Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellintus In Primary Care,
2019
University of North Dakota
Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellintus In Primary Care, Tracy Kirchner
Physician Assistant Scholarly Project Papers
Type II diabetes mellitus (T2DM) is a prevalent disease in our country. Bullard et al. (2018) report approximately 21 million adults have T2DM in the United States. “The total estimated cost of diagnosed diabetes in 2017 is $327 billion, including $237 billion in direct medical costs and $90 billion in reduced productivity” (Yang et al., 2018). Treatment of T2DM is individualized to each patient based on their co-morbidities, fiscal responsibility, and route of administration options. Sulfonylureas and Glucagon-like Peptide-1s (GLP-1) are two classes of antidiabetic drugs that are available for use as second line treatment options after metformin. This review …
Pediatric Ppi Use And Fractures,
2019
Children's Mercy Hospital
Pediatric Ppi Use And Fractures, Nathan R. Fleishman, Troy Richardson, Thomas M. Attard
Posters
This study compared the rate of fracture among pediatric patients exposed to proton pump inhibitors to the rate among patients without exposure, and also considered the fracture location among children exposed to proton pump inhibitors.
Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients,
2019
Children's Mercy Hospital, Kansas City, MO
Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron, Susan M. Abdel-Rahman
Posters
With the goal of developing a clinician-driven tacrolimus (TAC) pharmacokinetic dosing tool, our initial objectives were 1) to examine whether published TAC population pharmacokinetic (popPK) models could serve as a foundation for the dosing tool, and 2) evaluate their performance predicting TAC concentrations in an independent cohort of Children's Mercy patients.
A Nsqip Analysis Of Post-Operative Antibiotic Utilization In Uncomplicated Appendicitis,
2019
Children's Mercy Hospital
A Nsqip Analysis Of Post-Operative Antibiotic Utilization In Uncomplicated Appendicitis, Charlene Dekonenko, Robert M. Dorman, Janelle R. Noel-Macdonnell, Tolulope A. Oyetunji
Posters
APSA 2010 recommendations do not support antibiotic use post-operatively following appendectomy for uncomplicated appendicitis, but compliance varies by institution. This study determined the rate of post-operative antibiotic use in uncomplicated appendicitis and found that 10% of patients were discharged on antibiotics, using the NSQIP files.
Targeting Sec61Α By Ipomoeassin F Leads To Highly Cytotoxic Effect,
2019
University of Arkansas, Fayetteville
Targeting Sec61Α By Ipomoeassin F Leads To Highly Cytotoxic Effect, Zhijian Hu
Graduate Theses and Dissertations
Ipomoeassin F is a flagship congener of a resin glycoside family that inhibits growth of many tumor cell lines with only single-digital nanomolar IC50 values. However, biological and pharmacological mechanisms of ipomoeassin F have been undefined. To facilitate exploration of the biological and pharmacological properties, we performed sophisticate SAR (Structure–activity relationship) studies of ipomoeassin F to understand its pharmacophore and structure properties so that we can design favorable probes for further biological investigation. By applying appropriate deviates that possess fluorescent groups and similar bio-activity, the target protein was found to be localized in endoplasmic reticulum (ER). Through biotin affinity pull …
Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity.,
2019
University of Louisville
Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity., Matthew William Dent
Electronic Theses and Dissertations
This thesis describes the development of a novel lectin-Fc fusion protein and its antiviral and anti-cancer activity. The molecule, Avaren-Fc (AvFc), is a fusion of a variant of the actinomycete lectin actinohivin (Avaren) and the Fc region of human IgG1, and is selective for the terminal α1,2-mannose residues found at the ends of high-mannose-type glycans that can be found on the surface of certain heavily glycosylated viruses and cancer cells. Here, AvFc was found to be able to neutralize simian immunodeficiency virus as well as Hepatitis C virus with nanomolar IC50 values. Furthermore, AvFc recognizes a number of cell …
Comparison Of Rivaroxaban And Warfarin In The Prevention Of Recurrent Venous Thromboembolism,
2019
University of North Dakota
Comparison Of Rivaroxaban And Warfarin In The Prevention Of Recurrent Venous Thromboembolism, Philip Joel Heiden
Physician Assistant Scholarly Project Papers
The purpose of this systematic literature review is to determine the efficacy and safety of rivaroxaban (Xarelto) compared to warfarin (Coumadin), for the long term prophylaxis of recurrent venous thromboembolism (VTE). Rivaroxaban was chosen as the primary representative of factor Xa inhibitors because of its simplistic once a day dosing regimen. The PubMed database was extensively searched, using a variety of key terms, from September 10 to November 30, 2018. Works chosen include propensity-matched cohorts, retrospective studies, systematic reviews, and meta-analyses. All of which were published within the last 10 years; sources dated prior to 10 years were excluded. Studies …
The Impact Of Medical Marijuana On The Opioid Crisis,
2019
University of North Dakota
The Impact Of Medical Marijuana On The Opioid Crisis, Carl David Estep
Physician Assistant Scholarly Project Papers
In light of the current opioid crisis, research is needed to identify alternative treatments for acute and chronic pain. With medical marijuana being made available by rapidly changing state laws, it is prudent to identify what role it may play in pain control. This comprehensive literature review was conducted to determine what is known as to the effectiveness of medical marijuana, cannabis, or cannabinoids for treating acute and chronic pain as compared to prescription opiates. An additional comparison was also made between the addictive properties and adverse effects of medical marijuana and prescription opiates. The final parameter evaluated was the …
Heterocycle Synthesis From Quinols,
2019
CUNY Graduate Center
Heterocycle Synthesis From Quinols, Jing Wu
Dissertations, Theses, and Capstone Projects
Three cascade reactions that provide access to various heterocyclic skeletons from quinols were developed. Various substituted 1-hydroxyacridones, 4-hydroxycarbazoles and 4-hydroxy-indolin-3-ones were readily synthesized in moderate to excellent yields. The common sequential transformation involves carbamation/Michael addition/mixed Claisen condensation/decarboxylative aromatization which were realized in one-pot reactions in the synthesis of acridones and indolin-3-ones, or two-step reactions in the synthesis of carbazoles. A side reaction from oxidative dearomatization of phenols, affording iodo diaryl ethers in one step from commercial phenols, albeit in low yields, revealed an intricate mechanistic pathway. The synthesis of jaboticabin was realized in nine linear steps from commercial phloroglucinol and …
A Pretargeted Spect Imaging Strategy Employing Technetium-99m Based On Bioorthogonal Diels-Alder Click Chemistry,
2019
CUNY Graduate Center
A Pretargeted Spect Imaging Strategy Employing Technetium-99m Based On Bioorthogonal Diels-Alder Click Chemistry, Justin H. Walsh
Dissertations, Theses, and Capstone Projects
A series of related N3S 99mTc-peptide complexes were synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the 99mTc-peptide complexes for maximum tumor targeting with the in vivo “click” and minimum non-target uptake. The 99mTc–tetrazine constructs were prepared by reaction of 99mTc-peptide complexes (99mTc-FKC, 99mTc-FKCR, 99mTc-DKC, and 99mTc-SKC) with Tz-NHS or Tz-PEG5-NHS to form 99mTc FK(Tz)C, 99mTc-FK(PEG5-Tz)CR, 99mTc-DK(PEG5-Tz)C, …
Synthesis Of A Zn(Ii)-Responsive Paracest Mri Agent For Improved Diagnosis Of Prostate Cancer,
2019
The University of San Francisco
Synthesis Of A Zn(Ii)-Responsive Paracest Mri Agent For Improved Diagnosis Of Prostate Cancer, Megan Martin, Holly Clancy
Creative Activity and Research Day - CARD
In the United States, prostate cancer is the leading type of cancer diagnosed in men. Prostate cancer is currently diagnosed with the Prostate-Specific Antigen (PSA) test; however, it leads to many false positives and therefore unneeded biopsies. Previous studies have shown that cancerous prostates have a much lower concentration of zinc than healthy prostates. The goal of this project is to create an MRI contrast agent capable of non-invasively quantifying zinc in the human prostate. Five out of the eight synthetic steps have been successfully completed so far, and the identities of these intermediate products have been verified by 1 …
Impact Of Quinoline Amide Substituents On The Luminescence And Paracest Mri Properties Of Bimodal Europium (Iii) Complexes,
2019
The University of San Francisco
Impact Of Quinoline Amide Substituents On The Luminescence And Paracest Mri Properties Of Bimodal Europium (Iii) Complexes, Brooke Aloe, Marisa Poveda, Osasere M. Evbuomwan
Creative Activity and Research Day - CARD
Lanthanide ions exhibit optical imaging properties; however, the amount of energy needed to directly excite these ions could potentially be damaging to biological tissue. To overcome this limitation, organic chromophores, such as quinolines, can be used to absorb the excited light and transfer the energy obtained to the attached lanthanide ion. This intramolecular energy transfer results in the sensitization of the lanthanide ion luminescence. The goal of this project is to assess how the amide proton position in relation to the quinoline substituent affects the sensitivity of luminescence and the optical imaging properties of Europium (III) complexes. To achieve this …
Effect Of Salt Concentration On Electrochemical Detection Of Dna,
2019
University of San Francisco
Effect Of Salt Concentration On Electrochemical Detection Of Dna, Ziming Dong, Eddie Madrigal, Ryan West Dr.
Creative Activity and Research Day - CARD
Electrochemical approaches for biological sensing offer the potential advantages of facile sample preparation, fast response times, ease of parallel and multiplexed measurements, and the possibility of miniaturization (of sample sizes, electrodes, and associated electronics). All of these factors contribute towards the feasibility of electrochemical methods in biological sensing and analysis. This potential has already been achieved with the commercialization of blood glucose meters, which often rely on an electrochemical transduction mechanism. We have previously demonstrated the ability to electrochemically detect and differentiate complementary and mismatched DNA using our method of melting DNA duplexes at electrified gold surfaces, i.e. e-melting. Recently, …
Sensory Primary Cilium Is A Responsive Camp Microdomain In Renal Epithelia,
2019
Chapman University
Sensory Primary Cilium Is A Responsive Camp Microdomain In Renal Epithelia, Rinzhin T. Sherpa, Ashraf M. Mohieldin, Rajasekharreddy Pala, Dagmar Wachten, Rennolds S. Ostrom, Surya M. Nauli
Pharmacy Faculty Articles and Research
Primary cilia are hair-like cellular extensions that sense microenvironmental signals surrounding cells. The role of adenylyl cyclases in ciliary function has been of interest because the product of adenylyl cyclase activity, cAMP, is relevant to cilia-related diseases. In the present study, we show that vasopressin receptor type-2 (V2R) is localized to cilia in kidney epithelial cells. Pharmacologic inhibition of V2R with tolvaptan increases ciliary length and mechanosensory function. Genetic knockdown of V2R, however, does not have any effect on ciliary length, although the effect of tolvaptan on ciliary length is dampened. Our study reveals that tolvaptan may have a cilia-specific …
Amphiphilic Peptides For Efficient Sirna Delivery,
2019
Chapman University
Amphiphilic Peptides For Efficient Sirna Delivery, Saghar Mozaffari, Emira Bousoik, Farideh Amirrad, Robert Lamboy, Melissa Coyle, Ryley Hall, Abdulaziz Alasmari, Parvin Mahdipoor, Keykavous Parang, Hamidreza Montazeri Aliabadi
Pharmacy Faculty Articles and Research
A number of amphiphilic cyclic peptides—[FR]4, [WR]5, and [WK]5—containing hydrophobic and positively-charged amino acids were synthesized by Fmoc/tBu solid-phase peptide methods and evaluated for their efficiency in intracellular delivery of siRNA to triple-negative breast cancer cell lines, MDA-MB-231 and MDA-MB-468, in the presence and absence of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). Among the peptides, [WR]5, which contains alternate tryptophan (W) and arginine (R) residues, was found to be the most efficient in the delivery of siRNA by improving the delivery by more than 3-fold when compared to other synthesized cyclic peptides that were not efficient. The data also showed that co-formulation of [WR]5 …
Chemophobia And The Relation To Names,
2019
Tyler Junior College
Chemophobia And The Relation To Names, Justin Crow
Undergraduate Research Conference
Chemophobia is a recently identified cultural phenomena where people are afraid of chemicals in their lives, whether "chemicals" are in their food, their medicines, vaccinations, and other products. An increasing amount of people have a concern about the risk associated with chemicals in their everyday life. Chemistry professionals find this a bit strange as Chemistry states that all matter is made up of chemicals. Chemistry has many systems of naming and understanding chemicals which can exclude people from understanding the risk or lack thereof attributed to materials that are common in daily life. This effect could be accentuated by educational …
Adhd Medication: To Medicate Or Not To Medicate?,
2019
Tyler Junior College
Adhd Medication: To Medicate Or Not To Medicate?, Alyssa Henderson
Undergraduate Research Conference
Eleven percent of American children are diagnosed with at least one type of ADHD. That is 6.4 million children that are clinically diagnosed with the inability to focus attentively, restlessness, imbalanced mood swings and under-developed social skills. All of these lead to any learning environment being a daily battleground in the children both internally as well as externally. This is caused due to an under-activity in the frontal lobe of the child’s brain, which is responsible for their planning, motivation, social behavior and speech production. The symptoms associated with ADHD are currently being combated with the utilization of stimulants known …
March/April 2019,
2019
Southwestern Oklahoma State University
March/April 2019, Randy Curry, Cindy Brooks
RURAL ROCKS
Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis,
2019
University of New Mexico - Main Campus
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin
Nanoscience and Microsystems ETDs
Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The …
The Physiological Basis For Vitamin C As A Potential Treatment For Sepsis,
2019
Butler University
The Physiological Basis For Vitamin C As A Potential Treatment For Sepsis, Jennifer Johnston
BU Well
Accounting for one third of all hospital patient deaths in America, sepsis remains one of the most deadly and complicated conditions that healthcare providers treat. Septic shock, a progressed form of sepsis, is even more troublesome, as mortality rates typically fall between 50-72%. It has been proposed that administration of high doses of vitamin C could be an effective treatment for the condition due to the nutrient’s anti-stress and anti-shock properties. This investigation of the physiological reasoning for administering high doses of vitamin C evaluates the viability of its use in patients with septic shock.
