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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 30 of 38
Full-Text Articles in Biomedical Engineering and Bioengineering
Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia
Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia
McKelvey School of Engineering Theses & Dissertations
Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I …
Reconstruction Algorithms For Novel Joint Imaging Techniques In Pet, Homayoon Ranjbar
Reconstruction Algorithms For Novel Joint Imaging Techniques In Pet, Homayoon Ranjbar
McKelvey School of Engineering Theses & Dissertations
Positron emission tomography (PET) is an important functional in vivo imaging modality with many clinical applications. Its enormously wide range of applications has made both research and industry combine it with other imaging modalities such as X-ray computed tomography (CT) or magnetic resonance imaging (MRI). The general purpose of this work is to study two cases in PET where the goal is to perform image reconstruction jointly on two data types.
The first case is the Beta-Gamma image reconstruction. Positron emitting isotopes, such as 11C, 13N, and 18F, can be used to label molecules, and tracers, such …
Clinical Near-Infrared Spectroscopy Instrumentation: Postural Orthostatic Tachycardia Syndrome Studies, Parvathi Kadamati
Clinical Near-Infrared Spectroscopy Instrumentation: Postural Orthostatic Tachycardia Syndrome Studies, Parvathi Kadamati
Theses and Dissertations
ABSTRACT
CLINICAL NEAR-INFRARED SPECTROSCOPY INSTRUMENTATION: POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME STUDIES
by
Parvathi Kadamati
The University of Wisconsin-Milwaukee, 2017
Under the Supervision of Professor Mahsa Ranji
Aims: Postural orthostatic tachycardia syndrome (POTS) is a type of chronic orthostatic intolerance, annually affecting around 500,000 young Americans. Symptoms of POTS include lightheadedness and persistent increase in heart rate with upright body posture [1-3]. It requires a medical diagnosis. Impaired cerebral oxygenation of patients with POTS has been reported [4]. The pathophysiology remains unclear, and research is needed to understand the underlying conditions that lead to POTS. The aim of this research is to …
Computer-Aided Diagnoses (Cad) System: An Artificial Neural Network Approach To Mri Analysis And Diagnosis Of Alzheimer's Disease (Ad), Berizohar Padilla Cerezo
Computer-Aided Diagnoses (Cad) System: An Artificial Neural Network Approach To Mri Analysis And Diagnosis Of Alzheimer's Disease (Ad), Berizohar Padilla Cerezo
Master's Theses
Alzheimer’s disease (AD) is a chronic and progressive, irreversible syndrome that deteriorates the cognitive functions. Official death certificates of 2013 reported 84,767 deaths from Alzheimer’s disease, making it the 6th leading cause of death in the United States. The rate of AD is estimated to double by 2050. The neurodegeneration of AD occurs decades before symptoms of dementia are evident. Therefore, having an efficient methodology for the early and proper diagnosis can lead to more effective treatments.
Neuroimaging techniques such as magnetic resonance imaging (MRI) can detect changes in the brain of living subjects. Moreover, medical imaging techniques are the …
A High Accuracy Microwave Radiometric Thermometer To Measure Internal Body Temperature, Michael D. Grady
A High Accuracy Microwave Radiometric Thermometer To Measure Internal Body Temperature, Michael D. Grady
USF Tampa Graduate Theses and Dissertations
The Center for Disease Control and Prevention (CDC) released heat illness data which highlighted that ~29 heat stress hospitalizations and ~3 heat-related deaths occurred every day during the summer months within the US from years 2000 to 2014. Heatstroke- the most severe form of heat illness which oftentimes lead to death- has been cited to be entirely preventable if a timely intervention is introduced. This dissertation uses microwave radiometric thermometry to perform wireless non-invasive internal body temperature monitoring which can enable intervention methods that help to prevent deaths associated with heat-illness.
Overall, this dissertation develops a comprehensive closed-form analytical radiometric …
Design And Evaluation Of Neurosurgical Training Simulator, Trinette L. Wright
Design And Evaluation Of Neurosurgical Training Simulator, Trinette L. Wright
Electronic Thesis and Dissertation Repository
Surgical simulators are becoming more important in surgical training. Consumer smartphone technology has improved to allow deployment of VR applications and are now being targeted for medical training simulators. A surgical simulator has been designed using a smartphone, Google cardboard 3D glasses, and the Leap Motion (LM) hand controller. Two expert and 16 novice users were tasked with completing the same pointing tasks using both the LM and the medical simulator NeuroTouch. The novice users had an accuracy of 0.2717 bits (SD 0.3899) and the experts had an accuracy of 0.0925 bits (SD 0.1210) while using the NeuroTouch. Novices and …
Rf Sensing System For Continuous Blood Glucose Monitoring, Fabiola Araujo Cespedes
Rf Sensing System For Continuous Blood Glucose Monitoring, Fabiola Araujo Cespedes
USF Tampa Graduate Theses and Dissertations
The purpose of this research was to design a blood glucose sensing system based on the induced shift in the resonant frequency of an antenna patch operating in the ISM band (5.725 – 5.875 GHz). The underlying concept is the fact that when a person has variations in their blood glucose levels, the permittivity of their blood varies accordingly. This research analyzed the feasibility of using an antenna patch as a blood glucose sensing device in three configurations: 1) as an implantable active sensor, 2) as an implantable passive antenna sensor, and 3) as a non-invasive sensor. In the first …
Analyses Of Densely Crosslinked Phenolic Systems Using Low Field Nmr, Jigneshkumar Patel
Analyses Of Densely Crosslinked Phenolic Systems Using Low Field Nmr, Jigneshkumar Patel
Doctoral Dissertations
A uniform dispersion of reactants is necessary to achieve a complete reaction involving multi-components, especially for the crosslinking of rigid high-performance materials. In these reactions, miscibility is crucial for curing efficiency. This miscibility is typically enhanced by adding a third component, a plasticizer. For the reaction of the highly crystalline crosslinking agent hexamethylenetetramine (HMTA) with a strongly hydrogen-bonded phenol formaldehyde resin, furfural has been traditionally used as the plasticizer. However, the reason for its effectiveness is not clear. In this doctoral thesis work, miscibility and crosslinking efficiency of plasticizers in phenolic curing reactions are studied by thermal analysis and spectroscopic …
Hierarchical Fusion Based Deep Learning Framework For Lung Nodule Classification, Kazim Sekeroglu
Hierarchical Fusion Based Deep Learning Framework For Lung Nodule Classification, Kazim Sekeroglu
LSU Doctoral Dissertations
Lung cancer is the leading cancer type that causes the mortality in both men and women. Computer aided detection (CAD) and diagnosis systems can play a very important role for helping the physicians in cancer treatments. This dissertation proposes a CAD framework that utilizes a hierarchical fusion based deep learning model for detection of nodules from the stacks of 2D images. In the proposed hierarchical approach, a decision is made at each level individually employing the decisions from the previous level. Further, individual decisions are computed for several perspectives of a volume of interest (VOI). This study explores three different …
Co-Existence Of Microbial Ecology In A Chemostat Using A Robust Feedback, Hector Puebla, Mariana Rodriguez-Jara, Margarita M. Gonzalez-Brambila, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez, Ennio Piceno-Diaz
Co-Existence Of Microbial Ecology In A Chemostat Using A Robust Feedback, Hector Puebla, Mariana Rodriguez-Jara, Margarita M. Gonzalez-Brambila, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez, Ennio Piceno-Diaz
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Food Web Control And Synchronization Using A Robust Feedback, Hector Puebla, Mariana Rodriguez-Jara, Cesar S. Lopez-Monsalvo, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez
Food Web Control And Synchronization Using A Robust Feedback, Hector Puebla, Mariana Rodriguez-Jara, Cesar S. Lopez-Monsalvo, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Thermally Assisted Pulsed Electric Field Ablation For Cancer Therapy, James Michael Hornef
Thermally Assisted Pulsed Electric Field Ablation For Cancer Therapy, James Michael Hornef
Biomedical Engineering Theses & Dissertations
Pulsed Electric Fields (PEF) have promised improved treatment results in a variety of cancer types including melanoma, pancreatic and lung squamous cancer. Recent studies show that PEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. Experiments were performed to design, calibrate and implement a feedback-looped infrared laser irradiation system that could maintain specified temperatures during the treatment. The exact treatment area, penetration depth and thermal distribution of a 980-nm laser fiber were quantified using several methods, including the knife-edge technique and a tissue optical property study. In vivo and in vitro experiments using …
Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe
Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe
FIU Electronic Theses and Dissertations
Liver cancer ranks the third most common cause of cancer related mortality worldwide. Radiomicrosphere therapy (RMT), a form of radiation therapy, involves administration of Yttrium-90 (90Y) microspheres to the liver via the hepatic artery. 90Y microspheres bremsstrahlung SPECT/CT or PET/CT imaging could potentially identify an extrahepatic uptake. An early detection of such an uptake, thus, could initiate preventative measures early on. However, the quantitative accuracy of bremsstrahlung SPECT/CT images is limited by the wide and continuous energy spectrum of 90Y bremsstrahlung photons. 90Y PET/CT imaging is also possible but limited by the extremely small internal pair production decay. These limitation …
The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco
The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco
Libraries' Newsletters
No abstract provided.
Force Sensing Surgical Grasper With Folding Capacitive Sensor, Dave Bp Tripp
Force Sensing Surgical Grasper With Folding Capacitive Sensor, Dave Bp Tripp
Electronic Thesis and Dissertation Repository
Minimally-invasive surgery (MIS) has brought many benefits to the operating room, however, MIS procedures result in an absence of force feedback, and surgeons cannot as accurately feel the tissue they are working on, or the forces that they are applying. One of the barriers to introducing MIS instruments with force feedback systems is the high cost of manufacturing and assembly. Instruments must also be sterilized before every use, a process that can destroy embedded sensing systems. An instrument that can be disposed of after a single use and produced in bulk at a low cost is desirable. Printed circuit micro-electro-mechanical …
Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu
Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are useful tools to analyze brain activities given active stimulation. However, the electromagnetic noise from the MRI distorts the brain signal recording and damages the subject with excessive heat generated on the electrodes attached to the skin. MRI-compatible recording and stimulation systems previously developed at LIBI lab were capable of removing the electromagnetic noise during the imaging process. Previously, the hardware systems had required the integrative software that could control both circuits simultaneously and enable users to easily change recording and stimulation parameters. Graphical user interface (GUI) programmed with computer language informed …
The Influence Of The Electrode Dimension On The Detection Sensitivity Of Electric Cell–Substrate Impedance Sensing (Ecis) And Its Mathematical Modeling, Xudong Zhang, William Wang, Anis Nurashikin Nordin, Fang Li, Sunghoon Jang, Ioana Voiculescu
The Influence Of The Electrode Dimension On The Detection Sensitivity Of Electric Cell–Substrate Impedance Sensing (Ecis) And Its Mathematical Modeling, Xudong Zhang, William Wang, Anis Nurashikin Nordin, Fang Li, Sunghoon Jang, Ioana Voiculescu
Publications and Research
Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the …
Optimization Of Prosthetic Hands: Utilizing Modularity To Improve Grip Force, Grasp, And Versatility, Jordan William Harris
Optimization Of Prosthetic Hands: Utilizing Modularity To Improve Grip Force, Grasp, And Versatility, Jordan William Harris
UNLV Theses, Dissertations, Professional Papers, and Capstones
It has been demonstrated that although many varieties of upper limb prosthetics exist, commercially available prosthetics are outdated and unsatisfactory. Ineffectiveness and limitations have led to some prosthesis wearers having to own multiple devices, whereas others have given up on them entirely. Even though ample research has been conducted to design and test new hand designs, the industry appears to rest in an overall stagnated state.
It was proposed here, that one problem with prosthetic research is an excess of variables involved in testing, and therefore the improper application of the scientific method. It seems that each time a research …
Defects In Skeletal Muscle Subsarcolmmal Mitochondria In A Non-Obese Model Of Type 2 Diabetes Mellitus, Nicola Lai, China Kummitha, Charles Hoppel
Defects In Skeletal Muscle Subsarcolmmal Mitochondria In A Non-Obese Model Of Type 2 Diabetes Mellitus, Nicola Lai, China Kummitha, Charles Hoppel
Electrical & Computer Engineering Faculty Publications
Skeletal muscle resistance to insulin is related to accumulation of lipid-derived products, but it is not clear whether this accumulation is caused by skeletal muscle mitochondrial dysfunction. Diabetes and obesity are reported to have a selective effect on the function of subsarcolemmal and interfibrillar mitochondria in insulin-resistant skeletal muscle. The current study investigated the role of the subpopulations of mitochondria in the pathogenesis of insulin resistance in the absence of obesity. A non-obese spontaneous rat model of type 2 diabetes mellitus, (Goto-Kakizaki), was used to evaluate function and biochemical properties in both populations of skeletal muscle mitochondria. In subsarcolemmal mitochondria, …
A Magnetic Resonance Compatible Knee Extension Ergometer, Youssef Jaber
A Magnetic Resonance Compatible Knee Extension Ergometer, Youssef Jaber
Masters Theses
The product of this thesis aims to enable the study of the biochemical and physical dynamics of the lower limbs at high levels of muscle tension and fast contraction speeds. This is accomplished in part by a magnetic resonance (MR) compatible ergometer designed to apply a load as a torque of up to 420 Nm acting against knee extension at speeds as high as 4.7 rad/s. The system can also be adapted to apply the load as a force of up to 1200 N acting against full leg extension. The ergometer is designed to enable the use of magnetic resonance …
Understanding The Surface Fouling Mechanism Of Ultrananocrystalline Diamond Microelectrodes Using Microfluidics For Neurochemical Detection, An-Yi Chang
Doctoral Dissertations
Electrochemical methods are widely used for chronic neurochemical sensing, but thus far, the organic solution redox reactions fouled the electrodes' surface. It caused the reduction of sensitivity and the electrodes' lifetime.
Here, we present the boron-doped nanocrystalline diamond microelectrodes (BDUNCD) as the next generation electrode material for neurochemical sensor development. To aid in long-term chronic monitoring of neurochemicals, they have a wide window of electrochemical potential, extremely low background current, and excellent chemical inertness. The main research goal is to reduce the rate of electrode fouling due to the reaction by-products, and significantly extend their useful lifetime.
We systematically characterize …
Characterization Of Surface Charges And Compensating Charges For Gene Delivery To Tissue, Ravi Shanmugha Preethi Vangapattu
Characterization Of Surface Charges And Compensating Charges For Gene Delivery To Tissue, Ravi Shanmugha Preethi Vangapattu
USF Tampa Graduate Theses and Dissertations
Ever since the discovery of DNA, there has been many pathologies identified effecting mankind. With the development in technology, there are many methods to alleviate these pathologies. One such is gene therapy or gene delivery. It is a process of introducing some foreign material into the body to correct the effected cells. In principle, it is a modern method to cure cells or a method to transfer nucleic acid into a cell to treat specific cells in the body. The process of delivering a genetic material is carried out using vectors, namely, viral vectors and non-viral vectors. In viral vectors, …
Vital Sensory Kit For Use With Telemedicine In Developing Countries, Alejandra Pacheco, Jose Hernandez, Antonio Maldonado-Liu, Natalie Arrizon
Vital Sensory Kit For Use With Telemedicine In Developing Countries, Alejandra Pacheco, Jose Hernandez, Antonio Maldonado-Liu, Natalie Arrizon
Interdisciplinary Design Senior Theses
In many developing countries, a large percentage of the population lacks access to adequate healthcare. This is especially true in India where close to 70% of the population lives in rural areas and has little to no access to hospitals or clinics. People living in rural India often times cannot afford to pay to see a doctor should they need to make the journey to a hospital. Telemedicine, a breakthrough in the past couple decades, has broken down the barrier between the patient and the physician. It has slowly been implemented in India to make doctors more available to patients …
Skin Tone Tracking Device (Chromaband), Ziyang Bian
Skin Tone Tracking Device (Chromaband), Ziyang Bian
Computer Engineering
It’s long been said that your skin is a window into your health and with many illnesses the first signs of trouble actually show up in your skin. So if we have this natural warning system, then why isn’t anyone able to effectively use it to predict changes in our health? The problem is that currently there is no reliable way to accurately measure the change in skin tone and how these changes may or may not change with variations in health. This project’s aim is to design and develop a device that will record the changes in a user’s …
Poly Drop, Zachary T. Scott, Lilly J. Paul
Poly Drop, Zachary T. Scott, Lilly J. Paul
Computer Engineering
Poly Drop is a software interface to control an Open Drop digital micro-fluidics system. We obtained a hardware system from Gaudi labs. Our task was to create a Graphical User Interface that made the control of the device easier and more automated for better testing. We created software that had 3 parts: a control GUI, arduino code to control the hardware, and Image Analysis that gives the user information such as location and color of liquid drops as they move across the electrode grid of the Open Drop system. The GUI was developed using Java Swing. The communication between the …
A Battery-Operated Portable Standard Lead Ecg Monitor With Abnormal Heart Condition Detection System For Dogs, Zichen He
Theses and Dissertations
Long term monitoring the dog's heart condition is the best way to prevent being unable to treat the dog's heart failure in time when it occurs. Although, electro-cardio activity has been discovered by French scientist Mattencci in 1842, but there hasn't been any proper device developed so far for long term ECG (electrocardiogram) monitoring of cardiac dogs. Therefore, this paper has proposed an ECG monitor specially designed for dogs to fill this gap. The ECG monitor proposed is a 3-lead ECG monitoring system with diagnosis software that can detect heart failure, tachycardia, bradycardia, and arrhythmia according to dog's ECG signal. …
Dc Line-Interactive Uninterruptible Power Supply (Ups) With Load Leveling For Constant Power And Pulse Loads, Seyed Ahmad Hamidi
Dc Line-Interactive Uninterruptible Power Supply (Ups) With Load Leveling For Constant Power And Pulse Loads, Seyed Ahmad Hamidi
Theses and Dissertations
Uninterruptable Power Supply (UPS) systems are usually considered as a backup power for electrical systems, providing emergency power when the main power source fails. UPS systems ensure an uninterruptible, reliable and high quality electrical power for systems with critical loads in which a continuous and reliable power supply is a vital requirement.
A novel UPS system topology, DC line-interactive UPS, has been introduced. The new proposed UPS system is based on the DC concept where the power flow in the system has DC characteristic. The new DC UPS system has several advantageous with respect to the on-line 3-phase UPS which …
Low Temperature Plasma For The Treatment Of Epithelial Cancer Cells, Soheila Mohades
Low Temperature Plasma For The Treatment Of Epithelial Cancer Cells, Soheila Mohades
Electrical & Computer Engineering Theses & Dissertations
Biomedical applications of low temperature plasmas (LTP) may lead to a paradigm shift in treating various diseases by conducting fundamental research on the effects of LTP on cells, tissues, organisms (plants, insects, and microorganisms). This is a rapidly growing interdisciplinary research field that involves engineering, physics, life sciences, and chemistry to find novel solutions for urgent medical needs. Effects of different LTP sources have shown the anti-tumor properties of plasma exposure; however, there are still many unknowns about the interaction of plasma with eukaryotic cells which must be elucidated in order to evaluate the practical potential of plasma in cancer …
Simulation Studies On Ecg Vector Dipole Extraction In Liquid Medium, Pratheek Michael
Simulation Studies On Ecg Vector Dipole Extraction In Liquid Medium, Pratheek Michael
USF Tampa Graduate Theses and Dissertations
To circumvent some inherent problems in the conventional ECG, this research reinvestigates an ‘unassisted’ approach which enables ECG measurement without the placement of leads on the body. Employed in this research is a widely accepted assumption that the electrical activity of the heart may be represented, largely, by a 3-D time-varying current dipole (3D-CD). From the PhysioBank database, mECG and fECG data were obtained, and Singular Value Decomposition (SVD) was performed to estimate the time-varying Vector ECG dipole. To determine the sensing matrix responsible for transforming the activity of the 3D-CD into the potential distribution on the surface of the …
Using A Respiratory Navigator Significantly Reduces Variability When Quantifying Left Ventricular Torsion With Cardiovascular Magnetic Resonance, Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Richard J. Charnigo, Brandon K. Fornwalt
Using A Respiratory Navigator Significantly Reduces Variability When Quantifying Left Ventricular Torsion With Cardiovascular Magnetic Resonance, Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Richard J. Charnigo, Brandon K. Fornwalt
Electrical and Computer Engineering Faculty Publications
Background: Left ventricular (LV) torsion is an important indicator of cardiac function that is limited by high inter-test variability (50% of the mean value). We hypothesized that this high inter-test variability is partly due to inconsistent breath-hold positions during serial image acquisitions, which could be significantly improved by using a respiratory navigator for cardiovascular magnetic resonance (CMR) based quantification of LV torsion.
Methods: We assessed respiratory-related variability in measured LV torsion with two distinct experimental protocols. First, 17 volunteers were recruited for CMR with cine displacement encoding with stimulated echoes (DENSE) in which a respiratory navigator was used to measure …