodes For In Vivo Neural Recording, Esma Cetinkaya Dec 2017

Carbon Fiber Electrodes For In Vivo Neural Recording, Esma Cetinkaya

Theses

Multi-channel micro electrodes for neural recording is a growing field that thrives on novel materials and fabrication techniques offered by micro fabrication technology. The material and the design of microelectrodes have a critical role on the qualit


Development And Evaluation Of A Connective Tissue Phantom Model For Subsurface Visualization Of Cancers Requiring Wide Local Excision, Kimberly S. Samkoe, Brent D. Bates, Niki N. Tselepidakis, Alisha V. Dsouza, Jason R. Gunn, Dipak B. Ramkumar, Keith D. Paulsen, Brian W. Pogue, Eric R. Henderson Dec 2017

Development And Evaluation Of A Connective Tissue Phantom Model For Subsurface Visualization Of Cancers Requiring Wide Local Excision, Kimberly S. Samkoe, Brent D. Bates, Niki N. Tselepidakis, Alisha V. Dsouza, Jason R. Gunn, Dipak B. Ramkumar, Keith D. Paulsen, Brian W. Pogue, Eric R. Henderson

Open Dartmouth: Faculty Open Access Scholarship

Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be considered. We developed a phantom model for sarcoma resection with the near-infrared fluorophore IRDye 800CW and used it to iteratively define the properties of connective tissues that typically surround sarcoma tumors. We then tested the ability of a blinded surgeon to resect fluorescent tumor-simulating inclusions with ∼1-cm margins using predetermined target fluorescence intensities ...


Subject-Independent Emotion Recognition Based On Physiological Signals: A Three-Stage Decision Method, Jing Chen, Bin Hu, Yue Wang, Philip Moore, Yongqiang Dai, Lei Feng, Zhijie Ding Dec 2017

Subject-Independent Emotion Recognition Based On Physiological Signals: A Three-Stage Decision Method, Jing Chen, Bin Hu, Yue Wang, Philip Moore, Yongqiang Dai, Lei Feng, Zhijie Ding

Biomedical Engineering Faculty Publications

Background: Collaboration between humans and computers has become pervasive and ubiquitous, however current computer systems are limited in that they fail to address the emotional component. An accurate understanding of human emotions is necessary for these computers to trigger proper feedback. Among multiple emotional channels, physiological signals are synchronous with emotional responses; therefore, analyzing physiological changes is a recognized way to estimate human emotions. In this paper, a three-stage decision method is proposed to recognize four emotions based on physiological signals in the multi-subject context. Emotion detection is achieved by using a stage-divided strategy in which each stage deals with ...


An Application Of M-Matrices To Preserve Bounded Positive Solutions To The Evolution Equations Of Biofilm Models, Richard S. Landry Jr. Dec 2017

An Application Of M-Matrices To Preserve Bounded Positive Solutions To The Evolution Equations Of Biofilm Models, Richard S. Landry Jr.

University of New Orleans Theses and Dissertations

In this work, we design a linear, two step implicit finite difference method to approximate the solutions of a biological system that describes the interaction between a microbial colony and a surrounding substrate. Three separate models are analyzed, all of which can be described as systems of partial differential equations (PDE)s with nonlinear diffusion and reaction, where the biological colony grows and decays based on the substrate bioavailability. The systems under investigation are all complex models describing the dynamics of biological films. In view of the difficulties to calculate analytical solutions of the models, we design here a numerical ...


Optimizing Filter-Probe Diffusion Weighting In The Rat Spinal Cord For Human Translation, Matthew D. Budde, Nathan P. Skinner, L. Tugan Muftuler, Brian D. Schmit, Shekar N. Kurpad Dec 2017

Optimizing Filter-Probe Diffusion Weighting In The Rat Spinal Cord For Human Translation, Matthew D. Budde, Nathan P. Skinner, L. Tugan Muftuler, Brian D. Schmit, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

No abstract provided.


Brain Motion, Deformation, And Potential Injury During Soccer Heading, Charles F. Babbs Dec 2017

Brain Motion, Deformation, And Potential Injury During Soccer Heading, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

This paper addresses the problem of what is happening physically inside the skull during head-ball contact. Mathematical models based upon Newton’s laws of motion and numerical methods are used to create animations of brain motion and deformation inside the skull.

Initially a 1 cm gap filled with cerebrospinal fluid (CSF) separates the brain from the rigid skull in adults and older children. Whole head acceleration induces a pulse of artificial gravity within the skull. Because brain density differs slightly from that of CSF, the brain accelerates and strikes the inner aspect of the skull, undergoing viscoelastic deformation, ranging from ...


System Optimization And Iterative Image Reconstruction In Photoacoustic Computed Tomography For Breast Imaging, Yang Lou Dec 2017

System Optimization And Iterative Image Reconstruction In Photoacoustic Computed Tomography For Breast Imaging, Yang Lou

Engineering and Applied Science Theses & Dissertations

Photoacoustic computed tomography(PACT), also known as optoacoustic tomography (OAT), is an emerging imaging technique that has developed rapidly in recent years. The combination of the high optical contrast and the high acoustic resolution of this hybrid imaging technique makes it a promising candidate for human breast imaging, where conventional imaging techniques including X-ray mammography, B-mode ultrasound, and MRI suffer from low contrast, low specificity for certain breast types, and additional risks related to ionizing radiation. Though significant works have been done to push the frontier of PACT breast imaging, it is still challenging to successfully build a PACT breast ...


Image Reconstruction Of The Speed Of Sound And Initial Pressure Distributions In Ultrasound Computed Tomography And Photoacoustic Computed Tomography, Thomas Paul Matthews Dec 2017

Image Reconstruction Of The Speed Of Sound And Initial Pressure Distributions In Ultrasound Computed Tomography And Photoacoustic Computed Tomography, Thomas Paul Matthews

Engineering and Applied Science Theses & Dissertations

Ultrasound computed tomography (USCT) and photoacoustic computed tomography (PACT) are two emerging imaging modalities that have a wide range of potential applications from pre-clinical small animal imaging to cancer screening in human subjects. USCT is typically employed to measure acoustic contrasts, including the speed of sound (SOS) distribution, while PACT typically measures optical contrasts or some related quantity such as the initial pressure distribution. Their complementary contrasts and similar implementations make USCT and PACT a natural fit for a hybrid imaging system. Still, much work remains to realize this promise. First, USCT image reconstruction methods based on the acoustic wave ...


Identification Of Prognostic Cancer Biomarkers Through The Application Of Rna-Seq Technologies And Bioinformatics, Nathan Wong Dec 2017

Identification Of Prognostic Cancer Biomarkers Through The Application Of Rna-Seq Technologies And Bioinformatics, Nathan Wong

Engineering and Applied Science Theses & Dissertations

MicroRNAs (miRNAs) are short single-stranded RNAs that function as the guide sequence of the post-transcriptional regulatory process known as the RNA-induced silencing complex (RISC), which targets mRNA sequences for degradation through complementary binding to the guide miRNA. Changes in miRNA expression have been reported as correlated with numerous biological processes, including embryonic development, cellular differentiation, and disease manifestation. In the latter case, dysregulation has been observed in response to infection by human papillomavirus (HPV), which has also been established as both oncogenic in cervical cancers and oropharyngeal cancers and favorable for overall patient survival after tumor formation. The identification of ...


Characterization Of Structural Dynamics Of The Human Head Using Magnetic Resonance Elastography, Andrew Arun Badachhape Dec 2017

Characterization Of Structural Dynamics Of The Human Head Using Magnetic Resonance Elastography, Andrew Arun Badachhape

Engineering and Applied Science Theses & Dissertations

In traumatic brain injury (TBI), the skull-brain interface, composed of three meningeal layers: the dura mater, arachnoid mater, and pia mater, along with cerebrospinal fluid (CSF) between the layers, plays a vital role in transmitting motion from the skull to brain tissue. Magnetic resonance elastography (MRE) is a noninvasive imaging modality capable of providing in vivo estimates of tissue motion and material properties. The objective of this work is to augment human and phantom MRE studies to better characterize the mechanical contributions of the skull-brain interface to improve the parameterization and validation of computational models of TBI. Three specific aims ...


Comparison Of The Bi-Directional Performance Of Micro-Channel Sieve And Thin-Film Time Peripheral Nerve Interfaces, Robert Coker Dec 2017

Comparison Of The Bi-Directional Performance Of Micro-Channel Sieve And Thin-Film Time Peripheral Nerve Interfaces, Robert Coker

Engineering and Applied Science Theses & Dissertations

Sophisticated motorized prosthetic limbs contain multiple degrees of freedom of motion as well as embedded pressure and angle transducers to provide sensory feedback in amputees. Although several central neural recording and stimulation modalities exist for both controlling these motions and providing sensory feedback from a prosthetic limb, directly interfacing the peripheral nerves which originally innervated the limb has many advantages. A difficulty with this bi-directional approach is that electrically stimulating axons to provide haptic feedback creates stimulation artifacts at neighboring recording sites within the nerve that are several orders of magnitude larger than the electroneurogram used for control. In this ...


Characterizing Anisotropy In Fibrous Soft Materials By Mr Elastography Of Slow And Fast Shear Waves, John Larson Schmidt Dec 2017

Characterizing Anisotropy In Fibrous Soft Materials By Mr Elastography Of Slow And Fast Shear Waves, John Larson Schmidt

Engineering and Applied Science Theses & Dissertations

The general objective of this work was to develop experimental methods based on magnetic resonance elastography (MRE) to characterize fibrous soft materials. Mathematical models of tissue biomechanics capable of predicting injury, such as traumatic brain injury (TBI), are of great interest and potential. However, the accuracy of predictions from such models depends on accuracy of the underlying material parameters. This dissertation describes work toward three aims. First, experimental methods were designed to characterize fibrous materials based on a transversely isotropic material model. Second, these methods are applied to characterize the anisotropic properties of white matter brain tissue ex vivo. Third ...


Next Generation Sequencing Technologies For Real-Time Genotyping And Targeted Sequencing For Precision Medicine, Priyanka Rawat Dec 2017

Next Generation Sequencing Technologies For Real-Time Genotyping And Targeted Sequencing For Precision Medicine, Priyanka Rawat

Biomedical Engineering ETDs

Astounding success of Human genome project and accelerating success of sequencing technologies have enabled $ 1000 genome goals possible. But, this is still far-fetched from the reach of many resource refrained populations with high genetic variations causing lethal genetic diseases. Based on present technology principles, I have developed prototypes for affordable, scalable and customizable point-of-care genotyping and targeted sequencing. Ion-sensitive field effect transistors with novel read-out and signal amplification techniques are used for laying foundation of possible ISFET based allele-arrays. Sequencing-by-synthesis based full-fledge sequencer is made with novel immobilization, flow-cell and data acquisition methods for massive sequenciing.


System Characterizations And Optimized Reconstruction Methods For Novel X-Ray Imaging, Huifeng Guan Dec 2017

System Characterizations And Optimized Reconstruction Methods For Novel X-Ray Imaging, Huifeng Guan

Engineering and Applied Science Theses & Dissertations

In the past decade there have been many new emerging X-ray based imaging technologies developed for different diagnostic purposes or imaging tasks. However, there exist one or more specific problems that prevent them from being effectively or efficiently employed. In this dissertation, four different novel X-ray based imaging technologies are discussed, including propagation-based phase-contrast (PB-XPC) tomosynthesis, differential X-ray phase-contrast tomography (D-XPCT), projection-based dual-energy computed radiography (DECR), and tetrahedron beam computed tomography (TBCT). System characteristics are analyzed or optimized reconstruction methods are proposed for these imaging modalities. In the first part, we investigated the unique properties of propagation-based phase-contrast imaging technique ...


Development Of In Vitro Drug Screening Platforms Using Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells, Yosuke Kurokawa Dec 2017

Development Of In Vitro Drug Screening Platforms Using Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells, Yosuke Kurokawa

Engineering and Applied Science Theses & Dissertations

Drug-induced cardiotoxicity is a critical challenge in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes (CMs), researchers have explored ways to utilize these cells for in vitro preclinical drug screening applications. One area of interest is microphysiological systems (i.e. organ-on-a-chip), which aims to create more complex in vitro models of human organ systems, thus improving drug response predictions. In this dissertation, we investigated novel analysis methods and model platforms for detecting drug-induced cardiotoxicity using human induced pluripotent stem cell (iPSC)-derived cardiovascular cells.

First, we utilized human iPSC-derived CMs (iPS-CMs) to establish optical ...


Binding Affinity And Specificity Of Sh2 Domain Interactions In Receptor Tyrosine Kinase Signaling Networks, Tom Ronan Dec 2017

Binding Affinity And Specificity Of Sh2 Domain Interactions In Receptor Tyrosine Kinase Signaling Networks, Tom Ronan

Engineering and Applied Science Theses & Dissertations

Receptor tyrosine kinase (RTK) signaling mechanisms play a central role in intracellular signaling and control development of multicellular organisms, cell growth, cell migration, and programmed cell death. Dysregulation of these signaling mechanisms results in defects of development and diseases such as cancer. Control of this network relies on the specificity and selectivity of Src Homology 2 (SH2) domain interactions with phosphorylated target peptides. In this work, we review and identify the limitations of current quantitative understanding of SH2 domain interactions, and identify severe limitations in accuracy and availability of SH2 domain interaction data. We propose a framework to address some ...


Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia Dec 2017

Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia

Engineering and Applied Science Theses & Dissertations

Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I ...


Reconstruction Algorithms For Novel Joint Imaging Techniques In Pet, Homayoon Ranjbar Dec 2017

Reconstruction Algorithms For Novel Joint Imaging Techniques In Pet, Homayoon Ranjbar

Engineering and Applied Science Theses & Dissertations

Positron emission tomography (PET) is an important functional in vivo imaging modality with many clinical applications. Its enormously wide range of applications has made both research and industry combine it with other imaging modalities such as X-ray computed tomography (CT) or magnetic resonance imaging (MRI). The general purpose of this work is to study two cases in PET where the goal is to perform image reconstruction jointly on two data types.

The first case is the Beta-Gamma image reconstruction. Positron emitting isotopes, such as 11C, 13N, and 18F, can be used to label molecules, and tracers, such ...


Electrostatic Precipitator To Collect Large Quantities Of Particulate Matter, Chun Hoe Ong Dec 2017

Electrostatic Precipitator To Collect Large Quantities Of Particulate Matter, Chun Hoe Ong

Theses and Dissertations

Traditional aerosol samplers are limited in their abilities to collect large quantities of particulate matter due to their low flow rates, high pressure drops, and are noise intrusiveness. The goal of this study was to develop an alternate aerosol sampler using electrostatic precipitation technology that was safe and not noise intrusive to be deployed in homes. The O-Ion B-1000 was selected as the most suitable electrostatic precipitator (ESP) for achieving the goal of this study because of its affordability, the design of its collection electrode and its high flow rate. The collection efficiency of the ESP was assessed for three ...


Characterizing Occupational Instabilities Induced By A Four-Dof All-Terrain Vehicle Simulator, John Stuart Michael Dec 2017

Characterizing Occupational Instabilities Induced By A Four-Dof All-Terrain Vehicle Simulator, John Stuart Michael

Theses and Dissertations

All-terrain vehicles (ATVs) are used widely throughout the United States both for recreational activities, such as hunting and riding, and in occupational settings, such as agriculture. In both such activities, ATVs can pose a risk of injury and death resulting from a number of factors, including operator error, operating in an altered state, and misuse. In a study by Milosavlijevic et al. (2011), a survey of agricultural workers in New Zealand displayed that roughly 60% of workers who operated an ATV experienced a loss of control event. The same study showed that nearly 50% of those occurred while riding on ...


Nanoparticles: Nanoscale Systems For Medical Applications, David Allen Wadkins Dec 2017

Nanoparticles: Nanoscale Systems For Medical Applications, David Allen Wadkins

Theses and Dissertations

The goal of this project was to develop a series of nano platforms for single cell analysis and drug delivery. Nanoparticles are a promising option to improve our medical therapies by controlling biodistribution and pharmacokinetics of therapeutics. Nanosystems also offer significant opportunity to improve current imaging modalities. The systems developed during this thesis work can be foundations for developing advanced therapies for obesity and improving our fundamental understandings of single cell behavior.

The first of the two systems we attempt to create was a drug delivery system that could selectively target adipose tissue to deliver uncoupling agents and drive browning ...


Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed Dec 2017

Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed

Electronic Thesis and Dissertation Repository

The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of ...


Optical Fibre-Based Force Sensing Needle Driver For Minimally Invasive Surgery, Pouya Soltani Zarrin Dec 2017

Optical Fibre-Based Force Sensing Needle Driver For Minimally Invasive Surgery, Pouya Soltani Zarrin

Electronic Thesis and Dissertation Repository

Minimally invasive surgery has been limited from its inception by insufficient haptic feedback to surgeons. The loss of haptic information threatens patients safety and results in longer operation times. To address this problem, various force sensing systems have been developed to provide information about tool–tissue interaction forces. However, the provided results for axial and grasping forces have been inaccurate in most of these studies due to considerable amount of error and uncertainty in their force acquisition method. Furthermore, sterilizability of the sensorized instruments plays a pivotal role in accurate measurement of forces inside a patient's body. Therefore, the ...


Syngenic Adipose-Derived Stem/Stromal Cells Delivered In Decellularized Adipose Tissue Scaffolds Enhance In Vivo Tissue Regeneration Through Host Cell Recruitment, Kevin P. Robb Dec 2017

Syngenic Adipose-Derived Stem/Stromal Cells Delivered In Decellularized Adipose Tissue Scaffolds Enhance In Vivo Tissue Regeneration Through Host Cell Recruitment, Kevin P. Robb

Electronic Thesis and Dissertation Repository

Decellularized adipose tissue (DAT) represents a promising adipogenic bioscaffold for applications in soft tissue augmentation or reconstruction. With the goal of investigating the role of syngeneic donor adipose-derived stem/stromal cells (ASCs) and host myeloid cells during in vivo adipose tissue regeneration, transgenic reporter mouse strains were used to track these cell populations within ASC-seeded and unseeded DAT scaffolds. Donor ASCs were obtained from dsRed transgenic mice. These cells were shown to express characteristic cell surface markers, and multilineage differentiation capacity was confirmed. To facilitate cell tracking, DAT scaffolds were subcutaneously implanted into MacGreen mice in which myeloid cells express ...


Association Between Left Ventricular Mechanics And Diffuse Myocardial Fibrosis In Patients With Repaired Tetralogy Of Fallot: A Cross-Sectional Study, Christopher M. Haggerty, Jonathan D. Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J. Wehner, Linyuan Jing, Richard J. Charnigo, Brandon K. Fornwalt, Mark A. Fogel Dec 2017

Association Between Left Ventricular Mechanics And Diffuse Myocardial Fibrosis In Patients With Repaired Tetralogy Of Fallot: A Cross-Sectional Study, Christopher M. Haggerty, Jonathan D. Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J. Wehner, Linyuan Jing, Richard J. Charnigo, Brandon K. Fornwalt, Mark A. Fogel

Biomedical Engineering Faculty Publications

Background: Patients with repaired tetralogy of Fallot (TOF) have progressive, adverse biventricular remodeling, leading to abnormal contractile mechanics. Defining the mechanisms underlying this dysfunction, such as diffuse myocardial fibrosis, may provide insights into poor long-term outcomes. We hypothesized that left ventricular (LV) diffuse fibrosis is related to impaired LV mechanics.

Methods: Patients with TOF were evaluated with cardiac magnetic resonance in which modified Look-Locker (MOLLI) T1-mapping and spiral cine Displacement encoding (DENSE) sequences were acquired at three LV short-axis positions. Linear mixed modeling was used to define the association between regional LV mechanics from DENSE based on regional T1-derived diffuse ...


Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton Dec 2017

Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton

Articles

This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with ...


Design, Implementation And Control Of A Robotic Platform For Post-Stroke Upper- And Lower-Limb Rehabilitation, Vahid Mehrabi Dec 2017

Design, Implementation And Control Of A Robotic Platform For Post-Stroke Upper- And Lower-Limb Rehabilitation, Vahid Mehrabi

Electronic Thesis and Dissertation Repository

Stroke is the primary cause of permanent disabilities worldwide. Hemiparesis and hemiplegia (the most common consequences of stroke) are the decreases in motor-functionality of the brain on one side of the body which will affect the daily life activities of the patient. There are several challenges with the current state of delivering rehabilitation services such as limitations on the number of the clinics, financial resources needed for providing rehabilitation, associated costs of transportation, and human resources. To overcome the issues related to conventional ways of delivering therapy, different robotic systems have been developed to benefit healthcare systems and patient with ...


Reducing Biomass Recalcitrance By Heterologous Expression Of A Bacterial Peroxidase In Tobacco (Nicotiana Benthamiana), Ayalew Ligaba-Osena, Bertrand Hankoua, Kay Dimarco, Robert Pace, Mark Crocker, Jesse Mcatee, Nivedita Nagachar, Ming Tien, Tom L. Richard Dec 2017

Reducing Biomass Recalcitrance By Heterologous Expression Of A Bacterial Peroxidase In Tobacco (Nicotiana Benthamiana), Ayalew Ligaba-Osena, Bertrand Hankoua, Kay Dimarco, Robert Pace, Mark Crocker, Jesse Mcatee, Nivedita Nagachar, Ming Tien, Tom L. Richard

Center for Applied Energy Research Faculty Publications

Commercial scale production of biofuels from lignocellulosic feed stocks has been hampered by the resistance of plant cell walls to enzymatic conversion, primarily owing to lignin. This study investigated whether DypB, the lignin-degrading peroxidase from Rodococcus jostii, depolymerizes lignin and reduces recalcitrance in transgenic tobacco (Nicotiana benthamiana). The protein was targeted to the cytosol or the ER using ER-targeting and retention signal peptides. For each construct, five independent transgenic lines were characterized phenotypically and genotypically. Our findings reveal that expression of DypB in the cytosol and ER does not affect plant development. ER-targeting increased protein accumulation, and extracts from transgenic ...


Telesurgery: Surgery In The Digital Age, Dylan J. Cahill Dec 2017

Telesurgery: Surgery In The Digital Age, Dylan J. Cahill

Dartmouth Undergraduate Journal of Science

The dawn of the digital age has transformed the way we now receive and provide healthcare. Today, providers have instant access to all of their patients’ information, just as patients can connect with their providers on their smartphones in minutes from nearly anywhere in the world.


Clinical Near-Infrared Spectroscopy Instrumentation: Postural Orthostatic Tachycardia Syndrome Studies, Parvathi Kadamati Dec 2017

Clinical Near-Infrared Spectroscopy Instrumentation: Postural Orthostatic Tachycardia Syndrome Studies, Parvathi Kadamati

Theses and Dissertations

ABSTRACT

CLINICAL NEAR-INFRARED SPECTROSCOPY INSTRUMENTATION: POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME STUDIES

by

Parvathi Kadamati

The University of Wisconsin-Milwaukee, 2017

Under the Supervision of Professor Mahsa Ranji

Aims: Postural orthostatic tachycardia syndrome (POTS) is a type of chronic orthostatic intolerance, annually affecting around 500,000 young Americans. Symptoms of POTS include lightheadedness and persistent increase in heart rate with upright body posture [1-3]. It requires a medical diagnosis. Impaired cerebral oxygenation of patients with POTS has been reported [4]. The pathophysiology remains unclear, and research is needed to understand the underlying conditions that lead to POTS. The aim of this research is ...