Oral and Maxillofacial Surgery Commons^™

Investigation Of Inflammatory Responses Following The Use Of Novel Anisotropic Hydrogel Tissue Expander In The Skin Of Maxillofacial Region, Salim Igdayir Kholoud Mohamed Ali

Student Works (2020-2029)

Background: The purpose of tissue expander is to grow healthy supplementary tissue under the controlled of mechanical force exerted by the tissue expander. In the field of reconstructive and plastic surgery, the use of soft tissue expanders are important for growing healthy supplementary tissue. However, the molecular mechanism associated with the inflammatory response associated with the force generated from the use of tissue expanders is still not characterized. Among the many types of tissue expanders, anisotropic type of hydrogel tissue expander was chosen due to its ability to produce controlled incremental inflation on the tissue that enhance cellular adaptation and …

Differential Expression Of Mucin In Salivary Gland Tumours, Mahamad Apandi Nurul Inaas

Student Works (2020-2029)

Introduction: Varied alterations in types of secreted mucin may affect the regulation of cell growth, immune response and adhesion of cell. These changes may indirectly contribute to the ability of tumour invasion and metastasis. However, the expression of mucins in salivary gland tumours has not been explored in depth. Objectives: To investigate expressions of mucin in the salivary gland tumour microenvironment and make comparisons between benign and malignant, and minor and major salivary gland tumours. Methods: Special stains were used to stain neutral mucin (Periodic acid Schiff), sialomucin (Alcian Blue) and sulfomucin (Aldehyde Fuschin) within tissues from 6 normal salivary …

Effect Of Vitamin C Solution On Microtensile Bond Strength And Fracture Resistance Of Non-Vital Bleached Tooth Restored With Resin Composite, Pimduean Sivavong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to evaluate the effect of vitamin C containing sodium ascorbate prepared solution on dentin bond strength of resin composite to non-vital bleached tooth and on fracture resistance of restored non-vital bleached tooth. Sixty (30 pairs, left and right) extracted sound human maxillary premolar teeth were collected from 30 patients. All teeth were endodontically treated and each pair was randomized assigned into microtensile bond strength and fracture resistance tests. The teeth were divided into 3 groups for each test which were 1) non-bleach tooth, 2) bleached with 35% hydrogen peroxide and immediately restored with resin …

The Effect Of Acemannan In Implant Placement With Simultaneous Bone Graft In Esthetic Zone : A Randomized Controlled Trial, Nataporn Deesricharoenkiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Acemannan, a linear polysaccharide produced by Aloe vera has been shown to have important biological functions promoting wound healing and tissue regeneration. Objective: The aim of this randomized clinical trial was to investigate the impact of acemannan in guided bone regeneration (GBR) with simultaneous implant. Materials and methods: Twenty patients were randomly allocated to test- (Deproteinized bovine bone with Acemannan particulate with mean size of 32.45µm) and control groups (Deproteinized bovine bone only). Twenty implants were placed with simultaneous GBR. CBCT radiographic measurements were conducted immediately and at 3- and 6-months post-surgery. Vertical and horizontal dimensions of the buccal …

Anticancer Activity Of Ficus Deltoidea And Tualang Honey On Oral Cancer Cells: An In Vivo Study, Alkoshab May Ameen Saeed

Student Works (2020-2029)

The use of natural products have been gaining interest, notably in the area of cancer therapy and in this study, natural products rich in antioxidants such as Tualang Honey (Malaysian wild local honey) and Ficus deltoidea (Malaysian local herbal plant), were selected to assess their chemo-preventive and chemotherapeutic activities on oral cancer. The aim of this study is to evaluate the chemo-preventive and chemotherapeutic activities of Ficus deltoidea (FD) and Tualang Honey (TH) in an animal model induced for oral cancer using 4-Nitroquinoline1-oxide (4NQO). A total of 70 male Sprague-Dawley (SD) rats were distributed into ten groups (n=7 per group); …

Effect Of Food Impaction In The Interproximal Of Implant Supported Fixed Restoration Towards Oral Health Related Quality Of Life, Souknilan Chanthasan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To investigate the effect of food impaction between dental implant and adjacent teeth to the patients’ quality of life and periodontal/peri-implant tissue conditions. Materials and methods: Patients with implant supported single crown (ISSC) having implant checkup at the Faculty of Dentistry, Chulalongkorn University between July 2019 and July 2020 were recruited. Food impaction was evaluated by either patients’ experience or clinical examination by dentist. Self-administrative Oral impacts on Daily Performance questionnaire was used to assess the effect of food impaction to patients’ quality of life. Clinical and radiographic examination was performed to evaluate periodontal/peri-implant tissue conditions. Results: Totally 178 …

Comparison Of The Accuracy Of Implant Position Using Different Drilling System For Static Computer-Assisted Implant Surgery: In Vitro Study, Paknisa Sittikornpaiboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: The aim of this in vitro study was to compare the accuracy of implant placement among five drilling systems of sCAIS. Materials and Methods: Twenty-five 3D printed models with two edentulous bilateral premolar spaces were allocated to five different drilling systems: group A: sleeve-in-sleeve, group B: sleeve-in-sleeve with self-locking, group C: mounted sleeve-on-drill, group D: integrated sleeve-on-drill with metal sleeve in the guide, group E: integrated sleeve-on-drill without metal sleeve. All implants were digitally planned and 10 implants placed with sCAIS in each group. Postoperative 3D deviation of actual vs planned position was measured by means of platform, apex …

Comparing Patient-Reported Outcome Measures Among 3 Methods Of Dental Implant Placement, Sunida Engkawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to compare patient-reported outcome measures including post-operative pain, swelling, patient's expectation and satisfaction among 3 techniques of dental implant placement including a) conventional freehand, b) dynamic, and c) static Computer-Aided Implant Surgery. Ninety patients were randomly assigned to receive dental implant placement with one of the 3 protocols. Participants were asked to fill in a series of self-administered questionnaires assessing 1) pre-operative expectations, 2) post-operative healing events during the first week after surgery, and 3) overall satisfaction with the procedures at two weeks. Eighty-eight patients completed the study, 2 patients in dynamic CAIS group …

Microrna Profiles Associated With Bone Healing Of The Extraction Socket In Bisphosphonate Related Osteonecrosis Of The Jaw In Rat Model, Thapakorn Surajkulwatana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bisphoshonates (BPs) are widely used for treating osteoporosis, multiple myeloma, breast cancer, and bone metastasis cancer. Trauma or tooth extraction in patients treated with BPs can lead to MRONJ development because of its mechanism of action by which interferes bone homeostasis and angiogenesis. Once MRONJ has occurred, this hard-to-cure disease posed the risk of having poor quality of life to the patients. The application of miRNA for curing the diseases is now being of interest in medical field. Aiming at elucidating the role of miRNAs in the pathogenesis of MRONJ, a rat model was used in creating MRONJ and the …

Accuracy Of Blx And Blt Guided Implants In The Edentulous Maxilla: An In Vivo Study, Benjamin Andrew Kordusky

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objectives: To determine the accuracy of dental implants placed using a dual scan CBCT protocol with a SLA 3D printed mucosa supported surgical guide using a flapless surgical approach with regard to sleeve position, type of implant, and regional location in the maxillary arch.

Methods: Nine patients received 4 dental implants utilizing a fully guided, flapless approach with a mucosa supported SLA surgical guide with 3 fixation pins. Implants were immediately loaded using an attachment placed in an existing Maxillary complete denture. Accuracy of implant positions were evaluated by the Treatment Evaluation module of coDiagnostiX (DentalWings, Montreal, Canada). Statistical analysis …

Functional Significance Of Senescence And Autophagy In Cancer-Associated Fibroblasts From Oral Squamous Cell Carcinoma, May Leng Tan

Student Works (2020-2029)

Oral squamous cell carcinoma (OSCC) is a malignancy that arises from the epithelial cells within the oral cavity. It accounts for approximately 355,000 new cases worldwide and is exceptionally prevalent in particular geographical areas such as Papua New Guinea, the Indian subcontinent and South-East Asian countries. Despite advances in surgical management and therapeutic approaches, the five-year survival rate of OSCC patients has not improved significantly over the past few decades. The mortality associated with OSCC is particularly high often due to late presentation, locoregional recurrence, distant metastases and the development of second primary tumours. A comprehensive understanding of the molecular …

Expression Of Ki-67, Fscni And Tnfrsf 12a In Histologically Non-Involved Mucosal Surgical Margins As Predictive Markers For Local Relapse In Oral Squamous Cell Carcinoma, Zainul Abidin Nur Fauziani

Student Works (2020-2029)

Introduction: The presence tumour-related genetic alterations in histologically noninvolved mucosal surgical margins was linked to development of local relapse in OSCC. Aims: The present study aimed to determine the association between expression of Ki67, FSCN1 and TNFRSF12A in histologically non-involved mucosal surgical margins of OSCC patients and local relapse. Materials and methods: The study involved a total of 34 OSCC cases including 15 cases of patients who had relapse within the 5 years followup period and 19 cases of patients who did not had relapse. Two-stage sampling was carried out to select the margins’ site, followed by the representative sections …

Hazards Of Short- And Long-Term Administration Of Glucocorticoids On The Periodontium In Rats: A Histological And Electron Microscopic Study, Tahani Abd El Karim Hagag, Elham Fathy, Mahmoud Fathy Mahmoud, Zeinab Salem

Journal of Dentistry Indonesia

The administration of glucocorticoids is proven to cause serious adverse events. Objectives: This study was conducted to compare the possible hazards of the short- and long-term administration of glucocorticoids on the periodontium in rats, using histological examination and scanning electron microscopy. Methods: Fifteen adult male albino rats were included in the study and divided into the 3 groups. Group I served as a control, group II received 7 mg/kg dexamethasone intramuscularly once a week for 5 wk, and group III received 7 mg/kg dexamethasone intramuscularly once a week for 10 wk. The mandibles were dissected and examined histologically as well …

Orthodontic Camouflage Treatment Of A High-Angle Severe Skeletal Class Ii Discrepancy, Deryana Marshadhianti, Miesje Karmiati Purwanegara

Journal of Dentistry Indonesia

Proper orthodontic treatment in adult patients with severe skeletal Class II discrepancy can be challenging. Recently, miniscrew implants have been used as a strategy to treat skeletal Class II patients. Objective: This report illustrates a skeletal Class II malocclusion management combining straight wire technique and miniscrew implant anchorage. Case report: The patient was a 21-years- old Indonesian female with Class II skeletal discrepancy, a retrognathic mandible, a high mandibular plane angle, and a mouth breathing habit due to a history of allergic rhinitis. Anchorage control is important in the sagittal and vertical directions. Miniscrew implants were placed in the …

Antimicrobial Efficacy Of Myrmecodia Pendens Extract And Fraction Combination Against Enterococcus Faecalis Atcc 29212, Faisal Kuswandani, Mieke H. Satari, Ani M. Maskoen

Journal of Dentistry Indonesia

Enterococcus faecalis can withstand harsh environmental conditions in the root canal and cause a secondary infection. Myrmecodia pendens is an herbal medicine rich in polyphenol compounds that have antibacterial, antioxidant, and anticancer properties. Objectives: To analyze the effects of M. pendens fraction combination on the sensitivity of E. faecalis. Methods: The minimum inhibitory concentration (MIC) was determined using a serial microdilution method, and the minimum bactericidal concentration (MBC) was determined by adding the test sample to sterile Mueler Hinton agar medium. Results: The MIC of combination 1 (hexane-ethyl acetate, HE) was 0.049 mg/mL, whereas those of combinations 2 (hexane-water, HA) …

Persistent Endodontics Pathogens Biofilm Inhibited By Lactobacillus Reuteri Indonesian Strain, Armelia Sari Widyarman, Njoo Kiky Elysia Lazaroni

Journal of Dentistry Indonesia

Lactobacillus reuteri is known as probiotics that effective to improve oral health. Objective: To analyze the effect of L. reuteri Indonesian strain, towards Enterococcus faecalis and Candida albicans biofilm growth. Methods: This study was conducted using biofilm assay. Each E. faecalis ATCC-29212 and C. albicans ATCC-10231 were cultured in Brain Heart Infusion Broth, distributed into 96 well-microplate and incubated for 24h, 37°C, anaerobic condition for E. faecalis and aerobic condition for C. albicans. L. reuteri LC382415 (Indonesian strain) was cultured in deMann Rogosa Shar pe Broth and diluted into different concentrations (10⁸,10⁶, and 10^{4 …}

Sarcoidosis Of The Mandibular Condyle: A Rare Disease That Can Mimic Malignancy, Chad Sloan, Ben Lacrosse, Lei Yu, Alexander Braun, Scott Lauer, Timothy Donovan, John Baker, Jason Untrauer

Graduate Medical Education Research Journal

Sarcoidosis can involve any of the organs, however intraosseous involvement is rare and ranges from 5 to 15%, with lesions of the mandible being even rarer – currently with few known cases reported. Intraosseous lesions involving the mandible have been noted to be asymptomatic or associated with chronic jaw pain. Additionally, mandibular involvement can present as a lytic bone lesion mimicking osseous malignancy. Chronic polyarthritis is commonly associated with the progression of sarcoidosis and intraosseous involvement has been considered a late-stage sequelae. We report a case of biopsy-proven sarcoidosis within the mandibular condyle in an asymptomatic 56-year-old Caucasian female who …

Epigenomic Dysregulation-Mediated Alterations Of Key Biological Pathways And Tumor Immune Evasion Are Hallmarks Of Gingivo-Buccal Oral Cancer, Debodipta Das, Sahana Ghosh, Arindam Maitra, Nidhan K. Biswas, Chinmay K. Panda, Bidyut Roy, Rajiv Sarin, Partha P. Majumder

Journal Articles

Background: Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in its genomic presentation and its clinical behavior, it is treated identically as tongue cancer. Predictive markers of prognosis and therapy that are specific to OSCC-GB are, therefore, required. Although genomic drivers of OSCC-GB have been identified by whole exome and whole genome sequencing, no epigenome-wide study has been conducted in OSCC-GB; our study has filled this gap, and has discovered and validated epigenomic hallmarks of gingivobuccal …

A Prospective Clinical Study On Implant Impression Accuracy, Motaz Osman, Hassan Ziada, Ahmed Suliman, Neamat Hassan Abubakr

Dental Medicine Faculty Research

Background An accurate impression is crucial to the long-term success of dental implants. This investigation evaluated the accuracy of the open and closed implant impression techniques in partially edentulous patients who received two adjacent implants. Material and methods Forty patients received Osstem Implants (Osstem Implant System, Seoul, Korea). Two impressions were made for each patient, one using an open tray and a second with a closed tray technique. The horizontal distances between two impression copings were measured and compared to similar measurements on the master casts. Also, under a stereomicroscope (AmScop14370, Myford Road, #150, Irvine, CA 92606 USA) at a …

Pink Tooth Of Mummery In The Maxillary Left Canine After Fixed Partial Denture (Fpd) Preparation, Eger V. Korolevsky, Takashi Komabayashi, Denise Foran

Dental Medicine Faculty Publications

Pink tooth of Mummery is typically found after trauma. However, this case report describes an unusual occurrence of pink tooth in a 67-year-old Caucasian male after fixed partial denture (FPD) tooth preparation. Pink tooth in this case may be due to one or more factors: tooth reduction and heat generation during tooth preparation; heat generation during polymerization of provisional material; and hyperocclusion of a provisional FPD. This case highlights the importance of choosing the appropriate materials and techniques to avoid pulpal complications after dental prosthesis work.