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Loma Linda University Dentistry - Volume 23, Number 2, Mathew T. Kattadiyil, Charles J. Goodacre

Charles Goodacre, DDS, MSD

Contents:

9 | Gathering of Alumni 2012
14 | Joni Stephens Retires
16 | CAD/CAM Technology
26 | Student Research Awards
30 | Commencement Number 56
48 | Donor Appreciation
58 | Recently Departed

Llusd Articulator - Volume 29, Number 2, Loma Linda University School Of Dentistry

Articulator (Dentistry Journal)

Contents:

4 | Good news for 2019 and beyond
9 | New Center for Computer Aided Digital Design
12 | Tord Lundgren’s multifaceted career
16 | LLUSD’s 62nd conferring of degrees
20 | Servants of service: the improbable journey of Yiming Li and Wu Zhang
28 | Student Achievement Awards
39 | NASDAD grateful for 75 years
44 | Dental hygiene students published

Calhm3 Is Essential For Rapid Ion Channel-Mediated Purinergic Neurotransmission Of Gpcr-Mediated Tastes, Zhongming Ma, Akiyuki Taruno, Makoto Ohmoto, Masafumi Jyotaki, Jason C. Lim, Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka, Robert J. Lee, Henry Hoff, Riley Payne, Angelo Demuro, Ian Parker, Claire H. Mitchell, Jorge Henao-Mejia, Jessica E. Tanis, Ichiro Matsumoto, Michael G. Tordoff, Kevin J. Foskett

Departmental Papers (Dental)

Binding of sweet, umami, and bitter tastants to G protein-coupled receptors (GPCRs) in apical membranes of type II taste bud cells (TBCs) triggers action potentials that activate a voltage-gated nonselective ion channel to release ATP to gustatory nerves mediating taste perception. Although calcium homeostasis modulator 1 (CALHM1) is necessary for ATP release, the molecular identification of the channel complex that provides the conductive ATP-release mechanism suitable for action potential-dependent neurotransmission remains to be determined. Here we show that CALHM3 interacts with CALHM1 as a pore-forming subunit in a CALHM1/CALHM3 hexameric channel, endowing it with fast voltage-activated gating identical to that …

Intraoral Imaging At Insertion Of Implant Supported Restorations At An Academic Institution : Conformity To Established Guidelines., J. Alec Power

Electronic Theses and Dissertations

The objective of this study was to establish the frequency of intraoral imaging at the time of insertion of implant supported restorations at University of Louisville School of Dentistry (ULSD). After IRB approval (14.1215), patients on whom an implant-supported single unit fixed restoration was placed were identified from the electronic health record over a 4-year period. Type of prosthesis retention (cement vs. screw) and discipline responsible for crown placement was recorded. Bitewing (BWx) or periapical (pa) images taken at the time of prosthesis placement were accessed and reviewed. Overall radiographic frequency according to modality was tallied and compared using Chi-square …

A Survey Of The Implementation And Usage Of Electronic Dental Records And Digital Radiographs In Private Dental Practices In Mississippi, Barbara K. Brent

Electronic Theses and Dissertations

Implementation of electronic health records by the Health Information Technology for Economic and Clinical Health has led to the implementation of electronic dental records (EDRs) and digital radiography in dental offices. The purpose of this study was to determine the state of the implementation and usage of EDRs and digital radiographs by the private general and pediatric dental practices in Mississippi as well as reasons why the dental practices are not moving forward with the advanced technology.

A survey was emailed to 712 dental practices: 116 responded (16% response rate), and 104 consented to participate (89.66%). Results indicated dental practices …

1st Place Contest Entry: Provisional Patent Research Process, Joshua Goldfaden

Kevin and Tam Ross Undergraduate Research Prize

This is Joshua Goldfaden's submission for the 2018 Kevin and Tam Ross Undergraduate Research Prize, which won first place. He wrote about abrasive chemicals in commercial toothpastes and created a provisional patent to develop a safer alternative.

Joshua is a sophomore at Chapman University, majoring in Biochemistry and Molecular Biology. His faculty mentor is Dr. Yu-An (Peter) Chang.

Fibromodulin Reduces Scar Size And Increases Scar Tensile Strength In Normal And Excessive-Mechanical-Loading Porcine Cutaneous Wounds, Wenlu Jiang, Kang Ting, Soonchul Lee, Janette N. Zara, Richard Song, Chenshuang Li, Eric Chen, Xinli Zhang, Zhihe Zhao, Chia Soo, Zhong Zheng

Departmental Papers (Dental)

Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule—fibromodulin (FMOD) protein—can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and …

Neural Egfl-Like 1 Regulates Cartilage Maturation Through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling, Chenshuang Li, Zhong Zheng, Jie Jiang, Wenlu Jiang, Kevin Lee, Emily A. Berthiaume, Eric C. Chen, Cymbeline T. Culiat, Yan-Heng Zhou, Xinli Zhang, Kang Ting, Chia Soo

Departmental Papers (Dental)

The pro-chondrogenic function of runt-related transcription factor 2 (Runx2) was previously considered to be dependent on direct binding with the promoter of Indian hedgehog (Ihh)—the major regulator of chondrocyte differentiation, proliferation, and maturation. The authors’ previous studies identified neural EGFL like 1 (Nell-1) as a Runx2-responsive growth factor for chondrogenic differentiation and maturation. In this study, it was further revealed that the pro-chondrogenic activities of Nell-1 also rely on Ihh signaling, by showing: i) Nell-1 significantly elevated Ihh signal transduction; ii) Nell-1 deficiency markedly reduced Ihh activation in chondrocytes; and iii) Nell-1–stimulated chondrogenesis was significantly reduced by the specific hedgehog …

Llusd Articulator - Volume 29, Number 1, Loma Linda University School Of Dentistry, So Ran Kwon, Abhishek Batra, Trina Kindred, Kayla Perez-Ortiz, Min Wang, Euni Cho, Udochukwu Oyoyo

Articulator (Dentistry Journal)

Contents:

4 | Dean’s brown bag
6 | Robert Smith’s generous gift
8 | Inaugural RDAEF class graduates
10 | Zambian miracle
13 | Mark Estey new academic dean
17 | Esther Valenzuela assistant dean
18 | Graham Stacey retires
20 | One Homecoming Number 2
26 | Fostering LLUSD student research
34 | Student research winners
42 | LLUSD at ASDR
46 | News

Consideration For Care For Your Patient With Cerebral Palsy, Katlin R. Cannon, Melissa Stowe, Brooke Ryan

Dental Hygiene Student Scholarship

Cerebral palsy (CP) is a common developmental neurological disorder affecting about 2-3 children out of 1,000. CP is the result of infant brain damage or abnormal development resulting in impaired muscle control, coordination, tone, reflex, posture, and balance. These patients are unable to control motor movements of their muscles of mastication and facial expression, causing excessive drooling, clenching, bruxism, and other oral health-related issues. This lack of motor control affects their ability to swallow and often limits these patients to a liquid diet. This can lead to vitamin deficiencies and result in further developmental problems. As an example, a deficiency …

The Lasting Impact Of Intraprofessional Education Between Dentists And Dental Hygienists, Kimber Satter

EWU Masters Thesis Collection

Purpose: The Regional Initiatives in Dental Education (RIDE) program at the University of Washington (UW) allows first year dental students to take courses with Eastern Washington University dental hygiene (DH) students. This study was conducted to see if the RIDE program is effective as an Intraprofessional Education (IntraPE) program in improving dentists’ attitudes towards teamwork and understanding the roles and responsibilities of the DH.

Methods: UW School of Dentistry alumni from 2012-2017 were invited to participate in this study. Attitudes towards teamwork and roles and responsibilities were assessed using two online surveys: a demographic survey containing open-ended questions, and a …

Methodological Quality Assessment Of Meta-Analyses In Endodontics, Sereen Kattan, Su-Min Lee, Meetu R. Kohli, Frank C. Setzer, Bekir Karabucak

Departmental Papers (Dental)

Introduction The objectives of this review were to assess the methodological quality of published meta-analyses related to endodontics using the assessment of multiple systematic reviews (AMSTAR) tool and to provide a follow-up to previously published reviews. Methods Three electronic databases were searched for eligible studies according to the inclusion and exclusion criteria: Embase via Ovid, The Cochrane Library, and Scopus. The electronic search was amended by a hand search of 6 dental journals (International Endodontic Journal; Journal of Endodontics; Australian Endodontic Journal; Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology; Endodontics and Dental Traumatology; and Journal of Dental Research). The …

Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem

Theses & Dissertations

The treatment of obstructive sleep apnea (OSA) allows for a multidisciplinary approach between dentistry and medicine. Continuous positive airway pressure (CPAP) is the gold standard for OSA treatment, but the non-adherence rates are high. The mandibular advancement device (MAD) has a higher acceptance rate than the CPAP, however the efficacy is much lower in cases of moderate to severe OSA. This thesis attempted to evaluate if there was a change in compliance when a MAD was added as a combination therapy to moderate to severe OSA subjects that were currently non-compliant with their CPAP. In addition, the change in air …

Progesterone Attenuates Temporomandibular Joint Inflammation Through Inhibition Of Nf-Κb Pathway In Ovariectomized Rats, Xin-Tong Xue, Xiao-Xing Kou, Chen-Shuang Li, Rui-Yun Bi, Zhen Meng, Xue-Dong Wang, Yan-Heng Zhou, Ye-Hua Gan

Departmental Papers (Dental)

Sex hormones may contribute to the symptomatology of female-predominant temporomandibular disorders (TMDs) inflammatory pain. Pregnant women show less symptoms of TMDs than that of non-pregnant women. Whether progesterone (P4), one of the dominant sex hormones that regulates multiple biological functions, is involved in symptoms of TMDs remains to be explored. Freund's complete adjuvant were used to induce joint inflammation. We evaluated the behavior-related and histologic effects of P4 and the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the synovial membrane. Primary TMJ synoviocytes were treated with TNF-α or IL-1β with the combination of P4. Progesterone receptor …

Llusd Articulator - Volume 28, Number 2, Loma Linda University School Of Dentistry, Montry S. Suprono

Articulator (Dentistry Journal)

Contents:

4 | The dean's brown bag
9 | Handysides appointed 6th LLUSD dean
10 | Tory Silvetrin runs life's marathon at a sprint
16 | Jess Hayden family donates his 50,000 prosection slides
20 | LLUSD's 61st Commencement
32 | Bonding & zirconia: a literature review
44 | Falling in L-O-V-E with dentistry
46 | Postgraduate Endo celebrates 50 years
48 | LLUSD News

Foxo1 Deletion In Keratinocytes Improves Diabetic Wound Healing Through Mmp9 Regulation, Chenying Zhang, Jason Lim, Hyeran H. Jeon, Fanxing Xu, Chen Tian, Fang Miao, Alhassan Hameedaldeen, Dana T. Graves

Departmental Papers (Dental)

Keratinocyte migration is a key aspect of re-epithelialization during wound healing. Matric metalloproteinase 9 (MMP9) contributes to this process and deificiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP0 expression in vivo in full thickness dermal scalp wounds creared in experimental K14.Cre⁺.Foxo1^L/L mice with lineage-specific Cre recombinase deletion of floxed FOXO1 and compared the results to control littermates. MMP9 was induced during …

Student Self-Assessment Of Operative Dentistry Experiences : A Time Dependent Exercise In Best Practice Outcomes., Celine Joyce Cornelius Timothius

Electronic Theses and Dissertations

Purpose: The purpose of this project was to evaluate student self-assessment of operative dentistry experiences. Methods: First, a retrospective analysis of student self-assessment and faculty assessment grade sheets were evaluated for mean differences and correlations across time. Both preclinical (D2: n=120) and clinical (D3: n=120; D4: n=120) grades sheets were evaluated. Secondly, twenty-five (n=25) students from each of the D1, D2, D3 and D4 classes were asked to evaluate dentoform work. Twenty-five (n=25) operative calibrated faculty graded the same two dentoforms. Results: D2 student’s self-assessment scores were significantly higher than the faculty assessment scores (t-test; p0.05) and there was a …

Effective And Ineffective Clinical Teaching And Instruction In Dental Hygiene School, Vicki Gianopoulos Pizanis

Teacher Education, Educational Leadership & Policy ETDs

Introduction

Educators who teach in a clinical setting, primarily in healthcare fields, while having knowledge of the subject, having skills in what is taught, and having experience in the field, often have little-to-no training in teaching. This results in instructional practices being based upon intuition and experience. Becoming aware of how qualities and characteristics of clinical instructors affect adult learners’ educational experience through evidence-based research, and using its implications, would help promote more effective instruction and ultimately improve student learning.

Methodology

A mixed methods study using Grounded Theory and Critical Incidence technique was conducted to study junior student, senior student …

Llusd Articulator - Volume 28, Number 1, Loma Linda University School Of Dentistry, Clyde Roggenkamp

Articulator (Dentistry Journal)

Contents:

4 | Dean's message
7 | Careers in Dentistry Workshop
8 | Marlene Schultz: first female dental student
10 | Dean's Circle
13 | Norman Britton's "last chance" fund
16 | Beau Story's story
21 | First One Loma Linda Homecoming
30 | Dental caries research revisited
38 | Student research poster competition: LLU to CDA
46 | NEWS
50 | CDR acquires hi-res, 3D Micro-CT scanner

Orofacial Pain Overview: Getting Rid Of The Riddles, Andrew L. Young

Andrew L. Young

While most pains that find their way to the dental office are dental in origin, some have less familiar roots: muscular, joint, neurological, headache, sinus or psychological. All of these roots can at times masquerade as a toothache. The purpose of this article is to alert the dentist to the select features of each root that distinguish it from the rest, resulting in efficient and appropriate treatment.