Is Extract Err731 From The Rheum Rhaponticum Effective In Relieving Menopausal Symptoms In Women Aged 45 To 55 Years Of Age?,
2011
Philadelphia College of Osteopathic Medicine
Is Extract Err731 From The Rheum Rhaponticum Effective In Relieving Menopausal Symptoms In Women Aged 45 To 55 Years Of Age?, Annette M. Merlino
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine whether ERr 731 extract from the Rheum rhaponticum plant is effective in relieving symptoms of menopausal symptoms in women aged 45 to 55 years of age
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?,
2011
Philadelphia College of Osteopathic Medicine
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?, Jackie Linh
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “how safe and effective is infliximab in treatment of children with moderate to severe Crohn’s disease?”
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?,
2011
Philadelphia College of Osteopathic Medicine
Is Chronic Use Of Bacopa Monnieri An Effective Treatment To Improve Memory Performance In Healthy And Aging Adults?, Brian M. Kairalla
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of the systematic review is to determine whether or not chronic use of Bacopa monnieri is an effective treatment to improve memory performance in healthy and aging adults.
Is Monotherapy Treatment Of Etanercept Effective Against Plaque Psoriasis?,
2011
Philadelphia College of Osteopathic Medicine
Is Monotherapy Treatment Of Etanercept Effective Against Plaque Psoriasis?, Joseph Devito
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not monotherapy treatment of etanercept is effective against plaque psoriasis.
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?,
2011
Philadelphia College of Osteopathic Medicine
Does Caffeine Consumption Effect Exercise Performance In Healthy Adults?, Meaghan E. Jones
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not caffeine ingestion prior to exercise effects exercise performance in healthy adults.
Is Growth Hormone An Effective Adjunct To Standard Treatment Regimens For Promoting Fat Mass Loss And Retention Of Lean Body Mass In The Treatment Of Obesity?,
2011
Philadelphia College of Osteopathic Medicine
Is Growth Hormone An Effective Adjunct To Standard Treatment Regimens For Promoting Fat Mass Loss And Retention Of Lean Body Mass In The Treatment Of Obesity?, J. Caleb Henson
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether growth hormone is an effective adjunct in the treatment of obesity for promoting fat loss while retaining lean body mass.
Is Besifloxacin Ophthalmic Suspension 0.6% Safe And Effective For The Treatment Of Bacterial Conjunctivitis?,
2011
Philadelphia College of Osteopathic Medicine
Is Besifloxacin Ophthalmic Suspension 0.6% Safe And Effective For The Treatment Of Bacterial Conjunctivitis?, Hetal R. Desai
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not besifloxacin ophthalmic suspension 0.6% is safe and effective for the treatment of bacterial conjunctivitis.
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?,
2011
Philadelphia College of Osteopathic Medicine
Is White Bean Extract A Safe And Effective Treatment For Weight Loss?, Jamie Berkowitz
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not white bean extract is a safe and effective treatment for weight loss.
Is Green Tea An Effective Aid In Weight Reduction?,
2011
Philadelphia College of Osteopathic Medicine
Is Green Tea An Effective Aid In Weight Reduction?, Lindsey A. Brown
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not green tea extract is effective in aiding in weight reduction.
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression,
2011
Philadelphia College of Osteopathic Medicine
Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression, Lauren Cabana
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does fish oil supplementation (omega-3 PUFA) cause mood improvement in adults with depression?”
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?,
2011
Philadelphia College of Osteopathic Medicine
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?, Allison Berneking
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does venlafaxine (Effexor) decrease the frequency of hot flashes in women with breast cancer?”
Is Vitamin E Supplementation Effective In Reducing Mortality Related To Cardiovascular Events In People With Type 2 Diabetes Mellitus?,
2011
Philadelphia College of Osteopathic Medicine
Is Vitamin E Supplementation Effective In Reducing Mortality Related To Cardiovascular Events In People With Type 2 Diabetes Mellitus?, Payal Amin
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not Vitamin E is effective in reducing the mortality related to cardiovascular event in patients with Type 2 Diabetes mellitus.
The Energy Landscape Analysis Of Cancer Mutations In Protein Kinases,
2011
University of Kansas - Main Campus
The Energy Landscape Analysis Of Cancer Mutations In Protein Kinases, Anshuman Dixit, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of protein kinases to characterize the interplay between oncogenic mutations and locally frustrated sites as important catalysts of allostetric kinase activation. While structurally rigid kinase core constitutes a minimally frustrated hub of the catalytic domain, locally frustrated residue clusters, whose interaction networks are not energetically optimized, are prone to dynamic modulation and could enable allosteric conformational transitions. The results …
Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe,
2011
Technological University Dublin
Synthesis, Biochemical And Molecular Modelling Studies Of Antiproliferative Azetidinones Causing Microtubule Disruption And Mitotic Catastrophe, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Niall O. Keely, Andrew Js Knox, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan
Articles
The structure-activity relationships of antiproliferative β-lactams, focusing on modifications at the 4-position of the β-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger and Reformatsky reactions. The antiproliferative activity was assessed in MCF-7 cells, where the 4-(4-ethoxy)phenyl substituted compound 26 displayed the most potent activity with an IC50 value of 0.22 μM. The mechanism of action was demonstrated to be by inhibition of tubulin. Cell exposure to combretastatin A-4 and 26 led to arrest of MCF-7 cells in the G2/M phase of the cell cycle and induction of apoptosis. Additionally, mitotic catastrophe for …
The Release Of Calcium In Bacillus Anthracis Pathogenicity,
2011
University of Nevada, Las Vegas
The Release Of Calcium In Bacillus Anthracis Pathogenicity, Natiera Magnuson, Manomita Patra, Maria Elena Reynaga, Ernesto Abel-Santos
McNair Poster Presentations
Bacillus anthracis spores form in response to starvation and can withstand extremes of heat, radiation, and chemical toxins, making B. anthracis spores ideal vehicles for infections.1 The resistance and dormancy of bacterial spores are dependent on a largely dehydrated core.2 The spore core is not only devoid of water, but contains between 0.8 to 1M calcium complexed with 2,6-pyridinedicarboxylic acid (dipicolinic acid, DPA). The DPA-calcium complex (CaDPA) helps protect DNA, RNA, and the metabolic enzymes needed for the establishment of a vegetative cell cytoplasm.3 An anthrax infection starts with the germination of B. anthracis spores in a macrophage.4 The germinated …
Lead Identification Of Β-Lactam And Related Imine Inhibitors Of The Molecular Caperone Heat Shock Protein 90,
2011
Technological University Dublin
Lead Identification Of Β-Lactam And Related Imine Inhibitors Of The Molecular Caperone Heat Shock Protein 90, Niamh O'Boyle, Andrew Js Knox, Trevor P. Price, D. Clive Williams, Daniela M. Zisterer, David G. Lloyd, Mary J. Meegan
Articles
Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical trials and represent a new and exciting area in the treatment of cancer. Heat shock protein 90 inhibitors have huge structural diversity, and here we present the identification of inhibitors based on β-lactam and imine templates. β-Lactam 5 and imines 12 and 18 exhibit binding to heat shock protein 90-α with IC50 values of 5.6 μM, 14.5 μM and 22.1 μM respectively. The binding affinity displayed …
Induction Of Labor With Oxytocin: When Should Oxytocin Be Held?,
2011
Lehigh Valley Health Network
Induction Of Labor With Oxytocin: When Should Oxytocin Be Held?, Liany C. Diven Md, Julia Gogle Rn, Meredith Rochon Md, Sherrine Eid Mph3, John C. Smulian Md,Mph, Joanne N. Quiñones Md, Msce
Department of Obstetrics & Gynecology
No abstract provided.
Pegylated Interferon Α-2b Up-Regulates Specific Cd8+ T Cells In Patients With Chronic Hepatitis B,
2010
Wright State University - Main Campus
Pegylated Interferon Α-2b Up-Regulates Specific Cd8+ T Cells In Patients With Chronic Hepatitis B, Ji Chen, Yan Wang, Jun Li, Feng-Qin Hou, Gui-Qiang Wang
Pharmacology and Toxicology Faculty Publications
AIM: To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS: Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density: 1.077 g/L, Pharmingen) at weeks 0, 4, 8, 12, and 24, respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS: The frequency of circulating HBV core or env-specific CD8 T cells was higher (P …
Catch A Near Miss And Prevent A Harmful Error,
2010
Lehigh Valley Health Network
Catch A Near Miss And Prevent A Harmful Error, Georgene Saliba Mba, Cphrm, Leroy Kromis, Kristie Lowery Rn, Bs, Cphq, Cphrm
Administration & Leadership
No abstract provided.
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry,
2010
Technological University Dublin
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone
Articles
A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The …
