Toxicology Commons^™

The Next Generation Beneficial Actions Of Novel Probiotics As Potential Therapeutic Targets And Prediction Tool For Metabolic Diseases, Hsin-Lin Cheng, Gow-Chin Yen, Shih-Chien Huang, Shiuan-Chih Chen, Chin-Lin Hsu

Journal of Food and Drug Analysis

The prevalence of metabolic disease has rising and affected over 1,000 million populations globally. Since the metabolic disease and its related complication are board, it has become the major health hazard of modern world. However, Long term medication of metabolic disease may cause serious side effects and risk for adverse health problems. Recently, emerging studies focus on exploring the mechanistic details of metabolic state in disease development and progression. Gut bacteria ecosystem was considered to play a pivotal role in regulating energy homeostasis and great associated with the development of metabolic disease. Accumulated evidences indicated that Akkermansia muciniphila, Faecalibacterium prausnitzii, …

The Unexpected Influence On Talent From Air Pollution, Singapore Management University

Perspectives@SMU

CUHK research shows air pollution in China is driving educated and skilled company executives to move away from highly polluted areas, hampering the performance of firms located there

Mise En Visibilité Des Situations D’Exposition Cutanée Aux Pesticides Et Des Pratiques De Prévention : Développement Méthodologique Réalisé En Collaboration Avec Des Producteurs De Pommes Québécois (2e Édition), Caroline Jolly, Sylvie Beaugrand, Ludovic Tuduri, Élise Ledoux, Alain Garrigou

Rapports de recherche scientifique

Dans une optique de rentabilité visant la survie de l’entreprise, et pour répondre aux attentes de qualité du marché, les agriculteurs utilisent des pesticides. La littérature scientifique documente largement les effets à la santé susceptibles d’être liés à l’utilisation des pesticides. Plusieurs auteurs mentionnent l’importance de la voie cutanée comme voie d’exposition aux pesticides. Ce rapport présente le développement d’une méthodologie mixte alliant ergonomie et expologie visant à documenter l’exposition cutanée, les situations d’exposition et les pratiques de prévention associées.

Il s’appuie sur un devis de recherche par étude de cas qui se décline en quatre étapes : une étude …

In Vitro Toxicological Evaluation Of Mesoporous Silica Microparticles Functionalised 1 With Carvacrol And Thymol, Cristina Fuentes, Ana Fuentes, Hugh Byrne, José Barat, María José Ruiz

Articles

The cytotoxicity of carvacrol- and thymol- functionalised mesoporous silica microparticles (MCM-41) was assessed in the human hepatocarcinoma cell line (HepG2). Cell viability, lactate dehydrogenase (LDH) activity, reactive oxygen species (ROS) production, mitochondrial membrane potential (ΔΨm), lipid peroxidation (LPO) and apoptosis/necrosis analysis were used as endpoints. Results showed that both materials induced cytotoxicity in a time and concentration-dependent manner, being more cytotoxic than free essential oil components and bare MCM-41. This effect was caused by the cell-particle interactions and not from degradation products released to the culture media, as demonstrated in the extract dilution assays. LDH release was seen to be …

Wastewater-Based Estimation Of Substances Discharged At The Rest Areas Along The State Highways In Kentucky, Katherine E. Gray, Eugene Shin, Tyler Whitt, Andrew Windhorst, Houston Hampton, Chris Delcher, Bikram Subedi

Posters-at-the-Capitol

The availability of licit and illicit stimulants and its adverse consequences on public health has emerged as a major drug threat to communities in the United States. Despite several drug-involved traffic incidents along the interstate highways, this report represents the first comprehensive and quantitative report of drugs discharged at the rest areas along the interstate highways. In this National Institute of Justice-funded study, the amount of several discharged drugs focusing on stimulants but also including opioids and prescription antipsychotics are being measured in raw wastewater collected from five rest areas and a truck servicing facility using a state-of-the-art mass …

Ephemeroptera Culturing Methods: An Analysis On Rearing And Toxcity Testing On Sensitive Early Life Stages Of Native Mayfly Taxa, Geneve Rainette Edwards

Theses, Dissertations and Capstones

Standard toxicity testing organisms are utilized for regulatory purposes and often ecological risk assessments. Ephemeroptera taxa have been reported to be more sensitive to aquatic contaminants than the standard toxicity testing organisms currently used in determining effects on aquatic ecosystems. Establishing methods for culturing native Ephemeroptera taxa will provide a more sensitive test organism to determine the toxicity of contaminants and will be more representative of the responses of native taxa. Additionally, it will provide a test organism at the most sensitive life stages. The objective of this research is to develop methods for culturing and testing of native Ephemeroptera …

Investigation Of The Effects Of Prenatal Drug Exposure On Astrocyte-Mediated Synaptogenic Signaling, Taylor Christian Boggess

Theses, Dissertations and Capstones

One of the most significant outcomes of the rise in rates of opioid abuse in the United States has been a dramatic increase in the incidence of neonatal abstinence syndrome (NAS), the clinical diagnosis for the collection of withdrawal-like signs and symptoms commonly observed in the newborns of mothers who abused certain drugs, such as opioids, during pregnancy. While a great deal of research has investigated the short-term symptoms and potential treatments for NAS, including my own studies to identify emerging trends among a local population of NAS patients, there remains a critical need to investigate the long-term effects of …

Dithiocarbamates Mancozeb And Disulfiram Induce Striated Muscle Myopathy And Neuropathy In Long-Evans Rats, Olivia Stephenson

Theses and Dissertations

Mancozeb (MZ), an ethylene bis-dithiocarbamate complexed with the metals manganese and zinc, is a broad-spectrum fungicide used primarily on orchards and vineyards. Disulfiram (DS, Antabuse®), a diethyldithiocarbamate, is an FDA-approved drug used for alcohol aversion therapy. Both dithiocarbamates (DTCs) have shown neurological effects including motor impairment, muscle weakness, and hind-limb paralysis, although the mechanism of toxicity is not understood. The purpose of this study is to determine how these neurotoxic compounds are damaging striated muscle of rats. Adult, male Long-Evans rats were administered either 250mg/kg MZ or 750mg/kg DS via oral gavage 3x/week for four weeks. Animals were euthanized 24 …

The Role Of Dichloro(Ethylenediamine) Platinum Ii In Altering Cellular Iron And Copper Transport, Megan Hall

Mahurin Honors College Capstone Experience/Thesis Projects

Approximately 50% of all chemotherapy cancer patients receive a platinum chemotherapeutic during their treatment. Although these drugs are widely utilized, little is known about the cellular transport of platinum drugs. It is hypothesized that platinum utilizes transporters for other metals to enter the cell. Structural differences between compounds are predicted to affect the compounds’ ability to exploit different transporters. Also, different cell types express different transporters. Therefore, compound structure is expected to influence transport of platinum compounds differently in different cell types. This study investigated the role of the platinum drug cisplatin and platinum compound Pt(en)Cl₂ in altering iron …

Cellular Activation Following Acute And Chronic Ethanol In Glutamatergic Projection Neurons, Annalise Hassan, Sam Gottlieb, Michael F. Miles Md, Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

Effect Of Metal-Containing Nanoparticles On Bacterial Biofilms And On The Microbiome Of Girardia Tigrina, Azar Saikali

West Chester University Master’s Theses

Anthropogenically-produced nanoparticles are a form of nanotechnology being used in industries including food and textiles. Humans and livestock are frequently exposed to metal-containing nanoparticles (MCNPs), that have been washed into streams and rivers, have been deliberately used in food packaging as antimicrobials, preservatives or for supplementation. The animal microbiome, which consists of a diverse community of microorganisms, provides a number of benefits to the host in terms of nutrition availability, immune support, and can influence behavior. Biofilms of diverse microbes may cause detrimental effects, for instance by causing dental diseases in humans. However, the scientific community has not reached consensus …

Pfas Environmental Contamination In Central Maine, Megan H. Andersen

Honors Theses

PFAS (per- and polyfluoroalkyl substances) are toxic, persistent, and bioaccumulative chemicals that are used in a variety of consumer products and industrial applications. Paper mills across the state of Maine have used PFAS in their industrial paper making processes, and their wastes often flow for treatment into municipal sewage treatment facilities. PFAS contaminated municipal wastewater from the general use of PFAS consumer products are also processed by these plants. Liquid waste is condensed into solid waste septage and sludge, and in what was thought to be an environmentally friendly repurposing practice, municipal sludge and septage has been spread on plots …

Recyclage Primaire Des Matières Résiduelles Électroniques Au Québec : Portrait De La Santé Et De La Sécurité Du Travail Et Appréciation Du Risque Sanitaire, Sabrina Gravel, Bouchra Bakhiyi, Joseph Zayed, Sylvie Gravel, Daniel Côté, Brigitte Roberge, Jacques Lavoie, Loïc Wingert, France Labrèche

Rapports de recherche scientifique

En raison de l’utilisation croissante de composants et d’appareils électriques et électroniques, de même que de leur durée de vie relativement courte, la quantité de matières résiduelles électroniques ne cesse d’augmenter. Conséquemment, le nombre d’entreprises spécialisées dans le recyclage électronique (e-recyclage) est en nette croissance au Québec, comme ailleurs dans le monde. Ces entreprises emploient des travailleurs qui ont pour tâche de démonter les appareils afin d’en trier les composants qui seront subséquemment valorisés ou éliminés de manière sécuritaire. Ces tâches peuvent cependant entraîner l’exposition des travailleurs à un mélange de substances potentiellement toxiques, comprenant entre autres des poussières, des …

Effects Of Perchlorate Exposure On Swimming Performance Of Zebrafish (Danio Rerio) And Organ Development Of Mice (Mus Musculus), Quentin Phillips

All Graduate Theses, Dissertations, and Other Capstone Projects

Biomimetic properties of endocrine disrupting compounds (EDC) enable these chemicals to induce physiological responses in organisms at the cellular level, affecting fishes, amphibians, reptiles, birds, and mammals. Perchlorate is a ubiquitous EDC to which nearly all humans of industrialized countries are exposed. Perchlorate competitively inhibits the sodium-iodide symporters located within the follicular cells of the thyroid gland, reducing the body’s ability to uptake iodide and synthesize thyroid hormone (TH), a crucial hormone in the regulation of many metabolic processes. Threespine stickleback (Gasterosteus aculeatus) and zebrafish (Danio rerio) are aquatic model organisms used in perchlorate exposure research. Exposure causes many common …

Avian Haemosporidian Blood Parasite Diversity, Prevalence, And Distribution In Michigan’S Western Upper Peninsula, Maria M. Ferrer

Dissertations, Master's Theses and Master's Reports

Avian haemosporidian parasites, known as avian malaria (phylum Apicomplexa) can diminish an individual bird’s fitness by causing parasitemia, anemia, and reduced survival. Climate change is predicted to increase the spread of malarial parasites into more northerly latitudes where little is known about community compositions of these parasites. I assessed the prevalence and diversity of haemosporidian parasites in the first-ever community-level sampling of malaria in songbirds across the western Upper Peninsula of Michigan. In total, 179 blood samples were collected from birds representing 17 species, at five locations in the Upper Peninsula, including a mature forest, an early successional forest, and …

Determining The Effects Of Chemical Exposure On Hepatocyte Mitochondrial Networks And Cell Viability, Bethany Eaton

All Master's Theses

Mitochondria are cellular organelles that are becoming more recently studied. One of their main functions is the production of energy through cellular respiration, which is crucial to cell life. However, they are also associated with numerous disease states. It is hypothesized that reactive oxygen species (ROS), largely produced in mitochondria, induce oxidative stress and affect mitochondrial morphology along with cell viability. This study compares chemical exposure of menadione, an ROS producer, and phthalates (plasticizers) on two mouse hepatocyte cell lines to determine the effects they have on mitochondrial morphology and cell viability. Three experiments were performed to analyze the effects …

Chromatographic Studies Of Some Hormone And Metabolic Modulators Used For Doping In Sports, Ruth Marie Speidel

Online Theses and Dissertations

The World Anti-Doping Agency (WADA) is an international agency that monitors the use of Performance Enhancing Drugs (PEDs) in sports; their mission is “to lead a collaborative worldwide movement for doping-free sport” (Who We Are, 2022). For this mission, the WADA needs quick, sensitive, reproducible, and accurate methods for analyzing athletes’ biological fluids for possible PEDs. This research focuses on developing and validating simple, sensitive, rapid, and reliable gas chromatography- mass spectrometry (GC-MS) methods for the analysis of two hormone and metabolic modulators, toremifene and trimetazidine. Previously, there has been limited GC-MS methods used to analyze toremifene and trimetazidine. Quantification …

Identification Of The New Synthetic Opioid Bucinnazine And Its Metabolites Using Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms), Karissa N. Resnik

Master of Science in Forensic Science Directed Research Projects

In the past 20 years, the rate of opioid use increased drastically in the United States. The country has experienced an enormous number of deaths caused by opioid overdose, opioid use disorder (OUD), as well as other harms as a consequence of the high numbers of opioid prescriptions. Fentanyl, a well-known synthetic opioid, has been a contributor to the opioid crisis since 2013 due to its popularity in clinical and illicit use. It has a high potency, which makes it an effective analgesic but a dangerous illicit substance. A new synthetic opioid, bucinnazine, has recently become a new black-market opioid …

Toxicity Of The Technology Critical Elements Germanium And Yttrium To Daphnia Magna And Hyalella Azteca And The Influence Of Toxicity Modifying Factors, Rashid Shah

Theses and Dissertations (Comprehensive)

Technology critical elements (TCEs) are increasingly used in high and green technologies but there is little aquatic toxicity data for TCEs, particularly in fresh water. The objective of this study was to investigate the toxicity of two TCEs, Ge and Y, to Daphnia magna and Hyalella azteca and to understand the role of natural organic matter and cations on toxicity modification. Testing followed standard methods. The 48 h EC50 for D. magna was 11.6 (95% CI of 9.64-13.8) mg Ge/L based on measured dissolved concentrations at test end. The addition of NOM at 10 mg DOC/L resulted in a significant …

Modulating Ketamine’S Locomotor Activating And Reinforcing Effects Through Drug Combinations, Tegshjargal Baasansukh

Theses and Dissertations

Major Depressive Disorder (MDD) affects approximately 280 million people worldwide. The standard of care for pharmacological treatment of MDD has been monoaminergic antidepressants (MAA). However, MAAs have serious clinical limitations including a relatively slow onset of action and up to 40% of patients failing to respond and being diagnosed as “treatment resistant”. Ketamine, an N-methyl-D-aspartate antagonist, was originally approved for use as an injectable anesthetic. In addition, ketamine has been shown to rapidly improve depressive symptoms in patients with treatment resistant depression. In 2019, (S)-ketamine was approved as a nasal spray (Spravato®) for patients with MDD and treatment-resistant depression in …