Open Access. Powered by Scholars. Published by Universities.®

Toxicology Commons

Open Access. Powered by Scholars. Published by Universities.®

1,857 Full-Text Articles 5,042 Authors 415,791 Downloads 143 Institutions

All Articles in Toxicology

Faceted Search

1,857 full-text articles. Page 1 of 80.

Comparing Effects Of Atrazine Exposure On Neuroendocrine Molecular Targets At Two Developmental Exposure Periods In The Zebrafish, Jenna Swihart 2024 Purdue University

Comparing Effects Of Atrazine Exposure On Neuroendocrine Molecular Targets At Two Developmental Exposure Periods In The Zebrafish, Jenna Swihart

The Journal of Purdue Undergraduate Research

No abstract provided.


Lake Water Chemistry And Local Adaptation Shape Nacl Toxicity In Daphnia Ambigua, Mary Alta Rogalski, Elizabeth S. Baker, Clara M. Benadon 2024 Bowdoin College

Lake Water Chemistry And Local Adaptation Shape Nacl Toxicity In Daphnia Ambigua, Mary Alta Rogalski, Elizabeth S. Baker, Clara M. Benadon

Biology Faculty Publications

Increasing application of road deicing agents (e.g., NaCl) has caused widespread salinization of freshwater environments. Chronic exposure to toxic NaCl levels can impact freshwater biota at genome to ecosystem scales, yet the degree of harm caused by road salt pollution is likely to vary among habitats and populations. The background ion chemistry of freshwater environments may strongly impact NaCl toxicity, with greater harm occurring in ion-poor, soft water conditions. In addition, populations exposed to salinization may evolve increased NaCl tolerance. Notably, if organisms are adapted to their natal lake water chemistry, toxicity responses may also vary among populations in a …


Aversion Properties Of Retrorsine, Retrorsine Nitrogen Oxide And Frosted Senecio Latifolius, Leendert D. Snyman 2023 Toxicology, Agricultural Research Council, Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, South Africa

Aversion Properties Of Retrorsine, Retrorsine Nitrogen Oxide And Frosted Senecio Latifolius, Leendert D. Snyman

Poisonous Plant Research (PPR)

Two pilot trials, investigating the aversive properties of retrorsine and retrorsine nitrogen oxide and that of frosted Senecio latifolius, were executed. Retrorsine and retrorsine-NO (the toxic principles of Senecio retrorsus), unlke sceleratine-NO (the toxic principle of another hepatotoxic pyrrolizidine alkaloid containing plant, namely S. latifolius), were not capable of establishing aversion when given to a sheep. Frosted S. latifolius given to a sheep also did not induce aversion. However, a sheep averted to S. latifolius (non-frosted) refused eating frosted S. latifolius.


Sceleratin Nitrogen Oxide As Aversive Agent In Conditioning Livestock To Avoid Senecio Latifolius, Leendert D. Snyman 2023 Toxicology, Agricultural Research Council, Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, South Africa

Sceleratin Nitrogen Oxide As Aversive Agent In Conditioning Livestock To Avoid Senecio Latifolius, Leendert D. Snyman

Poisonous Plant Research (PPR)

Sceleratine nitrogen oxide, when administered together with a dichloromethane extract of Senecio latifolius, successfully conditioned cattle and sheep to avoid milled freeze dried S. latifolius mixed with maize meal. This treatment was effectively applied in conditioning steers to refuse eating S. latifolius grown in pots.


Corrigendum To "Ssr-Based Molecular Diagnosis For Taiwan Tea Cultivars And Its Application In Identifying Cultivar Composition Of The Processed Tea", 2023 Taiwan Food and Drug Administration

Corrigendum To "Ssr-Based Molecular Diagnosis For Taiwan Tea Cultivars And Its Application In Identifying Cultivar Composition Of The Processed Tea"

Journal of Food and Drug Analysis

No abstract provided.


Acknowledgment Of Reviewers, 2023 Taiwan Food and Drug Administration

Acknowledgment Of Reviewers

Journal of Food and Drug Analysis

No abstract provided.


Application Of The Us Food And Drug Administration’S Sentinel Routine Querying Tools To The Taiwan Sentinel Data Model-Formatted National Health Insurance Research Database, Fang-Ju Lin, Ling-Ya Huang, Chi-Chuan Wang, Sengwee Toh 2023 Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan

Application Of The Us Food And Drug Administration’S Sentinel Routine Querying Tools To The Taiwan Sentinel Data Model-Formatted National Health Insurance Research Database, Fang-Ju Lin, Ling-Ya Huang, Chi-Chuan Wang, Sengwee Toh

Journal of Food and Drug Analysis

The U.S. Food and Drug Administration’s Sentinel System is a leading distributed data network for drug safety surveillance in the world. The National Health Insurance Research Database (NHIRD) in Taiwan was converted into the Taiwan Sentinel Data Model (TSDM) based on the Sentinel Common Data Model (SCDM) version 6.0.2. The goal of this study was to investigate the feasibility of applying the same study designs, analytic choices, and analytic tools as used by the U.S. Sentinel System to examine the same drug-outcome associations in the TSDM-formatted NHIRD. Four known drug-outcome associations previously examined by the U.S. Sentinel System were selected …


Isolation Of Glp-1 Enhancing Indolizidine Alkaloids From Boehmeria Formosana, Ching-Yi Lu, Zheng-Ying Huang, Meng-Chin Chen, Hui-Kang Liu, Shoei-Sheng Lee, Chia-Chuan Chang 2023 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.

Isolation Of Glp-1 Enhancing Indolizidine Alkaloids From Boehmeria Formosana, Ching-Yi Lu, Zheng-Ying Huang, Meng-Chin Chen, Hui-Kang Liu, Shoei-Sheng Lee, Chia-Chuan Chang

Journal of Food and Drug Analysis

Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.


An Integrated Strategy To Evaluate Active Substances Of Astragali Radix-Carthami Flos Combination On The Treatment Of Cerebral Ischemia Reperfusion Injury Based On Tqsm Polypharmacokinetics And Pharmacodynamics, Qiang Zeng, Chang Li, Shouchao Xu, Yu He 2023 School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, PR China

An Integrated Strategy To Evaluate Active Substances Of Astragali Radix-Carthami Flos Combination On The Treatment Of Cerebral Ischemia Reperfusion Injury Based On Tqsm Polypharmacokinetics And Pharmacodynamics, Qiang Zeng, Chang Li, Shouchao Xu, Yu He

Journal of Food and Drug Analysis

As a classic herb pair, Astragali Radix-Carthami Flos (AR-CF) has revealed good biological activity in the treatment of cerebral ischemia/reperfusion injury (CI/RI), which remained to be further clarified together with the underlying efficacy related compounds for material basis. In this study, the nine formulations were obtained by L9(34) orthogonal array design of four active fractions (saponin and flavonoid extracted from AR, safflower yellow and safflower red extracted from CF). The concentrations of eleven components and the levels of four biochemical indicators in rat plasma were continuously detected after intragastric administration of nine formulations, respectively. The collected …


Cryptocaryone Induces Apoptosis In Human Hepatocellular Carcinoma Cells By Inhibiting Aerobic Glycolysis Through Akt And C-Src Signaling Pathways, Chen-Lin Yu, Yu-Wei Lai, Jih-Jung Chen, Jie-Jen Lee, Tsung-Hsien Chou, Chen-Chen Huang, Shih-Chia Liu, Guang-Wei Chen, Chung‐Hsin Tsai, Shih-Wei Wang 2023 Institute of Biomedical Science, MacKay Medical College, New Taipei City, Taiwan

Cryptocaryone Induces Apoptosis In Human Hepatocellular Carcinoma Cells By Inhibiting Aerobic Glycolysis Through Akt And C-Src Signaling Pathways, Chen-Lin Yu, Yu-Wei Lai, Jih-Jung Chen, Jie-Jen Lee, Tsung-Hsien Chou, Chen-Chen Huang, Shih-Chia Liu, Guang-Wei Chen, Chung‐Hsin Tsai, Shih-Wei Wang

Journal of Food and Drug Analysis

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with the second highest mortality rate in all cancer. Energy reprogramming is one of the hallmarks of cancer, and emerging evidence showed that targeting glycolysis is a promising strategy for HCC treatment. Cryptocaryone has been shown to display promising anti-cancer activity against numerous types of cancer. Previous study also indicated that cryptocaryone induces cytotoxicity by inhibiting glucose transport in cancer cells, but the detailed mechanism still needs to be elucidated. Therefore, this study aimed to investigate the relationship between the anti-cancer effect and glycolytic metabolism of cryptocaryone in human …


Dehulled Adlay (Coix Lachryma-Jobi L.) Ameliorates Hepatic Gluconeogenesis And Steatosis In Streptozotocin/High-Fat Diet-Induced Diabetic Rats, Shing-Hwa Liu, Wan-Hsin Wu, Huei-Ping Tzeng, Wenchang Chiang, Meng-Tsan Chiang 2023 Institute of Toxicology, National Taiwan University, Taipei, Taiwan

Dehulled Adlay (Coix Lachryma-Jobi L.) Ameliorates Hepatic Gluconeogenesis And Steatosis In Streptozotocin/High-Fat Diet-Induced Diabetic Rats, Shing-Hwa Liu, Wan-Hsin Wu, Huei-Ping Tzeng, Wenchang Chiang, Meng-Tsan Chiang

Journal of Food and Drug Analysis

Adlay (Coix lachryma-jobi L.) is a traditional Chinese herbal medicine with various biological activities. We investigated the anti-diabetic effects of different parts of adlay seeds, including polished adlay (PA), adlay bran (AB) and dehulled adlay (DA) in a streptozotocin (STZ)/high fat diet (HFD) diabetic rat model (DM). DM rats supplemented with or without PA (43%), AB (3%), or DA (46%) diet for 8 weeks. The plasma glucose and insulin levels and the insulin resistance index (HOMA-IR) were increased in DM group; among the three adlay diets, DA has the best effects attenuating all of these alterations in DM …


Biological And Clinical Significance Of The Age-Rage Axis In The Aggressiveness And Prognosis Of Prostate Cancer, Shih-Hong Khoo, Pei-Ru Wu, Kun-Tu Yeh, Shih-Lan Hsu, Chi-Hao Wu 2023 School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110301, Taiwan

Biological And Clinical Significance Of The Age-Rage Axis In The Aggressiveness And Prognosis Of Prostate Cancer, Shih-Hong Khoo, Pei-Ru Wu, Kun-Tu Yeh, Shih-Lan Hsu, Chi-Hao Wu

Journal of Food and Drug Analysis

Dietary factors and chronic hyperglycemia are linked to the formation of advanced glycation end products (AGEs) and prostate cancer (PCa) risk. The activation of the receptor for AGEs (RAGE) acts as a bridge between various RAGE ligands and certain malignancies. This study showed that the interaction of AGEs and RAGE promoted PCa cell proliferation, invasion, and autophagy-mediated survival in response to chemotherapeutic agents. RAGE-overexpressed PCa cells underwent epithelial-mesenchymal transition and showed increased cancer stem cell-like properties. In mouse xenograft models, RAGE-overexpressed cells showed more substantial tumorigenic capacity than parental cells, whereas RAGE knockdown decreased tumorigenicity. The clinical data validated a …


Steamed Daylily Flower (Hemerocallis Fulva L.) Protected Cardiac And Hepatic Cells Against Ethanol Induced Apoptotic And Oxidative Damage, Sheng-Lei Yan, Wen-Tzu Wu, Mei-Chin Mong, Mei-Chin Yin 2023 Department of Internal Medicine, Chang Bing Show-Chwan Memorial Hospital, Changhua County, Taiwan

Steamed Daylily Flower (Hemerocallis Fulva L.) Protected Cardiac And Hepatic Cells Against Ethanol Induced Apoptotic And Oxidative Damage, Sheng-Lei Yan, Wen-Tzu Wu, Mei-Chin Mong, Mei-Chin Yin

Journal of Food and Drug Analysis

Our previous study examined the phytochemical composition and bio-activities of raw daylily flower (Hemerocallis fulva L.). However, this plant food is usually served via heat process such as cooking in a soup. This study aimed to investigate the phytochemical profile and biofunctions of steamed daylily flower (SDF). The content of total phenolic acids, total flavonoids, total carotenoids, total anthocyanins and total triterpenoids in SDF aqueous extract was assessed. Normal cardiac and hepatic cells, H9c2 and L-02 cells, were used to evaluate the protective effects of SDF against ethanol. SDF concentrations of 0.25%, 0.5%, and 1% were applied to treat …


Analysis And Identification Of Phenolic Compounds With Antiproliferative Activity From Chinese Olive (Canarium Album L.) Fruit Extract By Hplc-Dad-Spe-Tt-Nmr, Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh 2023 Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan

Analysis And Identification Of Phenolic Compounds With Antiproliferative Activity From Chinese Olive (Canarium Album L.) Fruit Extract By Hplc-Dad-Spe-Tt-Nmr, Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh

Journal of Food and Drug Analysis

Chinese olives (Canarium album L.) are rich in phenolic compounds, exhibiting a broad spectrum of potential clinical applications. This study is the first report on the isolation and elucidation of bioactive compounds with high antiproliferative activity from the ethyl acetate fraction of a Chinese olive fruit methanolic extract (CO-EtOAc). We used the WST-1 assay to determine which subfractions of CO-EtOAc had significant antiproliferative activity using the murine colon cancer cell line CT26. Subsequently, the functional compounds were characterized by the hyphenated technique and high-performance liquid chromatography-diode array detector-solid phase extraction-transfer tube-nuclear magnetic resonance (HPLC-DAD-SPE-TT-NMR). Thirteen phenolic constituents were identified …


Glycine-Rich Peptides From Fermented Chenopodium Formosanum Sprout As An Antioxidant To Modulate The Oxidative Stress, Chen-Che Hsieh, Shu-Han Yu, Hsing-Chun Kuo, Darin Khumsupan, Hsiao-Chu Huang, Yu-Wei Liou, Chen-Yu Kao, Szu-Chuan Shen, Kuan-Chen Cheng 2023 Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan

Glycine-Rich Peptides From Fermented Chenopodium Formosanum Sprout As An Antioxidant To Modulate The Oxidative Stress, Chen-Che Hsieh, Shu-Han Yu, Hsing-Chun Kuo, Darin Khumsupan, Hsiao-Chu Huang, Yu-Wei Liou, Chen-Yu Kao, Szu-Chuan Shen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodium formosanum sprouts (FCS) in a bioreactor. Subsequently, the antioxidant activity of food proteins derived from FCS was investigated. Results showed that glycine-rich peptide (GGGGGKP, G-rich peptide), identified from the < 2 kDa FCS proteins, had antioxidant values. According to SwissADME, AllerTOP, ToxinPred, and BIOPEP-UWM analyses, G-rich peptide was identified as safe, non-toxic, and non-allergenic. Afterward, the peptide was examined using in silico and in vitro studies to evaluate its potential alleviating oxidative stress caused by particulate matter. This study proposed plausible mechanisms that involve the binding of G-rich peptide which inhibited phosphorylation of the v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) subunit on NF-κB pathway. The inhibition then resulted in down regulation of NF-κB transcription and genetic expression of inflammatory …


Investigation Of Microwave Extraction Of Red Cabbage And Its Neurotherapeutic Potential, Halil Koyu, Serdar Demir, Mehmet Zeki Haznedaroglu 2023 Department of Pharmaceutical Botany, Faculty of Pharmacy, Izmir Katip Celebi University, 35620, Cigli-Izmir, Turkey

Investigation Of Microwave Extraction Of Red Cabbage And Its Neurotherapeutic Potential, Halil Koyu, Serdar Demir, Mehmet Zeki Haznedaroglu

Journal of Food and Drug Analysis

In the pursuit of bioactive compounds with health benefits from food and medicinal plants, optimization of process to reduce solvent, raw material, energy and time consumption has been a valuable research objective. Sustainable management and efficient use of natural resources are of critical importance for sustainability goals. In this manner, microwave extraction of red cabbage which has been a mass cultivated plant for food purposes, was optimized for maximizing acetylcholinesterase, butyrylcholinesterase, tyrosinase inhibitory activity and bioactive content. Quantitative analysis of total phenol, flavonoid and anthocyanin content were performed using spectrophotometry and UPLC-DAD-ESI-MS/MS. Optimum conditions were determined as 600 W, 100% …


Abundance Of Prevotella Copri In Gut Microbiota Is Inversely Related To A Healthy Diet In Patients With Type 2 Diabetes, Chih-Yiu Tsai, Po-Yu Liu, Meng-Chuan Huang, Chiao-I Chang, Hsin-Yun Chen, Yu-Hsien Chou, Chi-Neu Tsai, Chia-Hung Lin 2023 Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Abundance Of Prevotella Copri In Gut Microbiota Is Inversely Related To A Healthy Diet In Patients With Type 2 Diabetes, Chih-Yiu Tsai, Po-Yu Liu, Meng-Chuan Huang, Chiao-I Chang, Hsin-Yun Chen, Yu-Hsien Chou, Chi-Neu Tsai, Chia-Hung Lin

Journal of Food and Drug Analysis

While the gut microbiota is known to be influenced by habitual food intake, this relationship is seldom explored in type 2 diabetes patients. This study aims to investigate the relationship between dietary patterns and gut microbial species abundance in 113 type 2 diabetes patients (mean age, 58 years; body mass index, 29.1; glycohemoglobin [HbA1c], 8.1%). We analyzed the gut microbiota using 16S amplicon sequencing, and all patients were catogorized into either the Bacteroides enterotype (57.5%, n = 65) or the Prevotella enterotype (42.5%, n = 48) using the partitioning around medoids clustering algorithm, based on the most representative genera. Patients …


Therapeutic Effects Of Orally Administration Of Viable And Inactivated Probiotic Strains Against Murine Urinary Tract Infection, Vo Thi Hong Van, Zhen-Shu Liu, Yueh Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen 2023 Department of Veterinary Medicine, National Chung Hsing University, Taichung 40249, Taiwan

Therapeutic Effects Of Orally Administration Of Viable And Inactivated Probiotic Strains Against Murine Urinary Tract Infection, Vo Thi Hong Van, Zhen-Shu Liu, Yueh Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen

Journal of Food and Drug Analysis

Urinary tract infections (UTIs) are highly prevalent bacterial infections that pose significant health risks. Specific probiotic strains have been recommended for UTI control and management of antibiotic resistance. Otherwise, paraprobiotics, defined as inactivated probiotic cells, offer potential advantages by minimizing risks associated with live microorganisms. However, the effectiveness of heat-killed probiotic strains against UTIs remains uncertain. Additionally, lactoferrin (LF), an iron-binding glycoprotein, exhibits immunomodulatory, antimicrobial, and anti-inflammatory properties. Recently, we had developed recombinant LF-expression probiotics, which can display considerate antibacterial activities against select food-borne pathogens in vitro. Thus, the present study aimed to evaluate the antibacterial activities of heat-killed natural …


Recent Advances In Combined Avant-Garde Technologies (Thermal-Thermal, Non-Thermal-Non-Thermal, And Thermal-Non-Thermal Matrix) To Extract Polyphenols From Agro Byproducts, Isaac Duah Boateng 2023 Division of Food, Nutrition and Exercise Sciences, University of Missouri, Columbia, MO, 65211, United States of America.

Recent Advances In Combined Avant-Garde Technologies (Thermal-Thermal, Non-Thermal-Non-Thermal, And Thermal-Non-Thermal Matrix) To Extract Polyphenols From Agro Byproducts, Isaac Duah Boateng

Journal of Food and Drug Analysis

Because food byproducts (waste) are rich in phytoconstituents, valorizing them is crucial for global food security. However, conventional extraction (CE), including decoction, maceration, Soxhlet, etc., for agro byproducts’ polyphenol extraction are time-consuming and rely significantly on vast volumes of potentially aggressive solvents. Hence, Avant-garde extraction technologies, including non-thermal (high hydrostatic pressure (HHPE), pulsed-electric field (PEF), high voltage electrical discharges (HVED), etc.) and thermal extraction (supercritical fluid (SCF), subcritical water extraction (SWE), microwave-assisted extraction (MAE), etc.), as well as their thermal combinations (SCF-PLE, SCCO2-SWE, SCCO2-MAE, etc.), non-thermal combinations (HHPE+UAE, PEF+UAE, HVED+UAE, etc.) and combined thermal-non-thermal (MAE-UAE, etc.) are increasingly replacing CE. …


Isolation Of The Toxic Principle Of Senecio Latifolius By Means Of The Sensory Receptors Of Sheep, Leendert D. Snyman 2023 Toxicology, Agricultural Research Council, Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, South Africa

Isolation Of The Toxic Principle Of Senecio Latifolius By Means Of The Sensory Receptors Of Sheep, Leendert D. Snyman

Poisonous Plant Research (PPR)

The aversive substance of Senecio latifolius was isolated by means of the sensory receptors of sheep averted to S. latifolius. Chemical fractions refused due to the presence of the aversive substance sensed by the sheep were fractionated until a purified substance had been isolated. Nuclear magnetic resonance (NMR) analysis of the purified substance showed it to be sceleratine nitrogen oxide, the toxic principle of S. latifolius.


Digital Commons powered by bepress