Dentistry Commons^™

Clinical Pharmacogenetics Implementation Consortium Guideline For Cyp2b6 Genotype And Methadone Therapy, Katherine M Robinson, Seenae Eum, Zeruesenay Desta, Rachel F Tyndale, Andrea Gaedigk, Richard C Crist, Cyrine E Haidar, Alan L Myers, Caroline F Samer, Andrew A Somogyi, Pablo Zubiaur, Otito F Iwuchukwu, Michelle Whirl-Carrillo, Teri E Klein, Kelly E Caudle, Roseann S Donnelly, Evan D Kharasch

Faculty, Staff and Student Publications

Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture of R- and S-enantiomers. R-methadone has 30-to 50-fold higher analgesic potency than S-methadone, and S-methadone has a greater adverse effect (prolongation) on the cardiac QTc interval. Methadone undergoes stereoselective metabolism. CYP2B6 is the primary enzyme responsible for catalyzing the metabolism of both enantiomers to the inactive metabolites, S- and R-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (S- and R-EDDP). Genetic variation in the CYP2B6 gene has been investigated in the context …

The Role Of Policy Entrepreneurs In Understanding Oral Health Care Policy: A Case Study Approach Analyzing Multiple Streams Framework In Nc Oral Health Policy, Lori Gordon Hendrick

School of Public Service Theses & Dissertations

The United States Surgeon General has defined oral diseases as a “silent epidemic” that affects the most vulnerable citizens. More often, this includes those from low socio-economic backgrounds, children, elderly, and many members of ethnic minority groups. Although preventative and treatment modalities have improved over the past fifty years, some Americans continue to have little to no access to educational and preventative programs. The lack of access to dental care for all ages and oral health care literacy remains one of the largest health concerns for American citizens making it a “wicked problem”. Historically, raising Medicaid enrollment has failed to …

Outcome Of Vital Pulp Therapy Using Mta And Biodentine In Permanent First Molars With Or Without Pulpitis In Pediatric Patients, Daniel Nho Dmd, Ms, Susan Paurazas Dds, Ms, Mhsa, Mazin Askar Bds, Ms, Salwa Atwan Dds, Ms

The Journal of the Michigan Dental Association

Purpose: This study evaluated the outcome of vital pulp therapy (VPT) in permanent first molar teeth using Biodentine (Septodont, Saint Maur des Fosses, France) or ProRoot MTA (Dentsply Tulsa Dental Specialties, Johnson City, Tenn.) in pediatric patients. Methods: Permanent first molar teeth with or without a history of pulpitis from patients aged 7 to 14 years old were treated at the Graduate Endodontic Clinic from September 2007 to August 2022. A retrospective cohort clinical trial was conducted. VPT was performed on a total of 22 teeth. There were 13 teeth in the Biodentine (BD) group and nine teeth in the …

The Nature Of Adverse Events In Dentistry, Bunmi Tokede, Alfa Yansane, Muhammad F. Walji, D. B. Rindal, Don Worley, Joel White, Elsbeth Kalenderian

School of Dentistry Faculty Research and Publications

Objectives

Learning from clinical data on the subject of safety with regards to patient care in dentistry is still largely in its infancy. Current evidence does not provide epidemiological estimates on adverse events (AEs) associated with dental care. The goal of the dental practice study was to quantify and describe the nature and severity of harm experienced in association with dental care, and to assess for disparities in the prevalence of AEs.

Methods

Through a multistaged sampling procedure, we conducted in-depth retrospective review of patients’ dental and medical records.

Results

We discovered an AE proportion of 1.4% (95% CI, 1.1% …

A Scoping Review Of Patient Safety Checklists In Dentistry, K. Zouaidi, T. W. Miner, M. F. Walji, E. Kalenderian, D. B. Rindal, K. J. Suda

School of Dentistry Faculty Research and Publications

Objectives

Not much is known about safety checklists use in dentistry. We aim to examine, assess, and provide a comprehensive understanding of the current knowledge concerning the use of checklists to improve patient safety in dentistry.

Methods

We conducted a comprehensive literature search using Medline and Embase for studies that use or describe the development of dental patient safety checklists. All study designs were included for citations published through December 2023.

Results

Following abstract and full-text screening, 27 studies remained for data extraction and analysis. Oral surgery emerged as the main dental specialty where the utilization and evaluation of checklists …

The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik

Publications and Research

No abstract provided.

Fully Digital Workflow From Bone Augmentation To Implant-Supported Prosthetic Reconstruction, Ufuk Tatli, Koray Soygun, Orcan Yuksel

School of Dentistry Faculty Research and Publications

No abstract provided.

Are Sleeves Necessary In Static Computer-Assisted Implant Surgery? A Comparative In Vitro Analysis, Jenna Hang, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Objectives

This study aims to examine differences in trueness and precision between surgical guides with (S) and without sleeves (SL). A secondary aim was to assess the impact of the sleeve-to-bone distance.

Materials and Methods

Mandible replicas (n = 120) were printed from an STL file obtained from a clinical CBCT. The mandibles were divided into sleeved (S, n = 60) and sleeveless (SL, n = 60) groups, each further divided into three categories (n = 20 each) with different heights from the guide to the implant platform: 2 mm (H2), 4 mm (H4), or 6 mm (H6). …

A Novel Model Of Autologous Tooth Transplantation For The Study Of Nerve Recruitment, Teresa E. Fowler, Doan T. Bloomquist, Caroline Glessner, Poonam Patel, Jeffrey N. James, Kathryn Bollinger, Lynnette P. Mccluskey, Ryan F. Bloomquist

School of Dentistry Faculty Publications

Background: Limited treatment options exist for damaged nerves and despite impressive advances in tissue engineering, scientists and clinicians have yet to fully replicate nerve development and recruitment. Innervation is a critical feature for normal organ function. While most organs are innervated prior to birth, a rare example of postnatal nerve recruitment occurs in the natural development of secondary teeth during adolescence. Many animals undergo postnatal shedding of deciduous teeth with development and eruption of secondary teeth, a process requiring recruitment of nerve and vasculature to each tooth pulp for viability. Here, the investigators created a novel model for the study …

Effect Of Addition Of Metal Oxide Nanoparticles On The Strength Of Heat-Cured Denture Base Resins: Protocol For Systematic Review And Meta-Analysis Of In Vitro Studies, Pragati Kaurani, Amit Hindocha, Amit Porwal, Abhijit Tambe, Carrie Price, Vidhani Goel, Henry Krasner, Jagdish Khubchandani, Kavita Batra

Department of Medical Education Faculty Research

Background: Metal oxide nanoparticle-reinforced polymethyl methacrylate (PMMA) has been shown to improve mechanical properties, such as strength. Different types of metal oxide nanoparticles have been used previously, but the comparative effect on the strength of heat-cured denture base resins remains unclear. Objective: This is a protocol for a systematic review and meta-analysis that will aim to pool evidence to compare and analyze the effects of the addition of different metal oxide nanoparticles, with varied sizes and concentrations, on the strength (flexural, impact, transverse, compressive tensile strength, and fracture toughness) of heat-cured PMMA. In addition, this review aims to analyze methodological …

Insight - Summer 2024, Dugoni School Of Dentistry

Insight

Insight is a newsletter celebrating the accomplishments of our community of scholars. We aim to spotlight insights from people at the Dugoni School working in all areas of scholarship, including clinical or biomedical research, the scholarship of teaching and learning, improvement of the health care system, and professional partnerships that advance the field.

Case Title: Uncovering The Truth: The Unexpected Incidental Discovery Of Metastatic Carcinoid Tumor In An Elderly Patient., Kavitha Chittaragi Dr, Shwetha R. Poojary Dr

Radiology Teaching Files

Carcinoid tumors are rare neuroendocrine neoplasms with varied clinical presentations. We report a case of a 70-year-old female patient who presented with history of loose stools, vomiting, and abdominal pain. Imaging revealed a small hyper-enhancing nodule in the small bowel, multiple liver lesions, and a mesenteric mass, all suggestive of metastatic carcinoid disease. Biopsy confirmed a neuroendocrine tumor. As these tumors can remain indolent for years, early detection and treatment are critical for effective management and better prognosis.

Sequence-To-Expression Approach To Identify Etiological Non-Coding Dna Variations In P53 And Cmyc-Driven Diseases, Katherine Kin, Shounak Bhogale, Lisha Zhu, Derrick Thomas, Jessica Bertol, W Jim Zheng, Saurabh Sinha, Walid D Fakhouri

Faculty, Staff and Student Publications

Disease risk prediction based on genomic sequence and transcriptional profile can improve disease screening and prevention. Despite identifying many disease-associated DNA variants, distinguishing deleterious non-coding DNA variations remains poor for most common diseases. In this study, we designed in vitro experiments to uncover the significance of occupancy and competitive binding between P53 and cMYC on common target genes. Analyzing publicly available ChIP-seq data for P53 and cMYC in embryonic stem cells showed that ~344-366 regions are co-occupied, and on average, two cis-overlapping motifs (CisOMs) per region were identified, suggesting that co-occupancy is evolutionarily conserved. Using U2OS and Raji cells untreated …

Wmdds Bulletin Winter 2021

West Michigan District Dental Society Bulletin

In the Winter 2021 issue, the reader will find the following feature articles:

• Seeking Out COVID-19 Vaccine Information
• Dentists Beyond the Chair: Trap and Skeet Shooting, Judd Carroll, DMD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Spring 2021

West Michigan District Dental Society Bulletin

In the Spring 2021 issue, the reader will find the following feature articles:

• Be Part of the Solution: The Dental Needs of Refugee and Immigrant Youth
• Dentists Beyond the Chair: Monoskiing, Jeffrey Heinz, DDS, MSD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Summer 2021

West Michigan District Dental Society Bulletin

In the Summer 2021 issue, the reader will find the following feature articles:

• Doppelgangers: Katie Swan and Katie Swanson
• GRCC 2021 Graduation Highlights

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Holiday 2021

West Michigan District Dental Society Bulletin

In the Holiday 2021 issue, the reader will find the following feature articles:

• Spectrum Health Youth Behavioral Health Initiatives: Increasing Dental Provider Awareness
• Dentists Doing Good: Local WMDDS Dentists Doing GREAT
• Free CE and Certification: Penn Dental Medicine’s Person with Disabilities Series

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Fall 2021

West Michigan District Dental Society Bulletin

In the Fall 2021 issue, the reader will find the following feature articles:

• Cover Story: Introducing Maxillofacial Prosthodontics to West Michigan
• Dentists Beyond the Chair: Wolverine One

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Summer 2020

West Michigan District Dental Society Bulletin

In the Summer 2020 issue, the reader will find the following feature articles:

• Ask an Expert: What Does This New Legislation Around PPP Mean for Me?
• COVID-19 Pandemic Results in Severe Operating Room Access Limitations for Pediatric Dentists

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Winter 2020

West Michigan District Dental Society Bulletin

In the Winter 2020 issue, the reader will find the following feature articles:

• 2020 Silent Bell Recipient: W. Erick Rupprecht, DDS
• Dentists Beyond the Chair: Aquarist and Fish Breeder – Chase Klinesteker, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.