Periodontics and Periodontology Commons^™

Voclosporin‐Induced Gingival Enlargement: A Case Report, Dimitris N. Tatakis

Faculty Scholarship

The gingiva (gums) is often a site in the mouth where changes or reactions can occur in response to certain systemic medications. Some drugs, particularly those used to treat autoimmune conditions or following organ transplants, can cause the gums to grow excessively, a condition known as drug-induced gingival enlargement (also known as gingival overgrowth). In this report, we document the case of a 27-year-old woman with lupus nephritis who developed gingival enlargement after starting a medication called voclosporin. This drug is a newer treatment option for lupus nephritis, but until now had not been linked to gingival enlargement. The patient …

Management Of Severe Gingival Recession Using A Double Papilla Connective Tissue Graft: A 2-Year Follow-Up Case Study, Dimitris N. Tatakis

Faculty Scholarship

Gum recession is a common condition where the gum tissue pulls away from the teeth, exposing the roots and making them more prone to damage. This report describes the treatment of a 30-year-old woman who had severe gum recession on her lower left canine tooth, caused by her long-term habit of scratching the gums with her fingernail. To restore the lost tissue and protect the tooth, a double papilla flap (a surgical technique that moves nearby tissue) along with a connective tissue graft (transplanted tissue from the roof of the mouth) was used. Over 2 years, the recession was reduced …

Cross-Institutional Dental Electronic Health Record Entity Extraction Via Generative Artificial Intelligence And Synthetic Notes, Yao-Shun Chuang, Chun-Teh Lee, Guo-Hao Lin, Ryan Brandon, Xiaoqian Jiang, Muhammad F Walji, Oluwabunmi Tokede

Faculty, Staff and Student Publications

Background: While most health-care providers now use electronic health records (EHRs) to document clinical care, many still treat them as digital versions of paper records. As a result, documentation often remains unstructured, with free-text entries in progress notes. This limits the potential for secondary use and analysis, as machine-learning and data analysis algorithms are more effective with structured data.

Objective: This study aims to use advanced artificial intelligence (AI) and natural language processing (NLP) techniques to improve diagnostic information extraction from clinical notes in a periodontal use case. By automating this process, the study seeks to reduce missing data in …

Bridging Oral And Systemic Health: Exploring Pathogenesis, Biomarkers, And Diagnostic Innovations In Periodontal Disease, Max Foroughi, Mahmoud Torabinejad, Nikola Angelov, David M. Ojcius, Keykavous Parang, Marcus Ravnan, Jerika Lam

Pharmacy Faculty Articles and Research

Purpose

This narrative review explores the multifaceted links between periodontal diseases (gingivitis and periodontitis) and systemic health conditions, including cardiovascular disease, diabetes, adverse pregnancy outcomes, Alzheimer’s disease, cancers, rheumatoid arthritis, and respiratory infections. It aims to synthesize evidence on how local oral infections exert systemic effects and evaluate the potential of diagnostic technologies to monitor these interactions.

Methods

This narrative review synthesizes current scientific literature on periodontal disease pathogenesis, focusing on key pathogens (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum) and their roles in driving local and systemic inflammation via virulence factors and microbial dysbiosis. It examines biomarker-based diagnostic approaches …

Bridging Oral And Systemic Health: Exploring Pathogenesis, Biomarkers, And Diagnostic Innovations In Periodontal Disease, Max Foroughi, Mahmoud Torabinejad, Nikola Angelov, David M Ojcius, Keykavous Parang, Marcus Ravnan, Jerika Lam

Faculty, Staff and Student Publications

Purpose: This narrative review explores the multifaceted links between periodontal diseases (gingivitis and periodontitis) and systemic health conditions, including cardiovascular disease, diabetes, adverse pregnancy outcomes, Alzheimer's disease, cancers, rheumatoid arthritis, and respiratory infections. It aims to synthesize evidence on how local oral infections exert systemic effects and evaluate the potential of diagnostic technologies to monitor these interactions.

Methods: This narrative review synthesizes current scientific literature on periodontal disease pathogenesis, focusing on key pathogens (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum) and their roles in driving local and systemic inflammation via virulence factors and microbial dysbiosis. It examines biomarker-based diagnostic approaches (e.g., IL-1β, …

Prevalence Of Peri-Implantitis And Assessment Of Oral Health-Related Quality Of Life Among Patients With Dental Implants At Hospital Universiti Sains Malaysia, Esther Li-Ching Ang, Zurairah Berahim, Normastura Abd Rahman, Akram Hassan, Siti Lailatul Akmar Zainuddin

Journal of Dentistry Indonesia

Patient-reported outcomes about peri-implantitis are lacking among the Asian population, impacting decision-making in dental implant therapy. Objectives: This study aimed to assess the prevalence of peri-implantitis among Malaysian adults, and its impact on oral health-related quality of life (OHRQoL). Methods: Randomly selected 105 participants (adults aged 18 and above) having 265 implants were examined and diagnosed as with or without peri-implantitis (PI). Clinical examinations, including peri-implant probing depth, bleeding, and suppuration on probing with radiographic bone loss, were used to determine peri-implant status. OHRQoL of all participants were recorded using the short version of the Malaysian Oral Health Impact Profile …

Evaluation Of Dentistry Students' Perceptions And Attitudes Towards Artificial Intelligence In Kazakhstan, Yasin Yasa, Kubeisin Altynbekov, Nazgul Onaibekova

Journal of Dentistry Indonesia

Objective: Artificial intelligence’s (AI) potential to analyze medical data and improve patient outcomes is driving its rapid integration into healthcare systems. This study addresses the knowledge gap regarding Kazakhstani dental students’ attitudes toward AI in dentistry. Methods: A survey with 213 participants assessed dental students’ views on AI in dentistry at two Kazakhstani universities. A self-administered questionnaire (22 items) via Google Forms was used to gather data on demographics, baseline knowledge (information sources, understanding of AI principles, and familiarity with dental AI applications), and attitudes/perceptions. Frequency analyses and chi-square tests (p < 0.05) explored the responses. Results: The survey included 213 dental students (mean …

Synthesis And Partial Characterization Of Chitosan Phosphorylation From Marine Cuttlefish Sepia Aculeata (Orbingy, 1848) And Its Antimicrobial Potentials Against Oral Pathogens, Yathin Reddy Putta, Annathai Pitchai, Pasiyappazham Ramasamy

Journal of Dentistry Indonesia

Objectives: This study investigated the synthesis and partial characterization of phosphorylated chitosan extracted from the cuttlebone of Sepia aculeata (Orbingy, 1848) and evaluated its antimicrobial potential against oral pathogens. Methods: The synthesis of phosphorylated chitosan from Sepia aculeata cuttlebone involved several steps: cleaning, deproteinization, demineralization to extract chitin, deacetylation to produce chitosan, and phosphorylation to introduce phosphate groups. Phosphorylation enhances the properties of chitosan, making it a promising candidate for oral health applications. Phosphorylated chitosan was purified and characterized using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM) to confirm structural changes. This process enhances …

Microstructural And Elemental Characterization Of Hydrated Carbonated Hydroxyapatite As Pulp Capping Agent: An In Vitro Study, S.Swathi Priyadharshini, Chinnasamy Ragavendran, J. Ramana Ramya, Anand Sherwood

Journal of Dentistry Indonesia

Understanding the microstructural and elemental composition of pulp capping materials is crucial for predicting their biocompatibility and effectiveness in promoting pulp healing. Objectives: This study aimed to characterize the microstructural and elemental properties of carbonated hydroxyapatite as a dental pulp-capping material. Methods: Carbonated hydroxyapatite was synthesized using the precipitation method. MTA and Apacal ART were obtained from commercial sources. The materials were prepared into disk-shaped specimens, hydrated in deionized water at 37°C for 14 days, and analyzed using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Results: SEM images revealed that MTA exhibited smooth, plate-like crystalline structures surrounded by …

Does Periodontal Treatment During Pregnancy Reduce The Incidence Of Preterm Birth Rates?: A Meta-Analysis Of Randomized Controlled Trials, Ashraf Elzer, Raga A. Elzahaf, Hameda Asrafel, Khalid Sassi, Mohamed Jedeh

Journal of Dentistry Indonesia

Objective: To find out if scaling and root planing for periodontal disease during pregnancy lowers the incidence of preterm births. Methods: This is a meta-analysis study design; searches were conducted in the PubMed database and on Google Scholar between January 2000 and December 2023. Only randomized controlled trials (RCTs) were considered. The studies will be examined to determine the relationship between non-surgical periodontal treatment and preterm birth rates among pregnant women. Results: Only 14 trials were included out of 194 articles identified. The overall result indicated a statistically significant reduction in preterm birth rate when we use the random …

Evaluation Of The Adjunctive Effect Of Photodynamic Therapy For The Treatment Of Residual Periodontal Pockets: A Systematic Review, Shankargouda Patil, Charles Miller, Ryan Moffat, Kade Janes, Brooklyn Janes, Peter M. Loomer, Frank W. Licari

Journal of Patient-Centered Research and Reviews

Purpose: Adjunctive use of photodynamic therapy in combination with scaling and root planing for periodontal maintenance offers an alternative to antibiotic therapy, potentially mitigating the risk of antibiotic resistance and its genotoxic or mutagenic effects. This systematic review analyzed studies, as of January 2023, that included the effects of a single application of photodynamic therapy in residual periodontal pockets with the probing depth and clinical attachment level as the primary and secondary outcomes, respectively.

Methods: PubMed, Scopus, and Web of Science databases, as well as the US National Institutes of Health and WHO Clinical Trials Registry, were searched for eligible …

Enhancing Periodontal Therapy With Non-Invasive Adjunctive Techniques A Comparative Literature Review, Stockton Stohl, Kamran H. Awan

Annual Research Symposium

No abstract provided.

The Oral-Gut Microbiome Axis: Implications For Systemic And Oral Health, Sana Shariff, Manas Mandal

Annual Research Symposium

The bidirectional relationship between the oral and gut microbiomes has gained attention for its role in systemic and oral diseases. Dysbiosis, or microbial imbalance, disrupts these ecosystems, leading to inflammatory conditions. This research investigates the connection between these microbiomes, focusing on microbial translocation, disease correlation, and targeted interventions such as probiotics or dietary modifications to restore microbial homeostasis and reduce disease incidence.

Effect Of Multiple Application Of Chlorhexidine Chips In Peri-Implantitis Treatment: A Systematic Review, Kirollos Semary, Kade Janes, Shilpa Bhandi, Shankargouda Patil, Frank Licari

Annual Research Symposium

No abstract provided.

Periodontitis Linked With Urinary Tract Infections- Coincidence Or Causality?, Ali Shariff, Shankargouda Patil, Shilpa Bhandi, Frank Licari

Annual Research Symposium

Urinary tract infection is a cumulative term used to describe an infection of any part of the urinary system. Periodontitis is a chronic inflammatory condition of the tooth-supporting structures. The literature points towards an inter-relationship between periodontitis and other systemic diseases such as metabolic syndrome, diabetes mellitus, coronary heart diseases, etc. Several studies indicate a pathophysiologic inter-relationship between periodontitis and urinary tract infections. Considering the inflammatory nature of periodontitis and urinary tract infections, a common link of causality may be present between the two diseases. P. gingivalis, a key periodontal pathogen, is a significant agent in disseminating infection …

Impact Of Drug Addiction On Oral Health: Unveiling The Link Between Substance Abuse, Rahi [email protected], Kamran Awan

Annual Research Symposium

No abstract provided.

Treatment Approaches For Immediate Implant Placement In Infected Site, Urwa Asad, Zainab Qazalbash, Jazmine Gill, Shilpa Bhandi, Frank Licari, Shankargouda Patil

Annual Research Symposium

No abstract provided.

Alterations Of Tnf-Α And Il-8 Levels In Gingival Crevicular Fluid Among Different Types Of Smoking Following Phase I Periodontal Therapy In Periodontitis Patients, Nouran Abdelmaged Dr., Nivine Ibrahim Ragy Professor, Zienab Farid Dr.

Future Dental Journal

Aim: The purpose of the current research was to evaluate the impacts of different smoking types on GCF levels of TNF-α & IL-8 after phase I periodontal therapy. The study compared between traditional cigarettes and heated tobacco products (HTPs) in contrast to non-smokers following non-surgical treatment of moderate periodontitis patients. Subjects & methods: Forty-five patients with moderate generalized chronic periodontitis had been enrolled in this research. They had been divided into 3 equal groups and received non-surgical periodontal treatment. Samples of gingival crevicular fluid had been collected from periodontal pockets at baseline & after six months. The collected …

Impact Of Coronavirus Disease 2019 On Dental Match Residency Applicant Statistics In The United States Of America: A Cross Sectional Analysis, Vinayak M. Joshi, Eswar Kandaswamy, Sivaraman Prakasam, Veerasathpurush Allareddy, Andrew G. Chapple

School of Dentistry Faculty Publications

Background: The purpose of this paper is to do a cross-sectional analysis to evaluate the impact of the Coronavirus Disease 2019 pandemic on Dental Match Residency statistics from the year 2019–2023. Methods: The Dental Match Residency statistics available from the Dental Match website were analyzed from years 2019–2023 to evaluate the impact of pre-pandemic (2019–2020), pandemic (2021, 2022) and post-pandemic year trends (2023). Important trends were evaluated and summarized using graphs, descriptive statistics, and two sample tests for proportions (chi-square test) comparing different pairs of years. Results: Total Match participants increased in 2021 followed by a drop in 2022, and …

Introducing Flowable Resin Composite As A Novel Palatal Dressing After Free Gingival Graft Harvesting: A Randomized Clinical Trial, Dalia Ghalwash, Mohamed Temraz, Ahmed Elbarbary, Eman Khalil, Nesma Shemais

Dentistry

Objectives This study aimed to evaluate the effectiveness of using a flowable resin composite compared to periodontal pack in reducing postoperative morbidity after free gingival graft (FGG) harvesting. Materials and methods In this randomized controlled clinical trial, 34 patients requiring FGG were allocated into two equal groups. The intervention group received a flowable resin composite dressing over the palatal wound, while the control group received Coe-Pak. Postoperative pain was assessed using a Visual Analogue Scale (VAS) and mean analgesic consumption over 14 days. Secondary outcomes included wound size and color match of the healing site assessed at weeks 1, 2, …