Treating Cytokine Storm In Patients With Covid-19,
2022
University of Louisville
Treating Cytokine Storm In Patients With Covid-19, Ahmed Abdelhaleem, Deekshitha Turaka, Shameera Shaik Masthan, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Resolving The Repression Pathway Of Virulence Gene Hila In Salmonella,
2022
University of Missouri-St. Louis
Resolving The Repression Pathway Of Virulence Gene Hila In Salmonella, Alexandra King, Lon Chubiz Phd, Brenda Pratte, Lauren Daugherty
Undergraduate Research Symposium
Salmonella is a relatively abundant, virulent species of bacteria that is most known for spreading gastrointestinal diseases through food. These illnesses result in approximately 1.35 million infections, including over 25,000 hospitalizations each year, in the U.S. alone (CDC.gov). As antibiotic resistance becomes an increasingly urgent public health problem, the importance of developing alternative treatment methods is only becoming more crucial. One of the genes responsible for this virulence is known as hilA. HilA is the main transcriptional regulator of Salmonella Pathogenicity Island-1 gene (UniProt). SPI-1 plays an important role in the invasion of Salmonella into epithelial ...
A Case Report Of Pulmonary Actinomycosis: A Diagnostic Quagmire,
2022
Piedmont Macon Medical Center
A Case Report Of Pulmonary Actinomycosis: A Diagnostic Quagmire, Sarah Akbani, Aderinsola O. Ademiluyi, Jonathan Dean, Vinita Mathur
Advances in Clinical Medical Research and Healthcare Delivery
The implications of misdiagnosis can be drastic, especially when the correct diagnosis is treatable. Pulmonary actinomycosis is one of the complications of infection with actinomyces, an anaerobic gram-positive organism that is usually found as a part of the normal flora in the human body infection. It is a very rare disease and is frequently mistaken with other diagnoses owing to its nonspecific presentation. In this report, we present a 67-year-old male with a mass like lesion on a CT scan of his chest that was done due to progressively worsening productive cough, weight loss and fatigue. These symptoms could have ...
Antimicrobial Stewardship Meets Transitions Of Care: Defining Length Of Therapy For Community-Acquired Pneumonia (Cap),
2022
Infirmary Health
Antimicrobial Stewardship Meets Transitions Of Care: Defining Length Of Therapy For Community-Acquired Pneumonia (Cap), Christopher Whitman, Sarah E. Moore Pharmd, Matthew Song Pharmd, Bcidp, Brian C. Bohn Pharmd, Bcidp, Ashley M. Wilde
The University of Louisville Journal of Respiratory Infections
Introduction: Hospital-based antimicrobial stewardship efforts have traditionally focused on inpatient settings. Antibiotic prescribing at discharge is often an overlooked area of focus for antimicrobial stewardship programs. Discharge prescribing optimization is necessary to combat antibiotic overuse.
Methods: This was an observational, retrospective cohort study at a four–adult community hospital system. Four hundred adult patients admitted with community-acquired pneumonia and discharged with antibiotics were included. The primary outcome was overall (inpatient and discharge) antibiotic length of therapy. The secondary outcome was percentage of patients discharged on a fluoroquinolone who had not received one in the hospital. Descriptive statistics were utilized.
Results ...
Effect Of Bovine Lactoferrin On Seroconversion Following Polio Vaccine Administration In Children: Protocol For A Double-Blinded Randomised Controlled Trial,
2022
Aga Khan University
Effect Of Bovine Lactoferrin On Seroconversion Following Polio Vaccine Administration In Children: Protocol For A Double-Blinded Randomised Controlled Trial, Atif Habib, Sidrah Nausheen, Shanila Nooruddin, Tooba Javed, Tariq Samejo, Amjad Hussain, Suneeta Namdave, Sehrish Amirali, Muhammad Umer, Lumaan Sheikh
Department of Paediatrics and Child Health
Introduction: The oral polio vaccine (OPV) has substantial results in eliminating wild poliovirus and the vaccine of choice in polio eradication. However, the mucosal immunity induced by the OPV is still uncertain. Literature has shown that bovine lactoferrin (BLF) is a safe and useful protein found in cow's milk with extraordinary antimicrobial, antiviral, antiinflammatory and immune-modulatory functions that help children's gut to fight against micro-organisms like poliovirus. However, limited data exist regarding the effect of BLF on polio vaccine immune response. The primary objective is to evaluate the effect of BLF in enhancing mucosal and humoral immunity in ...
Covid-19 Case Complicated With Organizing Pneumonia And Pneumothorax: Correspondence,
2022
Orlando VA
Covid-19 Case Complicated With Organizing Pneumonia And Pneumothorax: Correspondence, Hammad A. Bhatti, Minh Q. Ho
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Flippase Inhibitors As Antimicrobial Agents,
2022
Seton Hall University
Flippase Inhibitors As Antimicrobial Agents, Robert Tancer
Seton Hall University Dissertations and Theses (ETDs)
Drug resistant microbes are a considerable challenge for modern medicine to overcome. The research described in this dissertation involved development of lipid flippase inhibitors and investigating their potential as antimicrobial agents against various drug resistant microbes. The microbes primarily investigated were methicillin resistant Staphylococcus aureus (MRSA) & Cryptococcus neoformans. Chapter 1 reviews the historical perspective and summarizes the current state of the field of research. In Chapter 2, the design space of an antimicrobial peptide known as humimycin was explored and the effects of modifications on its structure were observed against MRSA. Several key observations resulted. Most notably, the nanoparticles formed ...
Covid-19, Vaccination, And Heart Transplantation,
2022
University of Louisville
Covid-19, Vaccination, And Heart Transplantation, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Neurosyphilis: A Monkey Among Men,
2022
Cape Fear Valley Medical Center
Neurosyphilis: A Monkey Among Men, Cameron Rowe Do, Nathan Buckley Do, Bhaskar Chhetri Md, Suresh Paudel Md
Journal of Community Hospital Internal Medicine Perspectives
Neurosyphilis is the progression of the untreated sexually transmitted infection caused by Treponema pallidum. When the initial infection is not adequately treated, progression of primary syphilis can lead to a wide variety of serious health sequelae. While neurosyphilis can appear up to 10-30 years after the initial infection, syphilis can invade the nervous system at any stage of infection and can imitate symptoms of many other diseases. This variety of symptoms is why syphilis has been called “The Great Pretender” or “The monkey among diseases” (12). This is a case report of an 83-year-old female with a history of multiple ...
Bacteriophages: Paving The Road For The Future Of Medicine,
2022
Ouachita Baptist University
Bacteriophages: Paving The Road For The Future Of Medicine, Luke Brinkerhoff
Honors Theses
Bacteriophages are a possible solution to antibiotic resistance, which is predicted to be detrimental world-wide by the year 2050. Personal field research was also conducted for a project studying the characteristics of two bacteriophages on a single bacterial host.
Investigation On Bacterial Signaling Through Generation Of A Ppgpp Biosensor,
2022
East Tennessee State University
Investigation On Bacterial Signaling Through Generation Of A Ppgpp Biosensor, Andrew Robinson
Undergraduate Honors Theses
Guanosine tetraphosphate (ppGpp) is a bacterial signaling molecule involved in activating the stringent response, a cellular reaction to environmental stress that downregulates cell division and metabolism processes to conserve nutrients. The stringent response is implicated in some instances of antibiotic persistence, so broadening the current understanding of ppGpp signaling is useful. This thesis seeks to generate a ppGpp biosensor that will bind ppGpp and emit fluorescent light in its presence, which will allow for improved research into the pathways and functions of the signaling molecule. To generate a novel ppGpp biosensor, I converted a biosensor previously used to detect cyclic ...
Bartonella Henselea Prosthetic Valve Endocarditis Mimicking Vasculitis: A Case Report With Literature Review,
2022
University of Central Florida, School of Medicine/HCA Florida North Florida Hospital
Bartonella Henselea Prosthetic Valve Endocarditis Mimicking Vasculitis: A Case Report With Literature Review, Troy J. Fishman, Efrain Irizarry, Ayesha Kaleem, Robert Yancey, Uma Iyer
HCA Healthcare Journal of Medicine
We present one of the first reported cases of Bartonella henselae prosthetic valve endocarditis, which mimicked p-antineutrophil cytoplasmic autoantibody (p-ANCA), an anti-proteinase 3 positive necrotizing glomerulonephritis caused by a cat scratch resulting in temporary dialysis. Documentation of such infections is necessary as zoonotic infections are becoming more prevalent with early identification essential for proper treatment. Although pauci-immune patterns are not a unique finding in bacterial endocarditis associated with glomerulonephritis, they are an atypical finding in Bartonella henselae endocarditis. Furthermore, p-ANCA-associated vasculitis can also be responsible for renal and cardiac disease. Because of the similar disease presentation of different etiologies (autoimmune ...
Bacteriophages: Paving The Road For The Future Of Medicine,
2022
Ouachita Baptist University
Bacteriophages: Paving The Road For The Future Of Medicine, Luke Brinkerhoff
Scholars Day Conference
Antibiotics will not be used forever by society due to antibiotic resistance. By the year 2050, it is predicted to have caused millions of casualties throughout the world. Thankfully, bacteriophages and phage therapy could be a potential solution to this problem.
New Paenibacillus Bacteria Genome Assembly,
2022
Ouachita Baptist University
New Paenibacillus Bacteria Genome Assembly, Makenna Kager
Scholars Day Conference
Due to DLA16’s ability to produce antibiotics it was selected for whole genome sequencing.
Diversity Of Bacteriophage In Burkholderia Species,
2022
Bowling Green State University
Diversity Of Bacteriophage In Burkholderia Species, Abigail Price
Honors Projects
Bacteriophages are viruses that infect and replicate within bacteria and offer the potential of a therapeutic alternative to chronic infections that do not respond to antibiotic-based therapies. B. vietnamiensis is one of a number of Burkholderia species involved with chronic drug resistant infections in the lungs of individuals with compromised respiratory systems, as found in those with chronic obstructive pulmonary disease and, most especially, are of particular significance in patients with cystic fibrosis. The diversity of the Burkholderia species is explored by using online databases and looking at bacteriophage or phage-encoding viruses found in B. vietnamiensis. The open reading frames ...
Predominantly Methicillin-Susceptible S. Aureus Bacteria Found In Csp Students’ S. Aureus Strains,
2022
Concordia University, St. Paul
Predominantly Methicillin-Susceptible S. Aureus Bacteria Found In Csp Students’ S. Aureus Strains, Roma Ambo
Research and Scholarship Symposium Posters
Positive Staphylococcus aureus strains from CSP students were tested for methicillin resistance (MRSA) using the Kirby-bauer assay. Kirby-bauer assay technique was used to determine the sensitivity of staphylococcus aureus bacteria against oxacillin. MRSA infection is the result of a bacteria that has built resistance against the antibiotics used to treat staph infections. The results of this experiment concludes that majority of the strains tested are methicillin-susceptible S. aureus (MSSA).
Sotrovimab: Neutralizing Antibody To Combat Covid-19,
2022
Menoufia University
Sotrovimab: Neutralizing Antibody To Combat Covid-19, Aya Allam, Steven Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?,
2022
University of Louisville
Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Mucormycosis: Covid-19 And Corticosteroids,
2022
Gujarat Medical Education and Research Society Medical College
Mucormycosis: Covid-19 And Corticosteroids, Mittal Savaliya, Nivedita Jha, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Characterisation Of Drug-Resistant Mycobacterium Tuberculosis Mutations And Transmission In Pakistan,
2022
London School of Hygiene and Tropical Medicine
Characterisation Of Drug-Resistant Mycobacterium Tuberculosis Mutations And Transmission In Pakistan, Gary Napier, Anwar Sheed Khan, Abdul Jabbar, Muhammad Tahir Khan, Sajid Ali, Muhammad Qasim, Noor Mohammad, Rumina Hasan, Zahra Hasan, Susana Campino
Department of Pathology and Laboratory Medicine
Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan, with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control. Whole genome sequencing (WGS) of M. tuberculosis is being used to infer lineages (strain-types), drug resistance mutations, and transmission patterns-all informing infection control and clinical decision making. Here we analyse WGS data on 535 M. tuberculosis isolates sourced across Pakistan between years 2003 and 2020, to understand the circulating strain-types and mutations related to 12 anti-TB drugs, as well as identify transmission clusters. Most isolates belonged to lineage 3 (n = 397; 74.2%) strain-types, and were MDR (n = 328 ...