Pharmacy and Pharmaceutical Sciences Commons^™

Brain Delivery Of Erythropoietin Results In A Significant Reduction Of Brain Aβ And Spatial Memory Deficits In The App Knock-In Mouse Model, Rudy Tieu Chang, Devaraj V. Chandrashekar, Grace-Ann Chuli Roules, Emi Iwasaki, Nataraj Jagadeesan, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Although novel treatments for Alzheimer’s disease (AD) have begun to show modest therapeutic effects, agents that target hallmark AD pathology and offer neuroprotection are desired. Erythropoietin (EPO) is a glycoprotein hormone with neuroprotective effects but is faced with challenges including limited brain uptake and increased hematopoietic side effects with long-term dosing. Therefore, EPO has been modified and bound to a chimeric transferrin receptor monoclonal antibody (cTfRMAb); the latter shuttles EPO past the blood-brain barrier (BBB) into brain parenchyma and reduces its plasma exposure and potential for side effects. Our study sought to characterize the safety and pharmacokinetics (PK) of …

Evaluation Of Tenecteplase In Patients With Acute Ischemic Stroke, Ithar Alsarraf, Rebecca Baker, Jennifer Pilotto, Emily Reich

Conference Presentation Abstracts

Purpose: As of January 2024, Corewell Health East hospitals updated their guidelines to include tenecteplase as the first line agent in the treatment of acute ischemic stroke. Tenecteplase is a high-risk medication, it is important to identify opportunities to improve its use and patient safety. This study aims to evaluate the appropriate usage and hemorrhagic events of tenecteplase in patients with suspected acute ischemic stroke according to Corewell Health Beaumont Troy Hospital guidelines. Methods: This was a single-center retrospective cohort study that evaluated adults age 18 years and older admitted to Corewell Health Beaumont Troy Hospital for acute ischemic stroke …

Evaluation Of Intravenous Surgical Prophylaxis Antibiotics Used In Colorectal And Hysterectomy Surgeries, Mehreen Hasan, Sandra Hartnagle, Sapna Shah

Conference Presentation Abstracts

Purpose: Colorectal and hysterectomy surgeries can expose patients to various bacterial organisms which can increase their risk of surgical site infections. The most common offending bacteria include Bacteroides fragilis, Escherichia coli, and other obligate anaerobes. Per the institution’s policy, cefazolin plus metronidazole is the preferred prophylactic antibiotic regimen in colorectal and hysterectomy surgeries. However, patient allergies or physician preference may lead towards utilization of alternative antibiotic therapy. This study will evaluate the number of patients who received antibiotics in accordance with the hospital guidelines, prior to colorectal and hysterectomy surgeries. Methods: This study will be a retrospective chart review including …

Mergers And Acquisitions (M&As) In Pharmaceutical Markets: Associations With Market Concentration, Prices, Drug Quantity Sold, And Shortages, J. Daniel Mcgeeney M.S., Aylin Sertkaya Ph.D., Leah Ross M.A., Fred Ledley M.D., Cody Hyman Ph.D.

CISI Publication

In recent decades, the pharmaceutical industry has become increasingly concentrated in the United States, in part due to mergers and acquisitions (M&As) between drug manufacturers. This consolidation from M&As has been cited as a key factor affecting drug prices and drug shortages (U.S. Federal Trade Commission, 2022). In this study, we assessed trends in pharmaceutical M&As during 2010–2023 and evaluated the characteristics of drugs and companies involved in those M&As. We considered the effects of M&As on market concentration, drug prices, drug quantity sold, and drug shortages. We also considered how these associations vary by drug characteristics, including brand drugs …

Risk Factors Which Effect The Maturity Of Placenta, Eftkar Hamza Skair, Saadya Hadi Humade, Rania Abd Elmohsen Abo El Nour, Maryam Amer Ajam

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Back ground Proper placental development is essential for a successful pregnancy. An important organ, the placenta carries out several physiological, immunological, and endocrine functions. It also performs vital roles in mediating the exchange of gasses, nutrients, and waste products between the fetal circulation and the physically separate mother circulation.

Aims: The purpose of the study was to evaluate how placental maturity affected the outcomes of pregnancies in Babylon City.

Setting and design: A Babylon City private clinic, a purposefully selected sample of one hundred pregnant patients who received a diagnosis at the private clinic.

Method, material: from medical records, …

Instruction Program For Patients With Cholecystectomy Regarding Nutritional Knowledge, Haider Naiser Mousa, Huda Baqir Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The primary objective of this study is to assess the level of patients' understanding of the educational program following cholecystectomy. Additionally, the study attempts to determine the correlation between patients' knowledge and their socio-demographic factors. A quasi-experimental design study was conducted at AL Imam Sadiq Teaching Hospital. The study employed a non-probability selection method, namely selecting 30 patients for the study group and 30 patients for the control group. The instrument consists of 14 items. The validity of the questionnaire was assessed by a panel of 11 experts. The reliability of the questionnaire was determined by calculating the Alpha Correlation …

Preparation And Characterization Using A New Schiff Base Ligand Derived From Benzoyl Isothiocyanate With Their Complexes And Study Of Their Biological Activity, Zaynab Faleh Ai-Janahi, Mohammed Hamid Said

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Complexes containing Nickel, Copper, and Zinc salts were prepared and studied in this study. Additionally, novel Schiff Base ligands were synthesized by reacting 6-aminopenicillinic acid with benzoyl isothiocyanate to produce L. The synthesized ligand was evaluated by physical measures and spectroscopic methods such as Fourier transform infrared spectroscopy, nuclear magnetic resonance, ultraviolet-visible light, mass spectroscopy, and micro elemental analysis. Metal salts of (Ni(II), Cu(II), and Zn(II)) were combined with novel ligands at a molar ratio of 1:2 [M:L] to prepare the complexes. Spectroscopic, magnetic susceptibility, molar conductivity, atomic absorption, and DTA methods were used to study the complexes that were …

Diclofenac: A Review On Its Synthesis, Mechanism Of Action, Pharmacokinetics, Prospect And Environmental Impact, Hind A. Satar, Emad Yousif, Ahmed Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Diclofenac, potent a nonsteroidal anti-inflammatory drug, used in the treatment of inflammation, pain and fever associated with a wide range of disease condition. This review article focuses the synthesis, mechanism of action, pharmacokinetics and derivatives of diclofenac and also highlights advances in the possible use of diclofenac in treating other condition outside its current clinical therapeutic use as an analgesic, anti-inflammatory and antipyretic agent as well the prospect of drug repurposing of diclofenac for treatment of disease like cancer. It further highlights the adverse effect of the drug as an emerging contaminant in the environment. Diclofenac acts by inhibition of …

Impact Of An Educational Program On Nurses' Knowledge Of Poisoning Management: A Quasi-Experimental Study, Ammar Ahmed Hatem, Tahseen Rajab Muhammad

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Despite the critical role nurses play in managing poisoning cases, gaps in their knowledge can hinder patient outcomes. An educational program may address this deficit, but its effectiveness on nurses’ knowledge in poisoning management remains to be systematically evaluated.

Objectives:

This study aimed to examine the effect of an educational program on nurses’ knowledge of poisoning management.

Methods:

A quasi-experimental study with a pre- and post-test design was conducted on 80 nurses working in an emergency department (ED) in Al-Qādisiyyah Governorate, Iraq. The 80 nurses were randomly allocated into two groups of 40 to either receive the …

Chronic Heavy Alcohol Intake And Liver-Specific Lrp-1 Reduction Increase Amyloidosis In Alzheimer’S Disease Mice, Devaraj V. Chandrashekar, G. Chuli Roules, Ross A. Steinberg, Urvashi R. Panchal, Nataraj Jagadeesan, Adenike Oyegbesan, Trinh Roselyn, Joshua Yang, Sharda R. Bhagwat, Hiya Rakholia, Rutvi D. Mevawala, Moom Roosan, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Chronic heavy alcohol drinking may be a modifiable risk factor for Alzheimer’s disease (AD), but studies in rodent AD models more closely mimic chronic moderate alcohol drinking in humans and largely focus on the brain. The role of the liver, which is significantly impacted by chronic heavy alcohol intake, in driving brain changes in alcohol-dependent AD remains unexplored. Our study using intragastric-ethanol feeding, which mimics chronic heavy alcohol intake in humans, in C57BL/6J mice showed significant AD-relevant changes in the brain and liver. Therefore, we aimed to investigate how hepatic changes using this model of chronic heavy drinking drive …

In Vivo Evaluation Of Novel Nanoparticles And Repurposed Pharmaceuticals To Combat Antimicrobial Resistance, Sarah E. Evans

Theses, Dissertations and Capstones

In a 2019 report by the Centers for Disease Control and Prevention (CDC), infections resistant to antibiotic treatment amount to about three million infections and 48,000 deaths. Antimicrobial resistance is an escalating global threat as existing antibiotics lose efficacy over time. The project described is focused on partnering with pharmaceutical researchers and producers to test new nanoparticle-based or repurposed compounds. The central hypothesis of this thesis is that pharmaceutical formulations such as nanoparticles may provide a cost-effective means of combating the emerging antimicrobial resistance. The nanoparticle compounds allowed for a wide range of customization for the pharmaceutical design, since the …

Regulation Of Human Il-9 Production By Lipid Metabolism, Swetha Peesari

Theses, Dissertations and Capstones

T lymphocytes contribute to host defense and inflammation producing cytokines in response to antigenic stimuli. CD4 T cell activation induces dramatic changes to cellular metabolism for supporting their growth and differentiation into effector subsets. Distinct subsets have been named Th1, Th2, Th9, Th17, Th22, Tfh and Treg based on their characteristic effector cytokines and transcription factors expressed. Th9 cells are one of the most recent subsets identified. While the cytokines IL-4, TGF-β and IL-21 promote differentiation into Th9 cells, metabolic factors regulating this process remain poorly understood. We hypothesized that lipid metabolism could regulate Th9 cell differentiation which may have …

Exosomes And Encapsulated Exomirs In Breast Cancer: Theragnostic Applications And Clinical Implications, Muhammad Imran Sajid, Shafia Bukhari, Hamid Ilyas, Rubina Malik, Minahil Fatima, Rakesh Kumar Tiwari, Surya M. Nauli, Khawaja Husnain Haider

Pharmacy Faculty Books and Book Chapters

Exosomes, released by cells, are small vesicles that have emerged as critical theranostic tools in breast cancer due to their unique ability to transport diverse biomolecules such as proteins, lipids, and RNAs, including microRNAs (ExomiRs). These vesicles are critical in modulating the tumor microenvironment, driving processes like cancer proliferation, invasion, metastasis, and drug resistance. Exosomal microRNAs such as ExomiR-21, ExomiR-1246, and ExomiR-155, with their profound influence on the gene expressions in the recipient cells, are the unsung heroes in tumor progression and immune modulation. This chapter delves into exosome's dual diagnostic and therapeutic potential in breast cancer. It highlights their …

Nutrition Assessment Of Substance Use Population Compared To Control Population, Lalitha Indrani Dasari

Theses, Dissertations and Capstones

This study aims to evaluate and compare the nutritional status of individuals undergoing treatment for substance use disorder (SUD) with a matched control population. Poor nutrition, micronutrient deficiencies and malabsorption are common in individuals with SUD, potentially affecting recovery outcomes. This study involves collection of biometric data, demographic information, conducting a structured nutrition survey and performing a one-time blood draw of 35ml to assess key nutritional markers such as lipid panel, folic acid, vitamin B12, vitamin D, thyroid stimulating hormone (TSH), magnesium, selenium, chromium, zinc, copper and lithium. While the original protocol was designed to recruit approximately 110 participants across …

Gattonrx Magazine - 2025, Bill Gatton College Of Pharmacy, East Tennessee State University

GattonRX Magazine

No abstract provided.

Decolonizing Health In Madagascar: A Francophone Perspective, Delaney K. Brenner

CISLA Senior Integrative Projects

No abstract provided.

Evaluation Of Disulfiram And Derivatives As Antimicrobial Adjuvants, Surya Bhaskar Karuturi

Theses, Dissertations and Capstones

Disulfiram (Antabuse) is an oral drug used for the treatment of alcohol dependence. Previous studies showed that disulfiram has antibiotic activity on multidrug-resistant bacteria. Here disulfiram was further evaluated for its ability to increase the potency of existing antimicrobials against the bacteria and yeast by acting as a drug adjuvant. Microbial cultures were treated with antibiotic or antifungal drugs in combination with disulfiram and its derivatives to determine whether potency is increased. The structure activity relationship (SAR) of disulfiram analogs was assessed against a triazole resistant Aspergillus panel. It showed that the shorter chained analogs of disulfiram are more potent …

Research News, Publications, 2025, Volume 1, Joshua Sharp

Publications (2015-)

Publications that appeared during the period of January 1 - March 31, 2025.

Catalytic Effect Of Amyloid-Β On Native Tau Aggregation At Physiologically Relevant Concentrations, Rakhi Chowdhury, Apu Chandra Das, Ruan Van Deventer, Luda S. Shlyakhtenko, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Alzheimer's disease (AD) is characterized by the accumulation and aggregation of tau and amyloid-β (Aβ). The pathophysiology and progression of AD are facilitated by the neurotoxic effects of these aggregated proteins, resulting in neurodegeneration and memory loss. In this context, the interaction between tau and Aβ42 is considered, but the mechanism underlying their pathogenic interplay remains unclear. Here, we addressed this question by studying the aggregation of full-length, unmodified tau and Aβ42 at physiologically low concentrations using atomic force microscopy (AFM). AFM imaging and data analyses demonstrate an increase in tau aggregation in the presence of Aβ42, characterized by increased …

Ashwagandha And Sexual Health In Women With Hypoactive Sexual Desire Disorder: Exploring Extent Of Adaptogenic Properties, Rhea Chatterjee

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Hypoactive Sexual Desire Disorder (HSDD) affects 40% of women and potentially decreases their quality of life. Currently, the primary treatment for HSDD is Flibanserin, which is a serotonergic agonist and an antidepressant. However, the limited efficacy of Flibanserin encourages the exploration of the utilization of traditional drugs such as Withania somnifera, otherwise known as Ashwagandha, as an alternative treatment for HSDD. Minimal studies examine ayurvedic medications or the symptoms of illnesses that traditional Western medicines are unable to treat. This comprehensive literature review investigated the efficacy of Ashwagandha in improving sexual function in women with HSDD. The paper evaluated …