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2012

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Articles 1 - 30 of 692

Full-Text Articles in Biomedical Engineering and Bioengineering

Quantification Of Thoracic Aorta Blood Flow By Magnetic Resonance Imaging During Supine Cycling Exercise Of Increasing Intensity, Laura M. Ellwein, John F. Ladisa, Stacy Leibham, Sheila M. Schindler-Ivens, Margaret M. Samyn Dec 2012

Quantification Of Thoracic Aorta Blood Flow By Magnetic Resonance Imaging During Supine Cycling Exercise Of Increasing Intensity, Laura M. Ellwein, John F. Ladisa, Stacy Leibham, Sheila M. Schindler-Ivens, Margaret M. Samyn

Biomedical Engineering Faculty Research and Publications

No abstract provided.


Correct Spectral Conversion Between Surface‐Enhanced Raman And Plasmon Resonance Scattering From Nanoparticle Dimers For Single‐Molecule Detection, Kyuwan Lee Dec 2012

Correct Spectral Conversion Between Surface‐Enhanced Raman And Plasmon Resonance Scattering From Nanoparticle Dimers For Single‐Molecule Detection, Kyuwan Lee

Kyuwan Lee

Simultaneous measurement of surface-enhanced Raman scattering (SERS) and localized surface plasmon resonance (LSPR) in nanoparticle dimers presents outstanding opportunities in molecular identification and in the elucidation of physical properties, such as the size, distance, and deformation of target species. SERS–LSPR instrumentation exists and has been used under limited conditions, but the extraction of SERS and LSPR readouts from a single measurement is still a challenge. Herein, the extraction of LSPR spectra from SERS signals is reported and a tool for measuring the interparticle distance from Raman enhancement data by the standardization of the SERS signal is proposed. The SERS ...


Comparison Of 4d Phase-Contrast Mri Flow Measurements To Computational Fluid Dynamics Simulations Of Cerebrospinal Fluid Motion In The Cervical Spine, Theresia Yiallourou, Jan Robert Kroger, Nikolaos Stergiopulos, David Maintz, Bryn A. Martin, Alexander C. Bunck Dec 2012

Comparison Of 4d Phase-Contrast Mri Flow Measurements To Computational Fluid Dynamics Simulations Of Cerebrospinal Fluid Motion In The Cervical Spine, Theresia Yiallourou, Jan Robert Kroger, Nikolaos Stergiopulos, David Maintz, Bryn A. Martin, Alexander C. Bunck

Mechanical Engineering Faculty Research

Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three directional velocity encoded phase-contrast MRI (4D PC MRI) in three healthy volunteers and four CM patients and compared the 4D PC MRI measurements to subject-specific 3D computational fluid dynamics (CFD) simulations. The CFD simulations considered the geometry to be rigid-walled and did not include small anatomical structures such as nerve roots, denticulate ligaments and arachnoid trabeculae. Results were compared at nine axial planes ...


Mechanical Properties And Tensile Failure Analysis Of Novel Bio-Absorbable Mg-Zn-Cu And Mg-Zn-Se Alloys For Endovascular Applications, Dharam Persaud, Noah Budiansky, Anthony J. Mcgoron Dec 2012

Mechanical Properties And Tensile Failure Analysis Of Novel Bio-Absorbable Mg-Zn-Cu And Mg-Zn-Se Alloys For Endovascular Applications, Dharam Persaud, Noah Budiansky, Anthony J. Mcgoron

Department of Biomedical Engineering Faculty Publications

In this paper, the mechanical properties and tensile failure mechanism of two novel bio-absorbable as-cast Mg-Zn-Se and Mg-Zn-Cu alloys for endovascular medical applications are characterized. Alloys were manufactured using an ARC melting process and tested as-cast with compositions of Mg-Zn-Se and Mg-Zn-Cu, being 98/1/1 wt.% respectively. Nanoindentation testing conducted at room temperature was used to characterize the elastic modulus (E) and surface hardness (H) for both the bare alloys and the air formed oxide layer. As compared to currently available shape memory alloys and degradable as-cast alloys, these experimental alloys possess superior as-cast mechanical properties that can increase ...


Automatic Assessment Of Cardiac Left Ventricular Function Via Magnetic Resonance Images, Mariam Afshin Dec 2012

Automatic Assessment Of Cardiac Left Ventricular Function Via Magnetic Resonance Images, Mariam Afshin

Electronic Thesis and Dissertation Repository

Automating global and segmental (regional) assessments of cardiac Left Ventricle (LV) function in Magnetic Resonance Images (MRI) has recently sparked an impressive research effort, which has resulted a number of techniques delivering promising performances. However, despite such an effort, the problem is still acknowledged to be challenging, with substantial room for improvements in regard to accuracy. Furthermore, most of the existing techniques are labour intensive, requiring delineations of the endo- and/or epi-cardial boundaries in all frames of a cardiac sequence.

On the one hand, global assessments of LV function focus on estimation of the Ejection Fraction (EF), which quantifies ...


Properties And Applications Of Sensory Outcome Measures In Carpal Tunnel Syndrome, Derek Km Cheung Dec 2012

Properties And Applications Of Sensory Outcome Measures In Carpal Tunnel Syndrome, Derek Km Cheung

Electronic Thesis and Dissertation Repository

This thesis aimed to determine the psychometric properties and applications of sensory threshold tools and outcome measures in patients with Carpal Tunnel Syndrome (CTS). The first chapter is a psychometric study that defines clinically important difference (CID), construct validity and responsiveness of touch and vibration threshold tools and in the Symptoms Severity Scale (SSS). The study found the CID for the PSSD and for the SSS was 0.15g/mm2 and 0.50 respectively. The study also found that the Vibrometer was more representative of hand function and responsive compared PSSD. The second objective of this thesis was to ...


A Depolymerization Based Model Of Neuron Growth Cone Shape And Motility, Neerajha Nagarajan Dec 2012

A Depolymerization Based Model Of Neuron Growth Cone Shape And Motility, Neerajha Nagarajan

Master's Theses

Cell migration is a ubiquitous process underlying critical biological mechanisms like wound healing, cancer metastasis and even neuron growth cone motility. It is a critical process for the living organisms as it ensures proper functioning of the system, for example, crawling fibroblasts endure closure of wounds during wound healing. Here we focus our interest on neuron growth cones, a sensory and motile organelle present at the tip of extending neurites, like the axons, in neurons. These are responsible for neuron pathfinding onto specific targets and synapses, in responses to various guidance cues. Interestingly, the motility of the growth cones is ...


Plantar Measurements To Determine Success Of Surgical Correction Of Stage Iib Adult Acquired Flatfoot Deformity, Erika Matheis Dec 2012

Plantar Measurements To Determine Success Of Surgical Correction Of Stage Iib Adult Acquired Flatfoot Deformity, Erika Matheis

Theses and Dissertations

Adult Acquired Flatfoot Deformity (AAFD) is a progressive disease characterized by mechanical degeneration of the soft tissue structure in the arch of the foot that leads to changes in joint alignment. Surgical intervention commonly via tendon transfer and bony osteotomy is used to restore arch architecture, however there is a lack of quantitative assessments that measure the success of the surgical correction in vivo. Using plantar pressures via Tekscan® HR Mat and surveys (SF-36, FAOS), pre-operative and post-operative measures for six participants were defined, analyzed and compared. A paired t-test showed significant lateral shift for percent body weight during walking ...


Optimal Inertial Sensor Placement And Motion Detection For Epileptic Seizure Patient Monitoring, Babak Kamalizonouzi Dec 2012

Optimal Inertial Sensor Placement And Motion Detection For Epileptic Seizure Patient Monitoring, Babak Kamalizonouzi

Electronic Thesis and Dissertation Repository

Use of inertial sensory systems to monitor and detect seizure episodes in patients suffering from epilepsy is investigated via numerical simulations and experiments. Numerical simulations employ a mathematical model that is able to predict human body dynamic responses during a typical epileptic seizure. An optimized inertial sensor placement procedure is developed to address achievement of highest possible sensing resolution in determining angular accelerations with minimal errors. In addition, a joint torque estimation procedure is formulated to assist in the future development of a possible detection scheme. Experimental motion data obtained from an epileptic seizure patient as well as a healthy ...


Impact Of Bioparticle Recirculation In A Circulating Fluidized Bed Biofilm Reactor On Simultaneous Organic And Nitrogen Removal, Ming Li Dec 2012

Impact Of Bioparticle Recirculation In A Circulating Fluidized Bed Biofilm Reactor On Simultaneous Organic And Nitrogen Removal, Ming Li

Electronic Thesis and Dissertation Repository

The Circulating Fluidized Bed Biofilm Reactor (CFBBR), a bioparticle technology designed for biological nutrient removal, has been implemented to achieve considerable biodegradation efficiency and low sludge production, compared with activated sludge system and typical biofilm technology. The inherent advantages of bioparticle technology are enhanced substantially by the CFBBR, for example, decoupling of hydraulic retention time (HRT) from solids retention time (SRT), large specific surface area, ideal conditions for biofilm ecosystem.

In this work, bioparticle recirculation, as a novel control method for bioparticle system, was demonstrated in CFBBRs. To verify the impact of bioparticle recirculation on the reactor performance, bio-kinetics and ...


Uses Of Remnant Human Lung Tissue For Mechanical Stretch Studies, Nurit Davidovich, Peter Chhour, Susan S. Margulies Dec 2012

Uses Of Remnant Human Lung Tissue For Mechanical Stretch Studies, Nurit Davidovich, Peter Chhour, Susan S. Margulies

Departmental Papers (BE)

Human lung tissue donated for research purposes is a precious resource which can enhance the exploration of mechanisms involved in ventilator-induced lung injury (VILI). The goal of this work was to establish methods and demonstrate the feasibility of obtaining viable primary human type I-like alveolar epithelial cells (AECs) from remnant tissue, even after a significant lapse in post-mortem time, as well as human precision-cut lung slices (PCLSs), and stretch them at magnitudes correlated with mechanical ventilation volumes. Although after 3 days in culture many of the isolated cells stained for the type II AEC marker pro-surfactant Protein C (pro-SPC), after ...


Role Of Epidermal Growth Factor-Triggered Pi3k/Akt Signaling In The Migration Of Medulloblastoma-Derived Cells, Veronica Dudu, Richard A. Able, Jr., Veronica Rotari, Qingjun Kong, Maribel Vazquez Dec 2012

Role Of Epidermal Growth Factor-Triggered Pi3k/Akt Signaling In The Migration Of Medulloblastoma-Derived Cells, Veronica Dudu, Richard A. Able, Jr., Veronica Rotari, Qingjun Kong, Maribel Vazquez

Publications and Research

Medulloblastoma (MB) is the most common brain cancer diagnosed among children. The cellular pathways that regulate MB invasion in response to environmental cues remain incompletely understood. Herein, we examine the migratory response of human MB-derived Daoy cells to different concentration profiles of Epidermal Growth Factor (EGF) using a microfluidic system. Our findings provide the first quantitative evidence that EGF concentration gradients modulate the chemotaxis of MB-derived cells in a dose-dependent manner via the EGF receptor (EGF-R). Data illustrates that higher concentration gradients caused increased number of cells to migrate. In addition, our results show that EGF-induced receptor phosphorylation triggered the ...


Nanomechanics Of Electrospun Nanofibres For Tissue Engineering Of The Tympanic Membrane, Sara Makaremi Dec 2012

Nanomechanics Of Electrospun Nanofibres For Tissue Engineering Of The Tympanic Membrane, Sara Makaremi

Electronic Thesis and Dissertation Repository

The Tympanic Membrane (TM), also known as the eardrum, includes layers of organized collagen nanofibres which play an essential role in sound transmission. Perforations that are caused by infection or accident must be repaired in order to restore hearing. Tympanoplasty is performed using grafts that are prepared from bladder, cartilage, temporal fascia and cadaveric skin. However, since mechanical properties of these grafts do not match those of the original TM, normal hearing is not fully restored. The goal of this study is to develop nanofibrous scaffolds for tissue engineering of the TM in order to circumvent the complications addressed with ...


Investigating The Therapeutic Potential Of Salivary Proteins For Oral Diseases, Dusa Vukosavljevic Dec 2012

Investigating The Therapeutic Potential Of Salivary Proteins For Oral Diseases, Dusa Vukosavljevic

Electronic Thesis and Dissertation Repository

ABSTRACT

Saliva is responsible for the formation of the acquired enamel pellicle (AEP), a protein

integument formed as a result of selective adsorption of salivary proteins to the enamel

surface. The AEP demonstrates an important role for modulating dental erosion as a

result of its physical properties, along with its salivary and exogenous protein

composition (Chapter 2). In addition, individual proteins that comprise the AEP have

important physiological functions. Histatin 5 (H5) has potent antifungal effect against C.

albicans, the yeast responsible for the initiation of oral candidiasis. We designed an in

vitro model and found, for the first time ...


خلاصه روابط و معادلات Dec 2012

خلاصه روابط و معادلات

Dr Alireza Zolfaghari

No abstract provided.


My Lecture Notes (Power Plant Engineering) - Chapter 4, Dr Alireza Zolfaghari Dec 2012

My Lecture Notes (Power Plant Engineering) - Chapter 4, Dr Alireza Zolfaghari

Dr Alireza Zolfaghari

No abstract provided.


Dc And Microwave Analysis Of Gallium Arsenide Field-Effect Transistor-Based Nucleic Acid Biosensors, John K. Kimani Dec 2012

Dc And Microwave Analysis Of Gallium Arsenide Field-Effect Transistor-Based Nucleic Acid Biosensors, John K. Kimani

Theses and Dissertations

Sensitive high-frequency microwave devices hold great promise for biosensor design. These devices include GaAs field effect transistors (FETs), which can serve as transducers for biochemical reactions, providing a platform for label-free biosensing. In this study, a two-dimensional numerical model of a GaAs FET-based nucleic acid biosensor is proposed and simulated. The electronic band structure, space charge density, and current-voltage relationships of the biosensor device are calculated. The intrinsic small signal parameters for the device are derived from simulated DC characteristics and used to predict AC behavior at high frequencies.

The biosensor model is based on GaAs field-effect device physics, semiconductor ...


Morphometric, Biochemical, And Raman Spectral Analyses Of Muscle Damage In Patients With Peripheral Arterial Disease: Providing Objective Criteria For Diagnosis And Treatment Monitoring, Kim Cluff Dec 2012

Morphometric, Biochemical, And Raman Spectral Analyses Of Muscle Damage In Patients With Peripheral Arterial Disease: Providing Objective Criteria For Diagnosis And Treatment Monitoring, Kim Cluff

Biological Systems Engineering--Dissertations, Theses, and Student Research

Peripheral arterial disease (PAD), which affects approximately 10 million Americans, is characterized by atherosclerosis of the non-coronary arteries. PAD produces a progressive accumulation of ischemic injury to the limbs that is reflected in a gradual worsening in the myofiber morphology and oxidative damage in the gastrocnemius muscle. In this study, we evaluated the hypothesis that quantitative morphological and biochemical parameters of gastrocnemius myofibers change in a consistent manner during the progression of PAD, provide an objective grading of muscle degeneration in the ischemic limb, and correlate to clinical stage of PAD. Myofiber morphometrics were determined precisely with mathematical equations that ...


Accelerating Mri Data Acquisition Using Parallel Imaging And Compressed Sensing, Haifeng Wang Dec 2012

Accelerating Mri Data Acquisition Using Parallel Imaging And Compressed Sensing, Haifeng Wang

Theses and Dissertations

Magnetic Resonance Imaging (MRI) scanners are one of important medical instruments, which can achieve more information of soft issues in human body than other medical instruments, such as Ultrasound, Computed Tomography (CT), Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), etc. But MRI's scanning is slow for patience of doctors and patients. In this dissertation, the author proposes some methods of parallel imaging and compressed sensing to accelerate MRI data acquisition. Firstly, a method is proposed to improve the conventional GRAPPA using cross-sampled auto-calibration data. This method use cross-sampled auto-calibration data instead of the conventional parallel-sampled auto-calibration ...


Computer Modeling And Signal Analysis Of Cardiovascular Physiology, Henian Xia Dec 2012

Computer Modeling And Signal Analysis Of Cardiovascular Physiology, Henian Xia

Doctoral Dissertations

This dissertation aims to study cardiovascular physiology from the cellular level to the whole heart level to the body level using numerical approaches.

A mathematical model was developed to describe electromechanical interaction in the heart. The model integrates cardio-electrophysiology and cardiac mechanics through excitation-induced contraction and deformation-induced currents. A finite element based parallel simulation scheme was developed to investigate coupled electrical and mechanical functions. The developed model and numerical scheme were utilized to study cardiovascular dynamics at cellular, tissue and organ levels. The influence of ion channel blockade on cardiac alternans was investigated. It was found that the channel blocker ...


Quaternionic Attitude Estimation With Inertial Measuring Unit For Robotic And Human Body Motion Tracking Using Sequential Monte Carlo Methods With Hyper-Dimensional Spherical Distributions, Gary To Dec 2012

Quaternionic Attitude Estimation With Inertial Measuring Unit For Robotic And Human Body Motion Tracking Using Sequential Monte Carlo Methods With Hyper-Dimensional Spherical Distributions, Gary To

Doctoral Dissertations

This dissertation examined the inertial tracking technology for robotics and human tracking applications. This is a multi-discipline research that builds on the embedded system engineering, Bayesian estimation theory, software engineering, directional statistics, and biomedical engineering.

A discussion of the orientation tracking representations and fundamentals of attitude estimation are presented briefly to outline the some of the issues in each approach. In addition, a discussion regarding to inertial tracking sensors gives an insight to the basic science and limitations in each of the sensing components.

An initial experiment was conducted with existing inertial tracker to study the feasibility of using this ...


Design Of A Pretreatment And Enzymatic Saccharification Scheme Of Understory From Managed Pine Forest For A Biochemical-Refinery Platform: The Example Of The Sweetgum Tree, Angele Djioleu Dec 2012

Design Of A Pretreatment And Enzymatic Saccharification Scheme Of Understory From Managed Pine Forest For A Biochemical-Refinery Platform: The Example Of The Sweetgum Tree, Angele Djioleu

Theses and Dissertations

The possibility of using sweetgum from southern pine dominated forests as a biobased refinery feedstock was investigated. First, a baseline hydrolysis scheme for sweetgum wood and bark was designed. Sweetgum wood and bark were pretreated with 0.98% (v/v) sulfuric acid at 140°C for 30, 40, 50, 60 or 70 min and at 160°C for 30, 40, 50 or 60 min. The water insoluble solid (WIS) fraction was hydrolyzed with a cellulase enzyme cocktail. Results showed that maximum xylose and glucose yields from the wood were 82 and 86%, respectively. Similarly, the respective maximum yields of xylose ...


Implementation Of Magnetic Resonance Elastography For The Investigation Of Traumatic Brain Injuries, Thomas Boulet Dec 2012

Implementation Of Magnetic Resonance Elastography For The Investigation Of Traumatic Brain Injuries, Thomas Boulet

Engineering Mechanics Dissertations & Theses

Magnetic resonance elastography (MRE) is a potentially transformative imaging modality allowing local and non-invasive measurement of biological tissue mechanical properties. It uses a specific phase contrast MR pulse sequence to measure induced vibratory motion in soft material, from which material properties can be estimated. Compared to other imaging techniques, MRE is able to detect tissue pathology at early stages by quantifying the changes in tissue stiffness associated with diseases. In an effort to develop the technique and improve its capabilities, two inversion algorithms were written to evaluate viscoelastic properties from the measured displacements fields. The first one was based on ...


Reducing In-Stent Restenosis Through Novel Stent Flow Field Augmentation, Eoin Murphy, Fergal Boyle Dec 2012

Reducing In-Stent Restenosis Through Novel Stent Flow Field Augmentation, Eoin Murphy, Fergal Boyle

Articles

In-stent restenosis (ISR), manifested as a re-narrowing of the arterial lumen post-implantation of a stent, is a detrimental limitation of stent technology. Understanding and consequently devising ways of reducing the frequency of ISR has been a continuing goal of research into improved stent designs. The biological processes that can lead to ISR have been found to be partially flow dependent with the local hemodynamics at the arterial wall of crucial importance. This paper investigates these biological processes and their instigating factors. Furthermore, the history and theory behind three stent technologies which endeavour to reduce ISR rates through stent flow field ...


On The Importance Of Modeling Stent Procedure For Predicting Arterial Mechanics, Shijia Zhao, Linxia Gu, Stacey R. Froemming Dec 2012

On The Importance Of Modeling Stent Procedure For Predicting Arterial Mechanics, Shijia Zhao, Linxia Gu, Stacey R. Froemming

Mechanical & Materials Engineering Faculty Publications

The stent-artery interactions have been increasingly studied using the finite element method for better understanding of the biomechanical environment changes on the artery and its implications. However, the deployment of balloon-expandable stents was generally simplified without considering the balloon-stent interactions, the initial crimping process of the stent, its overexpansion routinely used in the clinical practice, or its recoil process. In this work, the stenting procedure was mimicked by incorporating all the above-mentioned simplifications. The impact of various simplifications on the stent-induced arterial stresses was systematically investigated. The plastic strain history of stent and its resulted geometrical variations, as well as ...


Develop Novel Frap Techniques For Determining Anisotropic Solute Diffusion In Cartilaginous Tissues, Changcheng Shi Dec 2012

Develop Novel Frap Techniques For Determining Anisotropic Solute Diffusion In Cartilaginous Tissues, Changcheng Shi

All Dissertations

Cartilaginous tissue is a connective tissue composed of specialized cells (e.g., chondrocytes and fibroblasts) that produce a large amount of extracellular matrix (ECM), which is comprised mostly of collagen fibers, abundant ground substance rich in proteoglycan, and elastic fibers. It is characterized by its avascular structures within the tissue, implying that nutrition for normal tissue cells, for maintaining a healthy ECM, is mainly supplied through diffusion from nearby vascularized tissues and synovial fluid. Poor nutritional supply to the cartilaginous tissue is believed to be an important factor leading to tissue degeneration. Moreover, due to the complex collagen fiber structures ...


A Watershed Scale Evaluation Of Selected Second Generation Biofeedstocks On Water Quality, Gurdeep Singh Dec 2012

A Watershed Scale Evaluation Of Selected Second Generation Biofeedstocks On Water Quality, Gurdeep Singh

Theses and Dissertations

This study compares a novel simulation approach to the conventional Soil and Water Assessment Tool (SWAT) modeler's approach for targeting biofuel crop production on marginal lands. In conventional SWAT modeling approach, non-spatial definition of hydrological response units (HRUs) results in the simulation of biofuel crops on both marginal and non-marginal land. This study provides an alternative approach in which a marginal-land raster was integrated into the land use and land cover (LULC) raster in such a way that the land uses were divided into marginal and non-marginal components. This modified LULC was used for model setup which resulted in ...


Functional Classification Of Skeletal Muscle Networks. I. Normal Physiology, Yu Wang, John Winters, Shankar Subramaniam Dec 2012

Functional Classification Of Skeletal Muscle Networks. I. Normal Physiology, Yu Wang, John Winters, Shankar Subramaniam

Biomedical Engineering Faculty Research and Publications

Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models. Through integration of vast amounts of data present in databases and extant knowledge of muscle function combined with robust analyses that include a clustering approach, we present both a protein parts list and network models for skeletal muscle function. The model comprises the four key functional family networks that coexist within a functional space; namely, excitation-activation family (forward pathways that transmit a motoneuronal command signal into the spatial volume of the cell and then use Ca ...


The Effect Of Cone Opsin Mutations On Retinal Structure And The Integrity Of The Photoreceptor Mosaic, Joseph Carroll, Alfredo Dubra, Jessica C. Gardner, Liliana Mizrahi-Meissonnier, Robert F. Cooper, Adam M. Dubis, Rick Nordgren, Mohamed Genead, Thomas B. Connor Jr., Kimberly E. Stepien, Dror Sharon, David M. Hunt, Eyal Banin, Alison J. Hardcastle, Anthony T. Moore, David R. Williams, Gerald Fishman, Jay Neitz, Maureen Neitz, Michel Michaelides Dec 2012

The Effect Of Cone Opsin Mutations On Retinal Structure And The Integrity Of The Photoreceptor Mosaic, Joseph Carroll, Alfredo Dubra, Jessica C. Gardner, Liliana Mizrahi-Meissonnier, Robert F. Cooper, Adam M. Dubis, Rick Nordgren, Mohamed Genead, Thomas B. Connor Jr., Kimberly E. Stepien, Dror Sharon, David M. Hunt, Eyal Banin, Alison J. Hardcastle, Anthony T. Moore, David R. Williams, Gerald Fishman, Jay Neitz, Maureen Neitz, Michel Michaelides

Biomedical Engineering Faculty Research and Publications

Purpose.

To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations.

Methods.

Eleven subjects were recruited, eight of whom have been previously described. Cone and rod density was measured using images of the photoreceptor mosaic obtained from an adaptive optics scanning light ophthalmoscope (AOSLO). Total retinal thickness, inner retinal thickness, and outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness were measured using cross-sectional spectral-domain optical coherence tomography (SD-OCT) images. Molecular genetic analyses were performed to characterize the OPN1LW/OPN1MW gene array.

Results.

While disruptions in retinal lamination and cone mosaic structure were observed ...


Assessing Retinal Structure In Complete Congenital Stationary Night Blindness And Oguchi Disease, Pooja Godara, Robert F. Cooper, Panagiotis I. Sergouniotis, Melissa A. Diederichs, Megan R. Streb, Mohamed Genead, J. Jason Mcanany, Andrew R. Webster, Anthony T. Moore, Adam M. Dubis, Maureen Neitz, Alfredo Dubra, Edwin M. Stone, Gerald A. Fishman, Dennis P. Han, Michel Michaelides, Joseph Carroll Dec 2012

Assessing Retinal Structure In Complete Congenital Stationary Night Blindness And Oguchi Disease, Pooja Godara, Robert F. Cooper, Panagiotis I. Sergouniotis, Melissa A. Diederichs, Megan R. Streb, Mohamed Genead, J. Jason Mcanany, Andrew R. Webster, Anthony T. Moore, Adam M. Dubis, Maureen Neitz, Alfredo Dubra, Edwin M. Stone, Gerald A. Fishman, Dennis P. Han, Michel Michaelides, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Purpose

To examine retinal structure and changes in photoreceptor intensity after dark adaptation in patients with complete congenital stationary night blindness and Oguchi disease.

Design

Prospective, observational case series.

Methods

We recruited 3 patients with complete congenital stationary night blindness caused by mutations in GRM6, 2 brothers with Oguchi disease caused by mutations in GRK1, and 1 normal control. Retinal thickness was measured from optical coherence tomography images. Integrity of the rod and cone mosaic was assessed using adaptive optics scanning light ophthalmoscopy. We imaged 5 of the patients after a period of dark adaptation and examined layer reflectivity on ...