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Biomedical Engineering and Bioengineering Commons

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2016

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Full-Text Articles in Biomedical Engineering and Bioengineering

Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang Dec 2016

Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang

Engineering and Applied Science Theses & Dissertations

Antibody-antigen recognition enables antibody-conjugated nanostructures to serve as plasmonic biosensors with tunable specificity. However due to the instability of antibodies, these biosensors are susceptible to changes in the environment such as heat and aridity, leading to constraints on the transportation and handling of these sensors. Here we establish a method using a metal-organic framework crystal to preserve biosensor activity under severe environmental conditions, including exposure to high temperatures, an organic solvent and a proteolytic agent. After zeolitic imidazolate framework-8 (ZIF-8) crystals formed for 12 hours on a biosensor of gold nanorods conjugated with a model antibody, rabbit IgG, 80% of ...


Finite Element Simulation And Additive Manufacturing Of Stiffness-Matched Niti Fixation Hardware For Mandibular Reconstruction Surgery, Ahmadreza Jahadakbar, Narges Shayesteh Moghaddam, Amirhesam Amerinatanzi, David Dean, Haluk E. Karaca, Mohammad Elahinia Dec 2016

Finite Element Simulation And Additive Manufacturing Of Stiffness-Matched Niti Fixation Hardware For Mandibular Reconstruction Surgery, Ahmadreza Jahadakbar, Narges Shayesteh Moghaddam, Amirhesam Amerinatanzi, David Dean, Haluk E. Karaca, Mohammad Elahinia

Mechanical Engineering Faculty Publications

Process parameters and post-processing heat treatment techniques have been developed to produce both shape memory and superelastic NiTi using Additive Manufacturing. By introducing engineered porosity, the stiffness of NiTi can be tuned to the level closely matching cortical bone. Using additively manufactured porous superelastic NiTi, we have proposed the use of patient-specific, stiffness-matched fixation hardware, for mandible skeletal reconstructive surgery. Currently, Ti-6Al-4V is the most commonly used material for skeletal fixation devices. Although this material offers more than sufficient strength for immobilization during the bone healing process, the high stiffness of Ti-6Al-4V implants can cause stress shielding. In this paper ...


Design Of A Modified Stewart Platform Manipulator For Misalignment Correction, Adekunle Ayoko Dec 2016

Design Of A Modified Stewart Platform Manipulator For Misalignment Correction, Adekunle Ayoko

Master of Technology Management Plan II Graduate Projects

This thesis work is about the design of a modified Stewart platform manipulator for misalignment correction. The common version of the Stewart platform uses six actuators. The traditional Stewart platform of this kind has a moving top plate and a fixed base plate. However, in this research, the modified design of the traditional Stewart platform is studied. It is designed to be an easy connect-disconnect platform that can wrap around different structures with different cross sections and symmetrically designed. It is able to adjust position easily by using four identical but independent linear actuators populated evenly in two parts fastened ...


The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker Dec 2016

The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker

Electronic Thesis and Dissertation Repository

Hemiarthroplasty procedures replace the diseased side of the joint with an implant to maximize bone preservation while maintaining more native anatomy than a total joint replacement. Even though hemiarthroplasty procedures have been clinically successful, they cause progressive cartilage damage over time due to the use of relatively stiff metallic implant materials. This work investigates the role of low moduli implant material on implant-cartilage contact mechanics and early in vitro cartilage wear. A finite element simulation was developed to assess the effect of low moduli implants in the range of 0.015-0.288 GPa on contact mechanics. Higher contact area and ...


Multimodal Imaging Of Photoreceptor Structure In Choroideremia, Lynn W. Sun, Ryan D. Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V. Weinberg, Kimberly E. Stepien, Gerald A. Fishman, Joseph Carroll Dec 2016

Multimodal Imaging Of Photoreceptor Structure In Choroideremia, Lynn W. Sun, Ryan D. Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V. Weinberg, Kimberly E. Stepien, Gerald A. Fishman, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Purpose

Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions.

Methods

Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques.

Results

Eleven CHM gene mutations (3 novel) were identified; three subjects had the same mutation and one ...


The Role Of Scapular Morphology In Reverse Shoulder Arthroplasty, Ashish Gupta Dec 2016

The Role Of Scapular Morphology In Reverse Shoulder Arthroplasty, Ashish Gupta

Electronic Thesis and Dissertation Repository

Baseplate fixation in a reverse shoulder arthroplasty depends on adequate bone stock. In cases of severe glenoid bone loss and revision shoulder arthroplasty, deficiency of the glenoid vault compels the surgeon to attain screw fixation in the three columns of the scapula. The relationship of these columns demonstrated that the coracoid is closer to the lateral scapular pillar in females than in males. Significant gender dimorphism exists between the orientations of the three columns. The gender dimorphism is further evaluated by anthropometric measurements of the scapular body and the glenoid. The clinical significance lies in the ability to reconstruct the ...


Miniature Implantable Telemetry System For Pressure-Volume Cardiac Monitoring, Kyle G. Fricke Dec 2016

Miniature Implantable Telemetry System For Pressure-Volume Cardiac Monitoring, Kyle G. Fricke

Electronic Thesis and Dissertation Repository

Safety Pharmacology is becoming an increasingly important field to pharmaceutical companies in order to determine if medical treatments (drugs) are safe for use in human subjects. In the pre-clinical phase, test models, most commonly small rodents, undergo various gene alterations to affect, for example, their cardiovascular system in order to emulate human diseases. Pharmaceutical companies rely on these models to determine the drug efficacy and to ensure minimal side effects and safety for human subjects. Currently, no fully implantable left-ventricle pressure--volume (PV) telemetry systems have been implemented for Safety Pharmacology assessment applications. A fully implantable PV telemetry system would not ...


Quantitative Optical Studies Of Oxidative Stress In Rodent Models Of Eye And Lung Injuries, Zahra Ghanian Dec 2016

Quantitative Optical Studies Of Oxidative Stress In Rodent Models Of Eye And Lung Injuries, Zahra Ghanian

Theses and Dissertations

Optical imaging techniques have emerged as essential tools for reliable assessment of organ structure, biochemistry, and metabolic function. The recognition of metabolic markers for disease diagnosis has rekindled significant interest in the development of optical methods to measure the metabolism of the organ.

The objective of my research was to employ optical imaging tools and to implement signal and image processing techniques capable of quantifying cellular metabolism for the diagnosis of diseases in human organs such as eyes and lungs. To accomplish this goal, three different tools, cryoimager, fluorescent microscope, and optical coherence tomography system were utilized to study the ...


Sensitivity Analysis Of Geometry Changes In The Simulation Of Basilar Aneurysms, Paul Eserkaln Dec 2016

Sensitivity Analysis Of Geometry Changes In The Simulation Of Basilar Aneurysms, Paul Eserkaln

Theses and Dissertations

Computer simulation is a useful tool in the research and treatment of basilar aneurysms. Current technology allows researchers to create 3D models from cerebral vasculature in-vivo, allowing for the investigation of surgical options with minimal risk to the patient. The method used to construct these models overlooks smaller lateral arterial branches which are difficult to discern due to resolution limits of the imaging process. These lateral branches have minimal impact on the overall blood flow through the basilar artery, but they play a significant role in the health of the patient, so it is important to ensure sufficient blood will ...


Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews Dec 2016

Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews

Theses and Dissertations

This thesis describes the design and basic verification of a discrete event simulator for glucose metabolism in human beings. The simulator implements the glucose metabolism related behavior of various organs in the human body and tracks the blood plasma glucose level as the human body goes through a sequence of diet and exercise events. The simulator can mimic insulin resistance in various organs as well as the loss of insulin production in the pancreas and the adverse impact of these changes on the metabolic behavior of various organs. Thus, the simulator can serve as a model for people with diabetes ...


Study Of Computational Image Matching Techniques: Improving Our View Of Biomedical Image Data, Ahmadreza Baghaie Dec 2016

Study Of Computational Image Matching Techniques: Improving Our View Of Biomedical Image Data, Ahmadreza Baghaie

Theses and Dissertations

Image matching techniques are proven to be necessary in various fields of science and engineering, with many new methods and applications introduced over the years. In this PhD thesis, several computational image matching methods are introduced and investigated for improving the analysis of various biomedical image data. These improvements include the use of matching techniques for enhancing visualization of cross-sectional imaging modalities such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI), denoising of retinal Optical Coherence Tomography (OCT), and high quality 3D reconstruction of surfaces from Scanning Electron Microscope (SEM) images. This work greatly improves the process of data ...


Stem Cell And Tissue Engineering Research, Feng Zhao Dec 2016

Stem Cell And Tissue Engineering Research, Feng Zhao

TechTalks

My research focuses on stem cell and tissue engineering. By combining stem cell biology and engineering tools, the Zhao Lab seeks strategies to biofabricate completely biological tissues to regenerate or repair damaged tissues or organs. The function of engineered tissues is being strengthened by recapitulating the in vivo environment of natural tissues. The underlying mechanism is being explored through investigating the interaction of cells with environmental factors such as topographical cues, biophysical forces, and oxygen tensions. We also prompt stem cell research at Michigan Tech to meet the progress and advance of the outside scientific society. Training opportunities are consistently ...


Device Design Factors For Enhancing The Functionality Of Chronic Intracortical Microelectrodes, Heui Chang Lee Dec 2016

Device Design Factors For Enhancing The Functionality Of Chronic Intracortical Microelectrodes, Heui Chang Lee

Open Access Dissertations

Intracortical microelectrodes are devices used in brain-computer interfaces (BCI) to help regain lost motor, sensory, and cognitive functions of individuals with neurological disorders. However, the long-term performance of microelectrode arrays is hampered by a series of inflammatory tissue responses. The consequence of the inflammatory response is the formation of a dense astroglial sheath around the vicinity of the electrode, impeding the electrical conduction between the electrode and neurons. Furthermore, due to the cascade of neuroinflammatory events, the number of neurons is significantly reduced near the electrode, manifested by decrease in signal-to-noise ratio (SNR) and the yield of electrodes. Over time ...


Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo Dec 2016

Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo

Open Access Theses

Bone morphogenetic proteins (BMPs) drive a range of cellular processes especially in the early stages of embryonic development. This family of proteins acts as one of the most important extracellular signals in development pattern formation across the animal kingdom. Cells in embryos differentiate into different cell types in response to the concentration level of BMP. This complex process is regulated by multiple regulators that serve to tune the signal response.

Extensive experimental and computational research has been performed to analyze BMP regulation in Drosophila, a widely studied model organism, and has advanced our understanding of animal development. Because of BMP ...


Synchronization And Random Triggering Of Lymphatic Vessel Contractions, James W. Baish, Christian Kunert, Timothy P. Padera, Lance L. Munn Dec 2016

Synchronization And Random Triggering Of Lymphatic Vessel Contractions, James W. Baish, Christian Kunert, Timothy P. Padera, Lance L. Munn

Faculty Journal Articles

The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart–to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that ...


Development Of Breast Tissue Phantoms For Enhanced Terahertz Imaging Utilizing Microdiamond And Nano-Onion Particles, Alec Walter Dec 2016

Development Of Breast Tissue Phantoms For Enhanced Terahertz Imaging Utilizing Microdiamond And Nano-Onion Particles, Alec Walter

Electrical Engineering Undergraduate Honors Theses

This thesis presents the work performed to develop tissue phantoms and a contrast agent that will be used in future research of terahertz time-domain imaging of breast tumor margins. Since an excised breast tumor can contain healthy fibrous and fatty tissues along with invasive ductal carcinoma (IDC), three phantom materials were developed. Solid phantom materials were made by using TX151 to solidify water in order to tune the refractive index and absorption coefficient of the fibrous tissue phantom and IDC phantom to the properties of freshly excised breast tissue. Various amounts of olive oil were added to the water prior ...


Development Of A Semi-Interpenetrating Network Hydrogel To Study The Effects Of Mild Traumatic Brain Injury On Astrocyte Remodeling, Amanda Ederle Dec 2016

Development Of A Semi-Interpenetrating Network Hydrogel To Study The Effects Of Mild Traumatic Brain Injury On Astrocyte Remodeling, Amanda Ederle

Health, Human Performance and Recreation Undergraduate Honors Theses

Traumatic brain injuries (TBIs) are a widespread public health concern affecting over 2.5 million people in the United States alone (1). TBIs are the leading cause of death and disability in children (ages 0-14), and their devastating effects can also be seen in vast population subsets such as professional athletes and combat soldiers (1).

Damaged astrocytes, the specialized glial cells associated with the maintenance of the brain’s environment, respond to injury by altering regulation of certain proteins and ion channels in an attempt to maintain homeostasis (3). Studies have also shown that following a TBI, astrocytes seek to ...


Hollow Fiber Membranes For Artificial Lung Applications, Lauren Reed Dec 2016

Hollow Fiber Membranes For Artificial Lung Applications, Lauren Reed

Chemical Engineering Undergraduate Honors Theses

Artificial lungs are in use, but difficult issues remain in the field of membrane development related to fouling issues. Currently there are external artificial lungs circulating blood outside the body, taking out the carbon dioxide, and inserting oxygenated blood back into the body. An example of this type of machine is the ExtraCorporeal Membrane Oxygenation (ECMO) machine currently used in hospitals. The ECMO takes over the functions for both the lungs and the heart but is only available for short term use by patients with respiratory failure due to infections [1]. The fibers in the machine develop fouling due to ...


Ct Image Registration-Based Lung Mechanics In Copd, Sandeep Bodduluri Dec 2016

Ct Image Registration-Based Lung Mechanics In Copd, Sandeep Bodduluri

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) is a growing health concern associated with high morbidity and mortality, and is currently the third-ranked cause of death in the United States. COPD is characterized by airflow limitation that is not fully reversible and includes chronic bronchitis, functional small airway disease, and emphysema. The interrelationship between emphysema and airway disease in COPD makes it a highly complex and heterogeneous disorder. Appropriate diagnosis of COPD is vital to administer targeted therapy strategies that can improve patient’s quality of life and reduce the frequency of COPD associated exacerbations. Although spirometry or pulmonary function tests are ...


Enhanced Phagocytic Capacity Endows Chondrogenic Progenitor Cells With A Novel Scavenger Function Within Injured Cartilage, Cheng Zhou Dec 2016

Enhanced Phagocytic Capacity Endows Chondrogenic Progenitor Cells With A Novel Scavenger Function Within Injured Cartilage, Cheng Zhou

Theses and Dissertations

Articular cartilage underwent serious joint injuries seldom repair spontaneously and might progress to post-traumatic osteoarthritis. This is majorly because articular cartilage’s unique properties that lack blood and nerve supply intrinsically. This peculiar structure, in addition, generates an unfavorable environment for certain phagocytes (macrophages, monocytes, neutrophils, etc) to infiltrate to cartilage to scavenge debris from cartilage matrix and cell caused from joint injuries. Therefore, physiological and functional regeneration of damaged cartilage is urgently needed and several clinical techniques have been developed, including microfracture, autograft transplantation, autologous chondrocytes implantation.

We previously identified highly migratory cells emerged and repopulated in cartilage damaged ...


Psychophysiological Analysis Of A Pedagogical Agent And Robotic Peer For Individuals With Autism Spectrum Disorders., Mohammad Nasser Saadatzi Dec 2016

Psychophysiological Analysis Of A Pedagogical Agent And Robotic Peer For Individuals With Autism Spectrum Disorders., Mohammad Nasser Saadatzi

Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by ongoing problems in social interaction and communication, and engagement in repetitive behaviors. According to Centers for Disease Control and Prevention, an estimated 1 in 68 children in the United States has ASD. Mounting evidence shows that many of these individuals display an interest in social interaction with computers and robots and, in general, feel comfortable spending time in such environments. It is known that the subtlety and unpredictability of people’s social behavior are intimidating and confusing for many individuals with ASD. Computerized learning environments and robots, however, prepare a ...


A Portable And Automatic Biosensing Instrument For Detection Of Foodborne Pathogenic Bacteria In Food Samples, Zhuo Zhao Dec 2016

A Portable And Automatic Biosensing Instrument For Detection Of Foodborne Pathogenic Bacteria In Food Samples, Zhuo Zhao

Theses and Dissertations

Foodborne diseases are a growing public health problem. In recent years, many rapid detection methods have been reported, but most of them are still in lab research and not practical for use in the field. In this study, a portable and automatic biosensing instrument was designed and constructed for separation and detection of target pathogens in food samples using nanobead-based magnetic separation and quantum dots (QDs)-labeled fluorescence measurement. The instrument consisted of a laptop with LabVIEW software, a data acquisition card (DAQ), a fluorescent detector, micro-pumps, stepper motors, and 3D printed tube holders. First, a sample in a syringe ...


A Bifunctional Nanocomposites Based Electrochemical Biosensor For In-Field Detection Of Pathogenic Bacteria In Food, Meng Xu Dec 2016

A Bifunctional Nanocomposites Based Electrochemical Biosensor For In-Field Detection Of Pathogenic Bacteria In Food, Meng Xu

Theses and Dissertations

This research focused on the application of electrochemical biosensors for the rapid detection of pathogenic bacteria, Escherichia coli O157:H7 and Salmonella Typhimurium, in foods. The possible presence of pathogenic bacteria in foods has always been a great threat to the wellbeing of people and the revenue of food companies. Therefore, the demand for rapid and sensitive methods to detect foodborne pathogens is growing. In this research, an impedimetric immunosensor was first developed for the rapid detection of E. coli O157:H7 and S. Typhimurium in foods. It was based on the techniques of immunomagnetic separation, enzyme labelling, and electrochemical ...


Scaffold And Tissue Based Therapies To Improve Skeletal Muscle Regeneration After Volumetric Muscle Loss, Benjamin Kasukonis Dec 2016

Scaffold And Tissue Based Therapies To Improve Skeletal Muscle Regeneration After Volumetric Muscle Loss, Benjamin Kasukonis

Theses and Dissertations

Volumetric muscle loss (VML) is an injury to skeletal muscle characterized by a loss of more than 20% of a muscles volume. The combination of the bulk loss of tissue, transection and separation of myofibers proximal and distal to the injury, loss of innervation and blood supply, and the depletion of muscle progenitor cells results in permanent fibrosis and functional deficits due to loss of contractile tissue. Scaffolds, cells, and engineered constructs have been explored as potential therapeutic interventions to induce myogenesis at the site of a VML injury in animal models, in addition to limited clinical trials. This dissertation ...


An Emg-Based Patient Monitoring System Using Zynq Soc Device, Farhad Fallahlalehzari Dec 2016

An Emg-Based Patient Monitoring System Using Zynq Soc Device, Farhad Fallahlalehzari

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis describes the design, development, and testing of an EMG-based patient monitoring system using the Zynq device. Zynq is a system on chip device designed by Xilinx which consists of an ARM dual cortex-A9 processor as well as an FPGA integrated into one chip. This work also analyzes the performance of image-processing algorithms on this system and compares that performance to more traditional PC-based systems. Image processing algorithms, such as Sobel edge detection, dilation and erosion, could be used in conjunction with a camera for the patient monitoring purposes. These algorithms often perform sub-optimally on processors because of their ...


The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells, Allison Elaine Tomlin Dec 2016

The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells, Allison Elaine Tomlin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many studies have demonstrated clinical applications for the use of dental pulp stem cells (DPSC) for the treatment of various conditions. This has driven medical and scientific interest in the collection, isolation and banking of DPSC tissues for research into these potential therapies. Few studies to date have evaluated the viability of DPSC following long-term cryopreservation. The purpose of this study is to evaluate the effects of cryopreservation on dental pulp-derived stem cells (DPSC) viability over a period of three years. Dental pulp-derived stem cells were isolated and cultured from thirty-one healthy teeth. DPSC isolates were assessed for doubling-time and ...


Radiation Therapy And Dosing Material Transport Methodology, Robert O'Brien Dec 2016

Radiation Therapy And Dosing Material Transport Methodology, Robert O'Brien

UNLV Theses, Dissertations, Professional Papers, and Capstones

A technique is examined here that utilizes high energy beta decays from a short lived radioisotope to treat medical conditions such as shallow cancerous lesions. A major benefit of beta particle interaction in tissue is a fixed penetration depth for the charged particle, with dose limited to the ultimate range of the beta particle. This method improves on some current techniques of radioactive brachytherapy, where "seeds" are placed inside patients through temporary or permanent implantation in order to kill cancerous cells or inhibit growth of tissue. The use of low energy gamma-rays is the most common method of treatment currently ...


A Cad System For Early Diagnosis Of Autism Using Different Imaging Modalities., Marwa Maher Tawfik Ismail Dec 2016

A Cad System For Early Diagnosis Of Autism Using Different Imaging Modalities., Marwa Maher Tawfik Ismail

Electronic Theses and Dissertations

The term “autism spectrum disorder” (ASD) refers to a collection of neuro-developmental disorders that affect linguistic, behavioral, and social skills. Autism has many symptoms, most prominently, social impairment and repetitive behaviors. It is crucial to diagnose autism at an early stage for better assessment and investigation of this complex syndrome. There have been a lot of efforts to diagnose ASD using different techniques, such as imaging modalities, genetic techniques, and behavior reports. Imaging modalities have been extensively exploited for ASD diagnosis, and one of the most successful ones is Magnetic resonance imaging(MRI),where it has shown promise for the ...


Design Of A Flexible Control Platform And Miniature In Vivo Robots For Laparo-Endoscopic Single-Site Surgeries, Lou P. Cubrich Dec 2016

Design Of A Flexible Control Platform And Miniature In Vivo Robots For Laparo-Endoscopic Single-Site Surgeries, Lou P. Cubrich

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Minimally-invasive laparoscopic procedures have proven efficacy for a wide range of surgical procedures as well as benefits such as reducing scarring, infection, recovery time, and post-operative pain. While the procedures have many advantages, there are significant shortcomings such as limited instrument motion and reduced dexterity. In recent years, robotic surgical technology has overcome some of these limitations and has become an effective tool for many types of surgeries. These robotic platforms typically have an increased workspace, greater dexterity, improved ergonomics, and finer control than traditional laparoscopic methods. This thesis presents the designs of both a four degree-of-freedom (DOF) and 5-DOF ...


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff Dec 2016

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...