College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea
Using Lanthanide Ions As Magnetic And Sensing Probes For The Detection Of Tetracycline From Complex Samples,
2023
Department of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan
Using Lanthanide Ions As Magnetic And Sensing Probes For The Detection Of Tetracycline From Complex Samples, Yan-Cen Zhan, Chin-Poa Chiu, Yu-Chie Chen
Journal of Food and Drug Analysis
Tetracycline (TC) is a broad-spectrum antibiotic and has been added to animal feeds to grow livestock under healthy conditions, making it important to have effective methods for rapidly detecting TC in complex samples. In this study, a novel method that uses lanthanide ions (i.e. Eu3+ and Gd3+) as magnetic and sensing probes for the detection of TC from aqueous samples is explored. When dissolving Gd3+ in tris(hydroxymethyl)aminomethane (Tris) buffer at pH 9, magnetic Gd3+-Tris conjugates can be readily generated. The magnetic Gd3+-Tris conjugates possess trapping capacity toward TC from sample solutions via …
Urolithin A Exhibits A Neuroprotective Effect Against Alzheimer’S Disease By Inhibiting Dyrk1a Activity,
2023
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, No.250, Wu-Xing Street, Xinyi Dist., Taipei 110, Taiwan
Urolithin A Exhibits A Neuroprotective Effect Against Alzheimer’S Disease By Inhibiting Dyrk1a Activity, Huang-Ju Tu, Chih-Jou Su, Chao-Shiang Peng, Tony Eight Lin, Wei-Chun Huang Fu, Kai-Cheng Hsu, Tsong-Long Hwang, Shiow-Lin Pan
Journal of Food and Drug Analysis
Alzheimer’s disease (AD) is a devastating neurodegenerative disease with more than 50 million people suffer from it. Unfortunately, none of the currently available drugs is able to improve cognitive impairment in AD patients. Urolithin A (UA) is a metabolite obtained from ellagic acid and ellagitannin through the intestinal flora, and it has antioxidant and anti-inflammatory properties. Previous reports found that UA had neuroprotective effects in an AD animal model, but the detailed mechanism still needs to be elucidated. In this study, we performed kinase-profiling to show that dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is the main target of UA. Studies …
Chemometrics-Assisted Spectroscopic Methods For Rapid Analysis Of Combined Anti-Malarial Tablets,
2023
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
Chemometrics-Assisted Spectroscopic Methods For Rapid Analysis Of Combined Anti-Malarial Tablets, Panawan Pruksapha, Putthiporn Khongkaew, Chaweewan Suwanvecho, Nantana Nuchtavorn, Chutima Phechkrajang, Leena Suntornsuk
Journal of Food and Drug Analysis
Combination of piperaquine (PQ) (320 mg) and dihydroartemisinin (DHA) (40 mg) is an anti-malarial formulation, which is recommended by World Health Organization (WHO). Simultaneous analysis of PQ and DHA can be problematic due to the lack of chromophores or fluorophores in DHA molecule. Whereas PQ possesses strong UV absorption and it presents in 8 times of DHA contents in the formulation. In this study, two spectroscopic methods, Fourier transform infrared (FTIR) and Raman spectroscopy, were developed for the determination of both drugs in combined tablets. The FTIR and Raman spectra were recorded in the attenuate total reflectance (ATR) and scattering …
Three-Dimensional Strategies In The Quantitative Resolution Of Kinetic Uv Absorbance Measurements For Monitoring The Oxidation Of Quercetin By Oxidant Agents And Analyzing Dietary Supplement Product,
2023
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06560 Yenimahalle, Ankara, Turkey
Three-Dimensional Strategies In The Quantitative Resolution Of Kinetic Uv Absorbance Measurements For Monitoring The Oxidation Of Quercetin By Oxidant Agents And Analyzing Dietary Supplement Product, Erdal Di̇nç, Asiye Üçer, Nazangül Ünal
Journal of Food and Drug Analysis
Three-dimensional strategies involving the application of parallel factor analysis (PARAFAC) to the kinetic UV absorbance measurements were elaborated to monitor the oxidation of quercetin with oxidant agents (K2Cr2O7 and KIO3) and to quantify analyte in a dietary supplement product. Loadings (spectral, kinetic and concentration profiles) were obtained by the PARAFAC deconvolution. Spectral identification, kinetics and quantification of the relevant analyte in the presence of interferent(s) were performed. The elaborated chemometric strategies were carefully validated to demonstrate the capability of the method. Assay results of the PARAFAC strategies were statistically compared to that of …
Resveratrol Stimulates Star Expression And Progesterone Production By Gper-Mediated Downregulation Of Snail Expression In Human Granulosa Cells,
2023
Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Resveratrol Stimulates Star Expression And Progesterone Production By Gper-Mediated Downregulation Of Snail Expression In Human Granulosa Cells, Tinglin Song, Jiaye Chen, Sizhu Yang, Boqun Liu, Lingling Zhang, Qian Zhang, Jung-Chien Cheng, Lanlan Fang
Journal of Food and Drug Analysis
Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed the treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced induction of StAR expression and P4 production.
Selective Detection Of Tricyclazole By Optical Technique Using Thiomalic Acid–Modified Au And Ag Nanoparticle Mixtures,
2023
Department of Chemistry, National Changhua University of Education, 1 Jin-De road, Changhua City, 50007, Taiwan
Selective Detection Of Tricyclazole By Optical Technique Using Thiomalic Acid–Modified Au And Ag Nanoparticle Mixtures, Yu-Shu Pan, Tsunghsueh Wu, Cho-Chun Hu, Tai-Chia Chiu, Chen-Hao Yeh, Yang-Wei Lin
Journal of Food and Drug Analysis
This study proposes the use of thiomalic acid–modified Au and Ag nanoparticle mixtures (TMA-Au/AgNP mixes) for the selective detection of tricyclazole. Upon the addition of tricyclazole, the color of TMA-Au/AgNP mixes solution changes from orange-red to lavender (red-shift). According to the density-functional theory calculations, tricyclazole-induced aggregation of TMA-Au/AgNP mixes through electron donor–acceptor interactions was proved. The sensitivity and selectivity of the proposed method are affected by the amount of TMA, volume ratio of TMA-AuNPs to TMA-AgNPs, pH value, and buffer concentration. The ratio of absorbance (A654/A520) of TMA-Au/AgNP mixes solution is proportional to the concentration of …
Development Of A Lateral Flow Immunoassays-Based Method For The Screening Of Ractopamine In Foods And Evaluation Of The Optimal Strategy In Combination Of Screening And Confirmatory Tests,
2023
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan
Development Of A Lateral Flow Immunoassays-Based Method For The Screening Of Ractopamine In Foods And Evaluation Of The Optimal Strategy In Combination Of Screening And Confirmatory Tests, Yuan-Chih Chen, Jen-Yi Hsu, Chien-Sheng Chen, Yi-Ting Chen, Pao-Chi Liao
Journal of Food and Drug Analysis
Ractopamine has been authorized as a feed additive and permitted in animal husbandry. With the establishment of the regulation to limit the concentration of ractopamine, a rapid screening method for ractopamine is urgently needed. Additionally, how to combine the screening and confirmatory tests of ractopamine is also critical to maximizing the efficiency of testing. Here, we developed a lateral flow immunoassays-based method for the screening of ractopamine in foods and proposed a cost-benefit analysis approach to optimize cost allocation between screening and confirmatory tests. After verifying the analytical and clinical performance of the screening method, a mathematical model was established …
Sleep-Promoting Activity Of Amylase-Treated Ashwagandha (Withania Somnifera L. Dunal) Root Extract Via Gaba Receptors,
2023
BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul 02841, Korea
Sleep-Promoting Activity Of Amylase-Treated Ashwagandha (Withania Somnifera L. Dunal) Root Extract Via Gaba Receptors, Chun Woong Park, Ki-Bae Hong, Hyung Joo Suh, Yejin Ahn
Journal of Food and Drug Analysis
Ashwagandha (Withania somnifera L. Dunal), an Indian medicinal plant that has been used for centuries to treat insomnia, exhibits a variety of biological activities, such as improving cognitive function, immunity and anxiety. In this study, the effect of enzyme-treated Ashwagandha root extract (EA) and on sleep was evaluated using rodent models. Starch contained in the Ashwagandha root extract was removed by amylase treatment to prepare EA. To evaluate the sleep-promoting activity of EA, a pentobarbital-induced sleep test and electroencephalogram analysis were performed. In addition, the sleep-promoting mechanism of EA was elucidated by analyzing the expression of sleep-related receptors. In …
The Inhibitory Effect Of Quercetin-3-Glucuronide On Pulmonary Injury In Vitro And In Vivo,
2023
Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan
The Inhibitory Effect Of Quercetin-3-Glucuronide On Pulmonary Injury In Vitro And In Vivo, Pei-Rong Yua, Jen-Ying Hsu, Chiao-Yun Tseng, Jing-Hsien Chen, Hui-Hsuan Lin
Journal of Food and Drug Analysis
Pulmonary injury is defined as a progressive inflammation. Extensive pro-inflammatory cytokines are secreted from alveolus, associated with the production of reactive oxygen species (ROS) and apoptosis. The model of endotoxin lipopolysaccharide (LPS)-stimulated lung cells has been applied to mimic the pulmonary injury. Some antioxidants and anti-inflammatory compounds can be used as chemopreventive agents of pulmonary injury. Quercetin-3-glucuronide (Q3G) has been showed to exert antioxidant, anti-inflammatory, anti-cancer, anti-aging and anti-hypertension effects. The aim of the study is to examine the inhibitory potential of Q3G on pulmonary injury and inflammation in vitro and in vivo. Firstly, human lung fibroblasts MRC-5 cells pre-treated …
Electrochemically Synthesized Green Fluorescent Carbon Dots For Quantitation Of Hypochlorite And Carbendazim,
2023
Department of Applied Science, National Taitung University, Taitung, Taiwan
Electrochemically Synthesized Green Fluorescent Carbon Dots For Quantitation Of Hypochlorite And Carbendazim, Kuan-Min Lo, Yu-Shen Lin, Je-Wen Liou, Tai-Chia Chiu, Cho-Chun Hu
Journal of Food and Drug Analysis
Green emission carbon dots (CDs) electrochemically prepared from 2,6-pyridinedicarboxylic acid and o-phenylenediamine were applied separately for the quantitation of hypochlorite and carbendazim. The characteristic and optical properties of the CDs were studied through fluorescence, UV–vis absorption, X-ray photoelectron spectroscopy, and transmission electron microscopy. The synthesized CDs were mainly 0.8–2.2 nm in size, with an average size of 1.5 nm. The CDs exhibited green luminescence centered at 520 nm when excited by 420 nm light. The green emission of the CDs is quenched after the addition of hypochlorite, mainly through the redox reaction between hypochlorite and hydroxyl groups on the CDs …
Preparation Procedures Of Food And Beverage Samples For Oxygen Bomb Calorimetry: A Scoping Review And Reporting Checklist,
2023
School of Health Sciences and Social Work, Griffith University, Gold Coast, QLD, Australia
Preparation Procedures Of Food And Beverage Samples For Oxygen Bomb Calorimetry: A Scoping Review And Reporting Checklist, Zane Hopper, Ben Desbrow, Shelley Roberts, Chris Irwin
Journal of Food and Drug Analysis
Standardised bomb calorimetry methods are essential to accurately quantify the gross energy within food and beverages, yet no accepted protocols exist. The objective of this review was to synthesise literature on food and beverage sample preparation methods used for conducting bomb calorimetry. This synthesis enhances our understanding of the extent to which methodological variances may currently affect estimates of the caloric values of dietary items. Five electronic databases were searched for peer reviewed literature on food and beverage energy measurement via bomb calorimetry. Data were extracted on seven identified methodological themes, including: (1) initial homogenisation, (2) sample dehydration, (3) post-dehydration …
What Nature Has To Offer: Opportunities For Immuno-Oncology,
2023
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan
What Nature Has To Offer: Opportunities For Immuno-Oncology, Rubina Kousar, Cheng-Han Lin, Bbumba Patrick, Miao He, Dong-Chuan Wu, Xing-Guo Li
Journal of Food and Drug Analysis
Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologically active compounds in immuno-oncology may open new avenues for more effective cancer therapies. In this review, we …
The Therapeutic Potential Of Curcumin And Its Related Substances In Turmeric: From Raw Material Selection To Application Strategies,
2023
Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan
The Therapeutic Potential Of Curcumin And Its Related Substances In Turmeric: From Raw Material Selection To Application Strategies, Kai-Yu Hsu, Chi-Tang Ho, Min-Hsiung Pan
Journal of Food and Drug Analysis
Turmeric (Curcuma longa L.) is a medicinal plant used extensively in Chinese and Indian traditional medicine as a home remedy for various diseases. It has been used for medical purposes for centuries. Today, turmeric has become one of the most popular medicinal herbs, spices, and functional supplements worldwide. Curcuminoids are linear diarylheptanoids from the rhizomes that include curcumin and two related compounds: demethoxycurcumin and bisdemethoxycurcumin, which are the active components of the C. longa plant, play a crucial role in numerous functions. This review summarises the composition of turmeric and the properties of curcumin regarding its antioxidant, anti-inflammatory, anti-diabetic, …
Hydromethanolic Extract Of Ipomoea Cairica Leaf Extract Ameliorate The Oxidative Activity Of Cadmium Chloride In The Hearts And Testes Of Male Wistar Rats,
2023
Department of Biochemistry, Faculty of Science, Federal University Otuoke, Otuoke, Bayelsa State, Nigeria
Hydromethanolic Extract Of Ipomoea Cairica Leaf Extract Ameliorate The Oxidative Activity Of Cadmium Chloride In The Hearts And Testes Of Male Wistar Rats, Omotayo Babatunde Ilesanmi, Toyin Binang, Ridwan Abiodun Lawal
Al-Bahir Journal for Engineering and Pure Sciences
Background: Ipomoea cairica (L.) sweet Convolvulaceae also known as morning glory or ‘Railway creeper’ is a traditional herb that has been used in treating various diseases throughout the world. Some of the reported pharmacological activities include antioxidant, anti-inflammatory, and antiviral. Cadmium is a toxic metal that can cause both hearts and testicular damage and its major mechanism is oxidative stress. Objective: Therefore, this study was done to investigate the effect of I. cairica leaf extract (ICE) against cadmium chloride-induced hearts and testicular damage in Wistar rats. Materials and Methods: Twenty male Wistar rats were divided into 4 groups of 5 …
Drug Ideologies Of The United States,
2023
Liberty University
Drug Ideologies Of The United States, Macy Montgomery
Helm's School of Government Conference - American Revival: Citizenship & Virtue
The United States has been increasingly creating lenient drug policies. Seventeen states and Washington, the District of Columbia, legalized marijuana, and Oregon decriminalized certain drugs, including methamphetamine, heroin, and cocaine. The medical community has proven that drugs, including marijuana, have myriad adverse health side effects. This leads to two questions: Why does the United States government continue to create lenient drug policies, and what reasons do citizens give for legalizing drugs when the medical community has proven them harmful? The paper hypothesizes that the disadvantages of drug legalization outweigh its benefits because of the numerous harms it causes, such as …
Investigating Stormwater Parameters From Runoff On East Tennessee State University Campus,
2023
East Tennessee State University
Investigating Stormwater Parameters From Runoff On East Tennessee State University Campus, Abby Mciver, Dr. Joseph R. Bidwell
Undergraduate Honors Theses
Climate change has caused an increase in extreme rain events and flooding in certain regions across the globe. During rain events, water flows over impervious surfaces structures such as roads and sidewalks, picking up contaminants such as metals, fertilizers and other nutrients, and various organics that which may impact organisms in such as streams, river, and lakes. Previous work has found significant differences in survival of organisms that were exposed to contaminated stormwater runoff. This study investigated stormwater chemistry parameters at collection sites on the East Tennessee State University campus. Sites were selected based on the extent of human interaction …
Changes In Energy Metabolism Induced By Pfos And Dietary Oxylipins,
2023
Clemson University
Changes In Energy Metabolism Induced By Pfos And Dietary Oxylipins, William Evans
All Theses
Perfluorooctanesulfonate (PFOS), an emerging environmental toxicant in addition to 9- hydroxyoctadecadienoic acid (9-HODE) and 9-hydroxyoctadecatrienoic acid (9-HOTrE), endogenously produced oxylipins from polyunsaturated fatty acids (PUFAs) by Cytochrome P450 2B6 (CYP2B6) have been recently associated with hepatic steatosis and peroxisome proliferator- activated receptor signaling by data produced from our laboratory and others. Given the importance of mitochondrial energy metabolism in the maintenance of lipid homeostasis, an array of extracellular flux assays was performed using HepG2 cells to test for the ability of these compounds to disrupt overall mitochondrial activity and respiration associated with fatty acid oxidation and glycolysis specifically. PFOS and …
Role Of Salinity In Perfluorooctane Sulfonate (Pfos) Bioconcentration Between Aquatic Species And The Differential Regulation Of Transporters In Fundulus Heteroclitus,
2023
Clemson University
Role Of Salinity In Perfluorooctane Sulfonate (Pfos) Bioconcentration Between Aquatic Species And The Differential Regulation Of Transporters In Fundulus Heteroclitus, Tyler Davis
All Theses
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that is known for its surfactant properties and its resistance to degradation. The persistence and lipophilicity of PFOS in surface waters have led to its bioaccumulation in fish, which in turn leads to its accumulation and toxic effects in humans that consume fish. PFOS is also hypothesized to perturb reproduction and survival of low and mid-trophic level zooplankton species such as Daphnia magna that are food for multiple fish species. In this study, a 21-day D. magna chronic toxicity test was performed using 1,10, 100, 1000, and 5000 ppb of PFOS to …
Mechanisms Of Cigarette Smoke-Induced Mitochondrial Dysfunction In Striated Muscle And Aorta,
2023
University of Massachusetts Amherst
Mechanisms Of Cigarette Smoke-Induced Mitochondrial Dysfunction In Striated Muscle And Aorta, Stephen T. Decker
Doctoral Dissertations
Cigarette Smoke is a significant cause of morbidity and mortality in the United States, accounting for over 480,000 annual deaths. Of these deaths, the most common cause of mortality in chronic smokers is cardiometabolic diseases. Likewise, a significant portion of smokers experience some form of cardiac, vascular, or metabolic dysfunction throughout their lifetime. More specifically, smoking is shown to induce mitochondrial dysfunction in these tissues, causing an increase in oxidative damage and poor overall health. However, despite the advances in the health outcomes related to cigarette smoke exposure, the mechanisms underlying mitochondrial dysfunction in striated muscle and the vasculature remain …
Potential Of Constructed Wetlands For The Treatment Of Heavy Metals From Wastewater,
2023
Department of Soil and Environmental Sciences. MNS-University of Agriculture, Multan. Pakistan.
Potential Of Constructed Wetlands For The Treatment Of Heavy Metals From Wastewater, Hasnain Raza, Qurat Ul Ain, Haseena Bibi, Tehmina Bibi, Huda Bilal
Journal of Bioresource Management
Overpopulation, urbanization, and economic race increase the pressure on freshwater resources resulted in water scarcity challenges around the globe. Moreover, the generation of wastewater also enhancing the scarcity threats for freshwater resources. Water scarcity issues forced the policymaker, thinker, scientist, and researcher to think about non-conventional water resources to cope with the increasing demands. Because of this wastewater recycling and treatment play an evident role to fulfill the growing demand for freshwater in socioeconomic sectors especially, for agriculture due to its 70 % dependency on freshwater resources. Different wastewater treatment methods along with merits and demerits are in practice for …
