Corrigendum To “The Impact Of The Rare Disease And Orphan Drug Act In Taiwan” [J Food Drug Anal 29 (2021) 717-725],
2022
Taiwan Food and Drug Administration
Corrigendum To “The Impact Of The Rare Disease And Orphan Drug Act In Taiwan” [J Food Drug Anal 29 (2021) 717-725]
Journal of Food and Drug Analysis
No abstract provided.
The Study Of Distribution Of Ingested Terbinafine On Skin With Ambient Ionization Tandem Mass Spectrometry,
2022
Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, No. 15, Ln. 420, Dachang 2nd Rd. Sanmin Dist., Kaohsiung 807634, Taiwan
The Study Of Distribution Of Ingested Terbinafine On Skin With Ambient Ionization Tandem Mass Spectrometry, Yi-Tzu Cho, Hung Su, Ching-Ying Wu, Jingyueh Jeng, Chi-Wei Lee, Deng‐Chyang Wu, Tiao-Lai Huang, Jentaie Shiea
Journal of Food and Drug Analysis
We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient’s skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin ...
Chemiluminescence Of Lucigenin-Tetracycline And Itsapplication For Sensitive Determination Of Procyanidin,
2022
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, China
Chemiluminescence Of Lucigenin-Tetracycline And Itsapplication For Sensitive Determination Of Procyanidin, Shuai Quan, Kaixiang Ji, Fangshuo Liu, Tesfaye Hailemariam Barkae, Mohamed Ibrahim Halawa, Saima Hanif, Baohua Lou, Jianping Li, Guobao Xu
Journal of Food and Drug Analysis
Tetracycline was reported to trigger intense lucigenin chemiluminescence (CL). Based on its significant quenching to lucigenin-tetracycline CL, procyanidin was detected. The mechanism of the lucigenin-tetracycline CL and its quenching by procyanidin were proposed. Under the optimum conditions, the calibration curve is linear in the range of 10-1000 nM for procyanidin with a detection limit of 4.4 nM. The RSD for nine replicate determinations of procyanidin was less than 1.7%. Moreover, this method was satisfactorily applied to the determination of procyanidin in human urine samples and health food capsule of grape seed.
Quantitation Of Mycophenolic Acid And Metabolites By Uplc-Ms/Ms In Renal Transplant Patients,
2022
Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan
Quantitation Of Mycophenolic Acid And Metabolites By Uplc-Ms/Ms In Renal Transplant Patients, Yun-Fen Huang, Ya-Ching Huang, Hsiao-Chen Ning, Chia-Ni Lin
Journal of Food and Drug Analysis
Mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS), specific inhibitors of lymphocyte proliferation, are commonly used as adjuvant therapy with calcineurin inhibitor agents after kidney transplantation. After administration, MMF and EC-MPS are hydrolyzed to mycophenolic acid (MPA), the active form of the drug, which must be monitored due to its narrow therapeutic window, drug–drug interactions, and large intra-and inter-individual pharmacokinetic variability despite a fixed dose. Monitoring plasma MPA level is recommended to maintain the drug within the therapeutic window, optimize its efficacy, and minimize side effects. This study aims to develop a method for quantifying MPA and its major ...
Camphorataimide B Suppresses The Metastasis Of Human Colorectal Cancer Cell By Inhibiting Smad/Fak/Akt Axis And Promoting Degradation Of Snail/Bmp4 Complex,
2022
Department of Colorectal Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
Camphorataimide B Suppresses The Metastasis Of Human Colorectal Cancer Cell By Inhibiting Smad/Fak/Akt Axis And Promoting Degradation Of Snail/Bmp4 Complex, Chi-Chou Huang, Chia-Hung Hung, Yi-Ju Lee, Tsui-Hwa Tseng, Yean-Jang Lee, Shao-Hsuan Kao, Chau-Jong Wang
Journal of Food and Drug Analysis
Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.
Orally Delivered Perilla (Perilla Frutescens) Leaf Extract Effectively Inhibits Sars-Cov-2 Infection In A Syrian Hamster Model,
2022
Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan
Orally Delivered Perilla (Perilla Frutescens) Leaf Extract Effectively Inhibits Sars-Cov-2 Infection In A Syrian Hamster Model, Yuan-Fan Chin, Wen-Fan Tang, Yu-Hsiu Chang, Tein-Yao Chang, Wen-Chin Lin, Chia-Yi Lin, Chuen-Mi Yang, Hsueh-Ling Wu, Ping-Cheng Li, Jun-Ren Sun, Shu-Chen Hsu, Chia-Ying Lee, Hsuan-Ying Lu, Jia-Yu Chang, Jia-Rong Jheng, Cheng Cheung Chen, Jyh-Hwa Kau, Chih-Heng Huang, Cheng-Hsun Chiu, Yi-Jen Hung, Hui-Ping Tsai, Jim-Tong Horng
Journal of Food and Drug Analysis
On analyzing the results of cell-based assays, we have previously shown that perilla (Perilla frutescens) leaf extract (PLE), a food supplement and orally deliverable traditional Chinese medicine approved by the Taiwan Food and Drug Administration, effectively inhibits SARS-CoV-2 by directly targeting virions. PLE was also found to modulate virus-induced cytokine expression levels. In this study, we explored the anti-SARS-CoV-2 activity of PLE in a hamster model by examining viral loads and virus-induced immunopathology in lung tissues. Experimental animals were intranasally challenged with different SARS-CoV-2 doses. Jugular blood samples and lung tissue specimens were obtained in the acute disease stage (3 ...
Assessing The Fate Of Fatty Acid Esters Of Hydroxy Fatty Acids, Diglycerides And Monoacetyldiacylglycerides In Grilled Ruminant Meats Marinated With Unfiltered Beer-Based Marinades,
2022
School of Science and the Environment/Boreal Ecosystem Research Initiative, Grenfell Campus, Memorial University of Newfoundland, Corner Brook, NL A2H 5G4, Canada
Assessing The Fate Of Fatty Acid Esters Of Hydroxy Fatty Acids, Diglycerides And Monoacetyldiacylglycerides In Grilled Ruminant Meats Marinated With Unfiltered Beer-Based Marinades, Charles F. Manful, Thu H. Pham, Evan Wheeler, Muhammad Nadeem, Oludoyin A. Adigun, Nicole Walsh, Raymond H. Thomas
Journal of Food and Drug Analysis
Ruminant meats contain functional lipids including fatty acid esters of hydroxy fatty acids (FAHFA), diglycerides (DG), monoacetyldiglycerides (MAcDG) and medium chain triglycerides (McTG) whose consumption in the normal diet can confer benefits for consumer health. However, very little is known concerning how meat processing techniques such as marination and grilling affect the quantity and quality of these functional lipids in ruminant meats. We used ultra high-performance liquid chromatography coupled to high resolution accurate mass tandem mass spectrometry (UHPLC-HRAM-MS/MS) to show how grilling following marination with either India or Wheat ale unfiltered beer-based marinades affected the quantity and quality of ...
Exosomal Proteomics In Kidney Disease: From Technical Approaches To Clinical Applications,
2022
Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Exosomal Proteomics In Kidney Disease: From Technical Approaches To Clinical Applications, Ageng Brahmadhi, Yung-Kun Chuang, San-Yuan Wang, Chih-Chin Kao, I-Lin Tsai
Journal of Food and Drug Analysis
Exosomes are small extracellular vesicles (sEVs) secreted from cells and have a general diameter ranging from 30~150 nm. It was reported that exosomes have essential roles in intercellular communication and can be targeted as biomarkers of disease or as therapeutic agents. Among the different techniques used for exosome investigation, the mass spectrometry-based proteomics approach has accelerated the unraveling of the molecular composition of exosomes and has contributed to improved knowledge of molecular processes in various diseases. In this review, we focused on proteomics-based studies of exosomes and clinical applications in kidney diseases. A general introduction of exosomes, isolation and ...
Differential Scanning Calorimetry For Authentication Of Edible Fats And Oils - What Can We Learn From The Past To Face The Current Challenges?,
2022
Department of Food Quality and Safety Management, Poznań University of Life Sciences
Differential Scanning Calorimetry For Authentication Of Edible Fats And Oils - What Can We Learn From The Past To Face The Current Challenges?, Mahbuba Islam, Liliana Bełkowska, Piotr Konieczny, Emilia Fornal, Jolanta Tomaszewska-Gras
Journal of Food and Drug Analysis
Fats and oils authentication has become an important issue recently, due to the growing interest in consumption of cold-pressed oils. Therefore, it is becoming more and more difficult to maintain official control over the growing assortment of new cold-pressed oils. Authenticity of plant oils is also an important issue for religious or cultural reasons.This review article focuses on the application of differential scanning calorimetry (DSC) in the field of assessing authenticity of various fats and oils (e.g. olive oil, palm oil, confectionery fats, butter). Extra virgin olive oil (EVOO) is the most comprehensively tested oil by means of ...
Trends And Applications Of Food Protein-Origin Hydrolysates And Bioactive Peptides,
2022
Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
Trends And Applications Of Food Protein-Origin Hydrolysates And Bioactive Peptides, Yi-Hsieng Samuel Wu, Yi-Chen Chen
Journal of Food and Drug Analysis
It was reported that protein hydrolysates or derived peptides have more functionalities than their parent protein. Most functional protein hydrolysates or peptides are identified from various food products, including plant, fish, and land-animal protein sources. Within a few decades, the application of food protein-origin functional hydrolysates or peptides could be divided into two main categories according to their applied intentions: 1) preservatives and bioactive packing materials; 2) nutraceutical ingredients. According to the literature, the applications of food protein-origin functional hydrolysates or peptides on food preservative and nutraceutical ingredients have attracted much attention. However, the approach method should be changed. Multi-activities ...
Toxicological Assessment Of Zinc Oxide And Titanium Dioxide On Staghorn Coral, Acropora Cervicornis,
2022
Nova Southeastern University
Toxicological Assessment Of Zinc Oxide And Titanium Dioxide On Staghorn Coral, Acropora Cervicornis, Katherine E. Meurer
All HCAS Student Capstones, Theses, and Dissertations
Coral reefs are one of the most diverse and biologically significant ecosystems on the planet. However, anthropogenic impacts have led to a global decline in overall reef health in recent years. To address concerns that organic ultraviolet filters in sunscreen may contribute to reduced coral health, the mineral UV filters, zinc oxide (ZnO) and titanium dioxide (TiO2), have become more common in sunscreen formulas as they are often considered “reef safe” despite limited information on the toxicological effects of these compounds in corals. This study evaluated the effects of exposure to unmodified forms of zinc oxide or titanium dioxide ...
Atrazine Levels In Rural Nebraska Counties And Parkinson's Disease,
2022
University of Nebraska Medical Center
Atrazine Levels In Rural Nebraska Counties And Parkinson's Disease, Muhammad Zahid
Capstone Experience
Parkinson's disease (PD) is a multifactorial disorder, connecting both genetic susceptibility and environmental risk factors. Several epidemiological and experimental studies support the evidence that pesticides exposure is positively associated with enhancing neurodegenerative diseases. The high amount of atrazine used in Nebraska and increased PD cases led us to evaluate the association between the long-lived water-soluble pesticide atrazine and PD in Nebraska counties. A person's exposure to atrazine may come from inhalation, dermal absorption, and ingestion. Three types of atrazine data covering 1992 to 2017 were used for this study: applied atrazine, atrazine in surface water, and atrazine in ...
Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry,
2022
Western Kentucky University
Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry, Pallavi Ragi
Masters Theses & Specialist Projects
Steroidal hormones are naturally produced as a part of many physiological processes and are excreted in the urine and feces of animals and humans. Farm animals in concentrated animal feeding operations (CAFOs) are routinely implanted with synthetic and natural hormones to enhance growth and production, contributing significantly to environmental steroid hormone contamination. Every year around 49 tons of estrogens are generated by livestock waste in the United States alone. Due to rainfall and runoff, these steroid hormones reach the environment when animal waste is applied as manure. Studies show that estrogens and other steroidal hormones present in the surface waters ...
Floating Treatment Wetlands For Brackish Waters: Plant Selection And Nutrient Uptake Potential.,
2022
Clemson University
Floating Treatment Wetlands For Brackish Waters: Plant Selection And Nutrient Uptake Potential., Andrea Landaverde
All Theses
Brackish water bodies in coastal regions provide critical ecosystem services that support human and environmental health. Anthropogenic activities such as agricultural and industrial activities, construction, urban settlements, and tourism contribute to increased inputs of nitrogen (N) and phosphorus (P) in brackish coastal ecosystems. Excess nutrients can lead to impaired water quality and affect marine organisms. Floating treatment wetlands (FTWs) are a vegetated-base technology used to remove contaminants from water column, that has been mainly studied and applied in freshwater systems. Application of FTWs in brackish systems requires further investigation, as high salinity in brackish waters could result in toxicity to ...
Effects Of 2,4-Di-Tert-Butylphenol On Osteogenic And Myogenic Differentiation Of Human Induced Pluripotent Stem Cells,
2022
Clemson University
Effects Of 2,4-Di-Tert-Butylphenol On Osteogenic And Myogenic Differentiation Of Human Induced Pluripotent Stem Cells, Thanh-Bình Dương
All Theses
Synthetic phenolic antioxidants (SPAs) are a class of compounds used to increase the durability of polymers as well as to increase the shelf-life of food, cosmetics, and other personal care items. Of these SPAs is 2,4-di-tert-butylphenol (2,4-DBP). 2,4-DBP is primarily used in polyethylene crosspolymer pipes, which are now used as a replacement for the traditional copper pipes for household water distribution. However, 2,4-DBP has been found to leach from these pipes into the water, enabling a mode of exposure to humans. 2,4-DBP has been detected in human urine, serum, but more importantly, maternal ...
Differential Transcriptome Analysis Reveals That Cache Valley Pm2.5 Triggers The Unfolded Protein Response In Human Lung Cells,
2022
Utah State University
Differential Transcriptome Analysis Reveals That Cache Valley Pm2.5 Triggers The Unfolded Protein Response In Human Lung Cells, Morgan Eggleston
All Graduate Theses and Dissertations
Worldwide, exposure to air pollution is a serious human health threat. Particulate matter (PM) air pollution is a mixture of suspended solid and/or liquid particles and particle size is determined by its aerodynamic diameter. Fine, or “respirable” particles, typically from vehicle emissions, manufacturing, power generation, agriculture, as well as secondary photochemical reactions, are classified as ≤2.5μm in diameter (PM2.5). Upon inhalation, PM2.5 particles can reach the lower, more sensitive regions of the lung, enter the bloodstream, and be distributed to other areas in the body. Large-scale epidemiology studies have shown that PM2.5 ...
Evaluation Of Biochemical And Pathological Parameters At Different Doses Of Cisplatin In Experimental Animal Model: Toxicological Study On An Antineoplastic Drug,
2022
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka 1229, Bangladesh
Evaluation Of Biochemical And Pathological Parameters At Different Doses Of Cisplatin In Experimental Animal Model: Toxicological Study On An Antineoplastic Drug, Farhana Sultana, Muhammed Mohibul Islam, Mohammad Nurul Amin, Nusrat Jahan, Asma Kabir, Talha Bin Emran, Bibek Chandra Sutradhar, Sujan Banik
Makara Journal of Health Research
Background: This study aimed to assess the effect of cisplatin-induced toxicities on biochemical and pathological parameters such as body, liver, and kidney weights, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), and blood cells (RBCs and WBCs) in white Swiss albino mice.
Methods: Cisplatin’s potential toxic effects on body, liver, and kidney weights were evaluated using standard laboratory methods. Blood biochemical levels such as BUN, creatinine, and ALT levels were determined by an auto-hemolyzer using commercial diagnostic kits. Blood cells (RBCs and WBCs) were counted under a microscope by a hemocytometer.
Results: Cisplatin’s potential toxic effects on body ...
Accumulation Of Persistent Organic Pollutants In Marine Mammals: A Case Study On Cetaceans, Pinnipeds, And Sirenians,
2022
Nova Southeastern University
Accumulation Of Persistent Organic Pollutants In Marine Mammals: A Case Study On Cetaceans, Pinnipeds, And Sirenians, Alydia Moorhead
All HCAS Student Capstones, Theses, and Dissertations
Persistent organic pollutants (POPs) are lipophilic semi-volatile organic chemicals that present a range of challenges to marine biota, specifically marine mammals that often occupy a high trophic position in the food web. POPs have become a global problem since they have been shown to cause immunologic, teratogenic, carcinogenic, neurological, and reproductive complications in living organisms due to their resistance to biodegradation and their lipophilic nature. Marine mammals can accumulate these toxic substances through direct ingestion, trophic transfer, adsorption, and maternal offloading. They are susceptible to both bioaccumulation and biomagnification of POPs. Accumulation of POPs is affected by many variables, including ...
Black Carbon And Meteorological Parameters At Two Locations In Northern Mississippi,
2022
University of Mississippi
Black Carbon And Meteorological Parameters At Two Locations In Northern Mississippi, Ashton Swader
Honors Theses
Black Carbon, which is a component of fine particulate matter, is a known pollutant that has been linked to the development of several diseases including cardiovascular disease. This pollutant can be measured by taking samples of air within a certain region and analyzing them using a transmissometer. It is known that black carbon concentrations tend to be higher in urban areas when compared to rural areas within a region. Black carbon concentrations can also vary depending on certain meteorological parameters such as temperature and humidity. There were no current studies that analyze the air quality in northern Mississippi due to ...
The Effects Of Paclitaxel On Cellular Migration And The Cytoskeleton,
2022
University of Southern Maine
The Effects Of Paclitaxel On Cellular Migration And The Cytoskeleton, Ashley Salguero-Gonzalez
Thinking Matters Symposium
In a clinical setting, some patients are exposed to an anti-cancer chemotherapy agent, paclitaxel. Cancerous cells undergo rapid, continuous cell division without control. Chemotherapy treatments try to slow and stop the uncontrollable cell division cycles and eliminate cancerous cells in the process. Paclitaxel serves as a treatment for some types of cancers, including lung, melanoma, bladder, and esophageal. Because it targets the cytoskeleton, paclitaxel can also influence cell migration. This project utilizes a cellular migration assay and an immunohistochemistry assay to analyze the effects of paclitaxel on the movement of cells and on the cytoskeleton of neuroglia rat cells with ...