Pharmacy and Pharmaceutical Sciences Commons^™

Curcumin Induces Apoptosis Of Upper Aerodigestive Tract Cancer Cells By Targeting Multiple Pathways, Arm R. Amin, A. Haque, M. A. Rahman, Z. G. Chen, F. R. Khuri, D. M. Shin

Pharmaceutical Science and Research

Curcumin, a natural compound isolated from the Indian spice "Haldi" or "curry powder", has been used for centuries as a traditional remedy for many ailments. Recently, the potential use of curcumin in cancer prevention and therapy urges studies to uncover the molecular mechanisms associated with its anti-tumor effects. In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2. Treatment of cells with curcumin induced both p53 and the …

Fda Approves 18 New Molecular Entities/Biologics, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

Assessment Of Empathy Scores In A Pharmacy Professional Nutrition Support Elective Course, Megan M. Mayhew

Undergraduate Honors Thesis Collection

Background: Clinical empathy may be defined as "the ability to listen to, understand, sympathize with, and provide support to another individual." Empathy has been shown to influence patient satisfaction, adherence, and improve clinical outcomes. Teaching empathy skills in the classroom and clinical setting is imperative to allow students to develop and enhance their communication with patients.

Study Objective: To evaluate two empathy projects in the RX 618 Nutrition Support Professional Elective to identify if the projects are effective in improving pharmacy students' knowledge of empathy.

Methods: The study objective was met using a prospective cohort survey based study. An interactive …

Evaluating The Non-Evidence Based Practice Of Rounding Serum Creatinine In The Elderly And The Impact On Medication Dosing, Kelly Lynn Roden

Undergraduate Honors Thesis Collection

Background: The Cockcroft and Gault equation is widely accepted in practice as the most appropriate way to calculate an estimated creatinine clearance. Geriatric patients often present with reduced muscle mass, and therefore lower creatinine production, due to normal changes in body composition associated with aging. Because serum creatinine and creatinine clearance are inversely proportional using the Cockcroft and Gault equation, a lower serum creatinine may falsely overestimate renal function in the elderly population. Rounding to a normal serum creatinine is believed by some practitioners to prevent over estimation of creatinine clearance and renal function.

Objective: The objective of this study …

Drug-Drug Interactions Among Hepatitis C Virus (Hcv) And Human Immunodeficiency Virus (Hiv) Medications, Kirpal Kaur, Mona A. Gandhi, Judianne Slish

Doctoral External Publications

One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and mortality in HIV-HCV coinfected individuals. Optimal treatment in this patient population is critical, as coinfection has been linked to deterioration of both disease states. The objective of this review article is to highlight the current literature on drug-drug interactions between HIV and HCV treatments. The management of the treatment of coinfection patients has been covered extensively in numerous other publications.

Polymeric Nanoparticle-Based Delivery Of Microrna-199a-3p Inhibits Proliferation And Growth Of Osteosarcoma Cells, Linlin Zhang, Arun K. Iyer, Xiaoqian Yang, Eisuke Kobayashi, Yuqi Guo, Henry Mankin, Francis J. Hornicek, Mansoor M. Amiji, Zhenfeng Duan

Pharmaceutical Sciences Faculty Publications

Our prior screening of microRNAs (miRs) identified that miR-199a-3p expression is reduced in osteosarcoma cells, one of the most common types of bone tumor. miR-199a-3p exhibited functions of tumor cell growth inhibition, suggesting the potential application of miR-199a-3p as an anticancer agent. In the study reported here, we designed and developed a lipid-modified dextran-based polymeric nanoparticle platform for encapsulation of miRs, and determined the efficiency and efficacy of delivering miR-199a-3p into osteosarcoma cells. In addition, another potent miR, let-7a, which also displayed tumor suppressive ability, was selected as a candidate miR for evaluation. Fluorescence microscopy studies and real-time polymerase chain …

Swosu Research And Scholarly Activity Fair 2015, Jason L. Johnson

SWOSU Research and Scholarly Activity Fair Programs

Welcome to the Twenty-Second SWOSU Research and Scholarly Activity Fair! On display today are 103 presentations involving 169 student researchers, writers, performers, and artists, and 40 faculty sponsors encompassing scholarly activity from the Departments of: Accounting, Computer Science, and Entrepreneurship; Art, Communication, and Theatre; Biological Sciences; Chemistry and Physics; Education; Engineering Technology; Finance, Management, and Marketing; Language and Literature; Music; Nursing and Allied Health; Pharmaceutical Sciences; Psychology; and Social Sciences.

Microcystins As Agents For Treatment Of Cancer, Noel R. Monks, Shuqian Liu, Jeffrey A. Moscow

Pharmaceutical Sciences Faculty Patents

This invention relates to the use of microcystins as agents for treatment of cancer. Also provided are methods of screening for microcystins with improved cytotoxicity.

Clinical Evaluation Of Loop-Mediated Isothermal Amplification (Lamp) Assay For Rapid Detection Of Neisseria Meningitidis In Cerebrospinal Fluid, Dokyung Lee, Eun Jin Kim, Paul E. Kilgore, Soon Ae Kim, Hideyuki Takahashi, Makoto Ohnishi, Dang Duc Anh, Bai Qing Dong, Jung Soo Kim, Jun Tomono, Shigehiko Miyamoto, Tsugunori Notomi, Dong Wook Kim, Mitsuko Seki

Department of Pharmacy Practice

Background

Neisseria meningitidis (Nm) is a leading causative agent of bacterial meningitis in humans. Traditionally, meningococcal meningitis has been diagnosed by bacterial culture. However, isolation of bacteria from patients’ cerebrospinal fluid (CSF) is time consuming and sometimes yields negative results. Recently, polymerase chain reaction (PCR)-based diagnostic methods of detecting Nm have been considered the gold standard because of their superior sensitivity and specificity compared with culture. In this study, we developed a loop-mediated isothermal amplification (LAMP) method and evaluated its ability to detect Nm in cerebrospinal fluid (CSF).

Methodology/Principal Findings

We developed a meningococcal LAMP assay (Nm LAMP) that targets …

Filamin A Phosphorylation By Akt Promotes Cell Migration In Response To Arsenic, Lingzhi Li, Yongju Lu, Paul M. Stemmer, Fei Chen

Pharmaceutical Sciences Faculty Publications

We had previously reported that trivalent arsenic (As³⁺), a well-known environmental carcinogen, induces phosphorylation of several putative Akt substrates. In the present report, we characterized one of these substrates by immunoprecipitation and proteomics analysis. The results indicate that a cytoskeleton remodeling protein, filamin A, with a molecular weight around 280 kDa, is phosphorylated by Akt in HEK-293 cells treated with As³⁺, which was also confirmed in human bronchial epithelial cell line, BEAS-2B cells. Additional biochemical and biological studies revealed that serine 2152 (S2152) of filamin A is phosphorylated by activated Akt in the cells treated with …

Aggressive Anesthetic Management Of A Patient With Severely Dilated Cardiomyopathy For Non Cardiac Surgery, Muhammad F. Sarwar, Nabila Ahmed-Sarwar, David Vent

Pharmacy Faculty/Staff Publications

We report a case of a 37 year old man, with history of rhabdomyosarcoma as a child. Patient developed severe dilated cardiomyopathy secondary to the treatment of the cancer. He presented for resection of the small bowel. An intra-aortic balloon pump (IABP) was placed preoperatively for mechanical cardiac support. A combined general/epidural technique was used for the surgery. Transesophageal echocardiogram (TEE) was used to monitor patients cardiac status intraoperatively. Patient remained hemodynamically stable and tolerated the procedure well.

Facilitating Facilitators: Enhancing Pbl Through A Structured Facilitator Development Program, Francine D. Salinitri, Sheila M. Wilhelm, Brian L. Crabtree

Interdisciplinary Journal of Problem-Based Learning

With increasing adoption of the problem-based learning (PBL) model, creative approaches to enhancing facilitator training and optimizing resources to maintain effective learning in small groups is essential. We describe a theoretical framework for the development of a PBL facilitator training program that uses the constructivist approach as the program’s guiding philosophy. The structured, pedagogically sound program was designed for a multidisciplinary pool of basic and social/administrative scientists, clinical faculty, practicing pharmacists, and post-graduate residents enrolled in a teaching certificate program. The training program employs the PBL experience, along with interactive technology, case-based and debriefing sessions with small groups and experienced …

The Impact Of Care Coordination On Community Pharmacist-Delivered Medication Therapy Management, Stephanie A. Gernant

Open Access Theses

Background: Care coordination is imperative to successful patient outcomes. However, community pharmacists are commonly excluded from health information exchange during care coordination. One of the ways pharmacists deliver care, through medication therapy management (MTM), could be optimized if pharmacists engaged in care coordination through review of unedited patient medical records in preparation for a section of the MTM, the comprehensive medication review (CMR).^ Methods: This was a non-blinded randomized controlled trial undertaken within the Medication Safety Research network of Indiana, also known as RxSafeNet. RxSafeNet is a community pharmacy practice based research network. Pharmacists were randomized to deliver CMR’s to …

Fall 2014 - Spring 2015, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Fall 2014 - Spring 2015

Pharmacy Newsletter : April 2015, Pharmacy Department

Department of Pharmacy Archives

Content:

• Medication Safety Alert
• FDA Drug Safety Podcast of the Year 2014
• Operational Quality and Patient Safety Indicators – 2014
• Pharmacy Staff Appreciation Evening

Prescription Drug Monitoring Program Utilization In Kentucky Community Pharmacies, Sarah E. Wixson, Karen Blumenschein, Amie J. Goodin, Jeffery Talbert, Patricia R. Freeman

Pharmacy Practice and Science Faculty Publications

OBJECTIVE: Identify characteristics of Kentucky community pharmacists and community pharmacists' practice environment associated with utilization of the Kentucky All Schedule Prescription Electronic Reporting Program (KASPER).

METHODS: Surveys were mailed to all 1,018 Kentucky pharmacists with a KASPER account and an additional 1,000 licensed pharmacists without an account. Bivariate analyses examined the association between KASPER utilization and practice type (independent or chain) and practice location (rural or urban). A multivariate Poisson regression model with robust error variance estimated risk ratios (RR) of KASPER utilization by characteristics of pharmacists' practice environment.

RESULTS: Responses were received from 563 pharmacists (response …

Pharmdigest Volume 1, Issue 2, Philadelphia College Of Osteopathic Medicine, School Of Pharmacy

PharmDigest

This issue of the Pharmacy Student Council newsletter includes the following articles:

• PCOM PGY1 at Gwinnett Medical
• Getting the Residency
• Counsel On!
• The Daily Dose: Leadership
• AMCP visits the West Coast
• Introducing the New Council

Nsu Sharks Rx - Spring 2015, College Of Pharmacy

NSU Sharks Rx

No abstract provided.

Beta-Lactam Antimicrobial Dosing Optimization In Obese Patients Compared To Non-Obese Patients Using Population Pharmacokinetic/Pharmacodynamic Approach, Eun Kyoung Chung

Open Access Dissertations

Obesity is a significant global health problem and has been associated with altered pharmacokinetics and pharmacodynamics of many drugs. However, little is known regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, and cefepime. The objective of this study is to evaluate the population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, meropenem, and cefepime in hospitalized obese patients in order to determine dosing regimens that provide similar exposures between obese and non-obese patients. ^ For piperacillin/tazobactam, a retrospective analysis was conducted using prospectively collected serum concentration-time data from two previous studies (Study …

Shining The Spotlight On Diabetes, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.